Hypothetical_protein_conserved

Quick info Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH83_LEIDO

TriTrypDb:

LdBPK_100790.1 , LdCL_100014700 , LDHU3_10.1140

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 48

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IH83

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH83

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	42	46	PF00082	0.455
LIG_14-3-3_CanoR_1	116	120	PF00244	0.498
LIG_BIR_II_1	1	5	PF00653	0.560
LIG_FHA_1	116	122	PF00498	0.481
LIG_LIR_Nem_3	118	122	PF02991	0.527
LIG_SH2_GRB2like	113	116	PF00017	0.523
LIG_SH3_3	86	92	PF00018	0.575
MOD_CK1_1	100	106	PF00069	0.735
MOD_CK1_1	48	54	PF00069	0.423
MOD_GlcNHglycan	1	4	PF01048	0.609
MOD_GlcNHglycan	122	125	PF01048	0.537
MOD_GlcNHglycan	36	39	PF01048	0.444
MOD_GlcNHglycan	99	102	PF01048	0.649
MOD_GSK3_1	95	102	PF00069	0.726
MOD_N-GLC_1	10	15	PF02516	0.576
MOD_PIKK_1	10	16	PF00454	0.537
MOD_PIKK_1	76	82	PF00454	0.610
MOD_PKA_2	115	121	PF00069	0.480
MOD_PKA_2	26	32	PF00069	0.379
MOD_Plk_1	48	54	PF00069	0.423
MOD_Plk_2-3	68	74	PF00069	0.498
TRG_ENDOCYTIC_2	119	122	PF00928	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G2	Leptomonas seymouri	65%	81%
A0A0S4JNQ7	Bodo saltans	43%	88%
A0A422NWW8	Trypanosoma rangeli	48%	76%
A4HUI6	Leishmania infantum	100%	100%
E9AN84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	98%
Q4QHE0	Leishmania major	92%	99%