DnaJ domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IHA8_LEIDO

TriTrypDb:

LdBPK_323220.1 , LdCL_320038200 , LDHU3_32.4080

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IHA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHA8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051087	protein-folding chaperone binding	3	1
GO:0051787	misfolded protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.594
CLV_NRD_NRD_1	134	136	PF00675	0.500
CLV_NRD_NRD_1	155	157	PF00675	0.482
CLV_NRD_NRD_1	263	265	PF00675	0.602
CLV_PCSK_FUR_1	153	157	PF00082	0.415
CLV_PCSK_KEX2_1	127	129	PF00082	0.565
CLV_PCSK_KEX2_1	133	135	PF00082	0.509
CLV_PCSK_KEX2_1	153	155	PF00082	0.343
CLV_PCSK_KEX2_1	262	264	PF00082	0.687
CLV_PCSK_PC1ET2_1	133	135	PF00082	0.519
CLV_PCSK_SKI1_1	23	27	PF00082	0.360
DEG_SPOP_SBC_1	212	216	PF00917	0.570
DOC_PP1_RVXF_1	52	59	PF00149	0.266
DOC_USP7_MATH_1	144	148	PF00917	0.382
DOC_USP7_MATH_1	169	173	PF00917	0.586
DOC_USP7_MATH_1	211	215	PF00917	0.575
DOC_USP7_MATH_1	237	241	PF00917	0.571
DOC_USP7_MATH_1	47	51	PF00917	0.331
DOC_WW_Pin1_4	96	101	PF00397	0.579
LIG_14-3-3_CanoR_1	10	19	PF00244	0.542
LIG_14-3-3_CanoR_1	118	126	PF00244	0.602
LIG_14-3-3_CanoR_1	186	192	PF00244	0.522
LIG_14-3-3_CanoR_1	23	30	PF00244	0.360
LIG_14-3-3_CanoR_1	264	274	PF00244	0.524
LIG_APCC_ABBA_1	103	108	PF00400	0.569
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BIR_III_4	320	324	PF00653	0.423
LIG_BRCT_BRCA1_1	269	273	PF00533	0.435
LIG_BRCT_BRCA1_1	49	53	PF00533	0.331
LIG_CtBP_PxDLS_1	100	104	PF00389	0.497
LIG_FHA_1	10	16	PF00498	0.570
LIG_FHA_1	121	127	PF00498	0.537
LIG_FHA_1	172	178	PF00498	0.731
LIG_FHA_1	266	272	PF00498	0.536
LIG_FHA_2	185	191	PF00498	0.524
LIG_FHA_2	24	30	PF00498	0.286
LIG_FHA_2	299	305	PF00498	0.588
LIG_LIR_Apic_2	201	207	PF02991	0.598
LIG_LIR_Gen_1	13	21	PF02991	0.313
LIG_LIR_Gen_1	298	303	PF02991	0.486
LIG_LIR_Nem_3	13	19	PF02991	0.313
LIG_LIR_Nem_3	298	302	PF02991	0.446
LIG_LIR_Nem_3	50	56	PF02991	0.270
LIG_PTB_Apo_2	139	146	PF02174	0.431
LIG_PTB_Apo_2	293	300	PF02174	0.456
LIG_PTB_Phospho_1	293	299	PF10480	0.450
LIG_SH2_CRK	204	208	PF00017	0.692
LIG_SH2_CRK	297	301	PF00017	0.437
LIG_SH2_GRB2like	294	297	PF00017	0.453
LIG_SH2_STAP1	283	287	PF00017	0.479
LIG_SH2_STAT5	299	302	PF00017	0.445
LIG_SUMO_SIM_par_1	172	178	PF11976	0.500
LIG_WRC_WIRS_1	248	253	PF05994	0.493
LIG_WRC_WIRS_1	299	304	PF05994	0.532
MOD_CK1_1	2	8	PF00069	0.675
MOD_CK1_1	240	246	PF00069	0.634
MOD_CK1_1	247	253	PF00069	0.611
MOD_CK2_1	119	125	PF00069	0.480
MOD_CK2_1	144	150	PF00069	0.513
MOD_CK2_1	184	190	PF00069	0.544
MOD_CK2_1	23	29	PF00069	0.285
MOD_CK2_1	240	246	PF00069	0.683
MOD_CK2_1	298	304	PF00069	0.474
MOD_CK2_1	61	67	PF00069	0.337
MOD_GlcNHglycan	12	15	PF01048	0.540
MOD_GlcNHglycan	164	167	PF01048	0.652
MOD_GlcNHglycan	171	174	PF01048	0.655
MOD_GlcNHglycan	187	190	PF01048	0.636
MOD_GlcNHglycan	215	218	PF01048	0.624
MOD_GlcNHglycan	241	245	PF01048	0.760
MOD_GlcNHglycan	252	255	PF01048	0.687
MOD_GlcNHglycan	257	260	PF01048	0.634
MOD_GlcNHglycan	287	290	PF01048	0.623
MOD_GlcNHglycan	73	76	PF01048	0.496
MOD_GSK3_1	171	178	PF00069	0.695
MOD_GSK3_1	19	26	PF00069	0.411
MOD_GSK3_1	219	226	PF00069	0.509
MOD_GSK3_1	240	247	PF00069	0.596
MOD_GSK3_1	253	260	PF00069	0.538
MOD_GSK3_1	281	288	PF00069	0.586
MOD_N-GLC_1	212	217	PF02516	0.549
MOD_N-GLC_1	23	28	PF02516	0.287
MOD_NEK2_1	177	182	PF00069	0.577
MOD_NEK2_1	19	24	PF00069	0.377
MOD_NEK2_1	266	271	PF00069	0.429
MOD_NEK2_1	71	76	PF00069	0.536
MOD_NEK2_1	9	14	PF00069	0.591
MOD_NEK2_2	257	262	PF00069	0.516
MOD_PIKK_1	110	116	PF00454	0.495
MOD_PIKK_1	23	29	PF00454	0.411
MOD_PKA_2	110	116	PF00069	0.567
MOD_PKA_2	185	191	PF00069	0.570
MOD_PKA_2	9	15	PF00069	0.515
MOD_Plk_1	2	8	PF00069	0.591
MOD_Plk_2-3	298	304	PF00069	0.494
MOD_Plk_4	2	8	PF00069	0.585
MOD_Plk_4	247	253	PF00069	0.490
MOD_Plk_4	298	304	PF00069	0.497
MOD_ProDKin_1	96	102	PF00069	0.581
MOD_SUMO_for_1	145	148	PF00179	0.471
MOD_SUMO_rev_2	137	143	PF00179	0.466
TRG_DiLeu_BaEn_4	198	204	PF01217	0.572
TRG_ENDOCYTIC_2	16	19	PF00928	0.300
TRG_ENDOCYTIC_2	297	300	PF00928	0.454
TRG_ENDOCYTIC_2	34	37	PF00928	0.266
TRG_ER_diArg_1	126	128	PF00400	0.566
TRG_ER_diArg_1	153	156	PF00400	0.536
TRG_ER_diArg_1	261	264	PF00400	0.711
TRG_Pf-PMV_PEXEL_1	28	32	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IML6	Leptomonas seymouri	54%	100%
A0A0S4ILI1	Bodo saltans	35%	100%
A0A1X0NRT2	Trypanosomatidae	45%	100%
A0A422NYS2	Trypanosoma rangeli	42%	100%
A4HKU8	Leishmania braziliensis	80%	100%
A4I8C7	Leishmania infantum	100%	100%
D0AAU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B386	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4W9	Leishmania major	91%	100%
V5BL40	Trypanosoma cruzi	44%	100%