LeishMANIAdb
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Ubiquitin-conjugating enzyme family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-conjugating enzyme family protein
Gene product:
ubiquitin-conjugating enzyme E2, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IHC0_LEIDO
TriTrypDb:
LdBPK_340950.1 , LdCL_340015000 , LDHU3_34.1520
Length:
289

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0005634 nucleus 5 1
GO:0005783 endoplasmic reticulum 5 1
GO:0016020 membrane 2 2
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
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Expansion

Sequence features

A0A3Q8IHC0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHC0

Function

Biological processes
TermNameLevelCount
GO:0000209 protein polyubiquitination 8 1
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010033 response to organic substance 3 1
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 7
GO:0004842 ubiquitin-protein transferase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016746 acyltransferase activity 3 1
GO:0016874 ligase activity 2 7
GO:0019787 ubiquitin-like protein transferase activity 3 2
GO:0061631 ubiquitin conjugating enzyme activity 5 2
GO:0061650 ubiquitin-like protein conjugating enzyme activity 4 2
GO:0140096 catalytic activity, acting on a protein 2 2
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 135 137 PF00675 0.255
CLV_NRD_NRD_1 141 143 PF00675 0.256
CLV_NRD_NRD_1 16 18 PF00675 0.275
CLV_NRD_NRD_1 217 219 PF00675 0.485
CLV_NRD_NRD_1 269 271 PF00675 0.344
CLV_PCSK_KEX2_1 10 12 PF00082 0.253
CLV_PCSK_KEX2_1 134 136 PF00082 0.253
CLV_PCSK_KEX2_1 147 149 PF00082 0.326
CLV_PCSK_KEX2_1 154 156 PF00082 0.377
CLV_PCSK_KEX2_1 269 271 PF00082 0.314
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3R7ND33 Trypanosoma rangeli 43% 100%
A4HAK3 Leishmania braziliensis 80% 99%
A4HAK5 Leishmania braziliensis 80% 99%
A4HAK6 Leishmania braziliensis 81% 99%
A4I9P7 Leishmania infantum 99% 100%
E9B4R1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
P33296 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
Q4Q3B5 Leishmania major 95% 99%
Q6CMG6 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 36% 100%
Q74Z34 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 36% 100%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS