Pteridine transporter, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IH50_LEIDO

TriTrypDb:

LdBPK_100420.1 , LdCL_100009500 , LDHU3_10.0600

Length:

722

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A0A3Q8IH50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH50

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	271	273	PF00675	0.295
CLV_NRD_NRD_1	289	291	PF00675	0.340
CLV_NRD_NRD_1	718	720	PF00675	0.571
CLV_PCSK_KEX2_1	151	153	PF00082	0.302
CLV_PCSK_KEX2_1	552	554	PF00082	0.526
CLV_PCSK_KEX2_1	720	722	PF00082	0.499
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.302
CLV_PCSK_PC1ET2_1	552	554	PF00082	0.526
CLV_PCSK_PC1ET2_1	720	722	PF00082	0.477
CLV_PCSK_SKI1_1	134	138	PF00082	0.358
CLV_PCSK_SKI1_1	293	297	PF00082	0.270
CLV_PCSK_SKI1_1	33	37	PF00082	0.563
CLV_PCSK_SKI1_1	353	357	PF00082	0.355
CLV_PCSK_SKI1_1	677	681	PF00082	0.252
DEG_APCC_DBOX_1	292	300	PF00400	0.426
DEG_COP1_1	340	348	PF00400	0.393
DEG_Nend_UBRbox_2	1	3	PF02207	0.621
DOC_CDC14_PxL_1	638	646	PF14671	0.336
DOC_CYCLIN_yCln2_LP_2	655	661	PF00134	0.384
DOC_MAPK_gen_1	151	157	PF00069	0.511
DOC_MAPK_gen_1	290	298	PF00069	0.545
DOC_MAPK_gen_1	308	317	PF00069	0.530
DOC_MAPK_gen_1	552	560	PF00069	0.328
DOC_MAPK_MEF2A_6	245	252	PF00069	0.334
DOC_MAPK_MEF2A_6	290	298	PF00069	0.405
DOC_MAPK_MEF2A_6	552	560	PF00069	0.361
DOC_MAPK_MEF2A_6	81	88	PF00069	0.550
DOC_PP1_RVXF_1	528	534	PF00149	0.524
DOC_PP2B_LxvP_1	473	476	PF13499	0.381
DOC_PP2B_LxvP_1	655	658	PF13499	0.371
DOC_PP2B_LxvP_1	661	664	PF13499	0.337
DOC_USP7_MATH_1	217	221	PF00917	0.329
DOC_USP7_MATH_1	301	305	PF00917	0.495
DOC_USP7_MATH_1	478	482	PF00917	0.322
DOC_USP7_MATH_1	594	598	PF00917	0.485
DOC_USP7_MATH_1	678	682	PF00917	0.580
DOC_WW_Pin1_4	11	16	PF00397	0.743
DOC_WW_Pin1_4	39	44	PF00397	0.797
DOC_WW_Pin1_4	630	635	PF00397	0.353
LIG_14-3-3_CanoR_1	530	534	PF00244	0.496
LIG_APCC_ABBA_1	68	73	PF00400	0.648
LIG_APCC_ABBAyCdc20_2	330	336	PF00400	0.388
LIG_CSL_BTD_1	581	584	PF09270	0.404
LIG_EVH1_2	634	638	PF00568	0.364
LIG_FHA_1	135	141	PF00498	0.574
LIG_FHA_1	35	41	PF00498	0.699
LIG_FHA_1	415	421	PF00498	0.363
LIG_FHA_1	430	436	PF00498	0.262
LIG_FHA_1	468	474	PF00498	0.429
LIG_FHA_1	530	536	PF00498	0.497
LIG_FHA_1	658	664	PF00498	0.421
LIG_FHA_1	700	706	PF00498	0.582
LIG_LIR_Apic_2	449	455	PF02991	0.424
LIG_LIR_Gen_1	142	149	PF02991	0.525
LIG_LIR_Gen_1	201	212	PF02991	0.533
LIG_LIR_Gen_1	220	231	PF02991	0.467
LIG_LIR_Gen_1	470	479	PF02991	0.374
LIG_LIR_Gen_1	499	508	PF02991	0.335
LIG_LIR_Gen_1	518	524	PF02991	0.400
LIG_LIR_Gen_1	544	551	PF02991	0.341
LIG_LIR_Gen_1	599	608	PF02991	0.521
LIG_LIR_LC3C_4	362	367	PF02991	0.393
LIG_LIR_Nem_3	142	147	PF02991	0.500
LIG_LIR_Nem_3	150	156	PF02991	0.500
LIG_LIR_Nem_3	201	207	PF02991	0.543
LIG_LIR_Nem_3	220	226	PF02991	0.363
LIG_LIR_Nem_3	260	266	PF02991	0.365
LIG_LIR_Nem_3	377	383	PF02991	0.601
LIG_LIR_Nem_3	470	475	PF02991	0.400
LIG_LIR_Nem_3	497	501	PF02991	0.306
LIG_LIR_Nem_3	518	523	PF02991	0.349
LIG_LIR_Nem_3	544	549	PF02991	0.343
LIG_MYND_3	345	349	PF01753	0.385
LIG_Pex14_1	221	225	PF04695	0.381
LIG_Pex14_2	264	268	PF04695	0.293
LIG_Pex14_2	496	500	PF04695	0.316
LIG_Pex14_2	520	524	PF04695	0.378
LIG_SH2_CRK	120	124	PF00017	0.517
LIG_SH2_CRK	154	158	PF00017	0.382
LIG_SH2_CRK	169	173	PF00017	0.333
LIG_SH2_CRK	204	208	PF00017	0.520
LIG_SH2_CRK	412	416	PF00017	0.350
LIG_SH2_CRK	501	505	PF00017	0.308
LIG_SH2_NCK_1	501	505	PF00017	0.306
LIG_SH2_PTP2	557	560	PF00017	0.402
LIG_SH2_STAP1	149	153	PF00017	0.506
LIG_SH2_STAP1	204	208	PF00017	0.495
LIG_SH2_STAP1	412	416	PF00017	0.388
LIG_SH2_STAP1	602	606	PF00017	0.346
LIG_SH2_STAT3	103	106	PF00017	0.417
LIG_SH2_STAT5	149	152	PF00017	0.507
LIG_SH2_STAT5	380	383	PF00017	0.399
LIG_SH2_STAT5	466	469	PF00017	0.361
LIG_SH2_STAT5	472	475	PF00017	0.354
LIG_SH2_STAT5	483	486	PF00017	0.292
LIG_SH2_STAT5	498	501	PF00017	0.267
LIG_SH2_STAT5	522	525	PF00017	0.455
LIG_SH2_STAT5	557	560	PF00017	0.314
LIG_SH2_STAT5	566	569	PF00017	0.299
LIG_SH2_STAT5	90	93	PF00017	0.532
LIG_SH3_3	12	18	PF00018	0.694
LIG_SH3_3	170	176	PF00018	0.306
LIG_SH3_3	382	388	PF00018	0.577
LIG_SH3_3	488	494	PF00018	0.290
LIG_SH3_3	57	63	PF00018	0.567
LIG_SUMO_SIM_anti_2	312	319	PF11976	0.391
LIG_SUMO_SIM_par_1	584	590	PF11976	0.336
LIG_TRAF2_1	340	343	PF00917	0.391
LIG_TRAF2_1	355	358	PF00917	0.569
LIG_TRFH_1	169	173	PF08558	0.368
LIG_TYR_ITIM	167	172	PF00017	0.388
LIG_TYR_ITIM	284	289	PF00017	0.197
LIG_TYR_ITSM	497	504	PF00017	0.410
LIG_UBA3_1	392	400	PF00899	0.392
LIG_Vh1_VBS_1	421	439	PF01044	0.452
LIG_Vh1_VBS_1	500	518	PF01044	0.393
LIG_WRC_WIRS_1	479	484	PF05994	0.342
MOD_CDK_SPK_2	14	19	PF00069	0.519
MOD_CK1_1	525	531	PF00069	0.358
MOD_CK1_1	629	635	PF00069	0.304
MOD_CK1_1	681	687	PF00069	0.528
MOD_CK2_1	337	343	PF00069	0.324
MOD_CK2_1	700	706	PF00069	0.729
MOD_GlcNHglycan	177	180	PF01048	0.364
MOD_GlcNHglycan	252	255	PF01048	0.359
MOD_GlcNHglycan	308	311	PF01048	0.301
MOD_GlcNHglycan	322	325	PF01048	0.261
MOD_GlcNHglycan	680	683	PF01048	0.447
MOD_GSK3_1	125	132	PF00069	0.390
MOD_GSK3_1	410	417	PF00069	0.369
MOD_GSK3_1	496	503	PF00069	0.386
MOD_GSK3_1	525	532	PF00069	0.370
MOD_GSK3_1	611	618	PF00069	0.377
MOD_GSK3_1	626	633	PF00069	0.333
MOD_N-GLC_1	636	641	PF02516	0.205
MOD_N-GLC_1	700	705	PF02516	0.467
MOD_NEK2_1	108	113	PF00069	0.298
MOD_NEK2_1	129	134	PF00069	0.383
MOD_NEK2_1	147	152	PF00069	0.289
MOD_NEK2_1	155	160	PF00069	0.345
MOD_NEK2_1	187	192	PF00069	0.347
MOD_NEK2_1	410	415	PF00069	0.372
MOD_NEK2_1	416	421	PF00069	0.356
MOD_NEK2_1	429	434	PF00069	0.304
MOD_NEK2_1	467	472	PF00069	0.413
MOD_NEK2_1	496	501	PF00069	0.370
MOD_NEK2_1	533	538	PF00069	0.374
MOD_NEK2_1	611	616	PF00069	0.364
MOD_NEK2_2	478	483	PF00069	0.342
MOD_OFUCOSY	418	425	PF10250	0.404
MOD_PKA_2	529	535	PF00069	0.353
MOD_PKA_2	594	600	PF00069	0.335
MOD_Plk_1	53	59	PF00069	0.354
MOD_Plk_1	700	706	PF00069	0.659
MOD_Plk_4	217	223	PF00069	0.353
MOD_Plk_4	410	416	PF00069	0.362
MOD_Plk_4	424	430	PF00069	0.317
MOD_Plk_4	447	453	PF00069	0.389
MOD_Plk_4	467	473	PF00069	0.379
MOD_Plk_4	478	484	PF00069	0.345
MOD_Plk_4	496	502	PF00069	0.468
MOD_Plk_4	534	540	PF00069	0.326
MOD_Plk_4	54	60	PF00069	0.533
MOD_Plk_4	541	547	PF00069	0.333
MOD_Plk_4	596	602	PF00069	0.388
MOD_Plk_4	657	663	PF00069	0.388
MOD_ProDKin_1	11	17	PF00069	0.688
MOD_ProDKin_1	39	45	PF00069	0.763
MOD_ProDKin_1	630	636	PF00069	0.423
MOD_SUMO_rev_2	42	48	PF00179	0.579
MOD_SUMO_rev_2	670	679	PF00179	0.397
MOD_SUMO_rev_2	714	722	PF00179	0.460
TRG_DiLeu_BaEn_4	370	376	PF01217	0.203
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.327
TRG_ENDOCYTIC_2	120	123	PF00928	0.332
TRG_ENDOCYTIC_2	154	157	PF00928	0.360
TRG_ENDOCYTIC_2	169	172	PF00928	0.347
TRG_ENDOCYTIC_2	204	207	PF00928	0.351
TRG_ENDOCYTIC_2	286	289	PF00928	0.453
TRG_ENDOCYTIC_2	412	415	PF00928	0.352
TRG_ENDOCYTIC_2	466	469	PF00928	0.365
TRG_ENDOCYTIC_2	472	475	PF00928	0.367
TRG_ENDOCYTIC_2	501	504	PF00928	0.363
TRG_ENDOCYTIC_2	557	560	PF00928	0.485
TRG_ENDOCYTIC_2	602	605	PF00928	0.347
TRG_NES_CRM1_1	474	488	PF08389	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	51%	100%
A0A0N1HY49	Leptomonas seymouri	53%	100%
A0A0N1HZ06	Leptomonas seymouri	40%	100%
A0A0N1IHL1	Leptomonas seymouri	44%	100%
A0A0N1PAY4	Leptomonas seymouri	49%	82%
A0A0N1PB77	Leptomonas seymouri	38%	100%
A0A0N1PBZ2	Leptomonas seymouri	59%	100%
A0A0N1PCC1	Leptomonas seymouri	46%	100%
A0A381MBI0	Leishmania infantum	48%	100%
A0A3Q8I8X7	Leishmania donovani	48%	100%
A0A3Q8IAZ0	Leishmania donovani	58%	100%
A0A3Q8IVN0	Leishmania donovani	40%	100%
A0A3R7M4J1	Trypanosoma rangeli	43%	100%
A0A3S5H5P4	Leishmania donovani	49%	100%
A0A3S5H5V2	Leishmania donovani	45%	100%
A0A3S5H6F6	Leishmania donovani	59%	100%
A0A3S5H763	Leishmania donovani	62%	100%
A0A3S7WR10	Leishmania donovani	49%	97%
A0A3S7WR14	Leishmania donovani	59%	100%
A0A3S7WR15	Leishmania donovani	56%	85%
A0A3S7WR24	Leishmania donovani	59%	100%
A4H4T8	Leishmania braziliensis	44%	100%
A4H5Y4	Leishmania braziliensis	49%	100%
A4H617	Leishmania braziliensis	58%	100%
A4H618	Leishmania braziliensis	58%	100%
A4H619	Leishmania braziliensis	58%	100%
A4H620	Leishmania braziliensis	82%	100%
A4H6C3	Leishmania braziliensis	47%	98%
A4HNH7	Leishmania braziliensis	37%	96%
A4HSS2	Leishmania infantum	49%	100%
A4HUE4	Leishmania infantum	50%	100%
A4HUE5	Leishmania infantum	58%	100%
A4HUE6	Leishmania infantum	60%	100%
A4HUE7	Leishmania infantum	58%	100%
A4HUE8	Leishmania infantum	59%	100%
A4HUF4	Leishmania infantum	59%	100%
A4HUF5	Leishmania infantum	99%	100%
A4HYA9	Leishmania infantum	60%	100%
A4IC33	Leishmania infantum	39%	96%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AG72	Leishmania infantum	45%	100%
E9AI40	Leishmania braziliensis	60%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	98%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	98%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	95%
Q4QDC4	Leishmania major	60%	100%
Q4QH81	Leishmania major	46%	98%
Q4QHH7	Leishmania major	91%	100%
Q4QHH8	Leishmania major	58%	100%
Q4QHH9	Leishmania major	58%	100%
Q4QHI0	Leishmania major	59%	100%
Q4QHI1	Leishmania major	60%	97%
Q4QHI2	Leishmania major	58%	97%
Q4QIU9	Leishmania major	45%	100%
Q4QJ48	Leishmania major	49%	100%
Q7KIP2	Leishmania major	39%	95%