Protein KRI1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IHA2_LEIDO

TriTrypDb:

LdBPK_291490.1 , LdCL_290020400 , LDHU3_29.2180

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0030684	preribosome	3	1
GO:0030688	preribosome, small subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A0A3Q8IHA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IHA2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	8
GO:0022613	ribonucleoprotein complex biogenesis	4	8
GO:0042274	ribosomal small subunit biogenesis	5	8
GO:0044085	cellular component biogenesis	3	8
GO:0071840	cellular component organization or biogenesis	2	8
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000056	ribosomal small subunit export from nucleus	4	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0031503	protein-containing complex localization	2	1
GO:0033750	ribosome localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051656	establishment of organelle localization	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.649
CLV_C14_Caspase3-7	20	24	PF00656	0.594
CLV_C14_Caspase3-7	208	212	PF00656	0.532
CLV_C14_Caspase3-7	428	432	PF00656	0.611
CLV_NRD_NRD_1	251	253	PF00675	0.576
CLV_NRD_NRD_1	258	260	PF00675	0.630
CLV_NRD_NRD_1	401	403	PF00675	0.510
CLV_NRD_NRD_1	41	43	PF00675	0.550
CLV_NRD_NRD_1	478	480	PF00675	0.554
CLV_NRD_NRD_1	484	486	PF00675	0.564
CLV_NRD_NRD_1	493	495	PF00675	0.585
CLV_NRD_NRD_1	56	58	PF00675	0.629
CLV_NRD_NRD_1	588	590	PF00675	0.621
CLV_NRD_NRD_1	600	602	PF00675	0.428
CLV_NRD_NRD_1	611	613	PF00675	0.436
CLV_NRD_NRD_1	631	633	PF00675	0.333
CLV_NRD_NRD_1	640	642	PF00675	0.519
CLV_NRD_NRD_1	74	76	PF00675	0.500
CLV_NRD_NRD_1	77	79	PF00675	0.557
CLV_PCSK_FUR_1	256	260	PF00082	0.621
CLV_PCSK_FUR_1	609	613	PF00082	0.535
CLV_PCSK_FUR_1	75	79	PF00082	0.554
CLV_PCSK_KEX2_1	250	252	PF00082	0.559
CLV_PCSK_KEX2_1	256	258	PF00082	0.626
CLV_PCSK_KEX2_1	401	403	PF00082	0.521
CLV_PCSK_KEX2_1	41	43	PF00082	0.537
CLV_PCSK_KEX2_1	478	480	PF00082	0.539
CLV_PCSK_KEX2_1	484	486	PF00082	0.531
CLV_PCSK_KEX2_1	493	495	PF00082	0.553
CLV_PCSK_KEX2_1	56	58	PF00082	0.593
CLV_PCSK_KEX2_1	588	590	PF00082	0.558
CLV_PCSK_KEX2_1	600	602	PF00082	0.428
CLV_PCSK_KEX2_1	611	613	PF00082	0.436
CLV_PCSK_KEX2_1	631	633	PF00082	0.333
CLV_PCSK_KEX2_1	640	642	PF00082	0.511
CLV_PCSK_KEX2_1	74	76	PF00082	0.494
CLV_PCSK_KEX2_1	77	79	PF00082	0.563
CLV_PCSK_PC7_1	252	258	PF00082	0.584
CLV_PCSK_SKI1_1	10	14	PF00082	0.466
CLV_PCSK_SKI1_1	139	143	PF00082	0.725
CLV_PCSK_SKI1_1	236	240	PF00082	0.523
CLV_PCSK_SKI1_1	294	298	PF00082	0.447
CLV_PCSK_SKI1_1	327	331	PF00082	0.516
CLV_PCSK_SKI1_1	484	488	PF00082	0.651
CLV_PCSK_SKI1_1	552	556	PF00082	0.584
CLV_PCSK_SKI1_1	612	616	PF00082	0.471
CLV_PCSK_SKI1_1	632	636	PF00082	0.330
CLV_Separin_Metazoa	298	302	PF03568	0.484
DEG_SPOP_SBC_1	532	536	PF00917	0.620
DOC_CYCLIN_RxL_1	199	208	PF00134	0.546
DOC_MAPK_gen_1	401	408	PF00069	0.472
DOC_MAPK_gen_1	551	559	PF00069	0.627
DOC_MAPK_gen_1	576	585	PF00069	0.599
DOC_MAPK_MEF2A_6	127	135	PF00069	0.553
DOC_MAPK_MEF2A_6	576	585	PF00069	0.572
DOC_PP1_RVXF_1	200	207	PF00149	0.492
DOC_PP1_RVXF_1	639	646	PF00149	0.589
DOC_USP7_MATH_1	151	155	PF00917	0.709
DOC_USP7_MATH_1	368	372	PF00917	0.548
DOC_USP7_MATH_1	425	429	PF00917	0.787
DOC_USP7_MATH_1	477	481	PF00917	0.575
DOC_USP7_MATH_1	532	536	PF00917	0.629
DOC_USP7_UBL2_3	243	247	PF12436	0.477
DOC_USP7_UBL2_3	551	555	PF12436	0.633
DOC_USP7_UBL2_3	590	594	PF12436	0.530
DOC_USP7_UBL2_3	6	10	PF12436	0.539
DOC_USP7_UBL2_3	615	619	PF12436	0.459
DOC_WW_Pin1_4	423	428	PF00397	0.604
LIG_14-3-3_CanoR_1	250	260	PF00244	0.466
LIG_14-3-3_CanoR_1	294	303	PF00244	0.457
LIG_14-3-3_CanoR_1	478	486	PF00244	0.633
LIG_14-3-3_CanoR_1	612	622	PF00244	0.518
LIG_14-3-3_CanoR_1	640	644	PF00244	0.572
LIG_BIR_III_4	23	27	PF00653	0.630
LIG_BIR_III_4	372	376	PF00653	0.597
LIG_BIR_III_4	85	89	PF00653	0.623
LIG_Clathr_ClatBox_1	443	447	PF01394	0.637
LIG_deltaCOP1_diTrp_1	112	122	PF00928	0.675
LIG_FHA_1	11	17	PF00498	0.452
LIG_FHA_1	377	383	PF00498	0.512
LIG_FHA_1	395	401	PF00498	0.458
LIG_FHA_1	517	523	PF00498	0.632
LIG_FHA_1	541	547	PF00498	0.630
LIG_FHA_1	554	560	PF00498	0.541
LIG_FHA_1	569	575	PF00498	0.629
LIG_FHA_2	237	243	PF00498	0.516
LIG_FHA_2	328	334	PF00498	0.514
LIG_FHA_2	431	437	PF00498	0.648
LIG_FHA_2	499	505	PF00498	0.676
LIG_FHA_2	591	597	PF00498	0.468
LIG_FHA_2	619	625	PF00498	0.529
LIG_Integrin_RGD_1	523	525	PF01839	0.603
LIG_LIR_Apic_2	465	471	PF02991	0.474
LIG_LIR_Gen_1	293	303	PF02991	0.478
LIG_LIR_Nem_3	13	17	PF02991	0.439
LIG_LIR_Nem_3	222	227	PF02991	0.647
LIG_LIR_Nem_3	232	238	PF02991	0.538
LIG_LIR_Nem_3	462	467	PF02991	0.409
LIG_LIR_Nem_3	621	625	PF02991	0.514
LIG_Pex14_2	389	393	PF04695	0.469
LIG_RPA_C_Fungi	245	257	PF08784	0.553
LIG_SH2_CRK	14	18	PF00017	0.505
LIG_SH2_CRK	468	472	PF00017	0.538
LIG_SH2_GRB2like	467	470	PF00017	0.475
LIG_SH2_NCK_1	468	472	PF00017	0.538
LIG_SH2_NCK_1	62	66	PF00017	0.520
LIG_SH2_SRC	90	93	PF00017	0.639
LIG_SH2_STAP1	464	468	PF00017	0.411
LIG_SH2_STAP1	62	66	PF00017	0.520
LIG_SH2_STAT3	467	470	PF00017	0.475
LIG_SH2_STAT5	313	316	PF00017	0.523
LIG_SH2_STAT5	328	331	PF00017	0.431
LIG_SH2_STAT5	361	364	PF00017	0.502
LIG_SH3_3	125	131	PF00018	0.767
LIG_SH3_3	556	562	PF00018	0.625
LIG_SH3_4	6	13	PF00018	0.536
LIG_SUMO_SIM_anti_2	436	447	PF11976	0.646
LIG_TRAF2_1	101	104	PF00917	0.663
LIG_TRAF2_1	178	181	PF00917	0.721
LIG_TRAF2_1	331	334	PF00917	0.443
LIG_TRAF2_1	434	437	PF00917	0.662
LIG_TRAF2_1	593	596	PF00917	0.478
LIG_TRFH_1	14	18	PF08558	0.505
LIG_TYR_ITIM	12	17	PF00017	0.501
LIG_UBA3_1	355	360	PF00899	0.531
LIG_UBA3_1	443	451	PF00899	0.604
MOD_CK1_1	462	468	PF00069	0.479
MOD_CK1_1	505	511	PF00069	0.620
MOD_CK1_1	517	523	PF00069	0.730
MOD_CK1_1	535	541	PF00069	0.567
MOD_CK1_1	544	550	PF00069	0.579
MOD_CK1_1	568	574	PF00069	0.654
MOD_CK1_1	633	639	PF00069	0.525
MOD_CK2_1	236	242	PF00069	0.528
MOD_CK2_1	32	38	PF00069	0.508
MOD_CK2_1	327	333	PF00069	0.517
MOD_CK2_1	423	429	PF00069	0.611
MOD_CK2_1	430	436	PF00069	0.808
MOD_CK2_1	498	504	PF00069	0.679
MOD_CK2_1	563	569	PF00069	0.663
MOD_CK2_1	590	596	PF00069	0.473
MOD_CK2_1	618	624	PF00069	0.530
MOD_CK2_1	98	104	PF00069	0.562
MOD_Cter_Amidation	75	78	PF01082	0.465
MOD_GlcNHglycan	145	148	PF01048	0.689
MOD_GlcNHglycan	207	210	PF01048	0.600
MOD_GlcNHglycan	44	47	PF01048	0.626
MOD_GlcNHglycan	461	464	PF01048	0.484
MOD_GlcNHglycan	479	482	PF01048	0.549
MOD_GlcNHglycan	515	519	PF01048	0.645
MOD_GlcNHglycan	527	530	PF01048	0.590
MOD_GlcNHglycan	535	538	PF01048	0.643
MOD_GlcNHglycan	548	551	PF01048	0.581
MOD_GlcNHglycan	615	618	PF01048	0.517
MOD_GlcNHglycan	632	635	PF01048	0.519
MOD_GSK3_1	169	176	PF00069	0.636
MOD_GSK3_1	246	253	PF00069	0.420
MOD_GSK3_1	277	284	PF00069	0.593
MOD_GSK3_1	459	466	PF00069	0.476
MOD_GSK3_1	498	505	PF00069	0.709
MOD_GSK3_1	513	520	PF00069	0.621
MOD_GSK3_1	531	538	PF00069	0.560
MOD_GSK3_1	540	547	PF00069	0.616
MOD_N-GLC_1	505	510	PF02516	0.575
MOD_NEK2_1	152	157	PF00069	0.684
MOD_NEK2_1	271	276	PF00069	0.777
MOD_NEK2_1	335	340	PF00069	0.536
MOD_NEK2_1	533	538	PF00069	0.548
MOD_NEK2_1	618	623	PF00069	0.533
MOD_NEK2_1	630	635	PF00069	0.417
MOD_NEK2_2	639	644	PF00069	0.514
MOD_PIKK_1	285	291	PF00454	0.553
MOD_PIKK_1	633	639	PF00454	0.525
MOD_PKA_1	250	256	PF00069	0.570
MOD_PKA_2	250	256	PF00069	0.570
MOD_PKA_2	477	483	PF00069	0.605
MOD_PKA_2	544	550	PF00069	0.686
MOD_PKA_2	630	636	PF00069	0.572
MOD_PKA_2	639	645	PF00069	0.530
MOD_Plk_2-3	173	179	PF00069	0.623
MOD_Plk_2-3	311	317	PF00069	0.517
MOD_Plk_2-3	624	630	PF00069	0.528
MOD_Plk_4	377	383	PF00069	0.519
MOD_Plk_4	463	469	PF00069	0.481
MOD_Plk_4	517	523	PF00069	0.682
MOD_ProDKin_1	423	429	PF00069	0.609
MOD_SUMO_rev_2	119	128	PF00179	0.680
MOD_SUMO_rev_2	179	188	PF00179	0.613
MOD_SUMO_rev_2	240	245	PF00179	0.496
MOD_SUMO_rev_2	441	450	PF00179	0.614
MOD_SUMO_rev_2	591	599	PF00179	0.476
TRG_DiLeu_BaEn_1	233	238	PF01217	0.538
TRG_DiLeu_BaEn_1	439	444	PF01217	0.660
TRG_DiLeu_BaEn_3	439	445	PF01217	0.621
TRG_DiLeu_LyEn_5	233	238	PF01217	0.538
TRG_ENDOCYTIC_2	14	17	PF00928	0.493
TRG_ENDOCYTIC_2	622	625	PF00928	0.451
TRG_ER_diArg_1	250	252	PF00400	0.559
TRG_ER_diArg_1	256	259	PF00400	0.629
TRG_ER_diArg_1	40	42	PF00400	0.517
TRG_ER_diArg_1	400	402	PF00400	0.528
TRG_ER_diArg_1	405	408	PF00400	0.488
TRG_ER_diArg_1	477	479	PF00400	0.593
TRG_ER_diArg_1	484	486	PF00400	0.583
TRG_ER_diArg_1	587	589	PF00400	0.626
TRG_ER_diArg_1	599	601	PF00400	0.457
TRG_ER_diArg_1	630	632	PF00400	0.546
TRG_ER_diArg_1	74	77	PF00400	0.542
TRG_NLS_MonoCore_2	4	9	PF00514	0.538
TRG_NLS_MonoExtN_4	2	9	PF00514	0.504
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	290	295	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2D0	Leptomonas seymouri	51%	91%
A4HHE8	Leishmania braziliensis	67%	95%
A4I4J8	Leishmania infantum	99%	100%
E9ADZ7	Leishmania major	87%	99%
E9ALT4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BH77	Trypanosoma cruzi	38%	100%