LeishMANIAdb
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Ubiquitin-conjugating enzyme family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-conjugating enzyme family protein
Gene product:
ubiquitin-conjugating enzyme E2, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IHC0_LEIDO
TriTrypDb:
LdBPK_340950.1 , LdCL_340015000 , LDHU3_34.1520
Length:
289

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 3
GO:0016020 membrane 2 2

Expansion

Sequence features

A0A3Q8IHC0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHC0

Function

Biological processes
Term Name Level Count
GO:0000209 protein polyubiquitination 8 1
GO:0006508 proteolysis 4 1
GO:0006511 ubiquitin-dependent protein catabolic process 7 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0006950 response to stress 2 1
GO:0008152 metabolic process 1 1
GO:0009056 catabolic process 2 1
GO:0009057 macromolecule catabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010033 response to organic substance 3 1
GO:0010243 response to organonitrogen compound 4 1
GO:0010498 proteasomal protein catabolic process 5 1
GO:0016567 protein ubiquitination 7 1
GO:0019538 protein metabolic process 3 1
GO:0019941 modification-dependent protein catabolic process 6 1
GO:0030163 protein catabolic process 4 1
GO:0030433 ubiquitin-dependent ERAD pathway 6 1
GO:0032446 protein modification by small protein conjugation 6 1
GO:0033554 cellular response to stress 3 1
GO:0034976 response to endoplasmic reticulum stress 4 1
GO:0036211 protein modification process 4 1
GO:0036503 ERAD pathway 5 1
GO:0042221 response to chemical 2 1
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0043412 macromolecule modification 4 1
GO:0043632 modification-dependent macromolecule catabolic process 5 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044248 cellular catabolic process 3 1
GO:0044260 obsolete cellular macromolecule metabolic process 3 1
GO:0044265 obsolete cellular macromolecule catabolic process 4 1
GO:0050896 response to stimulus 1 1
GO:0051603 proteolysis involved in protein catabolic process 5 1
GO:0051716 cellular response to stimulus 2 1
GO:0070647 protein modification by small protein conjugation or removal 5 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901565 organonitrogen compound catabolic process 4 1
GO:1901575 organic substance catabolic process 3 1
GO:1901698 response to nitrogen compound 3 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004842 ubiquitin-protein transferase activity 4 2
GO:0016740 transferase activity 2 2
GO:0016874 ligase activity 2 7
GO:0019787 ubiquitin-like protein transferase activity 3 2
GO:0061631 ubiquitin conjugating enzyme activity 5 2
GO:0061650 ubiquitin-like protein conjugating enzyme activity 4 2
GO:0140096 catalytic activity, acting on a protein 2 2
GO:0016746 acyltransferase activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 135 137 PF00675 0.255
CLV_NRD_NRD_1 141 143 PF00675 0.256
CLV_NRD_NRD_1 16 18 PF00675 0.275
CLV_NRD_NRD_1 217 219 PF00675 0.485
CLV_NRD_NRD_1 269 271 PF00675 0.344
CLV_PCSK_KEX2_1 10 12 PF00082 0.253
CLV_PCSK_KEX2_1 134 136 PF00082 0.253
CLV_PCSK_KEX2_1 147 149 PF00082 0.326
CLV_PCSK_KEX2_1 154 156 PF00082 0.377
CLV_PCSK_KEX2_1 269 271 PF00082 0.314
CLV_PCSK_PC1ET2_1 10 12 PF00082 0.320
CLV_PCSK_PC1ET2_1 147 149 PF00082 0.393
CLV_PCSK_PC1ET2_1 154 156 PF00082 0.377
CLV_PCSK_SKI1_1 107 111 PF00082 0.253
CLV_PCSK_SKI1_1 154 158 PF00082 0.310
CLV_PCSK_SKI1_1 253 257 PF00082 0.427
DEG_APCC_DBOX_1 106 114 PF00400 0.453
DOC_CKS1_1 75 80 PF01111 0.453
DOC_MAPK_gen_1 10 16 PF00069 0.520
DOC_MAPK_gen_1 269 277 PF00069 0.520
DOC_MAPK_gen_1 81 90 PF00069 0.520
DOC_MAPK_HePTP_8 266 278 PF00069 0.520
DOC_MAPK_MEF2A_6 269 278 PF00069 0.564
DOC_MAPK_MEF2A_6 81 90 PF00069 0.453
DOC_PP4_FxxP_1 68 71 PF00568 0.520
DOC_USP7_MATH_1 112 116 PF00917 0.533
DOC_USP7_MATH_1 138 142 PF00917 0.459
DOC_USP7_MATH_1 203 207 PF00917 0.682
DOC_USP7_MATH_1 228 232 PF00917 0.668
DOC_USP7_MATH_1 237 241 PF00917 0.664
DOC_USP7_UBL2_3 143 147 PF12436 0.520
DOC_WW_Pin1_4 171 176 PF00397 0.723
DOC_WW_Pin1_4 217 222 PF00397 0.748
DOC_WW_Pin1_4 46 51 PF00397 0.463
DOC_WW_Pin1_4 74 79 PF00397 0.457
DOC_WW_Pin1_4 98 103 PF00397 0.453
LIG_14-3-3_CanoR_1 269 275 PF00244 0.520
LIG_deltaCOP1_diTrp_1 22 27 PF00928 0.451
LIG_deltaCOP1_diTrp_1 98 104 PF00928 0.453
LIG_DLG_GKlike_1 270 277 PF00625 0.386
LIG_FHA_1 106 112 PF00498 0.463
LIG_FHA_1 163 169 PF00498 0.564
LIG_FHA_1 254 260 PF00498 0.656
LIG_FHA_2 128 134 PF00498 0.520
LIG_FHA_2 186 192 PF00498 0.725
LIG_FHA_2 206 212 PF00498 0.602
LIG_FHA_2 47 53 PF00498 0.453
LIG_LIR_Apic_2 22 26 PF02991 0.450
LIG_LIR_Apic_2 65 71 PF02991 0.520
LIG_PCNA_PIPBox_1 34 43 PF02747 0.520
LIG_PCNA_yPIPBox_3 28 41 PF02747 0.505
LIG_Pex14_1 23 27 PF04695 0.451
LIG_PTB_Apo_2 89 96 PF02174 0.520
LIG_PTB_Phospho_1 89 95 PF10480 0.520
LIG_SH2_CRK 153 157 PF00017 0.500
LIG_SH2_CRK 271 275 PF00017 0.386
LIG_SH2_PTP2 56 59 PF00017 0.520
LIG_SH2_STAP1 271 275 PF00017 0.386
LIG_SH2_STAT5 40 43 PF00017 0.453
LIG_SH2_STAT5 56 59 PF00017 0.453
LIG_SH3_3 210 216 PF00018 0.674
LIG_SH3_3 64 70 PF00018 0.557
LIG_SUMO_SIM_anti_2 273 279 PF11976 0.386
LIG_SUMO_SIM_par_1 108 115 PF11976 0.520
LIG_SUMO_SIM_par_1 58 65 PF11976 0.532
LIG_TRAF2_1 130 133 PF00917 0.492
LIG_TRAF2_1 202 205 PF00917 0.689
LIG_WRC_WIRS_1 113 118 PF05994 0.453
MOD_CDK_SPK_2 171 176 PF00069 0.617
MOD_CDK_SPxxK_3 74 81 PF00069 0.453
MOD_CK1_1 180 186 PF00069 0.742
MOD_CK1_1 206 212 PF00069 0.719
MOD_CK1_1 240 246 PF00069 0.669
MOD_CK1_1 91 97 PF00069 0.520
MOD_CK2_1 127 133 PF00069 0.520
MOD_CK2_1 185 191 PF00069 0.756
MOD_CK2_1 205 211 PF00069 0.597
MOD_CK2_1 46 52 PF00069 0.453
MOD_GlcNHglycan 127 130 PF01048 0.361
MOD_GlcNHglycan 180 183 PF01048 0.550
MOD_GlcNHglycan 78 81 PF01048 0.347
MOD_GSK3_1 112 119 PF00069 0.520
MOD_GSK3_1 121 128 PF00069 0.445
MOD_GSK3_1 205 212 PF00069 0.772
MOD_GSK3_1 228 235 PF00069 0.771
MOD_LATS_1 251 257 PF00433 0.669
MOD_N-GLC_1 91 96 PF02516 0.284
MOD_N-GLC_1 98 103 PF02516 0.230
MOD_NEK2_1 90 95 PF00069 0.458
MOD_NEK2_2 112 117 PF00069 0.520
MOD_PK_1 69 75 PF00069 0.520
MOD_Plk_1 91 97 PF00069 0.521
MOD_Plk_2-3 185 191 PF00069 0.730
MOD_Plk_4 112 118 PF00069 0.471
MOD_Plk_4 209 215 PF00069 0.654
MOD_Plk_4 270 276 PF00069 0.311
MOD_ProDKin_1 171 177 PF00069 0.729
MOD_ProDKin_1 217 223 PF00069 0.749
MOD_ProDKin_1 46 52 PF00069 0.463
MOD_ProDKin_1 74 80 PF00069 0.457
MOD_ProDKin_1 98 104 PF00069 0.453
MOD_SUMO_for_1 175 178 PF00179 0.666
TRG_ENDOCYTIC_2 153 156 PF00928 0.504
TRG_ENDOCYTIC_2 271 274 PF00928 0.394
TRG_ENDOCYTIC_2 40 43 PF00928 0.453
TRG_ENDOCYTIC_2 56 59 PF00928 0.453
TRG_ER_diArg_1 134 136 PF00400 0.485
TRG_ER_diArg_1 268 270 PF00400 0.649
TRG_Pf-PMV_PEXEL_1 155 159 PF00026 0.380
TRG_Pf-PMV_PEXEL_1 17 22 PF00026 0.280

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3R7ND33 Trypanosoma rangeli 43% 100%
A4HAK3 Leishmania braziliensis 80% 99%
A4HAK5 Leishmania braziliensis 80% 99%
A4HAK6 Leishmania braziliensis 81% 99%
A4I9P7 Leishmania infantum 99% 100%
E9B4R1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
P33296 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 39% 100%
Q4Q3B5 Leishmania major 95% 99%
Q6CMG6 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 36% 100%
Q74Z34 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 36% 100%
Q9FK29 Arabidopsis thaliana 34% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS