H1_histone-like_protein/GeneDB:LmjF.33.3240

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

h1 histone-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IH60_LEIDO

TriTrypDb:

LdBPK_333390.1 , LdCL_330041600 , LDHU3_33.4900

Length:

136

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, H1 histone-like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3Q8IH60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.569
CLV_NRD_NRD_1	134	136	PF00675	0.629
CLV_PCSK_SKI1_1	113	117	PF00082	0.494
CLV_PCSK_SKI1_1	127	131	PF00082	0.484
CLV_PCSK_SKI1_1	74	78	PF00082	0.639
CLV_PCSK_SKI1_1	83	87	PF00082	0.679
DEG_Nend_Nbox_1	1	3	PF02207	0.576
DOC_MAPK_gen_1	90	99	PF00069	0.546
DOC_USP7_MATH_1	88	92	PF00917	0.693
DOC_USP7_UBL2_3	119	123	PF12436	0.672
DOC_USP7_UBL2_3	12	16	PF12436	0.589
DOC_USP7_UBL2_3	86	90	PF12436	0.592
DOC_WW_Pin1_4	34	39	PF00397	0.500
LIG_14-3-3_CanoR_1	3	9	PF00244	0.559
LIG_14-3-3_CanoR_1	54	64	PF00244	0.609
LIG_FHA_1	26	32	PF00498	0.540
LIG_SH3_3	112	118	PF00018	0.504
LIG_SH3_3	39	45	PF00018	0.673
LIG_SH3_3	94	100	PF00018	0.564
MOD_CK1_1	19	25	PF00069	0.605
MOD_CK1_1	91	97	PF00069	0.694
MOD_Cter_Amidation	72	75	PF01082	0.622
MOD_GlcNHglycan	119	122	PF01048	0.562
MOD_GlcNHglycan	21	24	PF01048	0.556
MOD_NEK2_1	2	7	PF00069	0.665
MOD_NEK2_2	49	54	PF00069	0.588
MOD_PIKK_1	55	61	PF00454	0.607
MOD_PKA_2	19	25	PF00069	0.557
MOD_PKA_2	2	8	PF00069	0.680
MOD_PKA_2	91	97	PF00069	0.614
MOD_ProDKin_1	34	40	PF00069	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HM32	Leishmania braziliensis	60%	100%
A4I9G5	Leishmania infantum	100%	100%
E9B4G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q3L2	Leishmania major	82%	100%