Glycosidase

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Glycosidase

Gene product:

Protein of unknown function (DUF1861), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHB3_LEIDO

TriTrypDb:

LdBPK_101380.1 , LdCL_100021000 , LDHU3_10.1760

Length:

321

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 42

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 42
NetGPI	no	yes: 0, no: 42

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IHB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHB3

PDB structure(s): 2b4w_A , 6q4w_A , 6q4w_B , 6q4x_A , 6q4x_B , 6q4y_A , 6q4y_B , 6q4z_A , 6q4z_B , 6q50_A

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.410
CLV_NRD_NRD_1	82	84	PF00675	0.468
CLV_PCSK_FUR_1	80	84	PF00082	0.320
CLV_PCSK_KEX2_1	82	84	PF00082	0.469
CLV_PCSK_SKI1_1	15	19	PF00082	0.452
CLV_PCSK_SKI1_1	27	31	PF00082	0.481
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.458
DOC_MAPK_gen_1	142	151	PF00069	0.405
DOC_MAPK_MEF2A_6	177	185	PF00069	0.447
DOC_MAPK_MEF2A_6	228	235	PF00069	0.320
DOC_MAPK_NFAT4_5	228	236	PF00069	0.320
DOC_USP7_MATH_1	237	241	PF00917	0.464
DOC_USP7_MATH_1	276	280	PF00917	0.459
DOC_USP7_UBL2_3	113	117	PF12436	0.439
DOC_USP7_UBL2_3	23	27	PF12436	0.420
DOC_WW_Pin1_4	126	131	PF00397	0.435
LIG_AP2alpha_2	94	96	PF02296	0.483
LIG_APCC_ABBA_1	98	103	PF00400	0.464
LIG_BIR_III_4	199	203	PF00653	0.455
LIG_BRCT_BRCA1_1	239	243	PF00533	0.464
LIG_BRCT_BRCA1_1	43	47	PF00533	0.464
LIG_BRCT_BRCA1_1	69	73	PF00533	0.444
LIG_BRCT_BRCA1_2	69	75	PF00533	0.444
LIG_FHA_1	180	186	PF00498	0.454
LIG_FHA_1	237	243	PF00498	0.467
LIG_FHA_1	245	251	PF00498	0.448
LIG_FHA_1	87	93	PF00498	0.464
LIG_LIR_Apic_2	199	204	PF02991	0.496
LIG_LIR_Gen_1	170	178	PF02991	0.434
LIG_LIR_Gen_1	300	309	PF02991	0.305
LIG_LIR_Gen_1	70	81	PF02991	0.452
LIG_LIR_Nem_3	170	175	PF02991	0.439
LIG_LIR_Nem_3	247	251	PF02991	0.451
LIG_LIR_Nem_3	300	305	PF02991	0.469
LIG_LIR_Nem_3	306	312	PF02991	0.475
LIG_LIR_Nem_3	31	35	PF02991	0.490
LIG_LIR_Nem_3	53	59	PF02991	0.478
LIG_LIR_Nem_3	70	76	PF02991	0.401
LIG_PDZ_Class_2	316	321	PF00595	0.526
LIG_Pex14_2	197	201	PF04695	0.464
LIG_SH2_CRK	292	296	PF00017	0.464
LIG_SH2_CRK	312	316	PF00017	0.338
LIG_SH2_PTP2	302	305	PF00017	0.305
LIG_SH2_STAT5	135	138	PF00017	0.443
LIG_SH2_STAT5	208	211	PF00017	0.474
LIG_SH2_STAT5	223	226	PF00017	0.433
LIG_SH2_STAT5	302	305	PF00017	0.305
LIG_SH2_STAT5	54	57	PF00017	0.408
LIG_SH3_3	239	245	PF00018	0.464
LIG_SH3_3	261	267	PF00018	0.448
LIG_SUMO_SIM_anti_2	182	188	PF11976	0.444
LIG_SUMO_SIM_par_1	147	153	PF11976	0.423
LIG_SxIP_EBH_1	5	15	PF03271	0.410
LIG_WRC_WIRS_1	29	34	PF05994	0.477
MOD_CK1_1	138	144	PF00069	0.464
MOD_CK1_1	167	173	PF00069	0.430
MOD_CK2_1	276	282	PF00069	0.603
MOD_GlcNHglycan	137	140	PF01048	0.436
MOD_GlcNHglycan	187	190	PF01048	0.451
MOD_GlcNHglycan	211	214	PF01048	0.456
MOD_GlcNHglycan	278	281	PF01048	0.462
MOD_GlcNHglycan	292	295	PF01048	0.435
MOD_GSK3_1	157	164	PF00069	0.470
MOD_GSK3_1	167	174	PF00069	0.452
MOD_GSK3_1	3	10	PF00069	0.559
MOD_GSK3_1	41	48	PF00069	0.473
MOD_N-GLC_1	41	46	PF02516	0.457
MOD_NEK2_1	106	111	PF00069	0.461
MOD_NEK2_1	209	214	PF00069	0.491
MOD_NEK2_1	3	8	PF00069	0.719
MOD_NMyristoyl	1	7	PF02799	0.660
MOD_PIKK_1	202	208	PF00454	0.478
MOD_Plk_1	179	185	PF00069	0.475
MOD_Plk_1	41	47	PF00069	0.437
MOD_Plk_2-3	179	185	PF00069	0.464
MOD_Plk_2-3	244	250	PF00069	0.464
MOD_Plk_4	237	243	PF00069	0.459
MOD_Plk_4	50	56	PF00069	0.466
MOD_Plk_4	67	73	PF00069	0.412
MOD_Plk_4	7	13	PF00069	0.566
MOD_ProDKin_1	126	132	PF00069	0.435
MOD_SUMO_rev_2	150	156	PF00179	0.444
MOD_SUMO_rev_2	16	24	PF00179	0.430
MOD_SUMO_rev_2	44	53	PF00179	0.428
TRG_ENDOCYTIC_2	292	295	PF00928	0.464
TRG_ENDOCYTIC_2	302	305	PF00928	0.464
TRG_ENDOCYTIC_2	312	315	PF00928	0.334
TRG_ER_diArg_1	81	83	PF00400	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5W3	Leptomonas seymouri	51%	100%
A0A0N1HYU8	Leptomonas seymouri	50%	100%
A0A0N1I429	Leptomonas seymouri	56%	98%
A0A0N1I5D6	Leptomonas seymouri	49%	100%
A0A0N1I720	Leptomonas seymouri	53%	100%
A0A0N1IL04	Leptomonas seymouri	51%	100%
A0A0N1PCE9	Leptomonas seymouri	87%	100%
A0A0R6XPC0	Leishmania donovani	48%	100%
A0A3S5H6H4	Leishmania donovani	54%	98%
A0A3S5H6H5	Leishmania donovani	54%	100%
A0A3S7WRC9	Leishmania donovani	48%	100%
A0A3S7WRD5	Leishmania donovani	50%	100%
A0A3S7WRE8	Leishmania donovani	51%	100%
A4H6B5	Leishmania braziliensis	53%	100%
A4H6B6	Leishmania braziliensis	90%	100%
A4H6B7	Leishmania braziliensis	49%	100%
A4H6B8	Leishmania braziliensis	51%	100%
A4H6B9	Leishmania braziliensis	54%	100%
A4H6C0	Leishmania braziliensis	47%	100%
A4H6C1	Leishmania braziliensis	52%	100%
A4HUN8	Leishmania infantum	54%	100%
A4HUN9	Leishmania infantum	100%	100%
A4HUP0	Leishmania infantum	49%	100%
A4HUP1	Leishmania infantum	50%	100%
A4HUP2	Leishmania infantum	54%	100%
A4HUP3	Leishmania infantum	48%	100%
A4HUP4	Leishmania infantum	51%	100%
E9AND7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
E9AND8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
E9AND9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9ANE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9ANE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E9ANE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9ANE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
Q4QH83	Leishmania major	52%	100%
Q4QH84	Leishmania major	48%	100%
Q4QH85	Leishmania major	53%	100%
Q4QH86	Leishmania major	50%	100%
Q4QH87	Leishmania major	49%	100%
Q4QH88	Leishmania major	98%	100%
Q4QH89	Leishmania major	53%	100%