Chromatin binding protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

regulator of chromatin condensation, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHE4_LEIDO

TriTrypDb:

LdBPK_110420.1 , LdCL_110009100 , LDHU3_11.0520

Length:

777

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHE4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.520
CLV_C14_Caspase3-7	504	508	PF00656	0.676
CLV_C14_Caspase3-7	708	712	PF00656	0.576
CLV_NRD_NRD_1	367	369	PF00675	0.511
CLV_NRD_NRD_1	448	450	PF00675	0.547
CLV_NRD_NRD_1	467	469	PF00675	0.600
CLV_PCSK_KEX2_1	367	369	PF00082	0.511
CLV_PCSK_KEX2_1	448	450	PF00082	0.548
CLV_PCSK_KEX2_1	467	469	PF00082	0.617
CLV_PCSK_SKI1_1	401	405	PF00082	0.494
CLV_PCSK_SKI1_1	425	429	PF00082	0.590
CLV_PCSK_SKI1_1	499	503	PF00082	0.608
CLV_PCSK_SKI1_1	690	694	PF00082	0.561
CLV_PCSK_SKI1_1	700	704	PF00082	0.543
DEG_MDM2_SWIB_1	593	600	PF02201	0.605
DEG_SPOP_SBC_1	653	657	PF00917	0.630
DEG_SPOP_SBC_1	76	80	PF00917	0.358
DEG_SPOP_SBC_1	772	776	PF00917	0.767
DOC_CDC14_PxL_1	287	295	PF14671	0.545
DOC_CYCLIN_RxL_1	364	373	PF00134	0.566
DOC_MAPK_RevD_3	453	468	PF00069	0.485
DOC_USP7_MATH_1	13	17	PF00917	0.568
DOC_USP7_MATH_1	158	162	PF00917	0.434
DOC_USP7_MATH_1	219	223	PF00917	0.597
DOC_USP7_MATH_1	227	231	PF00917	0.477
DOC_USP7_MATH_1	278	282	PF00917	0.715
DOC_USP7_MATH_1	325	329	PF00917	0.662
DOC_USP7_MATH_1	370	374	PF00917	0.500
DOC_USP7_MATH_1	435	439	PF00917	0.742
DOC_USP7_MATH_1	493	497	PF00917	0.585
DOC_USP7_MATH_1	506	510	PF00917	0.670
DOC_USP7_MATH_1	56	60	PF00917	0.627
DOC_USP7_MATH_1	637	641	PF00917	0.746
DOC_USP7_MATH_1	644	648	PF00917	0.768
DOC_USP7_MATH_1	654	658	PF00917	0.445
DOC_USP7_MATH_1	730	734	PF00917	0.738
DOC_USP7_MATH_1	751	755	PF00917	0.472
DOC_USP7_MATH_1	766	770	PF00917	0.576
DOC_USP7_MATH_1	773	777	PF00917	0.738
DOC_USP7_UBL2_3	355	359	PF12436	0.708
DOC_WW_Pin1_4	215	220	PF00397	0.675
DOC_WW_Pin1_4	268	273	PF00397	0.743
DOC_WW_Pin1_4	274	279	PF00397	0.676
DOC_WW_Pin1_4	561	566	PF00397	0.764
DOC_WW_Pin1_4	632	637	PF00397	0.714
LIG_14-3-3_CanoR_1	265	272	PF00244	0.486
LIG_14-3-3_CanoR_1	327	331	PF00244	0.605
LIG_14-3-3_CanoR_1	391	400	PF00244	0.490
LIG_14-3-3_CanoR_1	407	414	PF00244	0.470
LIG_14-3-3_CanoR_1	537	547	PF00244	0.604
LIG_14-3-3_CanoR_1	595	601	PF00244	0.586
LIG_14-3-3_CanoR_1	632	636	PF00244	0.654
LIG_14-3-3_CanoR_1	650	654	PF00244	0.412
LIG_14-3-3_CanoR_1	700	709	PF00244	0.511
LIG_14-3-3_CanoR_1	752	756	PF00244	0.406
LIG_APCC_ABBAyCdc20_2	734	740	PF00400	0.393
LIG_BIR_II_1	1	5	PF00653	0.536
LIG_BRCT_BRCA1_1	372	376	PF00533	0.419
LIG_BRCT_BRCA1_1	598	602	PF00533	0.533
LIG_BRCT_BRCA1_1	656	660	PF00533	0.551
LIG_FHA_1	164	170	PF00498	0.439
LIG_FHA_1	183	189	PF00498	0.277
LIG_FHA_1	72	78	PF00498	0.366
LIG_FHA_2	122	128	PF00498	0.571
LIG_FHA_2	199	205	PF00498	0.702
LIG_FHA_2	39	45	PF00498	0.560
LIG_FHA_2	393	399	PF00498	0.658
LIG_FHA_2	408	414	PF00498	0.416
LIG_FHA_2	706	712	PF00498	0.633
LIG_Integrin_RGD_1	299	301	PF01839	0.534
LIG_LIR_Gen_1	16	23	PF02991	0.351
LIG_LIR_Gen_1	190	199	PF02991	0.433
LIG_LIR_Gen_1	310	319	PF02991	0.516
LIG_LIR_Gen_1	373	382	PF02991	0.553
LIG_LIR_Gen_1	500	508	PF02991	0.682
LIG_LIR_Gen_1	594	605	PF02991	0.577
LIG_LIR_Gen_1	736	747	PF02991	0.482
LIG_LIR_Nem_3	16	21	PF02991	0.361
LIG_LIR_Nem_3	190	194	PF02991	0.430
LIG_LIR_Nem_3	301	305	PF02991	0.406
LIG_LIR_Nem_3	310	315	PF02991	0.518
LIG_LIR_Nem_3	373	379	PF02991	0.504
LIG_LIR_Nem_3	500	505	PF02991	0.621
LIG_LIR_Nem_3	594	600	PF02991	0.498
LIG_LIR_Nem_3	736	742	PF02991	0.395
LIG_LYPXL_yS_3	290	293	PF13949	0.454
LIG_MLH1_MIPbox_1	372	376	PF16413	0.549
LIG_PCNA_yPIPBox_3	612	621	PF02747	0.574
LIG_Pex14_1	482	486	PF04695	0.431
LIG_Pex14_2	371	375	PF04695	0.529
LIG_Pex14_2	51	55	PF04695	0.559
LIG_Pex14_2	593	597	PF04695	0.559
LIG_SH2_CRK	18	22	PF00017	0.437
LIG_SH2_CRK	241	245	PF00017	0.494
LIG_SH2_CRK	72	76	PF00017	0.413
LIG_SH2_NCK_1	18	22	PF00017	0.437
LIG_SH2_NCK_1	739	743	PF00017	0.471
LIG_SH2_STAP1	18	22	PF00017	0.437
LIG_SH2_STAP1	739	743	PF00017	0.510
LIG_SH2_STAT5	170	173	PF00017	0.475
LIG_SH2_STAT5	18	21	PF00017	0.442
LIG_SH2_STAT5	189	192	PF00017	0.527
LIG_SH2_STAT5	486	489	PF00017	0.495
LIG_SH2_STAT5	624	627	PF00017	0.452
LIG_SH3_3	123	129	PF00018	0.576
LIG_SH3_3	132	138	PF00018	0.573
LIG_SH3_3	285	291	PF00018	0.377
LIG_SH3_3	387	393	PF00018	0.527
LIG_SH3_3	541	547	PF00018	0.697
LIG_SH3_3	569	575	PF00018	0.585
LIG_SH3_3	683	689	PF00018	0.546
LIG_SUMO_SIM_anti_2	43	50	PF11976	0.462
LIG_SUMO_SIM_par_1	73	80	PF11976	0.449
LIG_TRAF2_1	530	533	PF00917	0.581
LIG_TYR_ITIM	239	244	PF00017	0.517
LIG_TYR_ITIM	288	293	PF00017	0.524
LIG_TYR_ITIM	737	742	PF00017	0.380
LIG_WRC_WIRS_1	52	57	PF05994	0.596
MOD_CK1_1	121	127	PF00069	0.528
MOD_CK1_1	16	22	PF00069	0.505
MOD_CK1_1	248	254	PF00069	0.349
MOD_CK1_1	271	277	PF00069	0.762
MOD_CK1_1	281	287	PF00069	0.629
MOD_CK1_1	40	46	PF00069	0.481
MOD_CK1_1	462	468	PF00069	0.481
MOD_CK1_1	561	567	PF00069	0.781
MOD_CK1_1	57	63	PF00069	0.343
MOD_CK1_1	8	14	PF00069	0.640
MOD_CK1_1	99	105	PF00069	0.671
MOD_CK2_1	38	44	PF00069	0.466
MOD_CK2_1	392	398	PF00069	0.645
MOD_CK2_1	407	413	PF00069	0.428
MOD_CK2_1	485	491	PF00069	0.586
MOD_CK2_1	730	736	PF00069	0.631
MOD_DYRK1A_RPxSP_1	215	219	PF00069	0.694
MOD_DYRK1A_RPxSP_1	632	636	PF00069	0.654
MOD_GlcNHglycan	221	224	PF01048	0.529
MOD_GlcNHglycan	225	228	PF01048	0.544
MOD_GlcNHglycan	372	375	PF01048	0.545
MOD_GlcNHglycan	386	390	PF01048	0.589
MOD_GlcNHglycan	437	440	PF01048	0.706
MOD_GlcNHglycan	443	446	PF01048	0.698
MOD_GlcNHglycan	461	464	PF01048	0.258
MOD_GlcNHglycan	548	551	PF01048	0.652
MOD_GlcNHglycan	557	563	PF01048	0.707
MOD_GlcNHglycan	56	59	PF01048	0.527
MOD_GlcNHglycan	581	584	PF01048	0.508
MOD_GlcNHglycan	640	643	PF01048	0.736
MOD_GlcNHglycan	7	10	PF01048	0.605
MOD_GlcNHglycan	768	771	PF01048	0.649
MOD_GSK3_1	158	165	PF00069	0.354
MOD_GSK3_1	207	214	PF00069	0.749
MOD_GSK3_1	215	222	PF00069	0.593
MOD_GSK3_1	223	230	PF00069	0.531
MOD_GSK3_1	264	271	PF00069	0.649
MOD_GSK3_1	274	281	PF00069	0.725
MOD_GSK3_1	4	11	PF00069	0.658
MOD_GSK3_1	435	442	PF00069	0.712
MOD_GSK3_1	538	545	PF00069	0.584
MOD_GSK3_1	589	596	PF00069	0.528
MOD_GSK3_1	644	651	PF00069	0.709
MOD_GSK3_1	71	78	PF00069	0.413
MOD_GSK3_1	96	103	PF00069	0.584
MOD_LATS_1	423	429	PF00433	0.584
MOD_N-GLC_1	281	286	PF02516	0.619
MOD_N-GLC_2	175	177	PF02516	0.515
MOD_NEK2_1	162	167	PF00069	0.417
MOD_NEK2_1	264	269	PF00069	0.544
MOD_NEK2_1	326	331	PF00069	0.600
MOD_NEK2_1	385	390	PF00069	0.569
MOD_NEK2_1	440	445	PF00069	0.744
MOD_NEK2_1	593	598	PF00069	0.487
MOD_NEK2_1	75	80	PF00069	0.376
MOD_NEK2_2	13	18	PF00069	0.432
MOD_NEK2_2	150	155	PF00069	0.490
MOD_NEK2_2	611	616	PF00069	0.508
MOD_NEK2_2	751	756	PF00069	0.511
MOD_PIKK_1	271	277	PF00454	0.748
MOD_PKA_2	207	213	PF00069	0.746
MOD_PKA_2	242	248	PF00069	0.539
MOD_PKA_2	264	270	PF00069	0.451
MOD_PKA_2	326	332	PF00069	0.649
MOD_PKA_2	538	544	PF00069	0.573
MOD_PKA_2	631	637	PF00069	0.650
MOD_PKA_2	649	655	PF00069	0.407
MOD_PKA_2	751	757	PF00069	0.406
MOD_PKA_2	96	102	PF00069	0.556
MOD_Plk_1	158	164	PF00069	0.468
MOD_Plk_1	350	356	PF00069	0.699
MOD_Plk_1	385	391	PF00069	0.548
MOD_Plk_1	531	537	PF00069	0.464
MOD_Plk_1	589	595	PF00069	0.571
MOD_Plk_1	648	654	PF00069	0.703
MOD_Plk_4	13	19	PF00069	0.542
MOD_Plk_4	158	164	PF00069	0.459
MOD_Plk_4	251	257	PF00069	0.374
MOD_Plk_4	289	295	PF00069	0.554
MOD_Plk_4	531	537	PF00069	0.457
MOD_Plk_4	614	620	PF00069	0.449
MOD_Plk_4	71	77	PF00069	0.417
MOD_Plk_4	751	757	PF00069	0.403
MOD_ProDKin_1	215	221	PF00069	0.658
MOD_ProDKin_1	268	274	PF00069	0.746
MOD_ProDKin_1	561	567	PF00069	0.762
MOD_ProDKin_1	632	638	PF00069	0.719
MOD_SUMO_rev_2	557	562	PF00179	0.728
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.452
TRG_DiLeu_BaLyEn_6	572	577	PF01217	0.637
TRG_ENDOCYTIC_2	18	21	PF00928	0.442
TRG_ENDOCYTIC_2	241	244	PF00928	0.490
TRG_ENDOCYTIC_2	290	293	PF00928	0.431
TRG_ENDOCYTIC_2	72	75	PF00928	0.328
TRG_ENDOCYTIC_2	739	742	PF00928	0.546
TRG_ER_diArg_1	367	369	PF00400	0.551
TRG_ER_diArg_1	448	450	PF00400	0.556
TRG_ER_diArg_1	466	468	PF00400	0.600

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Q9	Leptomonas seymouri	46%	100%
A0A0S4IQ49	Bodo saltans	27%	100%
A0A1X0NV79	Trypanosomatidae	29%	100%
A0A3S5ISC4	Trypanosoma rangeli	30%	100%
A4H6F8	Leishmania braziliensis	77%	100%
A4HUV3	Leishmania infantum	99%	100%
D0A7K1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9ANI8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QH38	Leishmania major	90%	100%
V5BB49	Trypanosoma cruzi	30%	100%