Ubiquitin-conjugating enzyme family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme E2, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHC0_LEIDO

TriTrypDb:

LdBPK_340950.1 , LdCL_340015000 , LDHU3_34.1520

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005783	endoplasmic reticulum	5	1
GO:0016020	membrane	2	2
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

A0A3Q8IHC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHC0

Function

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Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	1
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016746	acyltransferase activity	3	1
GO:0016874	ligase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061631	ubiquitin conjugating enzyme activity	5	2
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.255
CLV_NRD_NRD_1	141	143	PF00675	0.256
CLV_NRD_NRD_1	16	18	PF00675	0.275
CLV_NRD_NRD_1	217	219	PF00675	0.485
CLV_NRD_NRD_1	269	271	PF00675	0.344
CLV_PCSK_KEX2_1	10	12	PF00082	0.253
CLV_PCSK_KEX2_1	134	136	PF00082	0.253
CLV_PCSK_KEX2_1	147	149	PF00082	0.326
CLV_PCSK_KEX2_1	154	156	PF00082	0.377
CLV_PCSK_KEX2_1	269	271	PF00082	0.314

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3R7ND33	Trypanosoma rangeli	43%	100%
A4HAK3	Leishmania braziliensis	80%	99%
A4HAK5	Leishmania braziliensis	80%	99%
A4HAK6	Leishmania braziliensis	81%	99%
A4I9P7	Leishmania infantum	99%	100%
E9B4R1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
P33296	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
Q4Q3B5	Leishmania major	95%	99%
Q6CMG6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	36%	100%
Q74Z34	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	36%	100%

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