Regulator_of_chromosome_condensation_(RCC1)_repea t_putative/Pfam:PF00415/Pfam:PF13540

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Regulator of chromosome condensation (RCC1) repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IH78_LEIDO

TriTrypDb:

LdBPK_341770.1 , LdCL_340025300 , LDHU3_34.3060

Length:

629

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005938	cell cortex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IH78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH78

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.692
CLV_C14_Caspase3-7	34	38	PF00656	0.687
CLV_C14_Caspase3-7	341	345	PF00656	0.571
CLV_NRD_NRD_1	12	14	PF00675	0.533
CLV_NRD_NRD_1	297	299	PF00675	0.482
CLV_NRD_NRD_1	346	348	PF00675	0.470
CLV_NRD_NRD_1	611	613	PF00675	0.683
CLV_PCSK_KEX2_1	12	14	PF00082	0.533
CLV_PCSK_KEX2_1	290	292	PF00082	0.557
CLV_PCSK_KEX2_1	297	299	PF00082	0.484
CLV_PCSK_KEX2_1	346	348	PF00082	0.485
CLV_PCSK_KEX2_1	611	613	PF00082	0.745
CLV_PCSK_KEX2_1	71	73	PF00082	0.641
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.530
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.653
CLV_PCSK_SKI1_1	240	244	PF00082	0.612
CLV_PCSK_SKI1_1	298	302	PF00082	0.523
CLV_PCSK_SKI1_1	353	357	PF00082	0.432
CLV_PCSK_SKI1_1	394	398	PF00082	0.564
CLV_PCSK_SKI1_1	431	435	PF00082	0.455
CLV_PCSK_SKI1_1	450	454	PF00082	0.496
CLV_PCSK_SKI1_1	64	68	PF00082	0.684
DEG_Nend_Nbox_1	1	3	PF02207	0.538
DEG_SCF_FBW7_2	40	46	PF00400	0.615
DEG_SPOP_SBC_1	112	116	PF00917	0.627
DEG_SPOP_SBC_1	201	205	PF00917	0.661
DOC_ANK_TNKS_1	476	483	PF00023	0.582
DOC_CKS1_1	293	298	PF01111	0.507
DOC_CKS1_1	40	45	PF01111	0.614
DOC_MAPK_DCC_7	450	460	PF00069	0.532
DOC_MAPK_gen_1	152	160	PF00069	0.503
DOC_PP1_RVXF_1	259	266	PF00149	0.462
DOC_PP1_RVXF_1	448	454	PF00149	0.512
DOC_PP4_FxxP_1	126	129	PF00568	0.555
DOC_PP4_FxxP_1	475	478	PF00568	0.687
DOC_USP7_MATH_1	138	142	PF00917	0.470
DOC_USP7_MATH_1	253	257	PF00917	0.465
DOC_USP7_MATH_1	31	35	PF00917	0.568
DOC_USP7_MATH_1	372	376	PF00917	0.342
DOC_USP7_MATH_1	420	424	PF00917	0.396
DOC_USP7_MATH_1	577	581	PF00917	0.814
DOC_USP7_UBL2_3	397	401	PF12436	0.475
DOC_USP7_UBL2_3	586	590	PF12436	0.743
DOC_USP7_UBL2_3	609	613	PF12436	0.719
DOC_USP7_UBL2_3	618	622	PF12436	0.628
DOC_USP7_UBL2_3	86	90	PF12436	0.621
DOC_WW_Pin1_4	104	109	PF00397	0.693
DOC_WW_Pin1_4	292	297	PF00397	0.509
DOC_WW_Pin1_4	302	307	PF00397	0.472
DOC_WW_Pin1_4	39	44	PF00397	0.624
DOC_WW_Pin1_4	400	405	PF00397	0.400
DOC_WW_Pin1_4	453	458	PF00397	0.470
DOC_WW_Pin1_4	500	505	PF00397	0.757
DOC_WW_Pin1_4	529	534	PF00397	0.720
LIG_14-3-3_CanoR_1	12	16	PF00244	0.653
LIG_14-3-3_CanoR_1	240	245	PF00244	0.592
LIG_14-3-3_CanoR_1	291	296	PF00244	0.545
LIG_14-3-3_CanoR_1	297	303	PF00244	0.477
LIG_14-3-3_CanoR_1	32	40	PF00244	0.693
LIG_14-3-3_CanoR_1	519	527	PF00244	0.727
LIG_14-3-3_CanoR_1	64	74	PF00244	0.644
LIG_Actin_WH2_2	81	97	PF00022	0.488
LIG_Clathr_ClatBox_1	317	321	PF01394	0.489
LIG_FHA_1	114	120	PF00498	0.575
LIG_FHA_1	223	229	PF00498	0.684
LIG_FHA_1	277	283	PF00498	0.493
LIG_FHA_1	432	438	PF00498	0.479
LIG_FHA_1	60	66	PF00498	0.627
LIG_FHA_2	1	7	PF00498	0.676
LIG_FHA_2	186	192	PF00498	0.522
LIG_FHA_2	39	45	PF00498	0.664
LIG_FHA_2	551	557	PF00498	0.741
LIG_FHA_2	591	597	PF00498	0.710
LIG_FHA_2	614	620	PF00498	0.571
LIG_Integrin_isoDGR_2	429	431	PF01839	0.502
LIG_LIR_Gen_1	181	191	PF02991	0.448
LIG_LIR_Gen_1	19	29	PF02991	0.475
LIG_LIR_Gen_1	6	15	PF02991	0.650
LIG_LIR_Nem_3	181	187	PF02991	0.441
LIG_LIR_Nem_3	272	277	PF02991	0.435
LIG_LIR_Nem_3	469	475	PF02991	0.533
LIG_LIR_Nem_3	6	11	PF02991	0.629
LIG_LRP6_Inhibitor_1	249	255	PF00058	0.573
LIG_PCNA_PIPBox_1	352	361	PF02747	0.531
LIG_PDZ_Class_1	624	629	PF00595	0.645
LIG_SH2_CRK	135	139	PF00017	0.498
LIG_SH2_NCK_1	135	139	PF00017	0.498
LIG_SH2_STAP1	468	472	PF00017	0.481
LIG_SH2_STAT3	359	362	PF00017	0.500
LIG_SH2_STAT5	131	134	PF00017	0.657
LIG_SH2_STAT5	350	353	PF00017	0.484
LIG_SH2_STAT5	359	362	PF00017	0.423
LIG_SH2_STAT5	426	429	PF00017	0.473
LIG_SH2_STAT5	468	471	PF00017	0.518
LIG_SH3_3	163	169	PF00018	0.488
LIG_SH3_3	290	296	PF00018	0.595
LIG_SH3_3	37	43	PF00018	0.621
LIG_SH3_3	449	455	PF00018	0.407
LIG_SH3_4	348	355	PF00018	0.550
LIG_SUMO_SIM_anti_2	225	230	PF11976	0.638
LIG_SUMO_SIM_anti_2	23	30	PF11976	0.625
LIG_SUMO_SIM_anti_2	456	462	PF11976	0.572
LIG_SUMO_SIM_par_1	316	321	PF11976	0.494
LIG_TRAF2_1	520	523	PF00917	0.692
LIG_Vh1_VBS_1	109	127	PF01044	0.626
LIG_WRC_WIRS_1	157	162	PF05994	0.480
LIG_WRC_WIRS_1	326	331	PF05994	0.464
MOD_CAAXbox	626	629	PF01239	0.683
MOD_CDK_SPK_2	292	297	PF00069	0.509
MOD_CDK_SPxK_1	292	298	PF00069	0.510
MOD_CDK_SPxK_1	39	45	PF00069	0.619
MOD_CDK_SPxxK_3	302	309	PF00069	0.504
MOD_CK1_1	113	119	PF00069	0.617
MOD_CK1_1	143	149	PF00069	0.459
MOD_CK1_1	202	208	PF00069	0.653
MOD_CK1_1	248	254	PF00069	0.521
MOD_CK1_1	384	390	PF00069	0.394
MOD_CK1_1	500	506	PF00069	0.723
MOD_CK2_1	13	19	PF00069	0.643
MOD_CK2_1	38	44	PF00069	0.586
MOD_CK2_1	550	556	PF00069	0.740
MOD_CK2_1	577	583	PF00069	0.803
MOD_CK2_1	613	619	PF00069	0.578
MOD_Cter_Amidation	609	612	PF01082	0.755
MOD_GlcNHglycan	15	18	PF01048	0.646
MOD_GlcNHglycan	161	164	PF01048	0.667
MOD_GlcNHglycan	195	198	PF01048	0.465
MOD_GlcNHglycan	247	250	PF01048	0.613
MOD_GlcNHglycan	311	314	PF01048	0.451
MOD_GlcNHglycan	33	36	PF01048	0.472
MOD_GlcNHglycan	363	366	PF01048	0.406
MOD_GlcNHglycan	386	389	PF01048	0.355
MOD_GlcNHglycan	560	564	PF01048	0.807
MOD_GlcNHglycan	575	578	PF01048	0.581
MOD_GSK3_1	140	147	PF00069	0.467
MOD_GSK3_1	236	243	PF00069	0.581
MOD_GSK3_1	298	305	PF00069	0.532
MOD_GSK3_1	367	374	PF00069	0.321
MOD_GSK3_1	514	521	PF00069	0.686
MOD_GSK3_1	573	580	PF00069	0.757
MOD_N-GLC_1	144	149	PF02516	0.605
MOD_N-GLC_1	384	389	PF02516	0.378
MOD_N-GLC_1	437	442	PF02516	0.585
MOD_N-GLC_1	512	517	PF02516	0.672
MOD_N-GLC_1	527	532	PF02516	0.759
MOD_N-GLC_1	534	539	PF02516	0.787
MOD_N-GLC_1	540	545	PF02516	0.791
MOD_N-GLC_1	573	578	PF02516	0.743
MOD_NEK2_1	140	145	PF00069	0.458
MOD_NEK2_1	199	204	PF00069	0.633
MOD_NEK2_1	371	376	PF00069	0.331
MOD_NEK2_1	437	442	PF00069	0.592
MOD_NEK2_2	144	149	PF00069	0.551
MOD_NEK2_2	420	425	PF00069	0.379
MOD_PIKK_1	518	524	PF00454	0.761
MOD_PIKK_1	613	619	PF00454	0.616
MOD_PKA_1	353	359	PF00069	0.402
MOD_PKA_2	11	17	PF00069	0.608
MOD_PKA_2	151	157	PF00069	0.488
MOD_PKA_2	31	37	PF00069	0.683
MOD_PKA_2	518	524	PF00069	0.730
MOD_Plk_1	144	150	PF00069	0.599
MOD_Plk_1	437	443	PF00069	0.587
MOD_Plk_1	522	528	PF00069	0.726
MOD_Plk_1	577	583	PF00069	0.803
MOD_Plk_2-3	466	472	PF00069	0.491
MOD_Plk_4	21	27	PF00069	0.595
MOD_Plk_4	222	228	PF00069	0.656
MOD_Plk_4	278	284	PF00069	0.457
MOD_Plk_4	420	426	PF00069	0.381
MOD_Plk_4	522	528	PF00069	0.731
MOD_ProDKin_1	104	110	PF00069	0.695
MOD_ProDKin_1	292	298	PF00069	0.510
MOD_ProDKin_1	302	308	PF00069	0.466
MOD_ProDKin_1	39	45	PF00069	0.619
MOD_ProDKin_1	400	406	PF00069	0.406
MOD_ProDKin_1	453	459	PF00069	0.477
MOD_ProDKin_1	500	506	PF00069	0.755
MOD_ProDKin_1	529	535	PF00069	0.721
TRG_ENDOCYTIC_2	274	277	PF00928	0.439
TRG_ER_diArg_1	11	13	PF00400	0.597
TRG_ER_diArg_1	172	175	PF00400	0.491
TRG_ER_diArg_1	296	298	PF00400	0.506
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFG4	Leptomonas seymouri	65%	100%
A0A1X0PAD3	Trypanosomatidae	56%	100%
A0A422NXS0	Trypanosoma rangeli	53%	100%
A4HAR5	Leishmania braziliensis	74%	100%
A4I9X9	Leishmania infantum	100%	100%
C9ZMQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9B4Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2Z9	Leishmania major	94%	100%
V5BIX4	Trypanosoma cruzi	57%	100%