Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHC5_LEIDO

TriTrypDb:

LdBPK_330470.1 , LdCL_330010200 , LDHU3_33.0720

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHC5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.706
CLV_C14_Caspase3-7	99	103	PF00656	0.488
CLV_NRD_NRD_1	133	135	PF00675	0.699
CLV_NRD_NRD_1	138	140	PF00675	0.654
CLV_NRD_NRD_1	248	250	PF00675	0.619
CLV_NRD_NRD_1	53	55	PF00675	0.827
CLV_PCSK_KEX2_1	133	135	PF00082	0.602
CLV_PCSK_KEX2_1	137	139	PF00082	0.624
CLV_PCSK_KEX2_1	148	150	PF00082	0.410
CLV_PCSK_KEX2_1	225	227	PF00082	0.536
CLV_PCSK_KEX2_1	248	250	PF00082	0.619
CLV_PCSK_KEX2_1	53	55	PF00082	0.753
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.617
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.574
CLV_PCSK_PC7_1	133	139	PF00082	0.709
CLV_PCSK_SKI1_1	267	271	PF00082	0.461
DEG_SPOP_SBC_1	185	189	PF00917	0.590
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.791
DOC_MAPK_gen_1	225	231	PF00069	0.544
DOC_PP1_RVXF_1	265	272	PF00149	0.594
DOC_PP2B_LxvP_1	112	115	PF13499	0.680
DOC_PP2B_LxvP_1	80	83	PF13499	0.794
DOC_USP7_MATH_1	197	201	PF00917	0.787
DOC_WW_Pin1_4	117	122	PF00397	0.632
DOC_WW_Pin1_4	155	160	PF00397	0.361
DOC_WW_Pin1_4	203	208	PF00397	0.782
LIG_14-3-3_CanoR_1	274	283	PF00244	0.631
LIG_APCC_ABBAyCdc20_2	272	278	PF00400	0.609
LIG_FAT_LD_1	150	158	PF03623	0.548
LIG_FHA_1	186	192	PF00498	0.822
LIG_FHA_1	264	270	PF00498	0.461
LIG_FHA_1	39	45	PF00498	0.704
LIG_FHA_1	69	75	PF00498	0.796
LIG_FHA_2	185	191	PF00498	0.747
LIG_LIR_Apic_2	155	159	PF02991	0.536
LIG_LIR_Gen_1	6	14	PF02991	0.701
LIG_LIR_Nem_3	6	10	PF02991	0.790
LIG_PCNA_yPIPBox_3	145	154	PF02747	0.561
LIG_PCNA_yPIPBox_3	234	245	PF02747	0.659
LIG_PDZ_Class_3	283	288	PF00595	0.769
LIG_SH2_STAT5	156	159	PF00017	0.573
LIG_SH2_STAT5	9	12	PF00017	0.704
LIG_SH3_1	29	35	PF00018	0.784
LIG_SH3_3	204	210	PF00018	0.776
LIG_SH3_3	29	35	PF00018	0.784
LIG_SUMO_SIM_par_1	69	75	PF11976	0.755
LIG_TRAF2_1	230	233	PF00917	0.581
LIG_WRC_WIRS_1	4	9	PF05994	0.789
MOD_CDC14_SPxK_1	120	123	PF00782	0.623
MOD_CDK_SPK_2	155	160	PF00069	0.361
MOD_CDK_SPK_2	208	213	PF00069	0.748
MOD_CDK_SPxK_1	117	123	PF00069	0.631
MOD_CDK_SPxxK_3	208	215	PF00069	0.741
MOD_CK1_1	155	161	PF00069	0.361
MOD_CK1_1	200	206	PF00069	0.814
MOD_CK1_1	208	214	PF00069	0.603
MOD_CK1_1	263	269	PF00069	0.525
MOD_CK2_1	49	55	PF00069	0.621
MOD_GlcNHglycan	193	196	PF01048	0.772
MOD_GlcNHglycan	198	202	PF01048	0.704
MOD_GlcNHglycan	80	83	PF01048	0.503
MOD_GSK3_1	256	263	PF00069	0.590
MOD_GSK3_1	49	56	PF00069	0.785
MOD_GSK3_1	68	75	PF00069	0.480
MOD_N-GLC_1	38	43	PF02516	0.624
MOD_PKA_1	53	59	PF00069	0.826
MOD_PKA_2	260	266	PF00069	0.615
MOD_PKA_2	53	59	PF00069	0.744
MOD_PKB_1	272	280	PF00069	0.617
MOD_Plk_1	256	262	PF00069	0.593
MOD_Plk_1	58	64	PF00069	0.799
MOD_Plk_1	68	74	PF00069	0.650
MOD_Plk_1	76	82	PF00069	0.517
MOD_Plk_4	152	158	PF00069	0.480
MOD_ProDKin_1	117	123	PF00069	0.631
MOD_ProDKin_1	155	161	PF00069	0.361
MOD_ProDKin_1	203	209	PF00069	0.776
MOD_SUMO_rev_2	186	194	PF00179	0.705
TRG_ER_diArg_1	133	135	PF00400	0.697
TRG_ER_diArg_1	137	139	PF00400	0.681
TRG_ER_diArg_1	212	215	PF00400	0.733
TRG_ER_diArg_1	248	250	PF00400	0.618
TRG_NES_CRM1_1	78	93	PF08389	0.613
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.635
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.712
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HL81	Leishmania braziliensis	66%	100%
A4I8Q9	Leishmania infantum	97%	100%
E9B3M4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q4G3	Leishmania major	93%	100%