2OG-Fe(II) oxygenase superfamily, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2OG-Fe(II) oxygenase superfamily, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IH64_LEIDO

TriTrypDb:

LdBPK_362080.1 , LdCL_360026300 , LDHU3_36.2700

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IH64

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH64

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0070988	demethylation	2	11
GO:0070989	oxidative demethylation	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0016491	oxidoreductase activity	2	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0032451	demethylase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	134	136	PF00675	0.338
CLV_NRD_NRD_1	142	144	PF00675	0.365
CLV_NRD_NRD_1	240	242	PF00675	0.401
CLV_NRD_NRD_1	266	268	PF00675	0.276
CLV_PCSK_FUR_1	264	268	PF00082	0.351
CLV_PCSK_KEX2_1	134	136	PF00082	0.338
CLV_PCSK_KEX2_1	142	144	PF00082	0.365
CLV_PCSK_KEX2_1	240	242	PF00082	0.401
CLV_PCSK_KEX2_1	266	268	PF00082	0.276
CLV_PCSK_SKI1_1	143	147	PF00082	0.462
CLV_PCSK_SKI1_1	148	152	PF00082	0.398
CLV_PCSK_SKI1_1	240	244	PF00082	0.282
DEG_Nend_UBRbox_2	1	3	PF02207	0.544
DOC_MAPK_gen_1	142	152	PF00069	0.511
DOC_MAPK_gen_1	264	272	PF00069	0.324
DOC_MAPK_MEF2A_6	264	272	PF00069	0.356
DOC_PP4_FxxP_1	226	229	PF00568	0.385
DOC_USP7_MATH_1	184	188	PF00917	0.303
DOC_USP7_MATH_1	34	38	PF00917	0.455
DOC_USP7_MATH_1	79	83	PF00917	0.400
DOC_USP7_UBL2_3	147	151	PF12436	0.390
LIG_14-3-3_CanoR_1	266	271	PF00244	0.270
LIG_14-3-3_CanoR_1	50	59	PF00244	0.344
LIG_APCC_ABBA_1	199	204	PF00400	0.276
LIG_BRCT_BRCA1_1	120	124	PF00533	0.395
LIG_BRCT_BRCA1_1	268	272	PF00533	0.282
LIG_BRCT_BRCA1_1	52	56	PF00533	0.295
LIG_BRCT_BRCA1_1	62	66	PF00533	0.260
LIG_deltaCOP1_diTrp_1	204	209	PF00928	0.282
LIG_FHA_2	105	111	PF00498	0.419
LIG_FHA_2	269	275	PF00498	0.268
LIG_FHA_2	38	44	PF00498	0.282
LIG_LIR_Apic_2	225	229	PF02991	0.382
LIG_LIR_Gen_1	163	172	PF02991	0.315
LIG_LIR_Gen_1	53	64	PF02991	0.307
LIG_LIR_Nem_3	163	169	PF02991	0.445
LIG_LIR_Nem_3	269	275	PF02991	0.309
LIG_LIR_Nem_3	53	59	PF02991	0.303
LIG_Pex14_2	162	166	PF04695	0.396
LIG_SH2_STAT5	237	240	PF00017	0.429
LIG_SH3_2	123	128	PF14604	0.483
LIG_SH3_3	120	126	PF00018	0.477
LIG_SH3_3	153	159	PF00018	0.355
LIG_SH3_3	233	239	PF00018	0.340
LIG_SUMO_SIM_anti_2	97	103	PF11976	0.255
LIG_WRC_WIRS_1	223	228	PF05994	0.251
MOD_CK1_1	170	176	PF00069	0.451
MOD_CK1_1	291	297	PF00069	0.442
MOD_CK1_1	37	43	PF00069	0.470
MOD_CK1_1	52	58	PF00069	0.329
MOD_CK1_1	6	12	PF00069	0.450
MOD_CK1_1	62	68	PF00069	0.253
MOD_CK2_1	168	174	PF00069	0.343
MOD_CK2_1	184	190	PF00069	0.335
MOD_CK2_1	268	274	PF00069	0.267
MOD_CK2_1	37	43	PF00069	0.424
MOD_Cter_Amidation	132	135	PF01082	0.323
MOD_Cter_Amidation	264	267	PF01082	0.375
MOD_GlcNHglycan	131	134	PF01048	0.368
MOD_GlcNHglycan	185	189	PF01048	0.342
MOD_GlcNHglycan	246	249	PF01048	0.354
MOD_GlcNHglycan	29	32	PF01048	0.446
MOD_GlcNHglycan	290	293	PF01048	0.371
MOD_GlcNHglycan	36	39	PF01048	0.495
MOD_GlcNHglycan	5	8	PF01048	0.403
MOD_GlcNHglycan	96	99	PF01048	0.432
MOD_GSK3_1	168	175	PF00069	0.420
MOD_GSK3_1	2	9	PF00069	0.519
MOD_GSK3_1	29	36	PF00069	0.558
MOD_GSK3_1	69	76	PF00069	0.424
MOD_GSK3_1	90	97	PF00069	0.329
MOD_NEK2_1	118	123	PF00069	0.356
MOD_NEK2_1	172	177	PF00069	0.447
MOD_NEK2_1	244	249	PF00069	0.333
MOD_NEK2_1	288	293	PF00069	0.289
MOD_NEK2_1	29	34	PF00069	0.475
MOD_NEK2_1	90	95	PF00069	0.412
MOD_PIKK_1	127	133	PF00454	0.345
MOD_PKA_1	266	272	PF00069	0.267
MOD_PKA_2	19	25	PF00069	0.368
MOD_PKA_2	266	272	PF00069	0.273
MOD_PKA_2	49	55	PF00069	0.356
MOD_PKB_1	264	272	PF00069	0.340
MOD_Plk_1	184	190	PF00069	0.285
MOD_Plk_1	20	26	PF00069	0.279
MOD_Plk_1	203	209	PF00069	0.223
MOD_Plk_4	161	167	PF00069	0.375
MOD_Plk_4	203	209	PF00069	0.388
MOD_Plk_4	222	228	PF00069	0.241
MOD_Plk_4	69	75	PF00069	0.356
MOD_SUMO_for_1	74	77	PF00179	0.367
MOD_SUMO_rev_2	187	197	PF00179	0.342
TRG_ENDOCYTIC_2	252	255	PF00928	0.301
TRG_ER_diArg_1	141	143	PF00400	0.430
TRG_ER_diArg_1	239	241	PF00400	0.386
TRG_ER_diArg_1	263	266	PF00400	0.322
TRG_NLS_Bipartite_1	134	152	PF00514	0.358
TRG_NLS_MonoCore_2	145	150	PF00514	0.404
TRG_NLS_MonoExtC_3	146	151	PF00514	0.425
TRG_NLS_MonoExtN_4	143	150	PF00514	0.403
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I860	Leptomonas seymouri	64%	97%
A0A0S4JT39	Bodo saltans	38%	87%
A0A1X0P7R1	Trypanosomatidae	47%	100%
A0A422N9C6	Trypanosoma rangeli	48%	100%
A4HP64	Leishmania braziliensis	81%	100%
A4IDG9	Leishmania infantum	100%	100%
D0A357	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	98%
E9ASX2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q1M6	Leishmania major	92%	100%
Q8MNT9	Caenorhabditis elegans	33%	100%
Q9D8F1	Mus musculus	33%	99%
Q9NXW9	Homo sapiens	31%	98%