Hypothetical_protein_conserved

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH91_LEIDO

TriTrypDb:

LdBPK_291380.1 , LdCL_290018900 , LDHU3_29.1880

Length:

118

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Promastigote/Amastigote: 62, 76

Expansion

Sequence features

A0A3Q8IH91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SPOP_SBC_1	5	9	PF00917	0.564
DOC_PP1_RVXF_1	40	47	PF00149	0.569
DOC_PP2B_LxvP_1	23	26	PF13499	0.497
DOC_USP7_MATH_1	11	15	PF00917	0.569
DOC_USP7_MATH_1	24	28	PF00917	0.457
DOC_USP7_UBL2_3	114	118	PF12436	0.551
LIG_14-3-3_CanoR_1	68	73	PF00244	0.517
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BRCT_BRCA1_1	75	79	PF00533	0.499
LIG_deltaCOP1_diTrp_1	29	35	PF00928	0.450
LIG_FHA_1	17	23	PF00498	0.553
LIG_LIR_Gen_1	40	51	PF02991	0.464
LIG_LIR_Gen_1	97	107	PF02991	0.452
LIG_LIR_Nem_3	40	46	PF02991	0.475
LIG_LIR_Nem_3	97	103	PF02991	0.503
LIG_Pex14_1	32	36	PF04695	0.444
LIG_SUMO_SIM_par_1	18	30	PF11976	0.604
LIG_TRAF2_1	86	89	PF00917	0.592
LIG_WRC_WIRS_1	46	51	PF05994	0.489
MOD_CK1_1	27	33	PF00069	0.577
MOD_CK1_1	66	72	PF00069	0.525
MOD_CK2_1	4	10	PF00069	0.559
MOD_CK2_1	83	89	PF00069	0.503
MOD_CMANNOS	32	35	PF00535	0.450
MOD_GlcNHglycan	32	35	PF01048	0.509
MOD_GlcNHglycan	75	78	PF01048	0.589
MOD_GSK3_1	1	8	PF00069	0.720
MOD_GSK3_1	11	18	PF00069	0.547
MOD_GSK3_1	110	117	PF00069	0.517
MOD_GSK3_1	59	66	PF00069	0.571
MOD_N-GLC_1	59	64	PF02516	0.687
MOD_NEK2_1	1	6	PF00069	0.701
MOD_NEK2_1	110	115	PF00069	0.593
MOD_PIKK_1	105	111	PF00454	0.552
MOD_PK_1	63	69	PF00069	0.636
MOD_Plk_1	96	102	PF00069	0.479
MOD_Plk_2-3	45	51	PF00069	0.511
MOD_Plk_4	11	17	PF00069	0.627
MOD_Plk_4	27	33	PF00069	0.529
MOD_SUMO_rev_2	38	44	PF00179	0.492
MOD_SUMO_rev_2	7	14	PF00179	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I688	Leptomonas seymouri	77%	100%
A0A1X0NZR9	Trypanosomatidae	54%	84%
A0A3R7RKT9	Trypanosoma rangeli	52%	81%
A4HHE0	Leishmania braziliensis	92%	100%
A4I4I6	Leishmania infantum	100%	100%
C9ZL73	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	86%
E9ADY7	Leishmania major	98%	100%
E9ALU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%