Nucleolar protein 12 (25kDa), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 12 (25kDa), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IH68_LEIDO

TriTrypDb:

LdBPK_340180.1 , LdCL_340006900 , LDHU3_34.0280

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3Q8IH68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH68

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.661
CLV_C14_Caspase3-7	234	238	PF00656	0.550
CLV_C14_Caspase3-7	42	46	PF00656	0.656
CLV_NRD_NRD_1	105	107	PF00675	0.339
CLV_NRD_NRD_1	176	178	PF00675	0.563
CLV_NRD_NRD_1	19	21	PF00675	0.596
CLV_NRD_NRD_1	241	243	PF00675	0.499
CLV_NRD_NRD_1	294	296	PF00675	0.452
CLV_NRD_NRD_1	297	299	PF00675	0.470
CLV_NRD_NRD_1	301	303	PF00675	0.523
CLV_NRD_NRD_1	307	309	PF00675	0.638
CLV_NRD_NRD_1	313	315	PF00675	0.587
CLV_NRD_NRD_1	316	318	PF00675	0.591
CLV_NRD_NRD_1	63	65	PF00675	0.277
CLV_NRD_NRD_1	77	79	PF00675	0.322
CLV_NRD_NRD_1	86	88	PF00675	0.346
CLV_NRD_NRD_1	89	91	PF00675	0.376
CLV_NRD_NRD_1	97	99	PF00675	0.325
CLV_PCSK_FUR_1	174	178	PF00082	0.687
CLV_PCSK_KEX2_1	105	107	PF00082	0.330
CLV_PCSK_KEX2_1	174	176	PF00082	0.555
CLV_PCSK_KEX2_1	179	181	PF00082	0.551
CLV_PCSK_KEX2_1	307	309	PF00082	0.596
CLV_PCSK_KEX2_1	313	315	PF00082	0.546
CLV_PCSK_KEX2_1	32	34	PF00082	0.508
CLV_PCSK_KEX2_1	63	65	PF00082	0.304
CLV_PCSK_KEX2_1	77	79	PF00082	0.322
CLV_PCSK_KEX2_1	86	88	PF00082	0.346
CLV_PCSK_KEX2_1	97	99	PF00082	0.330
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.631
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.596
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.546
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.550
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.364
CLV_PCSK_PC7_1	101	107	PF00082	0.399
CLV_PCSK_PC7_1	175	181	PF00082	0.689
CLV_PCSK_SKI1_1	180	184	PF00082	0.595
CLV_PCSK_SKI1_1	21	25	PF00082	0.502
CLV_PCSK_SKI1_1	228	232	PF00082	0.526
CLV_PCSK_SKI1_1	286	290	PF00082	0.479
CLV_PCSK_SKI1_1	32	36	PF00082	0.440
CLV_PCSK_SKI1_1	54	58	PF00082	0.274
DEG_APCC_DBOX_1	264	272	PF00400	0.524
DEG_APCC_DBOX_1	63	71	PF00400	0.285
DEG_SPOP_SBC_1	212	216	PF00917	0.613
DOC_CDC14_PxL_1	111	119	PF14671	0.267
DOC_CYCLIN_RxL_1	51	62	PF00134	0.399
DOC_MAPK_gen_1	63	70	PF00069	0.343
DOC_MAPK_JIP1_4	52	58	PF00069	0.399
DOC_PP1_RVXF_1	52	59	PF00149	0.267
DOC_PP2B_PxIxI_1	161	167	PF00149	0.333
DOC_USP7_MATH_1	169	173	PF00917	0.496
DOC_USP7_MATH_1	212	216	PF00917	0.639
DOC_USP7_UBL2_3	17	21	PF12436	0.529
DOC_USP7_UBL2_3	276	280	PF12436	0.534
DOC_USP7_UBL2_3	289	293	PF12436	0.466
DOC_USP7_UBL2_3	299	303	PF12436	0.507
DOC_USP7_UBL2_3	309	313	PF12436	0.553
DOC_USP7_UBL2_3	315	319	PF12436	0.586
DOC_USP7_UBL2_3	37	41	PF12436	0.368
DOC_USP7_UBL2_3	91	95	PF12436	0.356
LIG_14-3-3_CanoR_1	180	185	PF00244	0.628
LIG_FHA_1	119	125	PF00498	0.267
LIG_FHA_1	222	228	PF00498	0.526
LIG_FHA_1	247	253	PF00498	0.617
LIG_FHA_2	200	206	PF00498	0.746
LIG_FHA_2	40	46	PF00498	0.645
LIG_FHA_2	5	11	PF00498	0.628
LIG_FHA_2	55	61	PF00498	0.166
LIG_FHA_2	94	100	PF00498	0.344
LIG_LIR_Apic_2	119	125	PF02991	0.273
LIG_LIR_Gen_1	160	171	PF02991	0.333
LIG_LIR_Gen_1	219	230	PF02991	0.512
LIG_LIR_LC3C_4	259	264	PF02991	0.507
LIG_LIR_Nem_3	160	166	PF02991	0.399
LIG_LIR_Nem_3	219	225	PF02991	0.521
LIG_SH2_CRK	111	115	PF00017	0.316
LIG_SH2_CRK	122	126	PF00017	0.219
LIG_SH2_NCK_1	111	115	PF00017	0.399
LIG_SH2_PTP2	222	225	PF00017	0.649
LIG_SH2_STAP1	120	124	PF00017	0.399
LIG_SH2_STAT3	147	150	PF00017	0.333
LIG_SH2_STAT5	120	123	PF00017	0.399
LIG_SH2_STAT5	222	225	PF00017	0.649
LIG_SH2_STAT5	4	7	PF00017	0.654
LIG_SH2_STAT5	66	69	PF00017	0.285
LIG_SH3_3	112	118	PF00018	0.267
LIG_SH3_3	206	212	PF00018	0.646
LIG_TRAF2_2	125	130	PF00917	0.333
LIG_UBA3_1	287	296	PF00899	0.467
LIG_UBA3_1	67	74	PF00899	0.285
MOD_CK1_1	148	154	PF00069	0.412
MOD_CK1_1	213	219	PF00069	0.665
MOD_CK1_1	232	238	PF00069	0.455
MOD_CK1_1	248	254	PF00069	0.670
MOD_CK1_1	93	99	PF00069	0.399
MOD_CK2_1	93	99	PF00069	0.361
MOD_Cter_Amidation	305	308	PF01082	0.549
MOD_Cter_Amidation	311	314	PF01082	0.557
MOD_GlcNHglycan	150	153	PF01048	0.392
MOD_GlcNHglycan	186	189	PF01048	0.753
MOD_GlcNHglycan	234	237	PF01048	0.635
MOD_GlcNHglycan	310	313	PF01048	0.658
MOD_GlcNHglycan	92	95	PF01048	0.399
MOD_GSK3_1	180	187	PF00069	0.682
MOD_GSK3_1	199	206	PF00069	0.668
MOD_GSK3_1	213	220	PF00069	0.653
MOD_GSK3_1	4	11	PF00069	0.638
MOD_GSK3_1	54	61	PF00069	0.399
MOD_NEK2_1	230	235	PF00069	0.684
MOD_NEK2_1	58	63	PF00069	0.399
MOD_NEK2_2	66	71	PF00069	0.310
MOD_PIKK_1	146	152	PF00454	0.426
MOD_PIKK_1	169	175	PF00454	0.498
MOD_PKA_1	298	304	PF00069	0.504
MOD_PKA_1	308	314	PF00069	0.707
MOD_PKA_1	90	96	PF00069	0.399
MOD_PKB_1	270	278	PF00069	0.587
MOD_Plk_1	118	124	PF00069	0.289
MOD_Plk_2-3	221	227	PF00069	0.516
MOD_SUMO_rev_2	220	230	PF00179	0.509
TRG_ENDOCYTIC_2	111	114	PF00928	0.281
TRG_ENDOCYTIC_2	222	225	PF00928	0.649
TRG_ENDOCYTIC_2	31	34	PF00928	0.579
TRG_ER_diArg_1	174	177	PF00400	0.625
TRG_ER_diArg_1	283	286	PF00400	0.627
TRG_ER_diArg_1	77	79	PF00400	0.289
TRG_NLS_Bipartite_1	295	317	PF00514	0.526
TRG_NLS_Bipartite_1	72	91	PF00514	0.399
TRG_NLS_MonoExtC_3	16	21	PF00514	0.651
TRG_NLS_MonoExtC_3	294	299	PF00514	0.461
TRG_NLS_MonoExtC_3	312	317	PF00514	0.557
TRG_NLS_MonoExtC_3	85	90	PF00514	0.399
TRG_NLS_MonoExtN_4	293	299	PF00514	0.459
TRG_NLS_MonoExtN_4	313	318	PF00514	0.563
TRG_NLS_MonoExtN_4	86	91	PF00514	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCQ5	Leptomonas seymouri	65%	95%
A0A1X0P8J9	Trypanosomatidae	46%	100%
A0A422N280	Trypanosoma rangeli	45%	100%
A4I9I6	Leishmania infantum	97%	100%
D0A1U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B4I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q3J1	Leishmania major	90%	100%
V5DIL2	Trypanosoma cruzi	48%	91%