Bromo domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH72_LEIDO

TriTrypDb:

LdBPK_291080.1 , LdCL_290015700 , LDHU3_29.1480

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IH72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	560	566	PF00089	0.541
CLV_NRD_NRD_1	188	190	PF00675	0.579
CLV_NRD_NRD_1	218	220	PF00675	0.695
CLV_NRD_NRD_1	239	241	PF00675	0.746
CLV_NRD_NRD_1	283	285	PF00675	0.721
CLV_NRD_NRD_1	321	323	PF00675	0.527
CLV_NRD_NRD_1	426	428	PF00675	0.448
CLV_NRD_NRD_1	52	54	PF00675	0.616
CLV_NRD_NRD_1	616	618	PF00675	0.480
CLV_NRD_NRD_1	812	814	PF00675	0.608
CLV_PCSK_KEX2_1	188	190	PF00082	0.579
CLV_PCSK_KEX2_1	217	219	PF00082	0.686
CLV_PCSK_KEX2_1	226	228	PF00082	0.711
CLV_PCSK_KEX2_1	283	285	PF00082	0.671
CLV_PCSK_KEX2_1	321	323	PF00082	0.467
CLV_PCSK_KEX2_1	426	428	PF00082	0.539
CLV_PCSK_KEX2_1	52	54	PF00082	0.616
CLV_PCSK_KEX2_1	641	643	PF00082	0.462
CLV_PCSK_KEX2_1	812	814	PF00082	0.638
CLV_PCSK_KEX2_1	847	849	PF00082	0.641
CLV_PCSK_KEX2_1	892	894	PF00082	0.627
CLV_PCSK_PC1ET2_1	226	228	PF00082	0.627
CLV_PCSK_PC1ET2_1	641	643	PF00082	0.490
CLV_PCSK_PC1ET2_1	847	849	PF00082	0.612
CLV_PCSK_PC1ET2_1	892	894	PF00082	0.583
CLV_PCSK_SKI1_1	105	109	PF00082	0.524
CLV_PCSK_SKI1_1	426	430	PF00082	0.454
CLV_PCSK_SKI1_1	652	656	PF00082	0.632
CLV_PCSK_SKI1_1	666	670	PF00082	0.566
CLV_PCSK_SKI1_1	72	76	PF00082	0.575
DEG_COP1_1	23	32	PF00400	0.623
DEG_MDM2_SWIB_1	146	154	PF02201	0.567
DEG_Nend_UBRbox_2	1	3	PF02207	0.698
DEG_SCF_FBW7_2	383	389	PF00400	0.636
DEG_SPOP_SBC_1	517	521	PF00917	0.658
DOC_ANK_TNKS_1	111	118	PF00023	0.518
DOC_CKS1_1	168	173	PF01111	0.540
DOC_CKS1_1	383	388	PF01111	0.636
DOC_CKS1_1	669	674	PF01111	0.608
DOC_CYCLIN_yClb3_PxF_3	856	862	PF00134	0.606
DOC_CYCLIN_yCln2_LP_2	669	675	PF00134	0.530
DOC_MAPK_gen_1	47	56	PF00069	0.590
DOC_MAPK_gen_1	617	627	PF00069	0.447
DOC_PP1_RVXF_1	50	57	PF00149	0.559
DOC_PP2B_LxvP_1	388	391	PF13499	0.628
DOC_PP2B_LxvP_1	4	7	PF13499	0.586
DOC_PP2B_LxvP_1	854	857	PF13499	0.568
DOC_USP7_MATH_1	124	128	PF00917	0.644
DOC_USP7_MATH_1	173	177	PF00917	0.588
DOC_USP7_MATH_1	285	289	PF00917	0.653
DOC_USP7_MATH_1	410	414	PF00917	0.572
DOC_USP7_MATH_1	446	450	PF00917	0.528
DOC_USP7_MATH_1	508	512	PF00917	0.737
DOC_USP7_MATH_1	647	651	PF00917	0.484
DOC_USP7_MATH_1	662	666	PF00917	0.561
DOC_USP7_MATH_1	724	728	PF00917	0.683
DOC_USP7_MATH_1	9	13	PF00917	0.699
DOC_USP7_MATH_1	917	921	PF00917	0.619
DOC_USP7_MATH_1	954	958	PF00917	0.728
DOC_USP7_UBL2_3	486	490	PF12436	0.600
DOC_USP7_UBL2_3	529	533	PF12436	0.679
DOC_WW_Pin1_4	167	172	PF00397	0.506
DOC_WW_Pin1_4	220	225	PF00397	0.661
DOC_WW_Pin1_4	28	33	PF00397	0.582
DOC_WW_Pin1_4	382	387	PF00397	0.739
DOC_WW_Pin1_4	466	471	PF00397	0.714
DOC_WW_Pin1_4	478	483	PF00397	0.764
DOC_WW_Pin1_4	5	10	PF00397	0.642
DOC_WW_Pin1_4	668	673	PF00397	0.752
DOC_WW_Pin1_4	716	721	PF00397	0.634
DOC_WW_Pin1_4	773	778	PF00397	0.724
DOC_WW_Pin1_4	927	932	PF00397	0.667
DOC_WW_Pin1_4	949	954	PF00397	0.622
LIG_14-3-3_CanoR_1	218	224	PF00244	0.607
LIG_14-3-3_CanoR_1	441	446	PF00244	0.544
LIG_14-3-3_CanoR_1	447	454	PF00244	0.726
LIG_14-3-3_CanoR_1	84	92	PF00244	0.682
LIG_14-3-3_CanoR_1	893	897	PF00244	0.765
LIG_14-3-3_CanoR_1	925	930	PF00244	0.798
LIG_14-3-3_CanoR_1	942	951	PF00244	0.527
LIG_Actin_WH2_2	256	271	PF00022	0.409
LIG_Actin_WH2_2	428	443	PF00022	0.469
LIG_Actin_WH2_2	697	714	PF00022	0.433
LIG_BIR_III_2	794	798	PF00653	0.623
LIG_CaM_IQ_9	627	643	PF13499	0.429
LIG_FHA_1	102	108	PF00498	0.588
LIG_FHA_1	173	179	PF00498	0.490
LIG_FHA_1	253	259	PF00498	0.545
LIG_FHA_1	383	389	PF00498	0.774
LIG_FHA_1	519	525	PF00498	0.677
LIG_FHA_1	669	675	PF00498	0.729
LIG_FHA_1	717	723	PF00498	0.710
LIG_FHA_1	733	739	PF00498	0.665
LIG_FHA_1	791	797	PF00498	0.615
LIG_FHA_1	833	839	PF00498	0.505
LIG_FHA_1	862	868	PF00498	0.612
LIG_FHA_1	876	882	PF00498	0.596
LIG_FHA_1	924	930	PF00498	0.568
LIG_FHA_2	185	191	PF00498	0.529
LIG_FHA_2	247	253	PF00498	0.695
LIG_FHA_2	36	42	PF00498	0.655
LIG_FHA_2	410	416	PF00498	0.504
LIG_FHA_2	689	695	PF00498	0.386
LIG_FHA_2	827	833	PF00498	0.632
LIG_LIR_Apic_2	162	167	PF02991	0.489
LIG_LIR_Gen_1	144	154	PF02991	0.540
LIG_LIR_Gen_1	573	582	PF02991	0.525
LIG_LIR_Gen_1	815	825	PF02991	0.668
LIG_LIR_LC3C_4	971	976	PF02991	0.513
LIG_LIR_Nem_3	144	149	PF02991	0.460
LIG_LIR_Nem_3	172	177	PF02991	0.529
LIG_LIR_Nem_3	425	431	PF02991	0.539
LIG_LIR_Nem_3	815	820	PF02991	0.679
LIG_LIR_Nem_3	832	837	PF02991	0.602
LIG_MYND_1	386	390	PF01753	0.763
LIG_Pex14_2	146	150	PF04695	0.468
LIG_Pex14_2	63	67	PF04695	0.531
LIG_PTAP_UEV_1	677	682	PF05743	0.583
LIG_PTB_Apo_2	921	928	PF02174	0.580
LIG_SH2_CRK	817	821	PF00017	0.679
LIG_SH2_STAP1	174	178	PF00017	0.490
LIG_SH2_STAP1	686	690	PF00017	0.535
LIG_SH2_STAT5	174	177	PF00017	0.492
LIG_SH2_STAT5	318	321	PF00017	0.535
LIG_SH2_STAT5	80	83	PF00017	0.556
LIG_SH2_STAT5	837	840	PF00017	0.572
LIG_SH2_STAT5	921	924	PF00017	0.570
LIG_SH3_1	269	275	PF00018	0.632
LIG_SH3_1	363	369	PF00018	0.554
LIG_SH3_2	678	683	PF14604	0.628
LIG_SH3_3	165	171	PF00018	0.541
LIG_SH3_3	176	182	PF00018	0.524
LIG_SH3_3	26	32	PF00018	0.638
LIG_SH3_3	269	275	PF00018	0.633
LIG_SH3_3	363	369	PF00018	0.693
LIG_SH3_3	388	394	PF00018	0.764
LIG_SH3_3	521	527	PF00018	0.766
LIG_SH3_3	536	542	PF00018	0.700
LIG_SH3_3	669	675	PF00018	0.635
LIG_SH3_3	761	767	PF00018	0.698
LIG_SH3_3	854	860	PF00018	0.576
LIG_SH3_3	869	875	PF00018	0.589
LIG_SH3_3	926	932	PF00018	0.766
LIG_SH3_3	950	956	PF00018	0.622
LIG_SUMO_SIM_anti_2	412	419	PF11976	0.525
LIG_SUMO_SIM_anti_2	758	765	PF11976	0.649
LIG_TRAF2_1	577	580	PF00917	0.429
LIG_UBA3_1	627	635	PF00899	0.525
LIG_WW_2	391	394	PF00397	0.609
MOD_CDC14_SPxK_1	223	226	PF00782	0.721
MOD_CDK_SPK_2	28	33	PF00069	0.582
MOD_CDK_SPxK_1	220	226	PF00069	0.719
MOD_CDK_SPxxK_3	220	227	PF00069	0.632
MOD_CDK_SPxxK_3	466	473	PF00069	0.563
MOD_CK1_1	127	133	PF00069	0.704
MOD_CK1_1	199	205	PF00069	0.532
MOD_CK1_1	222	228	PF00069	0.751
MOD_CK1_1	231	237	PF00069	0.666
MOD_CK1_1	297	303	PF00069	0.661
MOD_CK1_1	330	336	PF00069	0.542
MOD_CK1_1	449	455	PF00069	0.657
MOD_CK1_1	469	475	PF00069	0.720
MOD_CK1_1	476	482	PF00069	0.673
MOD_CK1_1	519	525	PF00069	0.719
MOD_CK1_1	532	538	PF00069	0.684
MOD_CK1_1	650	656	PF00069	0.508
MOD_CK1_1	688	694	PF00069	0.389
MOD_CK1_1	756	762	PF00069	0.550
MOD_CK1_1	772	778	PF00069	0.814
MOD_CK1_1	826	832	PF00069	0.649
MOD_CK1_1	895	901	PF00069	0.691
MOD_CK2_1	184	190	PF00069	0.527
MOD_CK2_1	194	200	PF00069	0.478
MOD_CK2_1	222	228	PF00069	0.654
MOD_CK2_1	233	239	PF00069	0.694
MOD_CK2_1	246	252	PF00069	0.534
MOD_CK2_1	35	41	PF00069	0.653
MOD_CK2_1	452	458	PF00069	0.674
MOD_CK2_1	688	694	PF00069	0.493
MOD_CK2_1	917	923	PF00069	0.589
MOD_DYRK1A_RPxSP_1	466	470	PF00069	0.607
MOD_GlcNHglycan	126	129	PF01048	0.568
MOD_GlcNHglycan	131	134	PF01048	0.582
MOD_GlcNHglycan	196	199	PF01048	0.544
MOD_GlcNHglycan	204	207	PF01048	0.535
MOD_GlcNHglycan	230	233	PF01048	0.746
MOD_GlcNHglycan	286	290	PF01048	0.649
MOD_GlcNHglycan	296	299	PF01048	0.619
MOD_GlcNHglycan	432	435	PF01048	0.512
MOD_GlcNHglycan	449	452	PF01048	0.716
MOD_GlcNHglycan	454	457	PF01048	0.706
MOD_GlcNHglycan	466	469	PF01048	0.736
MOD_GlcNHglycan	483	486	PF01048	0.619
MOD_GlcNHglycan	510	513	PF01048	0.631
MOD_GlcNHglycan	645	648	PF01048	0.651
MOD_GlcNHglycan	649	652	PF01048	0.639
MOD_GlcNHglycan	677	681	PF01048	0.583
MOD_GlcNHglycan	726	729	PF01048	0.760
MOD_GlcNHglycan	755	758	PF01048	0.532
MOD_GlcNHglycan	777	780	PF01048	0.597
MOD_GlcNHglycan	843	846	PF01048	0.661
MOD_GlcNHglycan	898	901	PF01048	0.600
MOD_GSK3_1	184	191	PF00069	0.602
MOD_GSK3_1	196	203	PF00069	0.511
MOD_GSK3_1	222	229	PF00069	0.639
MOD_GSK3_1	231	238	PF00069	0.720
MOD_GSK3_1	285	292	PF00069	0.647
MOD_GSK3_1	378	385	PF00069	0.734
MOD_GSK3_1	464	471	PF00069	0.702
MOD_GSK3_1	474	481	PF00069	0.761
MOD_GSK3_1	5	12	PF00069	0.650
MOD_GSK3_1	506	513	PF00069	0.778
MOD_GSK3_1	525	532	PF00069	0.664
MOD_GSK3_1	643	650	PF00069	0.650
MOD_GSK3_1	664	671	PF00069	0.653
MOD_GSK3_1	739	746	PF00069	0.707
MOD_GSK3_1	749	756	PF00069	0.560
MOD_GSK3_1	769	776	PF00069	0.749
MOD_GSK3_1	891	898	PF00069	0.718
MOD_GSK3_1	923	930	PF00069	0.748
MOD_GSK3_1	963	970	PF00069	0.705
MOD_N-GLC_1	220	225	PF02516	0.619
MOD_N-GLC_1	447	452	PF02516	0.717
MOD_N-GLC_1	732	737	PF02516	0.766
MOD_N-GLC_1	841	846	PF02516	0.473
MOD_N-GLC_1	923	928	PF02516	0.595
MOD_NEK2_1	184	189	PF00069	0.512
MOD_NEK2_1	194	199	PF00069	0.482
MOD_NEK2_1	590	595	PF00069	0.561
MOD_NEK2_1	823	828	PF00069	0.557
MOD_PIKK_1	13	19	PF00454	0.629
MOD_PK_1	892	898	PF00069	0.626
MOD_PK_1	925	931	PF00069	0.610
MOD_PKA_1	188	194	PF00069	0.535
MOD_PKA_1	226	232	PF00069	0.720
MOD_PKA_1	892	898	PF00069	0.626
MOD_PKA_2	184	190	PF00069	0.526
MOD_PKA_2	226	232	PF00069	0.691
MOD_PKA_2	446	452	PF00069	0.680
MOD_PKA_2	48	54	PF00069	0.593
MOD_PKA_2	525	531	PF00069	0.658
MOD_PKA_2	682	688	PF00069	0.602
MOD_PKA_2	729	735	PF00069	0.707
MOD_PKA_2	83	89	PF00069	0.522
MOD_PKA_2	892	898	PF00069	0.709
MOD_PKA_2	943	949	PF00069	0.617
MOD_PKA_2	963	969	PF00069	0.754
MOD_PKB_1	217	225	PF00069	0.669
MOD_Plk_1	199	205	PF00069	0.531
MOD_Plk_1	420	426	PF00069	0.593
MOD_Plk_1	506	512	PF00069	0.564
MOD_Plk_1	923	929	PF00069	0.587
MOD_Plk_2-3	21	27	PF00069	0.664
MOD_Plk_2-3	83	89	PF00069	0.479
MOD_Plk_4	173	179	PF00069	0.517
MOD_Plk_4	327	333	PF00069	0.520
MOD_Plk_4	623	629	PF00069	0.485
MOD_Plk_4	664	670	PF00069	0.620
MOD_Plk_4	73	79	PF00069	0.509
MOD_Plk_4	816	822	PF00069	0.702
MOD_Plk_4	917	923	PF00069	0.632
MOD_Plk_4	963	969	PF00069	0.751
MOD_ProDKin_1	167	173	PF00069	0.505
MOD_ProDKin_1	220	226	PF00069	0.662
MOD_ProDKin_1	28	34	PF00069	0.584
MOD_ProDKin_1	382	388	PF00069	0.741
MOD_ProDKin_1	466	472	PF00069	0.712
MOD_ProDKin_1	478	484	PF00069	0.764
MOD_ProDKin_1	5	11	PF00069	0.643
MOD_ProDKin_1	668	674	PF00069	0.751
MOD_ProDKin_1	716	722	PF00069	0.637
MOD_ProDKin_1	773	779	PF00069	0.721
MOD_ProDKin_1	927	933	PF00069	0.664
MOD_ProDKin_1	949	955	PF00069	0.621
MOD_SUMO_for_1	259	262	PF00179	0.385
MOD_SUMO_rev_2	489	497	PF00179	0.647
MOD_SUMO_rev_2	58	63	PF00179	0.532
MOD_SUMO_rev_2	684	691	PF00179	0.498
TRG_AP2beta_CARGO_1	144	153	PF09066	0.499
TRG_DiLeu_BaEn_2	189	195	PF01217	0.589
TRG_DiLeu_BaEn_3	579	585	PF01217	0.442
TRG_DiLeu_BaLyEn_6	539	544	PF01217	0.650
TRG_ENDOCYTIC_2	817	820	PF00928	0.666
TRG_ER_diArg_1	102	105	PF00400	0.553
TRG_ER_diArg_1	217	219	PF00400	0.686
TRG_ER_diArg_1	320	322	PF00400	0.522
TRG_ER_diArg_1	426	428	PF00400	0.539
TRG_ER_diArg_1	46	49	PF00400	0.652
TRG_ER_diArg_1	52	54	PF00400	0.600
TRG_ER_diArg_1	581	584	PF00400	0.474
TRG_ER_diArg_1	853	856	PF00400	0.705
TRG_ER_diArg_1	942	945	PF00400	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8D5	Leptomonas seymouri	43%	100%
A0A1X0P045	Trypanosomatidae	31%	98%
A4HHB1	Leishmania braziliensis	74%	100%
A4I4F7	Leishmania infantum	100%	100%
C9ZLK6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E9ADV7	Leishmania major	93%	100%
E9ALX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%