Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHD2_LEIDO

TriTrypDb:

LdBPK_330680.1 , LdCL_330012300 , LDHU3_33.0970

Length:

489

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.617
CLV_C14_Caspase3-7	439	443	PF00656	0.522
CLV_NRD_NRD_1	204	206	PF00675	0.607
CLV_NRD_NRD_1	228	230	PF00675	0.572
CLV_NRD_NRD_1	288	290	PF00675	0.552
CLV_PCSK_FUR_1	361	365	PF00082	0.404
CLV_PCSK_KEX2_1	204	206	PF00082	0.613
CLV_PCSK_KEX2_1	228	230	PF00082	0.572
CLV_PCSK_KEX2_1	287	289	PF00082	0.550
CLV_PCSK_KEX2_1	363	365	PF00082	0.410
CLV_PCSK_KEX2_1	46	48	PF00082	0.603
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.410
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.503
CLV_PCSK_PC7_1	284	290	PF00082	0.436
CLV_PCSK_SKI1_1	178	182	PF00082	0.558
CLV_PCSK_SKI1_1	229	233	PF00082	0.550
CLV_PCSK_SKI1_1	238	242	PF00082	0.370
CLV_PCSK_SKI1_1	25	29	PF00082	0.579
CLV_PCSK_SKI1_1	293	297	PF00082	0.599
CLV_PCSK_SKI1_1	3	7	PF00082	0.404
CLV_PCSK_SKI1_1	407	411	PF00082	0.363
CLV_PCSK_SKI1_1	47	51	PF00082	0.570
DEG_APCC_DBOX_1	177	185	PF00400	0.497
DEG_APCC_DBOX_1	402	410	PF00400	0.392
DEG_Nend_Nbox_1	1	3	PF02207	0.470
DOC_CKS1_1	357	362	PF01111	0.498
DOC_CYCLIN_RxL_1	287	298	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	221	227	PF00134	0.527
DOC_MAPK_gen_1	204	212	PF00069	0.642
DOC_MAPK_gen_1	287	297	PF00069	0.490
DOC_MAPK_gen_1	478	488	PF00069	0.351
DOC_MAPK_MEF2A_6	478	486	PF00069	0.457
DOC_PP2B_LxvP_1	210	213	PF13499	0.635
DOC_USP7_MATH_1	344	348	PF00917	0.460
DOC_USP7_MATH_1	381	385	PF00917	0.570
DOC_USP7_MATH_1	424	428	PF00917	0.638
DOC_USP7_MATH_1	440	444	PF00917	0.443
DOC_USP7_MATH_1	477	481	PF00917	0.402
DOC_USP7_UBL2_3	481	485	PF12436	0.370
DOC_WW_Pin1_4	307	312	PF00397	0.621
DOC_WW_Pin1_4	330	335	PF00397	0.565
DOC_WW_Pin1_4	356	361	PF00397	0.515
DOC_WW_Pin1_4	462	467	PF00397	0.442
DOC_WW_Pin1_4	471	476	PF00397	0.350
DOC_WW_Pin1_4	90	95	PF00397	0.748
LIG_14-3-3_CanoR_1	205	211	PF00244	0.613
LIG_14-3-3_CanoR_1	382	386	PF00244	0.371
LIG_APCC_ABBA_1	335	340	PF00400	0.436
LIG_BIR_III_4	117	121	PF00653	0.603
LIG_BRCT_BRCA1_1	274	278	PF00533	0.440
LIG_FHA_1	156	162	PF00498	0.423
LIG_FHA_1	207	213	PF00498	0.690
LIG_FHA_1	292	298	PF00498	0.538
LIG_FHA_1	357	363	PF00498	0.473
LIG_FHA_1	477	483	PF00498	0.487
LIG_FHA_1	57	63	PF00498	0.568
LIG_FHA_2	123	129	PF00498	0.505
LIG_FHA_2	148	154	PF00498	0.634
LIG_FHA_2	239	245	PF00498	0.403
LIG_FHA_2	28	34	PF00498	0.522
LIG_FHA_2	35	41	PF00498	0.498
LIG_FHA_2	437	443	PF00498	0.576
LIG_FHA_2	6	12	PF00498	0.461
LIG_FHA_2	95	101	PF00498	0.663
LIG_LIR_Gen_1	142	152	PF02991	0.355
LIG_LIR_Gen_1	445	455	PF02991	0.371
LIG_LIR_Nem_3	102	107	PF02991	0.701
LIG_LIR_Nem_3	138	144	PF02991	0.369
LIG_LIR_Nem_3	219	225	PF02991	0.620
LIG_LIR_Nem_3	244	248	PF02991	0.449
LIG_LIR_Nem_3	268	273	PF02991	0.398
LIG_LIR_Nem_3	445	450	PF02991	0.377
LIG_LYPXL_S_1	155	159	PF13949	0.516
LIG_LYPXL_yS_3	104	107	PF13949	0.654
LIG_LYPXL_yS_3	156	159	PF13949	0.501
LIG_PDZ_Class_2	484	489	PF00595	0.505
LIG_SH2_CRK	144	148	PF00017	0.326
LIG_SH2_CRK	472	476	PF00017	0.505
LIG_SH2_STAT5	250	253	PF00017	0.343
LIG_SH2_STAT5	273	276	PF00017	0.428
LIG_SH2_STAT5	455	458	PF00017	0.399
LIG_SH3_3	176	182	PF00018	0.571
LIG_SH3_3	328	334	PF00018	0.541
LIG_SUMO_SIM_par_1	293	298	PF11976	0.506
LIG_TYR_ITSM	100	107	PF00017	0.588
MOD_CDK_SPK_2	307	312	PF00069	0.548
MOD_CDK_SPK_2	356	361	PF00069	0.426
MOD_CDK_SPK_2	90	95	PF00069	0.613
MOD_CDK_SPxxK_3	356	363	PF00069	0.504
MOD_CDK_SPxxK_3	462	469	PF00069	0.447
MOD_CDK_SPxxK_3	471	478	PF00069	0.340
MOD_CK1_1	106	112	PF00069	0.670
MOD_CK1_1	307	313	PF00069	0.708
MOD_CK1_1	448	454	PF00069	0.305
MOD_CK1_1	96	102	PF00069	0.719
MOD_CK2_1	147	153	PF00069	0.488
MOD_CK2_1	238	244	PF00069	0.448
MOD_CK2_1	27	33	PF00069	0.531
MOD_CK2_1	373	379	PF00069	0.415
MOD_CK2_1	5	11	PF00069	0.378
MOD_GlcNHglycan	112	115	PF01048	0.705
MOD_GlcNHglycan	305	309	PF01048	0.627
MOD_GlcNHglycan	390	393	PF01048	0.581
MOD_GlcNHglycan	419	422	PF01048	0.583
MOD_GlcNHglycan	426	429	PF01048	0.574
MOD_GSK3_1	315	322	PF00069	0.635
MOD_GSK3_1	326	333	PF00069	0.546
MOD_GSK3_1	424	431	PF00069	0.584
MOD_GSK3_1	436	443	PF00069	0.570
MOD_GSK3_1	90	97	PF00069	0.733
MOD_GSK3_1	99	106	PF00069	0.631
MOD_NEK2_1	185	190	PF00069	0.477
MOD_NEK2_1	27	32	PF00069	0.456
MOD_NEK2_1	388	393	PF00069	0.426
MOD_PIKK_1	107	113	PF00454	0.733
MOD_PK_1	32	38	PF00069	0.501
MOD_PKA_2	381	387	PF00069	0.479
MOD_PKA_2	428	434	PF00069	0.502
MOD_PKA_2	440	446	PF00069	0.463
MOD_PKA_2	477	483	PF00069	0.429
MOD_PKA_2	94	100	PF00069	0.726
MOD_PKB_1	236	244	PF00069	0.411
MOD_Plk_1	32	38	PF00069	0.656
MOD_Plk_1	99	105	PF00069	0.634
MOD_Plk_4	103	109	PF00069	0.709
MOD_Plk_4	206	212	PF00069	0.642
MOD_Plk_4	217	223	PF00069	0.636
MOD_ProDKin_1	307	313	PF00069	0.620
MOD_ProDKin_1	330	336	PF00069	0.552
MOD_ProDKin_1	356	362	PF00069	0.505
MOD_ProDKin_1	462	468	PF00069	0.442
MOD_ProDKin_1	471	477	PF00069	0.348
MOD_ProDKin_1	90	96	PF00069	0.751
TRG_DiLeu_BaEn_1	16	21	PF01217	0.489
TRG_DiLeu_BaEn_2	22	28	PF01217	0.581
TRG_DiLeu_BaLyEn_6	176	181	PF01217	0.535
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.511
TRG_DiLeu_LyEn_5	16	21	PF01217	0.365
TRG_ENDOCYTIC_2	104	107	PF00928	0.694
TRG_ENDOCYTIC_2	144	147	PF00928	0.305
TRG_ENDOCYTIC_2	156	159	PF00928	0.501
TRG_ENDOCYTIC_2	250	253	PF00928	0.537
TRG_ER_diArg_1	286	289	PF00400	0.522
TRG_NES_CRM1_1	404	419	PF08389	0.452
TRG_Pf-PMV_PEXEL_1	178	183	PF00026	0.589
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.490
TRG_Pf-PMV_PEXEL_1	293	298	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUL5	Leptomonas seymouri	37%	100%
A0A1X0P1W2	Trypanosomatidae	23%	100%
A0A3R7K4P6	Trypanosoma rangeli	24%	100%
A4HLA3	Leishmania braziliensis	72%	100%
A4I8S9	Leishmania infantum	100%	100%
E9B3P5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4E2	Leishmania major	90%	100%
V5BJY6	Trypanosoma cruzi	25%	100%