LeishMANIAdb
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DNA-directed DNA polymerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
DNA-directed DNA polymerase
Gene product:
mitochondrial DNA polymerase I protein A, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IH45_LEIDO
TriTrypDb:
LdBPK_341370.1 * , LdCL_340019700 , LDHU3_34.2130
Length:
934

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IH45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH45

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 7
GO:0006259 DNA metabolic process 4 7
GO:0006260 DNA replication 5 7
GO:0006261 DNA-templated DNA replication 6 7
GO:0006725 cellular aromatic compound metabolic process 3 7
GO:0006807 nitrogen compound metabolic process 2 7
GO:0008152 metabolic process 1 7
GO:0009987 cellular process 1 7
GO:0034641 cellular nitrogen compound metabolic process 3 7
GO:0043170 macromolecule metabolic process 3 7
GO:0044237 cellular metabolic process 2 7
GO:0044238 primary metabolic process 2 7
GO:0044260 obsolete cellular macromolecule metabolic process 3 7
GO:0046483 heterocycle metabolic process 3 7
GO:0071704 organic substance metabolic process 2 7
GO:0090304 nucleic acid metabolic process 4 7
GO:1901360 organic cyclic compound metabolic process 3 7
GO:0006281 DNA repair 5 1
GO:0006302 double-strand break repair 6 1
GO:0006950 response to stress 2 1
GO:0006974 DNA damage response 4 1
GO:0033554 cellular response to stress 3 1
GO:0050896 response to stimulus 1 1
GO:0051716 cellular response to stimulus 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 7
GO:0003677 DNA binding 4 7
GO:0003824 catalytic activity 1 7
GO:0003887 DNA-directed DNA polymerase activity 5 7
GO:0005488 binding 1 7
GO:0016740 transferase activity 2 7
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 7
GO:0016779 nucleotidyltransferase activity 4 7
GO:0034061 DNA polymerase activity 4 7
GO:0097159 organic cyclic compound binding 2 7
GO:0140097 catalytic activity, acting on DNA 3 7
GO:0140640 catalytic activity, acting on a nucleic acid 2 7
GO:1901363 heterocyclic compound binding 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 112 114 PF00675 0.502
CLV_NRD_NRD_1 164 166 PF00675 0.628
CLV_NRD_NRD_1 19 21 PF00675 0.693
CLV_NRD_NRD_1 35 37 PF00675 0.581
CLV_NRD_NRD_1 40 42 PF00675 0.739
CLV_NRD_NRD_1 449 451 PF00675 0.344
CLV_NRD_NRD_1 507 509 PF00675 0.346
CLV_NRD_NRD_1 685 687 PF00675 0.346
CLV_NRD_NRD_1 796 798 PF00675 0.346
CLV_NRD_NRD_1 828 830 PF00675 0.346
CLV_NRD_NRD_1 883 885 PF00675 0.346
CLV_PCSK_KEX2_1 112 114 PF00082 0.502
CLV_PCSK_KEX2_1 163 165 PF00082 0.644
CLV_PCSK_KEX2_1 18 20 PF00082 0.690
CLV_PCSK_KEX2_1 35 37 PF00082 0.586
CLV_PCSK_KEX2_1 390 392 PF00082 0.450
CLV_PCSK_KEX2_1 42 44 PF00082 0.681
CLV_PCSK_KEX2_1 449 451 PF00082 0.275
CLV_PCSK_KEX2_1 685 687 PF00082 0.346
CLV_PCSK_KEX2_1 751 753 PF00082 0.342
CLV_PCSK_KEX2_1 796 798 PF00082 0.346
CLV_PCSK_KEX2_1 828 830 PF00082 0.346
CLV_PCSK_PC1ET2_1 163 165 PF00082 0.644
CLV_PCSK_PC1ET2_1 35 37 PF00082 0.867
CLV_PCSK_PC1ET2_1 390 392 PF00082 0.450
CLV_PCSK_PC1ET2_1 42 44 PF00082 0.659
CLV_PCSK_PC1ET2_1 751 753 PF00082 0.346
CLV_PCSK_PC7_1 747 753 PF00082 0.346
CLV_PCSK_SKI1_1 112 116 PF00082 0.533
CLV_PCSK_SKI1_1 160 164 PF00082 0.642
CLV_PCSK_SKI1_1 379 383 PF00082 0.470
CLV_PCSK_SKI1_1 391 395 PF00082 0.440
CLV_PCSK_SKI1_1 449 453 PF00082 0.346
CLV_PCSK_SKI1_1 460 464 PF00082 0.346
CLV_PCSK_SKI1_1 65 69 PF00082 0.674
CLV_PCSK_SKI1_1 752 756 PF00082 0.342
CLV_PCSK_SKI1_1 834 838 PF00082 0.346
CLV_PCSK_SKI1_1 858 862 PF00082 0.346
CLV_PCSK_SKI1_1 885 889 PF00082 0.332
DEG_APCC_DBOX_1 404 412 PF00400 0.490
DEG_APCC_DBOX_1 448 456 PF00400 0.546
DEG_APCC_DBOX_1 883 891 PF00400 0.559
DEG_Nend_UBRbox_3 1 3 PF02207 0.636
DEG_SPOP_SBC_1 721 725 PF00917 0.618
DOC_CYCLIN_RxL_1 457 465 PF00134 0.559
DOC_CYCLIN_RxL_1 62 72 PF00134 0.685
DOC_CYCLIN_yCln2_LP_2 905 911 PF00134 0.546
DOC_MAPK_DCC_7 208 218 PF00069 0.455
DOC_MAPK_gen_1 387 396 PF00069 0.440
DOC_MAPK_gen_1 863 871 PF00069 0.618
DOC_MAPK_gen_1 884 892 PF00069 0.559
DOC_MAPK_MEF2A_6 120 128 PF00069 0.501
DOC_MAPK_MEF2A_6 177 186 PF00069 0.566
DOC_MAPK_MEF2A_6 305 312 PF00069 0.492
DOC_MAPK_MEF2A_6 387 396 PF00069 0.440
DOC_MAPK_MEF2A_6 400 408 PF00069 0.397
DOC_MAPK_MEF2A_6 885 894 PF00069 0.559
DOC_MAPK_NFAT4_5 391 399 PF00069 0.412
DOC_PP1_RVXF_1 749 756 PF00149 0.546
DOC_PP2B_LxvP_1 905 908 PF13499 0.546
DOC_USP7_MATH_1 132 136 PF00917 0.543
DOC_USP7_MATH_1 142 146 PF00917 0.522
DOC_USP7_MATH_1 175 179 PF00917 0.571
DOC_USP7_MATH_1 286 290 PF00917 0.640
DOC_USP7_MATH_1 29 33 PF00917 0.847
DOC_USP7_MATH_1 350 354 PF00917 0.566
DOC_USP7_MATH_1 548 552 PF00917 0.667
DOC_USP7_MATH_1 6 10 PF00917 0.767
DOC_USP7_MATH_1 836 840 PF00917 0.546
DOC_USP7_MATH_1 893 897 PF00917 0.559
DOC_USP7_MATH_1 91 95 PF00917 0.551
DOC_USP7_UBL2_3 35 39 PF12436 0.806
DOC_USP7_UBL2_3 460 464 PF12436 0.559
DOC_WW_Pin1_4 531 536 PF00397 0.791
DOC_WW_Pin1_4 566 571 PF00397 0.779
DOC_WW_Pin1_4 58 63 PF00397 0.775
DOC_WW_Pin1_4 580 585 PF00397 0.683
DOC_WW_Pin1_4 617 622 PF00397 0.809
LIG_14-3-3_CanoR_1 149 155 PF00244 0.450
LIG_14-3-3_CanoR_1 164 173 PF00244 0.565
LIG_14-3-3_CanoR_1 413 422 PF00244 0.401
LIG_14-3-3_CanoR_1 483 491 PF00244 0.546
LIG_14-3-3_CanoR_1 588 597 PF00244 0.745
LIG_14-3-3_CanoR_1 630 636 PF00244 0.528
LIG_14-3-3_CanoR_1 648 656 PF00244 0.546
LIG_14-3-3_CanoR_1 65 71 PF00244 0.680
LIG_14-3-3_CanoR_1 822 826 PF00244 0.561
LIG_14-3-3_CanoR_1 828 832 PF00244 0.531
LIG_Actin_WH2_2 448 466 PF00022 0.559
LIG_BRCT_BRCA1_1 166 170 PF00533 0.656
LIG_BRCT_BRCA1_1 568 572 PF00533 0.684
LIG_Clathr_ClatBox_1 696 700 PF01394 0.546
LIG_EH1_1 900 908 PF00400 0.546
LIG_eIF4E_1 292 298 PF01652 0.474
LIG_FHA_1 198 204 PF00498 0.542
LIG_FHA_1 286 292 PF00498 0.616
LIG_FHA_1 307 313 PF00498 0.516
LIG_FHA_1 323 329 PF00498 0.613
LIG_FHA_1 644 650 PF00498 0.546
LIG_FHA_1 779 785 PF00498 0.609
LIG_FHA_2 484 490 PF00498 0.546
LIG_FHA_2 514 520 PF00498 0.546
LIG_FHA_2 69 75 PF00498 0.607
LIG_FHA_2 722 728 PF00498 0.597
LIG_LIR_Apic_2 191 197 PF02991 0.451
LIG_LIR_Gen_1 105 115 PF02991 0.431
LIG_LIR_Gen_1 167 176 PF02991 0.541
LIG_LIR_Gen_1 293 301 PF02991 0.517
LIG_LIR_Gen_1 698 709 PF02991 0.514
LIG_LIR_Gen_1 94 104 PF02991 0.561
LIG_LIR_Nem_3 105 111 PF02991 0.497
LIG_LIR_Nem_3 150 155 PF02991 0.619
LIG_LIR_Nem_3 167 173 PF02991 0.587
LIG_LIR_Nem_3 293 297 PF02991 0.532
LIG_LIR_Nem_3 367 372 PF02991 0.447
LIG_LIR_Nem_3 698 704 PF02991 0.514
LIG_LIR_Nem_3 785 791 PF02991 0.524
LIG_LIR_Nem_3 94 100 PF02991 0.492
LIG_NRBOX 226 232 PF00104 0.425
LIG_NRBOX 371 377 PF00104 0.441
LIG_NRBOX 394 400 PF00104 0.450
LIG_PCNA_APIM_2 458 464 PF02747 0.559
LIG_PCNA_yPIPBox_3 224 235 PF02747 0.442
LIG_Pex14_2 684 688 PF04695 0.546
LIG_SH2_CRK 194 198 PF00017 0.435
LIG_SH2_CRK 294 298 PF00017 0.444
LIG_SH2_CRK 369 373 PF00017 0.443
LIG_SH2_CRK 507 511 PF00017 0.614
LIG_SH2_CRK 524 528 PF00017 0.517
LIG_SH2_CRK 632 636 PF00017 0.411
LIG_SH2_NCK_1 194 198 PF00017 0.411
LIG_SH2_NCK_1 701 705 PF00017 0.559
LIG_SH2_PTP2 97 100 PF00017 0.583
LIG_SH2_SRC 292 295 PF00017 0.487
LIG_SH2_SRC 517 520 PF00017 0.546
LIG_SH2_STAP1 294 298 PF00017 0.389
LIG_SH2_STAT5 233 236 PF00017 0.395
LIG_SH2_STAT5 364 367 PF00017 0.392
LIG_SH2_STAT5 461 464 PF00017 0.618
LIG_SH2_STAT5 517 520 PF00017 0.546
LIG_SH2_STAT5 817 820 PF00017 0.546
LIG_SH2_STAT5 97 100 PF00017 0.471
LIG_SH3_3 344 350 PF00018 0.609
LIG_SH3_3 622 628 PF00018 0.737
LIG_SH3_3 90 96 PF00018 0.516
LIG_SUMO_SIM_anti_2 183 188 PF11976 0.548
LIG_SUMO_SIM_anti_2 867 873 PF11976 0.618
LIG_SUMO_SIM_par_1 695 700 PF11976 0.549
LIG_SUMO_SIM_par_1 852 857 PF11976 0.618
LIG_SUMO_SIM_par_1 907 912 PF11976 0.546
LIG_TRAF2_1 103 106 PF00917 0.527
LIG_TRAF2_1 613 616 PF00917 0.721
LIG_TRAF2_1 743 746 PF00917 0.546
LIG_TYR_ITIM 505 510 PF00017 0.618
LIG_TYR_ITIM 699 704 PF00017 0.546
LIG_TYR_ITIM 95 100 PF00017 0.585
LIG_UBA3_1 226 235 PF00899 0.542
LIG_UBA3_1 394 400 PF00899 0.528
LIG_UBA3_1 905 914 PF00899 0.546
LIG_WRC_WIRS_1 218 223 PF05994 0.367
MOD_CDK_SPxxK_3 58 65 PF00069 0.677
MOD_CK1_1 13 19 PF00069 0.811
MOD_CK1_1 131 137 PF00069 0.583
MOD_CK1_1 145 151 PF00069 0.464
MOD_CK1_1 259 265 PF00069 0.645
MOD_CK1_1 322 328 PF00069 0.618
MOD_CK1_1 5 11 PF00069 0.832
MOD_CK1_1 549 555 PF00069 0.826
MOD_CK1_1 595 601 PF00069 0.753
MOD_CK1_1 69 75 PF00069 0.691
MOD_CK1_1 782 788 PF00069 0.524
MOD_CK1_1 827 833 PF00069 0.546
MOD_CK1_1 867 873 PF00069 0.618
MOD_CK1_1 897 903 PF00069 0.546
MOD_CK2_1 100 106 PF00069 0.501
MOD_CK2_1 482 488 PF00069 0.546
MOD_CK2_1 513 519 PF00069 0.546
MOD_CK2_1 609 615 PF00069 0.639
MOD_CK2_1 647 653 PF00069 0.526
MOD_CK2_1 68 74 PF00069 0.604
MOD_CK2_1 740 746 PF00069 0.537
MOD_CK2_1 827 833 PF00069 0.546
MOD_GlcNHglycan 102 105 PF01048 0.580
MOD_GlcNHglycan 130 133 PF01048 0.490
MOD_GlcNHglycan 156 159 PF01048 0.578
MOD_GlcNHglycan 265 268 PF01048 0.606
MOD_GlcNHglycan 275 278 PF01048 0.697
MOD_GlcNHglycan 3 7 PF01048 0.757
MOD_GlcNHglycan 31 34 PF01048 0.724
MOD_GlcNHglycan 352 355 PF01048 0.548
MOD_GlcNHglycan 464 467 PF01048 0.426
MOD_GlcNHglycan 529 532 PF01048 0.642
MOD_GlcNHglycan 594 597 PF01048 0.771
MOD_GlcNHglycan 600 603 PF01048 0.744
MOD_GlcNHglycan 615 620 PF01048 0.777
MOD_GlcNHglycan 724 727 PF01048 0.418
MOD_GlcNHglycan 8 11 PF01048 0.792
MOD_GlcNHglycan 811 814 PF01048 0.346
MOD_GlcNHglycan 843 846 PF01048 0.346
MOD_GlcNHglycan 896 899 PF01048 0.346
MOD_GSK3_1 128 135 PF00069 0.557
MOD_GSK3_1 150 157 PF00069 0.462
MOD_GSK3_1 164 171 PF00069 0.567
MOD_GSK3_1 2 9 PF00069 0.813
MOD_GSK3_1 237 244 PF00069 0.453
MOD_GSK3_1 24 31 PF00069 0.659
MOD_GSK3_1 259 266 PF00069 0.562
MOD_GSK3_1 281 288 PF00069 0.705
MOD_GSK3_1 364 371 PF00069 0.405
MOD_GSK3_1 483 490 PF00069 0.520
MOD_GSK3_1 527 534 PF00069 0.632
MOD_GSK3_1 54 61 PF00069 0.673
MOD_GSK3_1 591 598 PF00069 0.769
MOD_GSK3_1 643 650 PF00069 0.546
MOD_GSK3_1 66 73 PF00069 0.633
MOD_GSK3_1 741 748 PF00069 0.524
MOD_GSK3_1 778 785 PF00069 0.524
MOD_GSK3_1 820 827 PF00069 0.546
MOD_GSK3_1 893 900 PF00069 0.546
MOD_N-GLC_1 150 155 PF02516 0.596
MOD_NEK2_1 321 326 PF00069 0.697
MOD_NEK2_1 375 380 PF00069 0.455
MOD_NEK2_1 462 467 PF00069 0.609
MOD_NEK2_1 476 481 PF00069 0.546
MOD_NEK2_1 513 518 PF00069 0.522
MOD_NEK2_1 590 595 PF00069 0.821
MOD_NEK2_1 68 73 PF00069 0.573
MOD_NEK2_1 688 693 PF00069 0.596
MOD_NEK2_1 778 783 PF00069 0.546
MOD_NEK2_1 807 812 PF00069 0.546
MOD_NEK2_1 894 899 PF00069 0.603
MOD_NEK2_1 909 914 PF00069 0.546
MOD_NEK2_1 915 920 PF00069 0.546
MOD_NEK2_2 364 369 PF00069 0.444
MOD_NEK2_2 487 492 PF00069 0.546
MOD_NEK2_2 631 636 PF00069 0.496
MOD_PIKK_1 292 298 PF00454 0.389
MOD_PIKK_1 870 876 PF00454 0.546
MOD_PKA_1 164 170 PF00069 0.589
MOD_PKA_1 508 514 PF00069 0.546
MOD_PKA_2 164 170 PF00069 0.571
MOD_PKA_2 482 488 PF00069 0.546
MOD_PKA_2 610 616 PF00069 0.768
MOD_PKA_2 647 653 PF00069 0.546
MOD_PKA_2 821 827 PF00069 0.561
MOD_PKB_1 506 514 PF00069 0.618
MOD_Plk_1 150 156 PF00069 0.536
MOD_Plk_1 286 292 PF00069 0.694
MOD_Plk_1 487 493 PF00069 0.546
MOD_Plk_1 745 751 PF00069 0.524
MOD_Plk_1 867 873 PF00069 0.618
MOD_Plk_1 923 929 PF00069 0.521
MOD_Plk_2-3 281 287 PF00069 0.688
MOD_Plk_4 234 240 PF00069 0.438
MOD_Plk_4 286 292 PF00069 0.694
MOD_Plk_4 364 370 PF00069 0.425
MOD_Plk_4 513 519 PF00069 0.546
MOD_Plk_4 779 785 PF00069 0.546
MOD_Plk_4 821 827 PF00069 0.546
MOD_Plk_4 836 842 PF00069 0.546
MOD_Plk_4 867 873 PF00069 0.618
MOD_ProDKin_1 531 537 PF00069 0.794
MOD_ProDKin_1 566 572 PF00069 0.779
MOD_ProDKin_1 58 64 PF00069 0.775
MOD_ProDKin_1 580 586 PF00069 0.683
MOD_ProDKin_1 617 623 PF00069 0.805
TRG_ENDOCYTIC_2 294 297 PF00928 0.462
TRG_ENDOCYTIC_2 369 372 PF00928 0.446
TRG_ENDOCYTIC_2 373 376 PF00928 0.456
TRG_ENDOCYTIC_2 401 404 PF00928 0.438
TRG_ENDOCYTIC_2 453 456 PF00928 0.504
TRG_ENDOCYTIC_2 507 510 PF00928 0.546
TRG_ENDOCYTIC_2 524 527 PF00928 0.500
TRG_ENDOCYTIC_2 632 635 PF00928 0.478
TRG_ENDOCYTIC_2 701 704 PF00928 0.528
TRG_ENDOCYTIC_2 97 100 PF00928 0.583
TRG_ER_diArg_1 111 113 PF00400 0.496
TRG_ER_diArg_1 164 166 PF00400 0.628
TRG_ER_diArg_1 18 20 PF00400 0.769
TRG_ER_diArg_1 684 686 PF00400 0.546
TRG_ER_diArg_1 796 798 PF00400 0.546
TRG_ER_diArg_1 814 817 PF00400 0.546
TRG_NLS_Bipartite_1 18 40 PF00514 0.839
TRG_NLS_MonoCore_2 35 40 PF00514 0.844
TRG_NLS_MonoExtC_3 34 39 PF00514 0.839
TRG_NLS_MonoExtN_4 160 167 PF00514 0.643
TRG_NLS_MonoExtN_4 35 40 PF00514 0.844
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.529
TRG_Pf-PMV_PEXEL_1 208 212 PF00026 0.458
TRG_Pf-PMV_PEXEL_1 450 454 PF00026 0.346
TRG_Pf-PMV_PEXEL_1 730 734 PF00026 0.329
TRG_Pf-PMV_PEXEL_1 797 801 PF00026 0.339
TRG_Pf-PMV_PEXEL_1 816 820 PF00026 0.399

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I668 Leptomonas seymouri 64% 73%
A4HAP3 Leishmania braziliensis 78% 100%
A4I9T9 Leishmania infantum 100% 100%
E9B4V0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q8IS90 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS