Cornichon protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cornichon protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IH86_LEIDO

TriTrypDb:

LdBPK_323990.1 , LdCL_320045900 , LDHU3_32.5120

Length:

188

Annotations

Annotations by Jardim et al.

Intracellular signaling, Cornichon , putative

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A0A3Q8IH86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH86

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	10
GO:0016192	vesicle-mediated transport	4	10
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.439
CLV_NRD_NRD_1	32	34	PF00675	0.316
CLV_PCSK_KEX2_1	34	36	PF00082	0.296
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.368
CLV_PCSK_SKI1_1	143	147	PF00082	0.304
CLV_PCSK_SKI1_1	35	39	PF00082	0.272
DEG_APCC_DBOX_1	34	42	PF00400	0.504
DOC_CDC14_PxL_1	15	23	PF14671	0.589
DOC_CYCLIN_RxL_1	138	150	PF00134	0.559
DOC_MAPK_gen_1	31	40	PF00069	0.573
DOC_MAPK_MEF2A_6	33	42	PF00069	0.489
DOC_PP1_RVXF_1	10	16	PF00149	0.558
LIG_14-3-3_CanoR_1	110	116	PF00244	0.439
LIG_14-3-3_CanoR_1	164	173	PF00244	0.504
LIG_14-3-3_CanoR_1	6	13	PF00244	0.654
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_FHA_1	2	8	PF00498	0.655
LIG_FHA_1	88	94	PF00498	0.380
LIG_FHA_2	27	33	PF00498	0.552
LIG_LIR_Gen_1	120	131	PF02991	0.509
LIG_LIR_Gen_1	167	177	PF02991	0.281
LIG_LIR_Gen_1	45	54	PF02991	0.300
LIG_LIR_Nem_3	120	126	PF02991	0.501
LIG_LIR_Nem_3	150	156	PF02991	0.420
LIG_LIR_Nem_3	167	172	PF02991	0.392
LIG_LIR_Nem_3	45	49	PF02991	0.326
LIG_NRBOX	37	43	PF00104	0.352
LIG_OCRL_FandH_1	38	50	PF00620	0.373
LIG_PDZ_Class_2	183	188	PF00595	0.420
LIG_Pex14_1	61	65	PF04695	0.281
LIG_Pex14_2	11	15	PF04695	0.549
LIG_SH2_CRK	169	173	PF00017	0.316
LIG_SH2_SRC	85	88	PF00017	0.439
LIG_SH2_STAP1	135	139	PF00017	0.438
LIG_SH2_STAP1	85	89	PF00017	0.446
LIG_SH2_STAT5	180	183	PF00017	0.359
LIG_SUMO_SIM_anti_2	45	51	PF11976	0.328
LIG_SUMO_SIM_par_1	100	106	PF11976	0.430
LIG_SUMO_SIM_par_1	18	24	PF11976	0.555
LIG_WRC_WIRS_1	156	161	PF05994	0.397
MOD_CK1_1	26	32	PF00069	0.567
MOD_CK2_1	26	32	PF00069	0.588
MOD_GlcNHglycan	68	71	PF01048	0.379
MOD_GSK3_1	1	8	PF00069	0.658
MOD_GSK3_1	137	144	PF00069	0.564
MOD_GSK3_1	53	60	PF00069	0.379
MOD_NEK2_1	119	124	PF00069	0.465
MOD_NEK2_1	137	142	PF00069	0.438
MOD_NEK2_1	42	47	PF00069	0.316
MOD_NEK2_1	55	60	PF00069	0.307
MOD_PIKK_1	137	143	PF00454	0.422
MOD_PKA_2	5	11	PF00069	0.540
MOD_Plk_1	147	153	PF00069	0.417
MOD_Plk_4	119	125	PF00069	0.431
MOD_Plk_4	148	154	PF00069	0.463
MOD_Plk_4	42	48	PF00069	0.402
MOD_Plk_4	57	63	PF00069	0.189
MOD_SUMO_rev_2	26	36	PF00179	0.595
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.497
TRG_ENDOCYTIC_2	169	172	PF00928	0.305
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.304

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3W0	Leptomonas seymouri	68%	99%
A0A0N1HVI2	Leptomonas seymouri	22%	100%
A0A0S4IRN3	Bodo saltans	24%	86%
A0A1X0P478	Trypanosomatidae	44%	99%
A0A3Q8IHH3	Leishmania donovani	23%	100%
A0A3R7KL43	Trypanosoma rangeli	43%	99%
A0A3R7KRD8	Trypanosoma rangeli	27%	100%
A4HL20	Leishmania braziliensis	23%	100%
A4HL21	Leishmania braziliensis	70%	100%
A4I8K1	Leishmania infantum	23%	100%
A4I8K2	Leishmania infantum	100%	100%
D0AAL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9B3G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B3G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q4N8	Leishmania major	89%	100%
Q4Q4N9	Leishmania major	23%	100%
Q8GWT5	Arabidopsis thaliana	25%	100%
V5BLE0	Trypanosoma cruzi	24%	100%