RING-variant domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RING-variant domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHD5_LEIDO

TriTrypDb:

LdBPK_270120.1 , LdCL_270006100 , LDHU3_27.0160

Length:

633

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 1
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A0A3Q8IHD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHD5

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0008270	zinc ion binding	6	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.698
CLV_NRD_NRD_1	439	441	PF00675	0.328
CLV_PCSK_KEX2_1	439	441	PF00082	0.328
CLV_PCSK_SKI1_1	189	193	PF00082	0.625
CLV_PCSK_SKI1_1	208	212	PF00082	0.576
CLV_PCSK_SKI1_1	266	270	PF00082	0.492
CLV_PCSK_SKI1_1	321	325	PF00082	0.451
CLV_PCSK_SKI1_1	376	380	PF00082	0.587
CLV_PCSK_SKI1_1	430	434	PF00082	0.325
CLV_PCSK_SKI1_1	498	502	PF00082	0.603
CLV_PCSK_SKI1_1	580	584	PF00082	0.671
CLV_PCSK_SKI1_1	60	64	PF00082	0.676
DEG_APCC_DBOX_1	265	273	PF00400	0.438
DEG_SCF_FBW7_1	139	144	PF00400	0.432
DEG_SPOP_SBC_1	141	145	PF00917	0.427
DOC_CYCLIN_RxL_1	474	486	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	95	101	PF00134	0.385
DOC_MAPK_MEF2A_6	266	274	PF00069	0.438
DOC_MAPK_MEF2A_6	30	37	PF00069	0.377
DOC_MAPK_MEF2A_6	376	385	PF00069	0.636
DOC_MAPK_MEF2A_6	66	75	PF00069	0.445
DOC_PP1_RVXF_1	352	358	PF00149	0.704
DOC_PP2B_LxvP_1	408	411	PF13499	0.525
DOC_PP2B_LxvP_1	95	98	PF13499	0.382
DOC_USP7_MATH_1	141	145	PF00917	0.427
DOC_USP7_MATH_1	176	180	PF00917	0.442
DOC_USP7_MATH_1	326	330	PF00917	0.682
DOC_USP7_MATH_1	6	10	PF00917	0.614
DOC_USP7_MATH_1	69	73	PF00917	0.452
DOC_WW_Pin1_4	137	142	PF00397	0.386
DOC_WW_Pin1_4	24	29	PF00397	0.680
DOC_WW_Pin1_4	444	449	PF00397	0.556
DOC_WW_Pin1_4	463	468	PF00397	0.602
LIG_14-3-3_CanoR_1	189	194	PF00244	0.429
LIG_14-3-3_CanoR_1	400	404	PF00244	0.542
LIG_14-3-3_CanoR_1	580	585	PF00244	0.397
LIG_Actin_WH2_2	484	500	PF00022	0.492
LIG_APCC_ABBA_1	383	388	PF00400	0.633
LIG_BRCT_BRCA1_1	205	209	PF00533	0.424
LIG_BRCT_BRCA1_1	416	420	PF00533	0.598
LIG_BRCT_BRCA1_1	557	561	PF00533	0.492
LIG_BRCT_BRCA1_1	574	578	PF00533	0.447
LIG_BRCT_BRCA1_1	76	80	PF00533	0.390
LIG_Clathr_ClatBox_1	559	563	PF01394	0.438
LIG_deltaCOP1_diTrp_1	512	515	PF00928	0.451
LIG_eIF4E_1	205	211	PF01652	0.431
LIG_FHA_1	262	268	PF00498	0.294
LIG_FHA_1	282	288	PF00498	0.517
LIG_FHA_1	32	38	PF00498	0.357
LIG_FHA_1	393	399	PF00498	0.514
LIG_FHA_1	530	536	PF00498	0.421
LIG_FHA_1	581	587	PF00498	0.473
LIG_FHA_2	104	110	PF00498	0.356
LIG_FHA_2	175	181	PF00498	0.467
LIG_FHA_2	235	241	PF00498	0.400
LIG_FHA_2	294	300	PF00498	0.633
LIG_FHA_2	503	509	PF00498	0.398
LIG_LIR_Gen_1	128	139	PF02991	0.412
LIG_LIR_Gen_1	277	287	PF02991	0.549
LIG_LIR_Gen_1	447	457	PF02991	0.588
LIG_LIR_Gen_1	558	569	PF02991	0.461
LIG_LIR_Gen_1	571	581	PF02991	0.260
LIG_LIR_Gen_1	602	611	PF02991	0.692
LIG_LIR_Gen_1	89	99	PF02991	0.384
LIG_LIR_Nem_3	128	134	PF02991	0.432
LIG_LIR_Nem_3	194	200	PF02991	0.401
LIG_LIR_Nem_3	277	283	PF02991	0.427
LIG_LIR_Nem_3	447	452	PF02991	0.558
LIG_LIR_Nem_3	512	516	PF02991	0.456
LIG_LIR_Nem_3	558	564	PF02991	0.461
LIG_LIR_Nem_3	571	576	PF02991	0.237
LIG_LIR_Nem_3	602	607	PF02991	0.684
LIG_LIR_Nem_3	89	95	PF02991	0.367
LIG_LIR_Nem_3	96	102	PF02991	0.346
LIG_LYPXL_SIV_4	525	533	PF13949	0.492
LIG_NRBOX	552	558	PF00104	0.422
LIG_Pex14_1	584	588	PF04695	0.342
LIG_Pex14_2	578	582	PF04695	0.517
LIG_Rb_pABgroove_1	501	509	PF01858	0.405
LIG_SH2_CRK	449	453	PF00017	0.592
LIG_SH2_STAP1	127	131	PF00017	0.465
LIG_SH2_STAP1	193	197	PF00017	0.433
LIG_SH2_STAP1	205	209	PF00017	0.314
LIG_SH2_STAP1	307	311	PF00017	0.705
LIG_SH2_STAP1	568	572	PF00017	0.461
LIG_SH2_STAT5	186	189	PF00017	0.454
LIG_SH2_STAT5	193	196	PF00017	0.379
LIG_SH2_STAT5	217	220	PF00017	0.405
LIG_SH2_STAT5	336	339	PF00017	0.659
LIG_SH2_STAT5	449	452	PF00017	0.559
LIG_SH2_STAT5	482	485	PF00017	0.500
LIG_SH2_STAT5	495	498	PF00017	0.296
LIG_SH2_STAT5	526	529	PF00017	0.401
LIG_SH2_STAT5	99	102	PF00017	0.338
LIG_SH3_2	363	368	PF14604	0.739
LIG_SH3_3	158	164	PF00018	0.384
LIG_SH3_3	297	303	PF00018	0.771
LIG_SH3_3	360	366	PF00018	0.745
LIG_SH3_3	451	457	PF00018	0.614
LIG_SUMO_SIM_anti_2	236	243	PF11976	0.346
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.602
LIG_SUMO_SIM_par_1	268	273	PF11976	0.492
LIG_SUMO_SIM_par_1	33	39	PF11976	0.431
LIG_TRAF2_1	387	390	PF00917	0.743
LIG_TYR_ITIM	97	102	PF00017	0.428
LIG_TYR_ITSM	445	452	PF00017	0.559
LIG_UBA3_1	210	215	PF00899	0.427
LIG_WRC_WIRS_1	275	280	PF05994	0.395
LIG_WRC_WIRS_1	601	606	PF05994	0.706
LIG_WRC_WIRS_1	611	616	PF05994	0.661
MOD_CDC14_SPxK_1	27	30	PF00782	0.401
MOD_CDK_SPxK_1	24	30	PF00069	0.516
MOD_CK1_1	104	110	PF00069	0.460
MOD_CK1_1	392	398	PF00069	0.637
MOD_CK1_1	74	80	PF00069	0.445
MOD_CK2_1	103	109	PF00069	0.499
MOD_CK2_1	193	199	PF00069	0.418
MOD_CK2_1	371	377	PF00069	0.711
MOD_CK2_1	384	390	PF00069	0.748
MOD_CK2_1	533	539	PF00069	0.492
MOD_CK2_1	610	616	PF00069	0.664
MOD_GlcNHglycan	103	106	PF01048	0.648
MOD_GlcNHglycan	173	177	PF01048	0.615
MOD_GlcNHglycan	205	208	PF01048	0.625
MOD_GlcNHglycan	388	394	PF01048	0.470
MOD_GlcNHglycan	570	573	PF01048	0.633
MOD_GlcNHglycan	593	596	PF01048	0.429
MOD_GSK3_1	137	144	PF00069	0.427
MOD_GSK3_1	14	21	PF00069	0.688
MOD_GSK3_1	172	179	PF00069	0.465
MOD_GSK3_1	185	192	PF00069	0.404
MOD_GSK3_1	270	277	PF00069	0.482
MOD_GSK3_1	301	308	PF00069	0.739
MOD_GSK3_1	40	47	PF00069	0.404
MOD_GSK3_1	49	56	PF00069	0.375
MOD_GSK3_1	502	509	PF00069	0.478
MOD_GSK3_1	529	536	PF00069	0.376
MOD_GSK3_1	564	571	PF00069	0.546
MOD_GSK3_1	58	65	PF00069	0.383
MOD_GSK3_1	580	587	PF00069	0.429
MOD_GSK3_1	76	83	PF00069	0.384
MOD_N-GLC_1	156	161	PF02516	0.586
MOD_N-GLC_1	381	386	PF02516	0.505
MOD_N-GLC_1	40	45	PF02516	0.623
MOD_N-GLC_1	414	419	PF02516	0.398
MOD_N-GLC_1	533	538	PF02516	0.492
MOD_N-GLC_2	348	350	PF02516	0.482
MOD_NEK2_1	14	19	PF00069	0.567
MOD_NEK2_1	142	147	PF00069	0.412
MOD_NEK2_1	20	25	PF00069	0.555
MOD_NEK2_1	270	275	PF00069	0.457
MOD_NEK2_1	381	386	PF00069	0.751
MOD_NEK2_1	46	51	PF00069	0.457
MOD_NEK2_1	483	488	PF00069	0.492
MOD_NEK2_1	501	506	PF00069	0.427
MOD_NEK2_1	533	538	PF00069	0.420
MOD_NEK2_1	600	605	PF00069	0.562
MOD_NEK2_1	62	67	PF00069	0.387
MOD_NEK2_2	58	63	PF00069	0.509
MOD_NEK2_2	76	81	PF00069	0.462
MOD_PIKK_1	626	632	PF00454	0.689
MOD_PKA_2	399	405	PF00069	0.542
MOD_PKA_2	542	548	PF00069	0.652
MOD_PKB_1	224	232	PF00069	0.403
MOD_Plk_1	376	382	PF00069	0.750
MOD_Plk_1	40	46	PF00069	0.423
MOD_Plk_1	533	539	PF00069	0.478
MOD_Plk_1	584	590	PF00069	0.325
MOD_Plk_2-3	234	240	PF00069	0.448
MOD_Plk_2-3	612	618	PF00069	0.728
MOD_Plk_4	234	240	PF00069	0.405
MOD_Plk_4	270	276	PF00069	0.427
MOD_Plk_4	301	307	PF00069	0.713
MOD_Plk_4	381	387	PF00069	0.706
MOD_Plk_4	447	453	PF00069	0.623
MOD_Plk_4	468	474	PF00069	0.698
MOD_Plk_4	483	489	PF00069	0.398
MOD_Plk_4	502	508	PF00069	0.470
MOD_Plk_4	533	539	PF00069	0.412
MOD_Plk_4	542	548	PF00069	0.669
MOD_Plk_4	555	561	PF00069	0.384
MOD_Plk_4	572	578	PF00069	0.356
MOD_Plk_4	6	12	PF00069	0.585
MOD_Plk_4	76	82	PF00069	0.460
MOD_ProDKin_1	137	143	PF00069	0.389
MOD_ProDKin_1	24	30	PF00069	0.673
MOD_ProDKin_1	444	450	PF00069	0.558
MOD_ProDKin_1	463	469	PF00069	0.601
TRG_DiLeu_BaEn_1	286	291	PF01217	0.654
TRG_ENDOCYTIC_2	118	121	PF00928	0.335
TRG_ENDOCYTIC_2	197	200	PF00928	0.440
TRG_ENDOCYTIC_2	449	452	PF00928	0.559
TRG_ENDOCYTIC_2	482	485	PF00928	0.415
TRG_ENDOCYTIC_2	519	522	PF00928	0.357
TRG_ENDOCYTIC_2	99	102	PF00928	0.431
TRG_ER_diArg_1	123	126	PF00400	0.425
TRG_ER_diArg_1	223	226	PF00400	0.413
TRG_ER_diArg_1	292	295	PF00400	0.717
TRG_ER_diArg_1	354	357	PF00400	0.643
TRG_ER_diArg_1	439	441	PF00400	0.510
TRG_NES_CRM1_1	551	563	PF08389	0.444

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAS2	Leptomonas seymouri	56%	100%
A0A3R7MRQ1	Trypanosoma rangeli	33%	97%
A4HFD1	Leishmania braziliensis	75%	98%
A4I364	Leishmania infantum	99%	100%
E9ACY9	Leishmania major	93%	100%
E9AYR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BGA4	Trypanosoma cruzi	33%	93%