XRN 5'-3' exonuclease N-terminus family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5'-3' exoribonuclease D, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IH53_LEIDO

TriTrypDb:

LdBPK_361870.1 , LdCL_360024200 , LDHU3_36.2430

Length:

879

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IH53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH53

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016071	mRNA metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004527	exonuclease activity	5	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004534	5'-3' RNA exonuclease activity	7	1
GO:0004540	RNA nuclease activity	4	1
GO:0008409	5'-3' exonuclease activity	6	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	16	20	PF00656	0.514
CLV_C14_Caspase3-7	24	28	PF00656	0.481
CLV_C14_Caspase3-7	407	411	PF00656	0.517
CLV_MEL_PAP_1	654	660	PF00089	0.440
CLV_NRD_NRD_1	115	117	PF00675	0.244
CLV_NRD_NRD_1	419	421	PF00675	0.359
CLV_NRD_NRD_1	742	744	PF00675	0.747
CLV_NRD_NRD_1	759	761	PF00675	0.450
CLV_NRD_NRD_1	773	775	PF00675	0.668
CLV_NRD_NRD_1	791	793	PF00675	0.723
CLV_NRD_NRD_1	846	848	PF00675	0.770
CLV_NRD_NRD_1	877	879	PF00675	0.745
CLV_PCSK_FUR_1	113	117	PF00082	0.244
CLV_PCSK_FUR_1	771	775	PF00082	0.775
CLV_PCSK_FUR_1	875	879	PF00082	0.623
CLV_PCSK_KEX2_1	115	117	PF00082	0.244
CLV_PCSK_KEX2_1	731	733	PF00082	0.719
CLV_PCSK_KEX2_1	744	746	PF00082	0.502
CLV_PCSK_KEX2_1	759	761	PF00082	0.553
CLV_PCSK_KEX2_1	773	775	PF00082	0.601
CLV_PCSK_KEX2_1	790	792	PF00082	0.684
CLV_PCSK_KEX2_1	821	823	PF00082	0.687
CLV_PCSK_KEX2_1	846	848	PF00082	0.755
CLV_PCSK_KEX2_1	877	879	PF00082	0.728
CLV_PCSK_PC1ET2_1	731	733	PF00082	0.740
CLV_PCSK_PC1ET2_1	744	746	PF00082	0.505
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.593
CLV_PCSK_PC1ET2_1	821	823	PF00082	0.736
CLV_PCSK_SKI1_1	166	170	PF00082	0.311
CLV_PCSK_SKI1_1	186	190	PF00082	0.113
CLV_PCSK_SKI1_1	459	463	PF00082	0.290
CLV_PCSK_SKI1_1	553	557	PF00082	0.305
CLV_PCSK_SKI1_1	707	711	PF00082	0.475
CLV_PCSK_SKI1_1	846	850	PF00082	0.729
CLV_PCSK_SKI1_1	852	856	PF00082	0.638
DEG_SPOP_SBC_1	801	805	PF00917	0.708
DEG_SPOP_SBC_1	806	810	PF00917	0.664
DEG_SPOP_SBC_1	840	844	PF00917	0.753
DOC_CDC14_PxL_1	497	505	PF14671	0.455
DOC_CDC14_PxL_1	530	538	PF14671	0.469
DOC_CKS1_1	156	161	PF01111	0.444
DOC_CYCLIN_RxL_1	88	101	PF00134	0.444
DOC_CYCLIN_yCln2_LP_2	637	643	PF00134	0.573
DOC_MAPK_gen_1	315	323	PF00069	0.455
DOC_MAPK_gen_1	420	428	PF00069	0.467
DOC_MAPK_gen_1	591	599	PF00069	0.549
DOC_MAPK_gen_1	88	98	PF00069	0.444
DOC_MAPK_MEF2A_6	78	87	PF00069	0.468
DOC_MAPK_MEF2A_6	91	100	PF00069	0.404
DOC_MAPK_NFAT4_5	93	101	PF00069	0.444
DOC_PP1_RVXF_1	473	480	PF00149	0.548
DOC_PP2B_LxvP_1	579	582	PF13499	0.455
DOC_PP2B_LxvP_1	637	640	PF13499	0.606
DOC_USP7_MATH_1	310	314	PF00917	0.530
DOC_USP7_MATH_1	389	393	PF00917	0.547
DOC_USP7_MATH_1	400	404	PF00917	0.500
DOC_USP7_MATH_1	414	418	PF00917	0.530
DOC_USP7_MATH_1	461	465	PF00917	0.516
DOC_USP7_MATH_1	626	630	PF00917	0.587
DOC_USP7_MATH_1	724	728	PF00917	0.657
DOC_USP7_MATH_1	801	805	PF00917	0.714
DOC_USP7_MATH_1	806	810	PF00917	0.650
DOC_USP7_MATH_1	840	844	PF00917	0.682
DOC_USP7_MATH_1	848	852	PF00917	0.686
DOC_USP7_UBL2_3	357	361	PF12436	0.502
DOC_USP7_UBL2_3	373	377	PF12436	0.375
DOC_USP7_UBL2_3	731	735	PF12436	0.745
DOC_USP7_UBL2_3	812	816	PF12436	0.748
DOC_WW_Pin1_4	155	160	PF00397	0.444
DOC_WW_Pin1_4	735	740	PF00397	0.745
DOC_WW_Pin1_4	802	807	PF00397	0.706
DOC_WW_Pin1_4	862	867	PF00397	0.613
LIG_14-3-3_CanoR_1	136	144	PF00244	0.546
LIG_14-3-3_CanoR_1	186	191	PF00244	0.505
LIG_14-3-3_CanoR_1	210	216	PF00244	0.495
LIG_14-3-3_CanoR_1	249	258	PF00244	0.537
LIG_14-3-3_CanoR_1	383	391	PF00244	0.505
LIG_14-3-3_CanoR_1	518	522	PF00244	0.503
LIG_14-3-3_CanoR_1	535	539	PF00244	0.353
LIG_BRCT_BRCA1_1	113	117	PF00533	0.444
LIG_BRCT_BRCA1_1	159	163	PF00533	0.444
LIG_Clathr_ClatBox_1	596	600	PF01394	0.552
LIG_deltaCOP1_diTrp_1	181	192	PF00928	0.455
LIG_deltaCOP1_diTrp_1	492	495	PF00928	0.455
LIG_EH1_1	523	531	PF00400	0.444
LIG_eIF4E_1	497	503	PF01652	0.505
LIG_FHA_1	220	226	PF00498	0.455
LIG_FHA_1	314	320	PF00498	0.444
LIG_FHA_1	422	428	PF00498	0.513
LIG_FHA_1	508	514	PF00498	0.462
LIG_FHA_1	61	67	PF00498	0.444
LIG_FHA_1	649	655	PF00498	0.541
LIG_FHA_2	268	274	PF00498	0.445
LIG_FHA_2	383	389	PF00498	0.561
LIG_FHA_2	700	706	PF00498	0.549
LIG_KLC1_Yacidic_2	46	51	PF13176	0.455
LIG_LIR_Apic_2	139	144	PF02991	0.532
LIG_LIR_Apic_2	490	496	PF02991	0.444
LIG_LIR_Gen_1	278	287	PF02991	0.390
LIG_LIR_Gen_1	292	301	PF02991	0.410
LIG_LIR_Gen_1	341	352	PF02991	0.474
LIG_LIR_Gen_1	44	52	PF02991	0.460
LIG_LIR_Gen_1	73	83	PF02991	0.455
LIG_LIR_LC3C_4	424	428	PF02991	0.480
LIG_LIR_Nem_3	182	188	PF02991	0.449
LIG_LIR_Nem_3	278	282	PF02991	0.398
LIG_LIR_Nem_3	292	297	PF02991	0.449
LIG_LIR_Nem_3	341	347	PF02991	0.444
LIG_LIR_Nem_3	363	369	PF02991	0.473
LIG_LIR_Nem_3	44	48	PF02991	0.473
LIG_LIR_Nem_3	490	494	PF02991	0.444
LIG_LIR_Nem_3	574	578	PF02991	0.458
LIG_LIR_Nem_3	705	709	PF02991	0.529
LIG_LIR_Nem_3	77	83	PF02991	0.457
LIG_LYPXL_S_1	559	563	PF13949	0.330
LIG_LYPXL_yS_3	560	563	PF13949	0.530
LIG_MAD2	136	144	PF02301	0.519
LIG_Pex14_1	479	483	PF04695	0.444
LIG_Pex14_1	491	495	PF04695	0.444
LIG_Pex14_2	296	300	PF04695	0.444
LIG_Pex14_2	350	354	PF04695	0.444
LIG_Pex14_2	603	607	PF04695	0.500
LIG_Pex14_2	76	80	PF04695	0.455
LIG_Rb_LxCxE_1	463	485	PF01857	0.485
LIG_Rb_LxCxE_1	605	624	PF01857	0.428
LIG_SH2_CRK	141	145	PF00017	0.549
LIG_SH2_CRK	367	371	PF00017	0.463
LIG_SH2_CRK	499	503	PF00017	0.444
LIG_SH2_CRK	575	579	PF00017	0.444
LIG_SH2_CRK	706	710	PF00017	0.488
LIG_SH2_GRB2like	265	268	PF00017	0.405
LIG_SH2_GRB2like	45	48	PF00017	0.505
LIG_SH2_STAP1	45	49	PF00017	0.505
LIG_SH2_STAP1	661	665	PF00017	0.484
LIG_SH2_STAT3	335	338	PF00017	0.522
LIG_SH2_STAT5	174	177	PF00017	0.530
LIG_SH2_STAT5	208	211	PF00017	0.440
LIG_SH2_STAT5	265	268	PF00017	0.320
LIG_SH2_STAT5	326	329	PF00017	0.444
LIG_SH2_STAT5	335	338	PF00017	0.444
LIG_SH2_STAT5	437	440	PF00017	0.462
LIG_SH2_STAT5	473	476	PF00017	0.450
LIG_SH2_STAT5	484	487	PF00017	0.432
LIG_SH2_STAT5	49	52	PF00017	0.455
LIG_SH2_STAT5	494	497	PF00017	0.444
LIG_SH2_STAT5	609	612	PF00017	0.445
LIG_SH3_1	863	869	PF00018	0.581
LIG_SH3_2	866	871	PF14604	0.583
LIG_SH3_3	153	159	PF00018	0.444
LIG_SH3_3	304	310	PF00018	0.444
LIG_SH3_3	519	525	PF00018	0.444
LIG_SH3_3	546	552	PF00018	0.444
LIG_SH3_3	637	643	PF00018	0.551
LIG_SH3_3	86	92	PF00018	0.469
LIG_SH3_3	863	869	PF00018	0.635
LIG_SH3_5	216	220	PF00018	0.549
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.505
LIG_SUMO_SIM_par_1	310	316	PF11976	0.444
LIG_SUMO_SIM_par_1	409	418	PF11976	0.493
LIG_SUMO_SIM_par_1	562	567	PF11976	0.526
LIG_SUMO_SIM_par_1	595	602	PF11976	0.576
LIG_TRAF2_1	815	818	PF00917	0.499
LIG_TYR_ITIM	342	347	PF00017	0.469
LIG_UBA3_1	349	357	PF00899	0.549
LIG_UBA3_1	359	364	PF00899	0.431
LIG_UBA3_1	412	421	PF00899	0.474
LIG_WW_3	738	742	PF00397	0.667
MOD_CDC14_SPxK_1	738	741	PF00782	0.706
MOD_CDK_SPxK_1	735	741	PF00069	0.699
MOD_CDK_SPxK_1	862	868	PF00069	0.615
MOD_CK1_1	313	319	PF00069	0.444
MOD_CK1_1	38	44	PF00069	0.479
MOD_CK1_1	647	653	PF00069	0.535
MOD_CK1_1	727	733	PF00069	0.705
MOD_CK1_1	802	808	PF00069	0.706
MOD_CK1_1	829	835	PF00069	0.734
MOD_CK1_1	842	848	PF00069	0.692
MOD_CK2_1	236	242	PF00069	0.438
MOD_CK2_1	267	273	PF00069	0.445
MOD_CK2_1	277	283	PF00069	0.488
MOD_CK2_1	382	388	PF00069	0.529
MOD_CK2_1	776	782	PF00069	0.759
MOD_CK2_1	812	818	PF00069	0.592
MOD_CK2_1	820	826	PF00069	0.757
MOD_CK2_1	829	835	PF00069	0.721
MOD_GlcNHglycan	40	43	PF01048	0.297
MOD_GlcNHglycan	417	420	PF01048	0.322
MOD_GlcNHglycan	454	458	PF01048	0.302
MOD_GlcNHglycan	519	522	PF01048	0.329
MOD_GlcNHglycan	628	631	PF01048	0.599
MOD_GSK3_1	123	130	PF00069	0.455
MOD_GSK3_1	186	193	PF00069	0.486
MOD_GSK3_1	31	38	PF00069	0.461
MOD_GSK3_1	644	651	PF00069	0.550
MOD_GSK3_1	786	793	PF00069	0.749
MOD_GSK3_1	795	802	PF00069	0.717
MOD_GSK3_1	808	815	PF00069	0.573
MOD_GSK3_1	820	827	PF00069	0.719
MOD_GSK3_1	858	865	PF00069	0.768
MOD_N-GLC_1	220	225	PF02516	0.330
MOD_N-GLC_1	266	271	PF02516	0.422
MOD_N-GLC_1	352	357	PF02516	0.335
MOD_N-GLC_1	571	576	PF02516	0.297
MOD_N-GLC_2	131	133	PF02516	0.305
MOD_NEK2_1	236	241	PF00069	0.446
MOD_NEK2_1	252	257	PF00069	0.416
MOD_NEK2_1	266	271	PF00069	0.299
MOD_NEK2_1	352	357	PF00069	0.497
MOD_NEK2_1	415	420	PF00069	0.454
MOD_NEK2_1	433	438	PF00069	0.389
MOD_NEK2_1	509	514	PF00069	0.542
MOD_NEK2_1	517	522	PF00069	0.513
MOD_NEK2_1	603	608	PF00069	0.427
MOD_NEK2_1	633	638	PF00069	0.654
MOD_NEK2_1	678	683	PF00069	0.502
MOD_NEK2_1	841	846	PF00069	0.701
MOD_NEK2_2	310	315	PF00069	0.444
MOD_NEK2_2	534	539	PF00069	0.530
MOD_PIKK_1	211	217	PF00454	0.505
MOD_PIKK_1	334	340	PF00454	0.522
MOD_PIKK_1	699	705	PF00454	0.524
MOD_PIKK_1	820	826	PF00454	0.764
MOD_PKA_1	761	767	PF00069	0.779
MOD_PKA_1	790	796	PF00069	0.772
MOD_PKA_1	820	826	PF00069	0.745
MOD_PKA_2	382	388	PF00069	0.549
MOD_PKA_2	517	523	PF00069	0.503
MOD_PKA_2	534	540	PF00069	0.353
MOD_PKA_2	761	767	PF00069	0.773
MOD_PKA_2	790	796	PF00069	0.707
MOD_PKA_2	829	835	PF00069	0.718
MOD_PKA_2	858	864	PF00069	0.760
MOD_PKB_1	760	768	PF00069	0.795
MOD_PKB_1	774	782	PF00069	0.782
MOD_Plk_1	220	226	PF00069	0.505
MOD_Plk_1	266	272	PF00069	0.382
MOD_Plk_1	421	427	PF00069	0.526
MOD_Plk_1	571	577	PF00069	0.497
MOD_Plk_1	611	617	PF00069	0.391
MOD_Plk_4	186	192	PF00069	0.532
MOD_Plk_4	394	400	PF00069	0.557
MOD_Plk_4	551	557	PF00069	0.444
MOD_Plk_4	603	609	PF00069	0.386
MOD_ProDKin_1	155	161	PF00069	0.444
MOD_ProDKin_1	735	741	PF00069	0.748
MOD_ProDKin_1	802	808	PF00069	0.709
MOD_ProDKin_1	862	868	PF00069	0.615
MOD_SUMO_for_1	854	857	PF00179	0.611
MOD_SUMO_rev_2	200	206	PF00179	0.444
MOD_SUMO_rev_2	547	555	PF00179	0.505
MOD_SUMO_rev_2	815	823	PF00179	0.614
MOD_SUMO_rev_2	826	834	PF00179	0.623
TRG_DiLeu_BaEn_1	422	427	PF01217	0.448
TRG_DiLeu_BaLyEn_6	498	503	PF01217	0.444
TRG_ENDOCYTIC_2	265	268	PF00928	0.320
TRG_ENDOCYTIC_2	344	347	PF00928	0.464
TRG_ENDOCYTIC_2	366	369	PF00928	0.460
TRG_ENDOCYTIC_2	45	48	PF00928	0.463
TRG_ENDOCYTIC_2	49	52	PF00928	0.447
TRG_ENDOCYTIC_2	499	502	PF00928	0.452
TRG_ENDOCYTIC_2	560	563	PF00928	0.500
TRG_ENDOCYTIC_2	575	578	PF00928	0.373
TRG_ENDOCYTIC_2	706	709	PF00928	0.490
TRG_ER_diArg_1	113	116	PF00400	0.444
TRG_ER_diArg_1	144	147	PF00400	0.485
TRG_ER_diArg_1	423	426	PF00400	0.469
TRG_ER_diArg_1	740	743	PF00400	0.792
TRG_ER_diArg_1	790	792	PF00400	0.710
TRG_ER_diArg_1	875	878	PF00400	0.785
TRG_NES_CRM1_1	504	516	PF08389	0.502
TRG_NLS_Bipartite_1	731	747	PF00514	0.789
TRG_NLS_MonoCore_2	758	763	PF00514	0.697
TRG_NLS_MonoExtC_3	742	747	PF00514	0.746
TRG_NLS_MonoExtN_4	740	747	PF00514	0.754
TRG_NLS_MonoExtN_4	759	764	PF00514	0.710
TRG_Pf-PMV_PEXEL_1	177	181	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.244
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.349

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA8	Leptomonas seymouri	87%	96%
A0A0S4IWC0	Bodo saltans	53%	100%
A0A1X0P7T7	Trypanosomatidae	59%	100%
A0A3R7LZH3	Trypanosoma rangeli	63%	100%
A4HP43	Leishmania braziliensis	86%	100%
A4IDF0	Leishmania infantum	100%	100%
D0A327	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9ASV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q1P5	Leishmania major	93%	100%
Q5ZIP4	Gallus gallus	33%	93%
Q60SG7	Caenorhabditis briggsae	32%	90%
Q9FQ02	Arabidopsis thaliana	33%	87%
Q9FQ03	Arabidopsis thaliana	33%	86%
Q9FQ04	Arabidopsis thaliana	34%	93%
Q9U299	Caenorhabditis elegans	32%	90%
Q9VM71	Drosophila melanogaster	34%	97%
V5DKX1	Trypanosoma cruzi	61%	100%