Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IHC1_LEIDO

TriTrypDb:

LdBPK_262710.1 , LdCL_260033100 , LDHU3_26.3540

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 0
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.611
CLV_C14_Caspase3-7	339	343	PF00656	0.541
CLV_C14_Caspase3-7	80	84	PF00656	0.611
CLV_MEL_PAP_1	123	129	PF00089	0.526
CLV_NRD_NRD_1	202	204	PF00675	0.584
CLV_PCSK_SKI1_1	204	208	PF00082	0.535
CLV_PCSK_SKI1_1	240	244	PF00082	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DEG_ODPH_VHL_1	44	56	PF01847	0.593
DEG_SPOP_SBC_1	56	60	PF00917	0.586
DOC_CKS1_1	155	160	PF01111	0.479
DOC_CYCLIN_yCln2_LP_2	155	161	PF00134	0.583
DOC_CYCLIN_yCln2_LP_2	67	73	PF00134	0.548
DOC_MAPK_gen_1	203	211	PF00069	0.554
DOC_MAPK_gen_1	244	250	PF00069	0.631
DOC_MAPK_MEF2A_6	203	211	PF00069	0.554
DOC_PP1_RVXF_1	206	212	PF00149	0.504
DOC_USP7_MATH_1	210	214	PF00917	0.612
DOC_USP7_MATH_1	252	256	PF00917	0.660
DOC_USP7_MATH_1	296	300	PF00917	0.556
DOC_USP7_MATH_1	345	349	PF00917	0.529
DOC_WW_Pin1_4	154	159	PF00397	0.553
DOC_WW_Pin1_4	34	39	PF00397	0.764
LIG_14-3-3_CanoR_1	294	299	PF00244	0.591
LIG_14-3-3_CanoR_1	72	81	PF00244	0.553
LIG_APCC_ABBAyCdc20_2	277	283	PF00400	0.576
LIG_BRCT_BRCA1_1	2	6	PF00533	0.604
LIG_BRCT_BRCA1_1	217	221	PF00533	0.596
LIG_FHA_1	150	156	PF00498	0.559
LIG_FHA_1	18	24	PF00498	0.646
LIG_FHA_1	215	221	PF00498	0.672
LIG_FHA_1	241	247	PF00498	0.608
LIG_FHA_1	255	261	PF00498	0.705
LIG_FHA_1	35	41	PF00498	0.692
LIG_FHA_1	58	64	PF00498	0.618
LIG_FHA_1	74	80	PF00498	0.604
LIG_FHA_2	30	36	PF00498	0.667
LIG_FHA_2	337	343	PF00498	0.539
LIG_FHA_2	365	371	PF00498	0.484
LIG_FHA_2	57	63	PF00498	0.718
LIG_FHA_2	78	84	PF00498	0.603
LIG_G3BP_FGDF_1	209	214	PF02136	0.525
LIG_GBD_Chelix_1	8	16	PF00786	0.607
LIG_LIR_Gen_1	297	307	PF02991	0.537
LIG_LIR_Nem_3	297	303	PF02991	0.547
LIG_LIR_Nem_3	358	364	PF02991	0.583
LIG_LIR_Nem_3	370	376	PF02991	0.416
LIG_LIR_Nem_3	95	100	PF02991	0.524
LIG_LYPXL_yS_3	164	167	PF13949	0.574
LIG_PTB_Apo_2	325	332	PF02174	0.500
LIG_SH2_CRK	124	128	PF00017	0.558
LIG_SH2_CRK	183	187	PF00017	0.607
LIG_SH2_CRK	300	304	PF00017	0.522
LIG_SH2_SRC	26	29	PF00017	0.655
LIG_SH2_SRC	373	376	PF00017	0.503
LIG_SH2_STAP1	225	229	PF00017	0.654
LIG_SH2_STAP1	300	304	PF00017	0.522
LIG_SH2_STAT5	179	182	PF00017	0.506
LIG_SH2_STAT5	373	376	PF00017	0.503
LIG_SH2_STAT5	7	10	PF00017	0.779
LIG_SH3_3	160	166	PF00018	0.562
LIG_SH3_3	264	270	PF00018	0.621
LIG_SUMO_SIM_anti_2	228	233	PF11976	0.596
LIG_SUMO_SIM_anti_2	62	67	PF11976	0.506
LIG_TYR_ITIM	162	167	PF00017	0.583
LIG_TYR_ITIM	298	303	PF00017	0.540
LIG_WRC_WIRS_1	211	216	PF05994	0.622
MOD_CK1_1	149	155	PF00069	0.618
MOD_CK1_1	190	196	PF00069	0.643
MOD_CK1_1	21	27	PF00069	0.679
MOD_CK1_1	255	261	PF00069	0.644
MOD_CK1_1	57	63	PF00069	0.577
MOD_CK2_1	56	62	PF00069	0.718
MOD_GlcNHglycan	127	130	PF01048	0.738
MOD_GlcNHglycan	222	225	PF01048	0.581
MOD_GlcNHglycan	345	348	PF01048	0.703
MOD_GlcNHglycan	83	86	PF01048	0.616
MOD_GSK3_1	10	17	PF00069	0.672
MOD_GSK3_1	210	217	PF00069	0.626
MOD_GSK3_1	236	243	PF00069	0.676
MOD_GSK3_1	314	321	PF00069	0.535
MOD_GSK3_1	341	348	PF00069	0.603
MOD_GSK3_1	351	358	PF00069	0.510
MOD_GSK3_1	48	55	PF00069	0.621
MOD_GSK3_1	73	80	PF00069	0.569
MOD_N-GLC_1	100	105	PF02516	0.582
MOD_N-GLC_1	21	26	PF02516	0.702
MOD_N-GLC_1	246	251	PF02516	0.656
MOD_N-GLC_1	253	258	PF02516	0.646
MOD_N-GLC_1	354	359	PF02516	0.606
MOD_N-GLC_1	92	97	PF02516	0.541
MOD_N-GLC_2	119	121	PF02516	0.518
MOD_N-GLC_2	143	145	PF02516	0.572
MOD_NEK2_1	100	105	PF00069	0.601
MOD_NEK2_1	11	16	PF00069	0.630
MOD_NEK2_1	125	130	PF00069	0.612
MOD_NEK2_1	214	219	PF00069	0.610
MOD_NEK2_1	220	225	PF00069	0.575
MOD_NEK2_1	311	316	PF00069	0.581
MOD_NEK2_1	341	346	PF00069	0.531
MOD_NEK2_1	363	368	PF00069	0.510
MOD_NEK2_1	54	59	PF00069	0.584
MOD_NEK2_2	284	289	PF00069	0.639
MOD_PIKK_1	110	116	PF00454	0.630
MOD_PIKK_1	146	152	PF00454	0.587
MOD_PK_1	294	300	PF00069	0.527
MOD_PKA_2	125	131	PF00069	0.556
MOD_PKA_2	215	221	PF00069	0.672
MOD_Plk_1	21	27	PF00069	0.679
MOD_Plk_1	246	252	PF00069	0.629
MOD_Plk_1	354	360	PF00069	0.600
MOD_Plk_1	77	83	PF00069	0.586
MOD_Plk_1	92	98	PF00069	0.490
MOD_Plk_2-3	336	342	PF00069	0.540
MOD_Plk_4	112	118	PF00069	0.459
MOD_Plk_4	175	181	PF00069	0.523
MOD_Plk_4	21	27	PF00069	0.688
MOD_Plk_4	210	216	PF00069	0.632
MOD_Plk_4	336	342	PF00069	0.540
MOD_Plk_4	36	42	PF00069	0.597
MOD_Plk_4	92	98	PF00069	0.590
MOD_ProDKin_1	154	160	PF00069	0.554
MOD_ProDKin_1	34	40	PF00069	0.760
TRG_ENDOCYTIC_2	124	127	PF00928	0.615
TRG_ENDOCYTIC_2	164	167	PF00928	0.579
TRG_ENDOCYTIC_2	183	186	PF00928	0.425
TRG_ENDOCYTIC_2	300	303	PF00928	0.525
TRG_ENDOCYTIC_2	373	376	PF00928	0.503
TRG_ENDOCYTIC_2	97	100	PF00928	0.580
TRG_NES_CRM1_1	69	83	PF08389	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCM7	Leptomonas seymouri	42%	100%
A4HFB2	Leishmania braziliensis	74%	100%
A4I2J4	Leishmania infantum	100%	100%
E9AYP9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q8S3	Leishmania major	95%	100%