Leucine Rich repeat/Leucine Rich Repeat/Leucine Rich repeats (2 copies), putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHB8_LEIDO

TriTrypDb:

LdBPK_323360.1 , LdCL_320039500 , LDHU3_32.4230

Length:

817

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005930	axoneme	2	1

Expansion

Sequence features

A0A3Q8IHB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHB8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.688
CLV_C14_Caspase3-7	275	279	PF00656	0.728
CLV_NRD_NRD_1	503	505	PF00675	0.470
CLV_NRD_NRD_1	509	511	PF00675	0.504
CLV_NRD_NRD_1	516	518	PF00675	0.510
CLV_NRD_NRD_1	63	65	PF00675	0.697
CLV_NRD_NRD_1	693	695	PF00675	0.666
CLV_NRD_NRD_1	788	790	PF00675	0.730
CLV_PCSK_KEX2_1	373	375	PF00082	0.606
CLV_PCSK_KEX2_1	503	505	PF00082	0.487
CLV_PCSK_KEX2_1	509	511	PF00082	0.510
CLV_PCSK_KEX2_1	602	604	PF00082	0.769
CLV_PCSK_KEX2_1	63	65	PF00082	0.697
CLV_PCSK_KEX2_1	693	695	PF00082	0.666
CLV_PCSK_KEX2_1	739	741	PF00082	0.791
CLV_PCSK_KEX2_1	788	790	PF00082	0.746
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.606
CLV_PCSK_PC1ET2_1	602	604	PF00082	0.769
CLV_PCSK_PC1ET2_1	739	741	PF00082	0.791
CLV_PCSK_PC7_1	689	695	PF00082	0.661
CLV_PCSK_PC7_1	784	790	PF00082	0.729
CLV_PCSK_SKI1_1	139	143	PF00082	0.503
CLV_PCSK_SKI1_1	510	514	PF00082	0.590
CLV_PCSK_SKI1_1	681	685	PF00082	0.506
CLV_PCSK_SKI1_1	694	698	PF00082	0.664
CLV_PCSK_SKI1_1	739	743	PF00082	0.696
CLV_PCSK_SKI1_1	96	100	PF00082	0.771
DEG_APCC_DBOX_1	434	442	PF00400	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.522
DEG_SCF_FBW7_1	118	125	PF00400	0.620
DEG_SCF_FBW7_1	715	722	PF00400	0.708
DEG_SPOP_SBC_1	596	600	PF00917	0.676
DEG_SPOP_SBC_1	729	733	PF00917	0.697
DOC_CKS1_1	119	124	PF01111	0.621
DOC_CKS1_1	756	761	PF01111	0.693
DOC_CYCLIN_RxL_1	689	699	PF00134	0.543
DOC_CYCLIN_RxL_1	93	102	PF00134	0.710
DOC_MAPK_gen_1	178	187	PF00069	0.475
DOC_MAPK_gen_1	461	471	PF00069	0.340
DOC_MAPK_MEF2A_6	178	187	PF00069	0.480
DOC_MAPK_MEF2A_6	638	647	PF00069	0.566
DOC_PP4_MxPP_1	581	584	PF00568	0.666
DOC_USP7_MATH_1	231	235	PF00917	0.747
DOC_USP7_MATH_1	279	283	PF00917	0.661
DOC_USP7_MATH_1	311	315	PF00917	0.796
DOC_USP7_MATH_1	596	600	PF00917	0.800
DOC_USP7_MATH_1	624	628	PF00917	0.649
DOC_USP7_MATH_1	72	76	PF00917	0.699
DOC_USP7_MATH_1	729	733	PF00917	0.789
DOC_USP7_UBL2_3	369	373	PF12436	0.546
DOC_USP7_UBL2_3	80	84	PF12436	0.779
DOC_USP7_UBL2_3	96	100	PF12436	0.599
DOC_WW_Pin1_4	111	116	PF00397	0.738
DOC_WW_Pin1_4	118	123	PF00397	0.672
DOC_WW_Pin1_4	139	144	PF00397	0.580
DOC_WW_Pin1_4	176	181	PF00397	0.604
DOC_WW_Pin1_4	267	272	PF00397	0.747
DOC_WW_Pin1_4	563	568	PF00397	0.783
DOC_WW_Pin1_4	592	597	PF00397	0.822
DOC_WW_Pin1_4	715	720	PF00397	0.781
DOC_WW_Pin1_4	755	760	PF00397	0.739
LIG_14-3-3_CanoR_1	181	186	PF00244	0.469
LIG_14-3-3_CanoR_1	259	264	PF00244	0.739
LIG_14-3-3_CanoR_1	409	414	PF00244	0.565
LIG_14-3-3_CanoR_1	475	482	PF00244	0.289
LIG_14-3-3_CanoR_1	603	611	PF00244	0.792
LIG_14-3-3_CanoR_1	747	756	PF00244	0.791
LIG_14-3-3_CanoR_1	788	792	PF00244	0.707
LIG_BIR_III_2	564	568	PF00653	0.561
LIG_Clathr_ClatBox_1	154	158	PF01394	0.445
LIG_FHA_1	119	125	PF00498	0.641
LIG_FHA_1	285	291	PF00498	0.617
LIG_FHA_1	32	38	PF00498	0.742
LIG_FHA_1	382	388	PF00498	0.643
LIG_FHA_1	422	428	PF00498	0.549
LIG_FHA_1	477	483	PF00498	0.424
LIG_FHA_1	564	570	PF00498	0.739
LIG_FHA_1	716	722	PF00498	0.746
LIG_FHA_1	740	746	PF00498	0.640
LIG_FHA_2	21	27	PF00498	0.544
LIG_FHA_2	352	358	PF00498	0.616
LIG_FHA_2	511	517	PF00498	0.524
LIG_FHA_2	668	674	PF00498	0.640
LIG_FHA_2	700	706	PF00498	0.736
LIG_FHA_2	788	794	PF00498	0.705
LIG_LIR_Apic_2	174	180	PF02991	0.593
LIG_LIR_Apic_2	338	343	PF02991	0.642
LIG_LIR_Apic_2	577	583	PF02991	0.666
LIG_LIR_Gen_1	12	20	PF02991	0.609
LIG_LIR_Gen_1	123	134	PF02991	0.520
LIG_LIR_Gen_1	168	177	PF02991	0.468
LIG_LIR_Gen_1	26	37	PF02991	0.526
LIG_LIR_Gen_1	531	538	PF02991	0.514
LIG_LIR_Gen_1	679	688	PF02991	0.606
LIG_LIR_Nem_3	12	16	PF02991	0.518
LIG_LIR_Nem_3	123	129	PF02991	0.606
LIG_LIR_Nem_3	168	172	PF02991	0.468
LIG_LIR_Nem_3	26	32	PF02991	0.552
LIG_LIR_Nem_3	344	349	PF02991	0.516
LIG_LIR_Nem_3	399	403	PF02991	0.637
LIG_LIR_Nem_3	531	535	PF02991	0.515
LIG_LIR_Nem_3	679	685	PF02991	0.604
LIG_MAD2	35	43	PF02301	0.718
LIG_MYND_1	719	723	PF01753	0.671
LIG_NRBOX	455	461	PF00104	0.493
LIG_PCNA_PIPBox_1	794	803	PF02747	0.507
LIG_PTAP_UEV_1	722	727	PF05743	0.675
LIG_SH2_CRK	169	173	PF00017	0.582
LIG_SH2_CRK	177	181	PF00017	0.614
LIG_SH2_CRK	29	33	PF00017	0.551
LIG_SH2_CRK	580	584	PF00017	0.669
LIG_SH2_PTP2	126	129	PF00017	0.621
LIG_SH2_PTP2	682	685	PF00017	0.645
LIG_SH2_STAP1	29	33	PF00017	0.589
LIG_SH2_STAP1	532	536	PF00017	0.598
LIG_SH2_STAT3	342	345	PF00017	0.610
LIG_SH2_STAT3	541	544	PF00017	0.634
LIG_SH2_STAT5	126	129	PF00017	0.588
LIG_SH2_STAT5	198	201	PF00017	0.650
LIG_SH2_STAT5	340	343	PF00017	0.624
LIG_SH2_STAT5	506	509	PF00017	0.549
LIG_SH2_STAT5	541	544	PF00017	0.570
LIG_SH2_STAT5	682	685	PF00017	0.645
LIG_SH3_1	146	152	PF00018	0.614
LIG_SH3_1	580	586	PF00018	0.706
LIG_SH3_2	585	590	PF14604	0.763
LIG_SH3_3	113	119	PF00018	0.765
LIG_SH3_3	146	152	PF00018	0.614
LIG_SH3_3	219	225	PF00018	0.668
LIG_SH3_3	34	40	PF00018	0.710
LIG_SH3_3	548	554	PF00018	0.696
LIG_SH3_3	580	586	PF00018	0.751
LIG_SH3_3	720	726	PF00018	0.769
LIG_SH3_3	759	765	PF00018	0.680
LIG_SUMO_SIM_anti_2	156	161	PF11976	0.536
LIG_SUMO_SIM_anti_2	670	676	PF11976	0.631
LIG_SUMO_SIM_anti_2	758	764	PF11976	0.662
LIG_SUMO_SIM_par_1	153	158	PF11976	0.449
LIG_SUMO_SIM_par_1	477	487	PF11976	0.391
LIG_SUMO_SIM_par_1	708	714	PF11976	0.692
LIG_TRAF2_1	101	104	PF00917	0.740
LIG_TRAF2_1	109	112	PF00917	0.727
LIG_TRAF2_1	495	498	PF00917	0.551
LIG_TRAF2_1	513	516	PF00917	0.548
LIG_TYR_ITIM	124	129	PF00017	0.515
LIG_WW_2	40	43	PF00397	0.725
LIG_WW_2	551	554	PF00397	0.722
MOD_CDK_SPK_2	176	181	PF00069	0.604
MOD_CDK_SPxxK_3	139	146	PF00069	0.587
MOD_CK1_1	153	159	PF00069	0.446
MOD_CK1_1	165	171	PF00069	0.481
MOD_CK1_1	194	200	PF00069	0.741
MOD_CK1_1	207	213	PF00069	0.514
MOD_CK1_1	250	256	PF00069	0.699
MOD_CK1_1	262	268	PF00069	0.735
MOD_CK1_1	272	278	PF00069	0.572
MOD_CK1_1	303	309	PF00069	0.707
MOD_CK1_1	333	339	PF00069	0.525
MOD_CK1_1	574	580	PF00069	0.735
MOD_CK1_1	595	601	PF00069	0.756
MOD_CK1_1	605	611	PF00069	0.704
MOD_CK1_1	717	723	PF00069	0.740
MOD_CK1_1	728	734	PF00069	0.760
MOD_CK1_1	75	81	PF00069	0.751
MOD_CK2_1	18	24	PF00069	0.543
MOD_CK2_1	351	357	PF00069	0.564
MOD_CK2_1	433	439	PF00069	0.613
MOD_CK2_1	491	497	PF00069	0.593
MOD_CK2_1	510	516	PF00069	0.362
MOD_CK2_1	667	673	PF00069	0.642
MOD_CK2_1	699	705	PF00069	0.643
MOD_CK2_1	729	735	PF00069	0.797
MOD_CK2_1	787	793	PF00069	0.714
MOD_CK2_1	98	104	PF00069	0.772
MOD_GlcNHglycan	12	16	PF01048	0.573
MOD_GlcNHglycan	164	167	PF01048	0.592
MOD_GlcNHglycan	192	196	PF01048	0.733
MOD_GlcNHglycan	252	255	PF01048	0.719
MOD_GlcNHglycan	271	274	PF01048	0.762
MOD_GlcNHglycan	281	284	PF01048	0.712
MOD_GlcNHglycan	29	32	PF01048	0.504
MOD_GlcNHglycan	307	310	PF01048	0.755
MOD_GlcNHglycan	312	316	PF01048	0.683
MOD_GlcNHglycan	329	335	PF01048	0.481
MOD_GlcNHglycan	576	579	PF01048	0.576
MOD_GlcNHglycan	599	602	PF01048	0.788
MOD_GlcNHglycan	626	629	PF01048	0.755
MOD_GlcNHglycan	634	637	PF01048	0.701
MOD_GlcNHglycan	66	69	PF01048	0.755
MOD_GlcNHglycan	723	726	PF01048	0.746
MOD_GlcNHglycan	727	730	PF01048	0.774
MOD_GlcNHglycan	742	745	PF01048	0.722
MOD_GlcNHglycan	89	92	PF01048	0.705
MOD_GSK3_1	118	125	PF00069	0.717
MOD_GSK3_1	16	23	PF00069	0.591
MOD_GSK3_1	262	269	PF00069	0.691
MOD_GSK3_1	27	34	PF00069	0.571
MOD_GSK3_1	433	440	PF00069	0.466
MOD_GSK3_1	524	531	PF00069	0.588
MOD_GSK3_1	590	597	PF00069	0.824
MOD_GSK3_1	603	610	PF00069	0.775
MOD_GSK3_1	624	631	PF00069	0.733
MOD_GSK3_1	715	722	PF00069	0.723
MOD_GSK3_1	72	79	PF00069	0.717
MOD_GSK3_1	725	732	PF00069	0.756
MOD_GSK3_1	735	742	PF00069	0.657
MOD_GSK3_1	746	753	PF00069	0.718
MOD_GSK3_1	783	790	PF00069	0.712
MOD_GSK3_1	808	815	PF00069	0.686
MOD_GSK3_1	94	101	PF00069	0.720
MOD_N-GLC_1	285	290	PF02516	0.800
MOD_N-GLC_1	446	451	PF02516	0.405
MOD_N-GLC_1	571	576	PF02516	0.743
MOD_N-GLC_1	801	806	PF02516	0.700
MOD_NEK2_1	16	21	PF00069	0.610
MOD_NEK2_1	239	244	PF00069	0.713
MOD_NEK2_1	300	305	PF00069	0.776
MOD_NEK2_1	451	456	PF00069	0.402
MOD_NEK2_1	476	481	PF00069	0.480
MOD_NEK2_1	484	489	PF00069	0.448
MOD_NEK2_1	573	578	PF00069	0.622
MOD_NEK2_1	632	637	PF00069	0.670
MOD_NEK2_1	801	806	PF00069	0.661
MOD_NEK2_1	98	103	PF00069	0.722
MOD_PIKK_1	253	259	PF00454	0.727
MOD_PIKK_1	303	309	PF00454	0.742
MOD_PIKK_1	341	347	PF00454	0.626
MOD_PIKK_1	351	357	PF00454	0.630
MOD_PIKK_1	433	439	PF00454	0.613
MOD_PIKK_1	539	545	PF00454	0.633
MOD_PIKK_1	750	756	PF00454	0.718
MOD_PIKK_1	99	105	PF00454	0.715
MOD_PK_1	181	187	PF00069	0.481
MOD_PKA_1	602	608	PF00069	0.794
MOD_PKA_1	739	745	PF00069	0.788
MOD_PKA_2	284	290	PF00069	0.719
MOD_PKA_2	300	306	PF00069	0.747
MOD_PKA_2	381	387	PF00069	0.600
MOD_PKA_2	474	480	PF00069	0.289
MOD_PKA_2	602	608	PF00069	0.794
MOD_PKA_2	641	647	PF00069	0.554
MOD_PKA_2	739	745	PF00069	0.793
MOD_PKA_2	746	752	PF00069	0.578
MOD_PKA_2	75	81	PF00069	0.793
MOD_PKA_2	783	789	PF00069	0.739
MOD_Plk_1	11	17	PF00069	0.629
MOD_Plk_1	239	245	PF00069	0.725
MOD_Plk_1	285	291	PF00069	0.718
MOD_Plk_1	571	577	PF00069	0.746
MOD_Plk_1	590	596	PF00069	0.490
MOD_Plk_1	801	807	PF00069	0.705
MOD_Plk_2-3	18	24	PF00069	0.481
MOD_Plk_2-3	528	534	PF00069	0.610
MOD_Plk_2-3	705	711	PF00069	0.749
MOD_Plk_2-3	787	793	PF00069	0.697
MOD_Plk_4	150	156	PF00069	0.467
MOD_Plk_4	165	171	PF00069	0.476
MOD_Plk_4	207	213	PF00069	0.665
MOD_Plk_4	313	319	PF00069	0.665
MOD_Plk_4	667	673	PF00069	0.517
MOD_Plk_4	681	687	PF00069	0.529
MOD_Plk_4	705	711	PF00069	0.749
MOD_Plk_4	758	764	PF00069	0.729
MOD_Plk_4	94	100	PF00069	0.712
MOD_ProDKin_1	111	117	PF00069	0.735
MOD_ProDKin_1	118	124	PF00069	0.659
MOD_ProDKin_1	139	145	PF00069	0.578
MOD_ProDKin_1	176	182	PF00069	0.596
MOD_ProDKin_1	267	273	PF00069	0.748
MOD_ProDKin_1	563	569	PF00069	0.781
MOD_ProDKin_1	592	598	PF00069	0.820
MOD_ProDKin_1	715	721	PF00069	0.784
MOD_ProDKin_1	755	761	PF00069	0.739
MOD_SUMO_rev_2	288	298	PF00179	0.742
MOD_SUMO_rev_2	365	375	PF00179	0.624
MOD_SUMO_rev_2	514	520	PF00179	0.638
TRG_DiLeu_BaEn_2	216	222	PF01217	0.697
TRG_DiLeu_BaEn_4	497	503	PF01217	0.503
TRG_DiLeu_BaLyEn_6	520	525	PF01217	0.691
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.693
TRG_ENDOCYTIC_2	126	129	PF00928	0.558
TRG_ENDOCYTIC_2	13	16	PF00928	0.596
TRG_ENDOCYTIC_2	131	134	PF00928	0.577
TRG_ENDOCYTIC_2	169	172	PF00928	0.470
TRG_ENDOCYTIC_2	29	32	PF00928	0.434
TRG_ENDOCYTIC_2	532	535	PF00928	0.516
TRG_ENDOCYTIC_2	682	685	PF00928	0.645
TRG_ER_diArg_1	502	504	PF00400	0.486
TRG_ER_diArg_1	63	65	PF00400	0.697
TRG_ER_diArg_1	693	695	PF00400	0.666
TRG_ER_diArg_1	773	776	PF00400	0.642
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4C3	Leptomonas seymouri	47%	97%
A0A1X0NTH1	Trypanosomatidae	31%	100%
A0A422NYL4	Trypanosoma rangeli	34%	100%
A4HKW1	Leishmania braziliensis	73%	100%
A4I8E1	Leishmania infantum	100%	100%
D0AAT2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B399	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q4V6	Leishmania major	91%	100%
V5BVG4	Trypanosoma cruzi	34%	100%