LysM domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH97_LEIDO

TriTrypDb:

LdBPK_330010.1 , LdCL_330005000 , LDHU3_33.0020

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IH97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH97

PDB structure(s): 7ane_e

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	586	590	PF00656	0.511
CLV_NRD_NRD_1	117	119	PF00675	0.529
CLV_NRD_NRD_1	2	4	PF00675	0.482
CLV_NRD_NRD_1	397	399	PF00675	0.342
CLV_NRD_NRD_1	530	532	PF00675	0.348
CLV_NRD_NRD_1	557	559	PF00675	0.531
CLV_NRD_NRD_1	669	671	PF00675	0.412
CLV_PCSK_FUR_1	223	227	PF00082	0.385
CLV_PCSK_FUR_1	667	671	PF00082	0.500
CLV_PCSK_KEX2_1	2	4	PF00082	0.482
CLV_PCSK_KEX2_1	225	227	PF00082	0.391
CLV_PCSK_KEX2_1	439	441	PF00082	0.449
CLV_PCSK_KEX2_1	497	499	PF00082	0.350
CLV_PCSK_KEX2_1	530	532	PF00082	0.348
CLV_PCSK_KEX2_1	557	559	PF00082	0.433
CLV_PCSK_KEX2_1	669	671	PF00082	0.412
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.427
CLV_PCSK_PC1ET2_1	439	441	PF00082	0.478
CLV_PCSK_PC1ET2_1	497	499	PF00082	0.350
CLV_PCSK_SKI1_1	131	135	PF00082	0.512
CLV_PCSK_SKI1_1	139	143	PF00082	0.493
CLV_PCSK_SKI1_1	226	230	PF00082	0.403
CLV_PCSK_SKI1_1	245	249	PF00082	0.299
CLV_PCSK_SKI1_1	530	534	PF00082	0.430
CLV_Separin_Metazoa	329	333	PF03568	0.279
DEG_APCC_DBOX_1	282	290	PF00400	0.519
DEG_APCC_DBOX_1	326	334	PF00400	0.378
DEG_Nend_UBRbox_1	1	4	PF02207	0.533
DEG_SCF_FBW7_1	723	729	PF00400	0.556
DEG_SCF_FBW7_2	772	779	PF00400	0.426
DOC_CDC14_PxL_1	698	706	PF14671	0.461
DOC_CKS1_1	715	720	PF01111	0.417
DOC_CKS1_1	723	728	PF01111	0.436
DOC_CYCLIN_yCln2_LP_2	784	790	PF00134	0.434
DOC_MAPK_gen_1	398	406	PF00069	0.298
DOC_MAPK_MEF2A_6	399	408	PF00069	0.388
DOC_PP1_RVXF_1	813	820	PF00149	0.389
DOC_PP2B_LxvP_1	599	602	PF13499	0.354
DOC_PP4_FxxP_1	23	26	PF00568	0.470
DOC_PP4_FxxP_1	311	314	PF00568	0.468
DOC_PP4_FxxP_1	43	46	PF00568	0.290
DOC_USP7_MATH_1	125	129	PF00917	0.441
DOC_USP7_MATH_1	200	204	PF00917	0.464
DOC_USP7_MATH_1	349	353	PF00917	0.502
DOC_USP7_MATH_1	357	361	PF00917	0.373
DOC_USP7_MATH_1	409	413	PF00917	0.332
DOC_USP7_MATH_1	552	556	PF00917	0.516
DOC_USP7_MATH_1	584	588	PF00917	0.556
DOC_USP7_MATH_1	642	646	PF00917	0.360
DOC_USP7_MATH_1	651	655	PF00917	0.532
DOC_USP7_MATH_1	657	661	PF00917	0.370
DOC_USP7_UBL2_3	221	225	PF12436	0.409
DOC_USP7_UBL2_3	741	745	PF12436	0.448
DOC_WW_Pin1_4	174	179	PF00397	0.390
DOC_WW_Pin1_4	535	540	PF00397	0.489
DOC_WW_Pin1_4	714	719	PF00397	0.419
DOC_WW_Pin1_4	722	727	PF00397	0.432
DOC_WW_Pin1_4	772	777	PF00397	0.406
LIG_14-3-3_CanoR_1	2	7	PF00244	0.505
LIG_14-3-3_CanoR_1	202	206	PF00244	0.461
LIG_14-3-3_CanoR_1	208	217	PF00244	0.401
LIG_14-3-3_CanoR_1	283	287	PF00244	0.486
LIG_14-3-3_CanoR_1	428	434	PF00244	0.376
LIG_14-3-3_CanoR_1	465	470	PF00244	0.377
LIG_14-3-3_CanoR_1	498	506	PF00244	0.308
LIG_14-3-3_CanoR_1	530	536	PF00244	0.410
LIG_14-3-3_CanoR_1	632	640	PF00244	0.303
LIG_14-3-3_CanoR_1	641	647	PF00244	0.294
LIG_14-3-3_CanoR_1	87	94	PF00244	0.427
LIG_Actin_WH2_2	252	270	PF00022	0.321
LIG_Actin_WH2_2	492	509	PF00022	0.310
LIG_AP_GAE_1	611	617	PF02883	0.500
LIG_APCC_ABBA_1	100	105	PF00400	0.396
LIG_BRCT_BRCA1_1	411	415	PF00533	0.330
LIG_BRCT_BRCA1_1	430	434	PF00533	0.433
LIG_BRCT_BRCA1_1	445	449	PF00533	0.459
LIG_Clathr_ClatBox_1	330	334	PF01394	0.272
LIG_deltaCOP1_diTrp_1	368	377	PF00928	0.365
LIG_FHA_1	149	155	PF00498	0.509
LIG_FHA_1	161	167	PF00498	0.515
LIG_FHA_1	241	247	PF00498	0.308
LIG_FHA_1	326	332	PF00498	0.324
LIG_FHA_1	349	355	PF00498	0.542
LIG_FHA_1	527	533	PF00498	0.488
LIG_FHA_1	536	542	PF00498	0.543
LIG_FHA_1	604	610	PF00498	0.349
LIG_FHA_1	680	686	PF00498	0.404
LIG_FHA_1	78	84	PF00498	0.398
LIG_FHA_2	384	390	PF00498	0.377
LIG_FHA_2	411	417	PF00498	0.394
LIG_FHA_2	428	434	PF00498	0.371
LIG_FHA_2	449	455	PF00498	0.426
LIG_FHA_2	510	516	PF00498	0.548
LIG_FHA_2	687	693	PF00498	0.395
LIG_FHA_2	773	779	PF00498	0.410
LIG_GBD_Chelix_1	322	330	PF00786	0.411
LIG_LIR_Apic_2	12	17	PF02991	0.448
LIG_LIR_Apic_2	40	46	PF02991	0.458
LIG_LIR_Apic_2	714	718	PF02991	0.411
LIG_LIR_Apic_2	816	822	PF02991	0.407
LIG_LIR_Gen_1	368	376	PF02991	0.402
LIG_LIR_Gen_1	382	393	PF02991	0.372
LIG_LIR_Gen_1	479	486	PF02991	0.415
LIG_LIR_Gen_1	490	499	PF02991	0.255
LIG_LIR_Gen_1	611	621	PF02991	0.439
LIG_LIR_Gen_1	624	633	PF02991	0.256
LIG_LIR_LC3C_4	598	601	PF02991	0.448
LIG_LIR_Nem_3	211	217	PF02991	0.362
LIG_LIR_Nem_3	241	247	PF02991	0.308
LIG_LIR_Nem_3	360	364	PF02991	0.350
LIG_LIR_Nem_3	382	388	PF02991	0.385
LIG_LIR_Nem_3	396	400	PF02991	0.401
LIG_LIR_Nem_3	479	483	PF02991	0.443
LIG_LIR_Nem_3	490	495	PF02991	0.313
LIG_LIR_Nem_3	611	617	PF02991	0.383
LIG_LIR_Nem_3	624	629	PF02991	0.254
LIG_LIR_Nem_3	732	738	PF02991	0.385
LIG_MYND_1	674	678	PF01753	0.390
LIG_Pex14_2	138	142	PF04695	0.371
LIG_Pex14_2	205	209	PF04695	0.345
LIG_Pex14_2	397	401	PF04695	0.319
LIG_Pex14_2	469	473	PF04695	0.354
LIG_Pex14_2	617	621	PF04695	0.444
LIG_Rb_LxCxE_1	494	515	PF01857	0.417
LIG_Rb_LxCxE_1	628	649	PF01857	0.334
LIG_SH2_CRK	14	18	PF00017	0.413
LIG_SH2_CRK	244	248	PF00017	0.296
LIG_SH2_SRC	69	72	PF00017	0.351
LIG_SH2_STAP1	215	219	PF00017	0.355
LIG_SH2_STAP1	355	359	PF00017	0.444
LIG_SH2_STAP1	738	742	PF00017	0.362
LIG_SH2_STAT3	113	116	PF00017	0.412
LIG_SH2_STAT3	123	126	PF00017	0.432
LIG_SH2_STAT5	113	116	PF00017	0.417
LIG_SH2_STAT5	400	403	PF00017	0.346
LIG_SH2_STAT5	480	483	PF00017	0.439
LIG_SH2_STAT5	581	584	PF00017	0.435
LIG_SH2_STAT5	69	72	PF00017	0.351
LIG_SH2_STAT5	716	719	PF00017	0.368
LIG_SH2_STAT5	738	741	PF00017	0.359
LIG_SH2_STAT5	74	77	PF00017	0.396
LIG_SH2_STAT5	742	745	PF00017	0.391
LIG_SH3_3	150	156	PF00018	0.375
LIG_SH3_3	172	178	PF00018	0.453
LIG_SH3_3	26	32	PF00018	0.478
LIG_SH3_3	343	349	PF00018	0.368
LIG_SH3_3	356	362	PF00018	0.350
LIG_SH3_3	403	409	PF00018	0.388
LIG_SH3_3	519	525	PF00018	0.540
LIG_SH3_3	59	65	PF00018	0.385
LIG_SH3_3	656	662	PF00018	0.364
LIG_SH3_3	699	705	PF00018	0.459
LIG_SH3_3	720	726	PF00018	0.450
LIG_TRAF2_1	512	515	PF00917	0.614
LIG_TRAF2_1	566	569	PF00917	0.405
LIG_TRAF2_1	776	779	PF00917	0.414
LIG_TRAF2_2	543	548	PF00917	0.606
LIG_TYR_ITIM	242	247	PF00017	0.300
LIG_TYR_ITIM	478	483	PF00017	0.435
LIG_WRC_WIRS_1	466	471	PF05994	0.371
LIG_WRC_WIRS_1	532	537	PF05994	0.417
LIG_WRPW_2	100	103	PF00400	0.396
LIG_WRPW_2	86	89	PF00400	0.386
MOD_CDK_SPxxK_3	714	721	PF00069	0.417
MOD_CK1_1	240	246	PF00069	0.290
MOD_CK1_1	285	291	PF00069	0.544
MOD_CK1_1	37	43	PF00069	0.483
MOD_CK1_1	380	386	PF00069	0.390
MOD_CK1_1	491	497	PF00069	0.362
MOD_CK1_1	534	540	PF00069	0.493
MOD_CK1_1	729	735	PF00069	0.434
MOD_CK2_1	174	180	PF00069	0.424
MOD_CK2_1	235	241	PF00069	0.361
MOD_CK2_1	381	387	PF00069	0.385
MOD_CK2_1	410	416	PF00069	0.364
MOD_CK2_1	427	433	PF00069	0.405
MOD_CK2_1	499	505	PF00069	0.335
MOD_CK2_1	509	515	PF00069	0.482
MOD_CK2_1	563	569	PF00069	0.411
MOD_CK2_1	580	586	PF00069	0.441
MOD_CK2_1	686	692	PF00069	0.402
MOD_CK2_1	772	778	PF00069	0.410
MOD_GlcNHglycan	237	240	PF01048	0.458
MOD_GlcNHglycan	445	448	PF01048	0.489
MOD_GlcNHglycan	474	477	PF01048	0.390
MOD_GlcNHglycan	526	529	PF01048	0.596
MOD_GlcNHglycan	582	585	PF01048	0.608
MOD_GlcNHglycan	586	589	PF01048	0.638
MOD_GlcNHglycan	663	666	PF01048	0.487
MOD_GlcNHglycan	695	698	PF01048	0.550
MOD_GlcNHglycan	89	92	PF01048	0.418
MOD_GSK3_1	141	148	PF00069	0.430
MOD_GSK3_1	278	285	PF00069	0.538
MOD_GSK3_1	376	383	PF00069	0.383
MOD_GSK3_1	520	527	PF00069	0.412
MOD_GSK3_1	530	537	PF00069	0.359
MOD_GSK3_1	580	587	PF00069	0.482
MOD_GSK3_1	603	610	PF00069	0.436
MOD_GSK3_1	642	649	PF00069	0.363
MOD_GSK3_1	657	664	PF00069	0.408
MOD_GSK3_1	722	729	PF00069	0.498
MOD_GSK3_1	813	820	PF00069	0.404
MOD_LATS_1	463	469	PF00433	0.382
MOD_N-GLC_1	232	237	PF02516	0.440
MOD_N-GLC_1	303	308	PF02516	0.536
MOD_N-GLC_1	35	40	PF02516	0.463
MOD_N-GLC_1	357	362	PF02516	0.506
MOD_N-GLC_1	509	514	PF02516	0.514
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	303	308	PF00069	0.552
MOD_NEK2_1	35	40	PF00069	0.476
MOD_NEK2_1	376	381	PF00069	0.387
MOD_NEK2_1	388	393	PF00069	0.350
MOD_NEK2_1	434	439	PF00069	0.494
MOD_NEK2_1	609	614	PF00069	0.342
MOD_NEK2_1	686	691	PF00069	0.467
MOD_NEK2_1	817	822	PF00069	0.468
MOD_PIKK_1	15	21	PF00454	0.436
MOD_PK_1	278	284	PF00069	0.458
MOD_PKA_1	118	124	PF00069	0.471
MOD_PKA_1	2	8	PF00069	0.607
MOD_PKA_1	530	536	PF00069	0.366
MOD_PKA_2	1	7	PF00069	0.533
MOD_PKA_2	157	163	PF00069	0.585
MOD_PKA_2	201	207	PF00069	0.516
MOD_PKA_2	282	288	PF00069	0.426
MOD_PKA_2	427	433	PF00069	0.376
MOD_PKA_2	530	536	PF00069	0.381
MOD_PKB_1	13	21	PF00069	0.438
MOD_Plk_1	200	206	PF00069	0.426
MOD_Plk_1	240	246	PF00069	0.316
MOD_Plk_1	303	309	PF00069	0.551
MOD_Plk_1	357	363	PF00069	0.487
MOD_Plk_1	381	387	PF00069	0.385
MOD_Plk_1	509	515	PF00069	0.539
MOD_Plk_1	610	616	PF00069	0.428
MOD_Plk_1	651	657	PF00069	0.345
MOD_Plk_1	779	785	PF00069	0.462
MOD_Plk_2-3	479	485	PF00069	0.395
MOD_Plk_4	157	163	PF00069	0.426
MOD_Plk_4	336	342	PF00069	0.414
MOD_Plk_4	537	543	PF00069	0.494
MOD_Plk_4	577	583	PF00069	0.544
MOD_Plk_4	69	75	PF00069	0.372
MOD_Plk_4	779	785	PF00069	0.425
MOD_ProDKin_1	174	180	PF00069	0.386
MOD_ProDKin_1	535	541	PF00069	0.488
MOD_ProDKin_1	714	720	PF00069	0.417
MOD_ProDKin_1	722	728	PF00069	0.433
MOD_ProDKin_1	772	778	PF00069	0.410
MOD_SUMO_rev_2	42	52	PF00179	0.410
MOD_SUMO_rev_2	452	460	PF00179	0.537
TRG_DiLeu_BaEn_3	320	326	PF01217	0.351
TRG_ENDOCYTIC_2	103	106	PF00928	0.432
TRG_ENDOCYTIC_2	244	247	PF00928	0.298
TRG_ENDOCYTIC_2	400	403	PF00928	0.321
TRG_ENDOCYTIC_2	480	483	PF00928	0.439
TRG_ER_diArg_1	1	3	PF00400	0.512
TRG_ER_diArg_1	530	532	PF00400	0.364
TRG_ER_diArg_1	556	558	PF00400	0.523
TRG_ER_diArg_1	667	670	PF00400	0.410
TRG_Pf-PMV_PEXEL_1	688	692	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Z7	Leptomonas seymouri	81%	100%
A0A0S4JL67	Bodo saltans	59%	100%
A0A1X0P2Q6	Trypanosomatidae	65%	94%
A0A3R7M7H0	Trypanosoma rangeli	68%	100%
A4HL37	Leishmania braziliensis	88%	100%
A4I8L7	Leishmania infantum	100%	100%
C9ZPU0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
E9B3H8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q4M2	Leishmania major	95%	100%
V5BJH2	Trypanosoma cruzi	69%	100%