Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH55_LEIDO

TriTrypDb:

LdBPK_341520.1 , LdCL_340021500 , LDHU3_34.2330

Length:

277

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IH55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH55

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.652
CLV_C14_Caspase3-7	188	192	PF00656	0.780
CLV_C14_Caspase3-7	19	23	PF00656	0.572
CLV_NRD_NRD_1	103	105	PF00675	0.669
CLV_NRD_NRD_1	123	125	PF00675	0.536
CLV_NRD_NRD_1	28	30	PF00675	0.532
CLV_PCSK_KEX2_1	105	107	PF00082	0.536
CLV_PCSK_KEX2_1	123	125	PF00082	0.531
CLV_PCSK_KEX2_1	28	30	PF00082	0.533
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.536
CLV_PCSK_SKI1_1	221	225	PF00082	0.571
CLV_PCSK_SKI1_1	55	59	PF00082	0.616
CLV_PCSK_SKI1_1	77	81	PF00082	0.576
DEG_SPOP_SBC_1	185	189	PF00917	0.580
DEG_SPOP_SBC_1	245	249	PF00917	0.546
DOC_CYCLIN_RxL_1	74	85	PF00134	0.634
DOC_PP1_RVXF_1	75	82	PF00149	0.542
DOC_PP2B_LxvP_1	115	118	PF13499	0.677
DOC_PP2B_LxvP_1	99	102	PF13499	0.558
DOC_PP4_FxxP_1	31	34	PF00568	0.650
DOC_USP7_MATH_1	118	122	PF00917	0.656
DOC_USP7_MATH_1	185	189	PF00917	0.730
DOC_USP7_MATH_1	198	202	PF00917	0.545
DOC_USP7_MATH_1	245	249	PF00917	0.557
DOC_USP7_MATH_1	36	40	PF00917	0.725
LIG_14-3-3_CanoR_1	132	136	PF00244	0.633
LIG_14-3-3_CanoR_1	221	230	PF00244	0.562
LIG_BIR_III_4	231	235	PF00653	0.522
LIG_CAP-Gly_1	274	277	PF01302	0.680
LIG_deltaCOP1_diTrp_1	22	31	PF00928	0.550
LIG_eIF4E_1	15	21	PF01652	0.493
LIG_eIF4E_1	205	211	PF01652	0.721
LIG_EVH1_2	67	71	PF00568	0.553
LIG_FHA_1	125	131	PF00498	0.556
LIG_FHA_1	223	229	PF00498	0.586
LIG_FHA_1	94	100	PF00498	0.603
LIG_FHA_2	108	114	PF00498	0.544
LIG_FHA_2	17	23	PF00498	0.578
LIG_LIR_Apic_2	203	208	PF02991	0.629
LIG_LIR_Nem_3	53	57	PF02991	0.571
LIG_MYND_1	208	212	PF01753	0.702
LIG_MYND_3	1	5	PF01753	0.523
LIG_SH2_CRK	205	209	PF00017	0.592
LIG_SH2_CRK	54	58	PF00017	0.588
LIG_SH2_GRB2like	109	112	PF00017	0.687
LIG_SH2_SRC	205	208	PF00017	0.666
LIG_SH2_STAT5	109	112	PF00017	0.636
LIG_SH2_STAT5	167	170	PF00017	0.575
LIG_SH2_STAT5	236	239	PF00017	0.550
LIG_SH2_STAT5	92	95	PF00017	0.612
LIG_WW_3	206	210	PF00397	0.697
MOD_CK1_1	10	16	PF00069	0.589
MOD_CK1_1	170	176	PF00069	0.637
MOD_CK1_1	53	59	PF00069	0.572
MOD_CK2_1	107	113	PF00069	0.598
MOD_CK2_1	189	195	PF00069	0.756
MOD_GlcNHglycan	12	15	PF01048	0.488
MOD_GlcNHglycan	141	144	PF01048	0.609
MOD_GlcNHglycan	155	160	PF01048	0.565
MOD_GlcNHglycan	191	194	PF01048	0.729
MOD_GlcNHglycan	200	203	PF01048	0.550
MOD_GlcNHglycan	38	41	PF01048	0.707
MOD_GSK3_1	131	138	PF00069	0.604
MOD_GSK3_1	167	174	PF00069	0.605
MOD_GSK3_1	175	182	PF00069	0.676
MOD_GSK3_1	185	192	PF00069	0.636
MOD_GSK3_1	222	229	PF00069	0.555
MOD_GSK3_1	3	10	PF00069	0.584
MOD_GSK3_1	46	53	PF00069	0.483
MOD_GSK3_1	55	62	PF00069	0.461
MOD_N-GLC_1	124	129	PF02516	0.691
MOD_N-GLC_1	226	231	PF02516	0.578
MOD_N-GLC_1	50	55	PF02516	0.615
MOD_NEK2_1	130	135	PF00069	0.592
MOD_NEK2_1	137	142	PF00069	0.599
MOD_NEK2_1	171	176	PF00069	0.613
MOD_NEK2_1	222	227	PF00069	0.567
MOD_NEK2_1	246	251	PF00069	0.635
MOD_NEK2_1	263	268	PF00069	0.559
MOD_NEK2_2	7	12	PF00069	0.634
MOD_PIKK_1	246	252	PF00454	0.675
MOD_PK_1	226	232	PF00069	0.697
MOD_PKA_2	131	137	PF00069	0.592
MOD_PKA_2	178	184	PF00069	0.741
MOD_PKB_1	219	227	PF00069	0.636
MOD_Plk_1	226	232	PF00069	0.577
MOD_Plk_1	50	56	PF00069	0.619
MOD_Plk_1	7	13	PF00069	0.676
MOD_Plk_4	16	22	PF00069	0.477
MOD_Plk_4	171	177	PF00069	0.600
TRG_DiLeu_BaEn_1	218	223	PF01217	0.634
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.720
TRG_DiLeu_LyEn_5	218	223	PF01217	0.634
TRG_ENDOCYTIC_2	54	57	PF00928	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P396	Leptomonas seymouri	63%	97%
A0A0S4J125	Bodo saltans	34%	100%
A0A0S4J4Y9	Bodo saltans	34%	100%
A0A1X0P9Q3	Trypanosomatidae	39%	100%
A0A3R7LYE4	Trypanosoma rangeli	41%	100%
A4H7T2	Leishmania braziliensis	81%	100%
A4I9V4	Leishmania infantum	100%	100%
C9ZMS8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4W7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q360	Leishmania major	89%	100%
V5DJW1	Trypanosoma cruzi	39%	96%