Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHE2_LEIDO

TriTrypDb:

LdBPK_342760.1 , LdCL_340035700 , LDHU3_34.4750

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHE2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	12	16	PF00082	0.597
CLV_PCSK_SKI1_1	127	131	PF00082	0.364
CLV_PCSK_SKI1_1	174	178	PF00082	0.402
CLV_PCSK_SKI1_1	184	188	PF00082	0.502
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DOC_MAPK_gen_1	44	52	PF00069	0.388
DOC_MAPK_MEF2A_6	44	52	PF00069	0.409
DOC_USP7_MATH_1	62	66	PF00917	0.652
DOC_USP7_MATH_1	78	82	PF00917	0.715
DOC_USP7_UBL2_3	12	16	PF12436	0.565
DOC_WW_Pin1_4	92	97	PF00397	0.530
LIG_14-3-3_CanoR_1	109	118	PF00244	0.458
LIG_14-3-3_CanoR_1	4	10	PF00244	0.561
LIG_14-3-3_CanoR_1	70	74	PF00244	0.554
LIG_BRCT_BRCA1_1	150	154	PF00533	0.454
LIG_eIF4E_1	148	154	PF01652	0.388
LIG_FHA_1	148	154	PF00498	0.349
LIG_FHA_1	166	172	PF00498	0.435
LIG_FHA_1	43	49	PF00498	0.424
LIG_FHA_1	98	104	PF00498	0.621
LIG_FHA_2	21	27	PF00498	0.605
LIG_LIR_Gen_1	38	43	PF02991	0.383
LIG_LIR_Gen_1	5	14	PF02991	0.579
LIG_LIR_Nem_3	38	42	PF02991	0.370
LIG_LIR_Nem_3	5	9	PF02991	0.520
LIG_Pex14_2	6	10	PF04695	0.536
LIG_SH2_CRK	161	165	PF00017	0.415
LIG_SH2_NCK_1	25	29	PF00017	0.418
LIG_SH2_NCK_1	58	62	PF00017	0.634
LIG_SH2_SRC	25	28	PF00017	0.414
LIG_SH2_STAP1	58	62	PF00017	0.619
LIG_SH3_3	128	134	PF00018	0.385
LIG_SH3_3	14	20	PF00018	0.562
LIG_SUMO_SIM_par_1	48	54	PF11976	0.449
MOD_CDK_SPK_2	92	97	PF00069	0.530
MOD_CDK_SPxxK_3	92	99	PF00069	0.528
MOD_CK1_1	110	116	PF00069	0.430
MOD_CK1_1	172	178	PF00069	0.460
MOD_CK1_1	5	11	PF00069	0.635
MOD_CK1_1	54	60	PF00069	0.550
MOD_CK1_1	66	72	PF00069	0.692
MOD_CK1_1	77	83	PF00069	0.737
MOD_CK1_1	86	92	PF00069	0.766
MOD_CK2_1	20	26	PF00069	0.488
MOD_GlcNHglycan	53	56	PF01048	0.403
MOD_GlcNHglycan	65	68	PF01048	0.665
MOD_GlcNHglycan	74	77	PF01048	0.726
MOD_GlcNHglycan	80	83	PF01048	0.720
MOD_GlcNHglycan	85	88	PF01048	0.749
MOD_GlcNHglycan	91	94	PF01048	0.693
MOD_GSK3_1	107	114	PF00069	0.448
MOD_GSK3_1	144	151	PF00069	0.433
MOD_GSK3_1	165	172	PF00069	0.428
MOD_GSK3_1	62	69	PF00069	0.622
MOD_GSK3_1	74	81	PF00069	0.726
MOD_N-GLC_1	78	83	PF02516	0.529
MOD_NEK2_1	107	112	PF00069	0.407
MOD_NEK2_1	2	7	PF00069	0.512
MOD_NEK2_1	42	47	PF00069	0.415
MOD_PK_1	169	175	PF00069	0.393
MOD_PKA_2	69	75	PF00069	0.530
MOD_PKB_1	167	175	PF00069	0.393
MOD_Plk_1	169	175	PF00069	0.409
MOD_Plk_4	148	154	PF00069	0.340
MOD_Plk_4	172	178	PF00069	0.424
MOD_Plk_4	5	11	PF00069	0.593
MOD_ProDKin_1	92	98	PF00069	0.529
MOD_SUMO_for_1	98	101	PF00179	0.601
MOD_SUMO_rev_2	124	129	PF00179	0.454
TRG_ENDOCYTIC_2	161	164	PF00928	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXG2	Leptomonas seymouri	70%	96%
A0A0S4J1H8	Bodo saltans	40%	100%
A0A0S4J255	Bodo saltans	40%	98%
A0A1X0PAS6	Trypanosomatidae	50%	100%
A0A3R7K5Q8	Trypanosoma rangeli	54%	100%
A4HB12	Leishmania braziliensis	79%	100%
A4IA69	Leishmania infantum	100%	100%
C9ZM37	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9B582	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2Q1	Leishmania major	91%	100%