Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IHB4_LEIDO

TriTrypDb:

LdCL_290022200 , LDHU3_29.2400

Length:

787

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	631	635	PF00656	0.617
CLV_C14_Caspase3-7	94	98	PF00656	0.558
CLV_NRD_NRD_1	177	179	PF00675	0.483
CLV_NRD_NRD_1	261	263	PF00675	0.583
CLV_NRD_NRD_1	333	335	PF00675	0.459
CLV_NRD_NRD_1	4	6	PF00675	0.560
CLV_NRD_NRD_1	487	489	PF00675	0.460
CLV_NRD_NRD_1	55	57	PF00675	0.592
CLV_NRD_NRD_1	672	674	PF00675	0.604
CLV_NRD_NRD_1	683	685	PF00675	0.494
CLV_NRD_NRD_1	73	75	PF00675	0.580
CLV_PCSK_KEX2_1	177	179	PF00082	0.483
CLV_PCSK_KEX2_1	19	21	PF00082	0.559
CLV_PCSK_KEX2_1	261	263	PF00082	0.701
CLV_PCSK_KEX2_1	327	329	PF00082	0.481
CLV_PCSK_KEX2_1	333	335	PF00082	0.441
CLV_PCSK_KEX2_1	4	6	PF00082	0.560
CLV_PCSK_KEX2_1	487	489	PF00082	0.460
CLV_PCSK_KEX2_1	55	57	PF00082	0.608
CLV_PCSK_KEX2_1	672	674	PF00082	0.604
CLV_PCSK_KEX2_1	683	685	PF00082	0.494
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.688
CLV_PCSK_PC1ET2_1	327	329	PF00082	0.458
CLV_PCSK_SKI1_1	177	181	PF00082	0.487
CLV_PCSK_SKI1_1	359	363	PF00082	0.461
CLV_PCSK_SKI1_1	408	412	PF00082	0.466
CLV_PCSK_SKI1_1	449	453	PF00082	0.522
CLV_PCSK_SKI1_1	487	491	PF00082	0.453
DEG_APCC_DBOX_1	176	184	PF00400	0.479
DEG_SCF_FBW7_1	186	193	PF00400	0.481
DEG_SCF_FBW7_2	115	121	PF00400	0.508
DOC_CKS1_1	115	120	PF01111	0.510
DOC_CKS1_1	187	192	PF01111	0.488
DOC_CKS1_1	544	549	PF01111	0.492
DOC_CYCLIN_RxL_1	482	492	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	345	351	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	415	421	PF00134	0.478
DOC_MAPK_gen_1	333	340	PF00069	0.447
DOC_PP1_RVXF_1	357	364	PF00149	0.492
DOC_PP4_FxxP_1	544	547	PF00568	0.488
DOC_PP4_FxxP_1	555	558	PF00568	0.546
DOC_USP7_MATH_1	108	112	PF00917	0.564
DOC_USP7_MATH_1	13	17	PF00917	0.662
DOC_USP7_MATH_1	145	149	PF00917	0.546
DOC_USP7_MATH_1	179	183	PF00917	0.476
DOC_USP7_MATH_1	391	395	PF00917	0.585
DOC_USP7_MATH_1	40	44	PF00917	0.621
DOC_USP7_MATH_1	464	468	PF00917	0.493
DOC_USP7_MATH_1	61	65	PF00917	0.592
DOC_USP7_MATH_1	645	649	PF00917	0.615
DOC_USP7_MATH_2	40	46	PF00917	0.546
DOC_WW_Pin1_4	114	119	PF00397	0.494
DOC_WW_Pin1_4	186	191	PF00397	0.477
DOC_WW_Pin1_4	255	260	PF00397	0.533
DOC_WW_Pin1_4	315	320	PF00397	0.513
DOC_WW_Pin1_4	543	548	PF00397	0.492
DOC_WW_Pin1_4	57	62	PF00397	0.609
DOC_WW_Pin1_4	696	701	PF00397	0.786
DOC_WW_Pin1_4	715	720	PF00397	0.459
LIG_14-3-3_CanoR_1	178	184	PF00244	0.483
LIG_14-3-3_CanoR_1	236	244	PF00244	0.558
LIG_14-3-3_CanoR_1	31	40	PF00244	0.550
LIG_14-3-3_CanoR_1	350	356	PF00244	0.477
LIG_14-3-3_CanoR_1	469	477	PF00244	0.466
LIG_14-3-3_CanoR_1	534	539	PF00244	0.518
LIG_14-3-3_CanoR_1	687	695	PF00244	0.523
LIG_BIR_III_4	654	658	PF00653	0.537
LIG_BRCT_BRCA1_1	513	517	PF00533	0.537
LIG_CaM_IQ_9	367	383	PF13499	0.480
LIG_EH1_1	775	783	PF00400	0.506
LIG_FHA_1	134	140	PF00498	0.554
LIG_FHA_1	255	261	PF00498	0.590
LIG_FHA_1	266	272	PF00498	0.475
LIG_FHA_1	310	316	PF00498	0.564
LIG_FHA_1	469	475	PF00498	0.644
LIG_FHA_1	666	672	PF00498	0.569
LIG_FHA_1	746	752	PF00498	0.607
LIG_FHA_1	753	759	PF00498	0.631
LIG_FHA_1	763	769	PF00498	0.549
LIG_FHA_2	187	193	PF00498	0.489
LIG_FHA_2	352	358	PF00498	0.493
LIG_FHA_2	450	456	PF00498	0.483
LIG_FHA_2	629	635	PF00498	0.620
LIG_FHA_2	732	738	PF00498	0.585
LIG_FHA_2	83	89	PF00498	0.620
LIG_FHA_2	92	98	PF00498	0.540
LIG_LIR_Apic_2	541	547	PF02991	0.695
LIG_LIR_Apic_2	553	558	PF02991	0.545
LIG_LIR_Apic_2	70	76	PF02991	0.578
LIG_LIR_Gen_1	211	220	PF02991	0.498
LIG_LIR_Gen_1	353	363	PF02991	0.464
LIG_LIR_Nem_3	185	191	PF02991	0.512
LIG_LIR_Nem_3	211	216	PF02991	0.507
LIG_LIR_Nem_3	353	358	PF02991	0.466
LIG_LIR_Nem_3	456	462	PF02991	0.562
LIG_NRBOX	182	188	PF00104	0.497
LIG_NRBOX	485	491	PF00104	0.490
LIG_PCNA_APIM_2	671	677	PF02747	0.541
LIG_PCNA_yPIPBox_3	399	411	PF02747	0.539
LIG_SH2_CRK	213	217	PF00017	0.470
LIG_SH2_CRK	496	500	PF00017	0.452
LIG_SH2_CRK	728	732	PF00017	0.555
LIG_SH2_CRK	73	77	PF00017	0.576
LIG_SH2_NCK_1	188	192	PF00017	0.528
LIG_SH2_STAP1	213	217	PF00017	0.470
LIG_SH2_STAP1	539	543	PF00017	0.518
LIG_SH2_STAT3	539	542	PF00017	0.512
LIG_SH2_STAT5	188	191	PF00017	0.527
LIG_SH2_STAT5	331	334	PF00017	0.490
LIG_SH2_STAT5	475	478	PF00017	0.483
LIG_SH2_STAT5	674	677	PF00017	0.543
LIG_SH2_STAT5	776	779	PF00017	0.512
LIG_SH3_2	667	672	PF14604	0.568
LIG_SH3_3	112	118	PF00018	0.657
LIG_SH3_3	226	232	PF00018	0.495
LIG_SH3_3	313	319	PF00018	0.524
LIG_SH3_3	653	659	PF00018	0.612
LIG_SH3_3	661	667	PF00018	0.642
LIG_Sin3_3	580	587	PF02671	0.474
LIG_SUMO_SIM_anti_2	312	318	PF11976	0.514
LIG_SUMO_SIM_anti_2	588	595	PF11976	0.497
LIG_SUMO_SIM_anti_2	66	73	PF11976	0.578
LIG_SUMO_SIM_par_1	318	324	PF11976	0.526
LIG_SUMO_SIM_par_1	417	423	PF11976	0.518
LIG_SUMO_SIM_par_1	728	737	PF11976	0.544
LIG_TRAF2_1	435	438	PF00917	0.479
LIG_TRAF2_1	65	68	PF00917	0.586
LIG_TRAF2_1	734	737	PF00917	0.588
LIG_TRFH_1	543	547	PF08558	0.484
LIG_TYR_ITIM	186	191	PF00017	0.514
LIG_TYR_ITIM	340	345	PF00017	0.433
LIG_TYR_ITIM	726	731	PF00017	0.541
MOD_CDK_SPxK_1	255	261	PF00069	0.497
MOD_CDK_SPxxK_3	255	262	PF00069	0.498
MOD_CK1_1	238	244	PF00069	0.488
MOD_CK1_1	286	292	PF00069	0.530
MOD_CK1_1	34	40	PF00069	0.548
MOD_CK1_1	353	359	PF00069	0.471
MOD_CK1_1	511	517	PF00069	0.554
MOD_CK2_1	351	357	PF00069	0.501
MOD_CK2_1	391	397	PF00069	0.560
MOD_CK2_1	449	455	PF00069	0.523
MOD_CK2_1	61	67	PF00069	0.592
MOD_CK2_1	731	737	PF00069	0.582
MOD_CK2_1	83	89	PF00069	0.570
MOD_CK2_1	95	101	PF00069	0.731
MOD_CMANNOS	605	608	PF00535	0.582
MOD_Cter_Amidation	2	5	PF01082	0.583
MOD_GlcNHglycan	105	109	PF01048	0.566
MOD_GlcNHglycan	110	113	PF01048	0.558
MOD_GlcNHglycan	168	171	PF01048	0.631
MOD_GlcNHglycan	192	196	PF01048	0.512
MOD_GlcNHglycan	240	243	PF01048	0.475
MOD_GlcNHglycan	28	31	PF01048	0.619
MOD_GlcNHglycan	281	284	PF01048	0.538
MOD_GlcNHglycan	285	288	PF01048	0.558
MOD_GlcNHglycan	33	36	PF01048	0.571
MOD_GlcNHglycan	392	396	PF01048	0.592
MOD_GlcNHglycan	44	47	PF01048	0.534
MOD_GlcNHglycan	514	517	PF01048	0.531
MOD_GlcNHglycan	63	66	PF01048	0.647
MOD_GlcNHglycan	646	650	PF01048	0.635
MOD_GlcNHglycan	651	654	PF01048	0.595
MOD_GlcNHglycan	691	694	PF01048	0.582
MOD_GlcNHglycan	85	88	PF01048	0.639
MOD_GSK3_1	104	111	PF00069	0.491
MOD_GSK3_1	133	140	PF00069	0.476
MOD_GSK3_1	152	159	PF00069	0.490
MOD_GSK3_1	186	193	PF00069	0.501
MOD_GSK3_1	236	243	PF00069	0.558
MOD_GSK3_1	26	33	PF00069	0.584
MOD_GSK3_1	279	286	PF00069	0.558
MOD_GSK3_1	34	41	PF00069	0.556
MOD_GSK3_1	449	456	PF00069	0.586
MOD_GSK3_1	464	471	PF00069	0.498
MOD_GSK3_1	508	515	PF00069	0.534
MOD_GSK3_1	57	64	PF00069	0.606
MOD_GSK3_1	635	642	PF00069	0.670
MOD_GSK3_1	645	652	PF00069	0.565
MOD_GSK3_1	689	696	PF00069	0.612
MOD_GSK3_1	711	718	PF00069	0.534
MOD_GSK3_1	78	85	PF00069	0.600
MOD_GSK3_1	91	98	PF00069	0.549
MOD_LATS_1	80	86	PF00433	0.617
MOD_N-GLC_1	133	138	PF02516	0.479
MOD_NEK2_1	104	109	PF00069	0.501
MOD_NEK2_1	235	240	PF00069	0.606
MOD_NEK2_1	265	270	PF00069	0.589
MOD_NEK2_1	501	506	PF00069	0.443
MOD_NEK2_1	508	513	PF00069	0.523
MOD_NEK2_1	517	522	PF00069	0.622
MOD_NEK2_1	573	578	PF00069	0.445
MOD_NEK2_2	145	150	PF00069	0.521
MOD_PIKK_1	158	164	PF00454	0.484
MOD_PIKK_1	553	559	PF00454	0.546
MOD_PKA_2	235	241	PF00069	0.598
MOD_PKA_2	30	36	PF00069	0.589
MOD_PKA_2	468	474	PF00069	0.498
MOD_PKA_2	78	84	PF00069	0.593
MOD_PKB_1	135	143	PF00069	0.512
MOD_Plk_1	145	151	PF00069	0.620
MOD_Plk_1	449	455	PF00069	0.508
MOD_Plk_1	67	73	PF00069	0.579
MOD_Plk_2-3	639	645	PF00069	0.584
MOD_Plk_4	212	218	PF00069	0.610
MOD_Plk_4	420	426	PF00069	0.558
MOD_Plk_4	534	540	PF00069	0.684
MOD_Plk_4	589	595	PF00069	0.515
MOD_Plk_4	67	73	PF00069	0.579
MOD_ProDKin_1	114	120	PF00069	0.492
MOD_ProDKin_1	186	192	PF00069	0.480
MOD_ProDKin_1	255	261	PF00069	0.534
MOD_ProDKin_1	315	321	PF00069	0.510
MOD_ProDKin_1	543	549	PF00069	0.488
MOD_ProDKin_1	57	63	PF00069	0.607
MOD_ProDKin_1	696	702	PF00069	0.784
MOD_ProDKin_1	715	721	PF00069	0.452
MOD_SUMO_for_1	609	612	PF00179	0.515
MOD_SUMO_for_1	620	623	PF00179	0.624
TRG_DiLeu_BaEn_1	589	594	PF01217	0.500
TRG_DiLeu_BaEn_1	67	72	PF01217	0.581
TRG_DiLeu_BaEn_4	568	574	PF01217	0.459
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.569
TRG_DiLeu_BaLyEn_6	485	490	PF01217	0.487
TRG_ENDOCYTIC_2	188	191	PF00928	0.609
TRG_ENDOCYTIC_2	213	216	PF00928	0.471
TRG_ENDOCYTIC_2	342	345	PF00928	0.448
TRG_ENDOCYTIC_2	723	726	PF00928	0.543
TRG_ENDOCYTIC_2	728	731	PF00928	0.539
TRG_ER_diArg_1	260	262	PF00400	0.588
TRG_ER_diArg_1	332	334	PF00400	0.448
TRG_ER_diArg_1	486	488	PF00400	0.462
TRG_ER_diArg_1	671	673	PF00400	0.582
TRG_ER_diArg_1	76	79	PF00400	0.595
TRG_NLS_MonoCore_2	73	78	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	487	492	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM3	Leptomonas seymouri	45%	99%
A4I4L6	Leishmania infantum	100%	100%
E9ALR9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%