Tetraspanin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Tetraspanin

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IHA4_LEIDO

TriTrypDb:

LdBPK_330170.1 , LdCL_330006600 , LDHU3_33.0190

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3Q8IHA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	140	144	PF00656	0.441
CLV_NRD_NRD_1	202	204	PF00675	0.759
CLV_NRD_NRD_1	334	336	PF00675	0.588
CLV_NRD_NRD_1	91	93	PF00675	0.433
CLV_PCSK_KEX2_1	200	202	PF00082	0.696
CLV_PCSK_KEX2_1	336	338	PF00082	0.535
CLV_PCSK_KEX2_1	90	92	PF00082	0.440
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.594
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.535
CLV_PCSK_PC7_1	197	203	PF00082	0.585
CLV_PCSK_SKI1_1	117	121	PF00082	0.605
CLV_PCSK_SKI1_1	197	201	PF00082	0.577
DEG_SCF_FBW7_1	249	256	PF00400	0.494
DEG_SPOP_SBC_1	254	258	PF00917	0.458
DEG_SPOP_SBC_1	311	315	PF00917	0.650
DOC_CDC14_PxL_1	21	29	PF14671	0.591
DOC_MAPK_gen_1	299	308	PF00069	0.736
DOC_PP2B_LxvP_1	70	73	PF13499	0.367
DOC_PP4_FxxP_1	22	25	PF00568	0.495
DOC_USP7_MATH_1	245	249	PF00917	0.537
DOC_USP7_MATH_1	253	257	PF00917	0.445
DOC_USP7_MATH_1	300	304	PF00917	0.741
DOC_USP7_MATH_1	311	315	PF00917	0.669
DOC_WW_Pin1_4	249	254	PF00397	0.602
DOC_WW_Pin1_4	307	312	PF00397	0.732
LIG_14-3-3_CanoR_1	299	308	PF00244	0.812
LIG_14-3-3_CterR_2	335	338	PF00244	0.831
LIG_APCC_ABBA_1	132	137	PF00400	0.507
LIG_BIR_II_1	1	5	PF00653	0.514
LIG_BRCT_BRCA1_1	186	190	PF00533	0.457
LIG_BRCT_BRCA1_1	301	305	PF00533	0.709
LIG_deltaCOP1_diTrp_1	181	190	PF00928	0.469
LIG_eIF4E_1	100	106	PF01652	0.367
LIG_FHA_1	166	172	PF00498	0.503
LIG_FHA_1	213	219	PF00498	0.385
LIG_FHA_1	224	230	PF00498	0.433
LIG_FHA_1	26	32	PF00498	0.416
LIG_FHA_2	255	261	PF00498	0.563
LIG_FHA_2	31	37	PF00498	0.449
LIG_GBD_Chelix_1	31	39	PF00786	0.699
LIG_LIR_Apic_2	152	156	PF02991	0.462
LIG_LIR_Apic_2	19	25	PF02991	0.618
LIG_LIR_Gen_1	226	236	PF02991	0.425
LIG_LIR_Nem_3	182	188	PF02991	0.412
LIG_LIR_Nem_3	226	231	PF02991	0.459
LIG_LIR_Nem_3	232	238	PF02991	0.498
LIG_LIR_Nem_3	302	308	PF02991	0.691
LIG_NRBOX	111	117	PF00104	0.315
LIG_NRBOX	66	72	PF00104	0.367
LIG_Pex14_1	151	155	PF04695	0.448
LIG_Pex14_1	96	100	PF04695	0.469
LIG_Pex14_2	10	14	PF04695	0.367
LIG_SH2_CRK	100	104	PF00017	0.440
LIG_SH2_CRK	153	157	PF00017	0.455
LIG_SH2_PTP2	228	231	PF00017	0.426
LIG_SH2_SRC	153	156	PF00017	0.516
LIG_SH2_SRC	262	265	PF00017	0.410
LIG_SH2_STAT5	113	116	PF00017	0.440
LIG_SH2_STAT5	228	231	PF00017	0.426
LIG_SH2_STAT5	262	265	PF00017	0.417
LIG_SUMO_SIM_par_1	289	295	PF11976	0.321
LIG_SUMO_SIM_par_1	68	74	PF11976	0.441
LIG_TRAF2_1	174	177	PF00917	0.456
LIG_TRAF2_1	180	183	PF00917	0.427
LIG_TYR_ITIM	111	116	PF00017	0.440
LIG_UBA3_1	319	323	PF00899	0.663
MOD_CK1_1	158	164	PF00069	0.524
MOD_CK1_1	26	32	PF00069	0.424
MOD_CK1_1	310	316	PF00069	0.731
MOD_CK2_1	171	177	PF00069	0.562
MOD_CK2_1	254	260	PF00069	0.530
MOD_CK2_1	30	36	PF00069	0.470
MOD_CK2_1	311	317	PF00069	0.758
MOD_CK2_1	41	47	PF00069	0.520
MOD_GlcNHglycan	120	123	PF01048	0.627
MOD_GlcNHglycan	157	160	PF01048	0.641
MOD_GlcNHglycan	194	197	PF01048	0.648
MOD_GlcNHglycan	47	51	PF01048	0.601
MOD_GSK3_1	155	162	PF00069	0.464
MOD_GSK3_1	163	170	PF00069	0.465
MOD_GSK3_1	23	30	PF00069	0.438
MOD_GSK3_1	245	252	PF00069	0.506
MOD_GSK3_1	307	314	PF00069	0.708
MOD_GSK3_1	46	53	PF00069	0.551
MOD_LATS_1	297	303	PF00433	0.690
MOD_N-GLC_1	128	133	PF02516	0.666
MOD_N-GLC_1	166	171	PF02516	0.610
MOD_N-GLC_1	245	250	PF02516	0.694
MOD_NEK2_1	10	15	PF00069	0.409
MOD_NEK2_1	237	242	PF00069	0.518
MOD_NEK2_1	267	272	PF00069	0.436
MOD_NEK2_1	27	32	PF00069	0.418
MOD_NEK2_1	279	284	PF00069	0.331
MOD_NEK2_2	16	21	PF00069	0.440
MOD_NEK2_2	245	250	PF00069	0.467
MOD_OFUCOSY	157	163	PF10250	0.715
MOD_PIKK_1	144	150	PF00454	0.444
MOD_PKA_2	300	306	PF00069	0.812
MOD_Plk_1	128	134	PF00069	0.466
MOD_Plk_1	166	172	PF00069	0.498
MOD_Plk_1	245	251	PF00069	0.493
MOD_Plk_1	35	41	PF00069	0.453
MOD_Plk_1	46	52	PF00069	0.385
MOD_Plk_2-3	177	183	PF00069	0.403
MOD_Plk_2-3	41	47	PF00069	0.412
MOD_Plk_4	282	288	PF00069	0.335
MOD_Plk_4	315	321	PF00069	0.686
MOD_Plk_4	51	57	PF00069	0.454
MOD_Plk_4	71	77	PF00069	0.479
MOD_ProDKin_1	249	255	PF00069	0.603
MOD_ProDKin_1	307	313	PF00069	0.730
MOD_SUMO_for_1	322	325	PF00179	0.729
TRG_ENDOCYTIC_2	100	103	PF00928	0.440
TRG_ENDOCYTIC_2	113	116	PF00928	0.273
TRG_ENDOCYTIC_2	135	138	PF00928	0.346
TRG_ENDOCYTIC_2	228	231	PF00928	0.426
TRG_ER_diArg_1	201	203	PF00400	0.499
TRG_ER_diArg_1	90	92	PF00400	0.637
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKK0	Leptomonas seymouri	38%	81%
A4HL53	Leishmania braziliensis	70%	100%
A4I8N2	Leishmania infantum	99%	100%
E9B3J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q4K7	Leishmania major	88%	100%