LeishMANIAdb
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Chloride channel protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Chloride channel protein
Gene product:
chloride channel protein, putative
Species:
Leishmania donovani
UniProt:
A0A3Q8IH43_LEIDO
TriTrypDb:
LdBPK_323570.1 , LdCL_320041600 , LDHU3_32.4510
Length:
885

Annotations

LeishMANIAdb annotations

Homologous to animal CLCN-group H+/Cl- exchangers.. The family seems to have duplicated in Kinetoplastida

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 17
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A0A3Q8IH43
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH43

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 17
GO:0005216 monoatomic ion channel activity 4 17
GO:0005244 voltage-gated monoatomic ion channel activity 4 17
GO:0005247 voltage-gated chloride channel activity 6 17
GO:0005253 monoatomic anion channel activity 5 17
GO:0005254 chloride channel activity 6 17
GO:0008308 voltage-gated monoatomic anion channel activity 5 17
GO:0008509 monoatomic anion transmembrane transporter activity 4 17
GO:0015075 monoatomic ion transmembrane transporter activity 3 17
GO:0015103 inorganic anion transmembrane transporter activity 4 17
GO:0015108 chloride transmembrane transporter activity 5 17
GO:0015267 channel activity 4 17
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 17
GO:0022803 passive transmembrane transporter activity 3 17
GO:0022832 voltage-gated channel activity 6 17
GO:0022836 gated channel activity 5 17
GO:0022857 transmembrane transporter activity 2 17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 43 47 PF00656 0.568
CLV_C14_Caspase3-7 727 731 PF00656 0.383
CLV_C14_Caspase3-7 98 102 PF00656 0.525
CLV_MEL_PAP_1 855 861 PF00089 0.441
CLV_MEL_PAP_1 88 94 PF00089 0.341
CLV_NRD_NRD_1 23 25 PF00675 0.451
CLV_NRD_NRD_1 518 520 PF00675 0.470
CLV_NRD_NRD_1 72 74 PF00675 0.349
CLV_PCSK_KEX2_1 22 24 PF00082 0.515
CLV_PCSK_KEX2_1 518 520 PF00082 0.470
CLV_PCSK_KEX2_1 71 73 PF00082 0.358
CLV_PCSK_KEX2_1 780 782 PF00082 0.507
CLV_PCSK_PC1ET2_1 780 782 PF00082 0.584
CLV_PCSK_SKI1_1 434 438 PF00082 0.252
CLV_PCSK_SKI1_1 478 482 PF00082 0.430
CLV_PCSK_SKI1_1 513 517 PF00082 0.424
DEG_APCC_DBOX_1 712 720 PF00400 0.210
DEG_MDM2_SWIB_1 362 369 PF02201 0.314
DOC_CDC14_PxL_1 840 848 PF14671 0.314
DOC_CKS1_1 14 19 PF01111 0.620
DOC_CKS1_1 463 468 PF01111 0.389
DOC_CYCLIN_RxL_1 430 440 PF00134 0.465
DOC_CYCLIN_RxL_1 510 520 PF00134 0.285
DOC_MAPK_gen_1 475 485 PF00069 0.221
DOC_MAPK_MEF2A_6 103 110 PF00069 0.430
DOC_MAPK_MEF2A_6 477 485 PF00069 0.278
DOC_MAPK_MEF2A_6 596 605 PF00069 0.263
DOC_MAPK_MEF2A_6 691 700 PF00069 0.336
DOC_MAPK_MEF2A_6 713 722 PF00069 0.262
DOC_MAPK_NFAT4_5 103 111 PF00069 0.398
DOC_MAPK_NFAT4_5 713 721 PF00069 0.249
DOC_PP1_RVXF_1 105 112 PF00149 0.249
DOC_PP1_RVXF_1 181 188 PF00149 0.292
DOC_PP1_RVXF_1 338 344 PF00149 0.476
DOC_PP1_RVXF_1 511 517 PF00149 0.251
DOC_PP1_RVXF_1 594 600 PF00149 0.243
DOC_PP1_RVXF_1 856 862 PF00149 0.351
DOC_PP2B_LxvP_1 213 216 PF13499 0.301
DOC_PP4_FxxP_1 14 17 PF00568 0.603
DOC_PP4_FxxP_1 297 300 PF00568 0.220
DOC_PP4_FxxP_1 319 322 PF00568 0.263
DOC_PP4_FxxP_1 571 574 PF00568 0.276
DOC_USP7_MATH_1 218 222 PF00917 0.430
DOC_USP7_MATH_1 610 614 PF00917 0.514
DOC_USP7_MATH_1 651 655 PF00917 0.381
DOC_USP7_MATH_1 8 12 PF00917 0.696
DOC_USP7_MATH_1 804 808 PF00917 0.261
DOC_WW_Pin1_4 13 18 PF00397 0.636
DOC_WW_Pin1_4 318 323 PF00397 0.277
DOC_WW_Pin1_4 462 467 PF00397 0.419
DOC_WW_Pin1_4 504 509 PF00397 0.268
DOC_WW_Pin1_4 666 671 PF00397 0.243
LIG_14-3-3_CanoR_1 145 154 PF00244 0.457
LIG_14-3-3_CanoR_1 183 188 PF00244 0.413
LIG_14-3-3_CanoR_1 282 287 PF00244 0.224
LIG_14-3-3_CanoR_1 518 525 PF00244 0.242
LIG_14-3-3_CanoR_1 596 600 PF00244 0.275
LIG_14-3-3_CanoR_1 830 836 PF00244 0.290
LIG_14-3-3_CanoR_1 858 862 PF00244 0.405
LIG_14-3-3_CanoR_1 96 106 PF00244 0.625
LIG_Actin_WH2_2 712 728 PF00022 0.228
LIG_Actin_WH2_2 767 782 PF00022 0.331
LIG_APCC_ABBA_1 811 816 PF00400 0.257
LIG_BIR_II_1 1 5 PF00653 0.651
LIG_BIR_III_4 101 105 PF00653 0.590
LIG_BIR_III_4 765 769 PF00653 0.367
LIG_BRCT_BRCA1_1 10 14 PF00533 0.655
LIG_BRCT_BRCA1_1 424 428 PF00533 0.413
LIG_Clathr_ClatBox_1 327 331 PF01394 0.263
LIG_EH1_1 238 246 PF00400 0.410
LIG_eIF4E_1 509 515 PF01652 0.250
LIG_FHA_1 394 400 PF00498 0.278
LIG_FHA_1 405 411 PF00498 0.343
LIG_FHA_1 463 469 PF00498 0.341
LIG_FHA_1 596 602 PF00498 0.277
LIG_FHA_1 607 613 PF00498 0.444
LIG_FHA_1 666 672 PF00498 0.264
LIG_FHA_1 847 853 PF00498 0.362
LIG_FHA_2 389 395 PF00498 0.365
LIG_FHA_2 65 71 PF00498 0.603
LIG_FHA_2 660 666 PF00498 0.299
LIG_FHA_2 670 676 PF00498 0.293
LIG_FHA_2 773 779 PF00498 0.346
LIG_GBD_Chelix_1 245 253 PF00786 0.314
LIG_LIR_Apic_2 11 17 PF02991 0.606
LIG_LIR_Apic_2 295 300 PF02991 0.220
LIG_LIR_Apic_2 316 322 PF02991 0.263
LIG_LIR_Apic_2 456 462 PF02991 0.243
LIG_LIR_Gen_1 184 195 PF02991 0.369
LIG_LIR_Gen_1 291 300 PF02991 0.283
LIG_LIR_Gen_1 364 374 PF02991 0.314
LIG_LIR_Gen_1 401 410 PF02991 0.440
LIG_LIR_Gen_1 484 493 PF02991 0.220
LIG_LIR_Gen_1 506 516 PF02991 0.271
LIG_LIR_Gen_1 598 606 PF02991 0.243
LIG_LIR_Gen_1 75 83 PF02991 0.504
LIG_LIR_Gen_1 807 815 PF02991 0.305
LIG_LIR_LC3C_4 598 603 PF02991 0.336
LIG_LIR_Nem_3 149 154 PF02991 0.458
LIG_LIR_Nem_3 184 190 PF02991 0.319
LIG_LIR_Nem_3 198 203 PF02991 0.237
LIG_LIR_Nem_3 291 297 PF02991 0.298
LIG_LIR_Nem_3 364 369 PF02991 0.302
LIG_LIR_Nem_3 401 405 PF02991 0.423
LIG_LIR_Nem_3 439 445 PF02991 0.516
LIG_LIR_Nem_3 484 489 PF02991 0.245
LIG_LIR_Nem_3 506 512 PF02991 0.254
LIG_LIR_Nem_3 598 602 PF02991 0.277
LIG_LIR_Nem_3 75 80 PF02991 0.496
LIG_LIR_Nem_3 807 811 PF02991 0.303
LIG_LIR_Nem_3 829 835 PF02991 0.311
LIG_MYND_3 646 650 PF01753 0.284
LIG_NRBOX 202 208 PF00104 0.258
LIG_NRBOX 412 418 PF00104 0.243
LIG_NRBOX 510 516 PF00104 0.309
LIG_NRBOX 715 721 PF00104 0.244
LIG_PALB2_WD40_1 29 37 PF16756 0.589
LIG_Pex14_2 235 239 PF04695 0.410
LIG_Pex14_2 362 366 PF04695 0.337
LIG_Pex14_2 450 454 PF04695 0.368
LIG_SH2_CRK 402 406 PF00017 0.389
LIG_SH2_CRK 509 513 PF00017 0.217
LIG_SH2_GRB2like 229 232 PF00017 0.424
LIG_SH2_NCK_1 77 81 PF00017 0.489
LIG_SH2_PTP2 459 462 PF00017 0.336
LIG_SH2_PTP2 808 811 PF00017 0.278
LIG_SH2_SRC 229 232 PF00017 0.424
LIG_SH2_SRC 82 85 PF00017 0.599
LIG_SH2_STAP1 400 404 PF00017 0.312
LIG_SH2_STAT3 821 824 PF00017 0.271
LIG_SH2_STAT5 131 134 PF00017 0.312
LIG_SH2_STAT5 197 200 PF00017 0.282
LIG_SH2_STAT5 229 232 PF00017 0.411
LIG_SH2_STAT5 388 391 PF00017 0.303
LIG_SH2_STAT5 400 403 PF00017 0.241
LIG_SH2_STAT5 421 424 PF00017 0.258
LIG_SH2_STAT5 459 462 PF00017 0.310
LIG_SH2_STAT5 536 539 PF00017 0.254
LIG_SH2_STAT5 590 593 PF00017 0.262
LIG_SH2_STAT5 661 664 PF00017 0.376
LIG_SH2_STAT5 724 727 PF00017 0.300
LIG_SH2_STAT5 808 811 PF00017 0.270
LIG_SH2_STAT5 814 817 PF00017 0.249
LIG_SH2_STAT5 821 824 PF00017 0.237
LIG_SH2_STAT5 833 836 PF00017 0.243
LIG_SH3_3 230 236 PF00018 0.434
LIG_SH3_3 441 447 PF00018 0.426
LIG_SH3_3 463 469 PF00018 0.266
LIG_SH3_3 789 795 PF00018 0.314
LIG_Sin3_3 599 606 PF02671 0.336
LIG_SUMO_SIM_anti_2 668 676 PF11976 0.291
LIG_SUMO_SIM_par_1 250 256 PF11976 0.265
LIG_SUMO_SIM_par_1 394 401 PF11976 0.198
LIG_SUMO_SIM_par_1 407 414 PF11976 0.328
LIG_SUMO_SIM_par_1 668 676 PF11976 0.253
LIG_TRAF2_1 67 70 PF00917 0.507
LIG_UBA3_1 618 626 PF00899 0.338
LIG_WRC_WIRS_1 832 837 PF05994 0.310
MOD_CK1_1 146 152 PF00069 0.469
MOD_CK1_1 289 295 PF00069 0.217
MOD_CK1_1 317 323 PF00069 0.251
MOD_CK1_1 348 354 PF00069 0.277
MOD_CK1_1 361 367 PF00069 0.335
MOD_CK1_1 398 404 PF00069 0.347
MOD_CK1_1 452 458 PF00069 0.264
MOD_CK1_1 517 523 PF00069 0.232
MOD_CK1_1 549 555 PF00069 0.282
MOD_CK1_1 595 601 PF00069 0.282
MOD_CK1_1 613 619 PF00069 0.299
MOD_CK1_1 669 675 PF00069 0.198
MOD_CK1_1 772 778 PF00069 0.350
MOD_CK2_1 164 170 PF00069 0.531
MOD_CK2_1 388 394 PF00069 0.328
MOD_CK2_1 64 70 PF00069 0.532
MOD_CK2_1 669 675 PF00069 0.213
MOD_CK2_1 772 778 PF00069 0.410
MOD_GlcNHglycan 1 4 PF01048 0.545
MOD_GlcNHglycan 10 13 PF01048 0.556
MOD_GlcNHglycan 161 164 PF01048 0.712
MOD_GlcNHglycan 166 169 PF01048 0.676
MOD_GlcNHglycan 17 20 PF01048 0.315
MOD_GlcNHglycan 187 190 PF01048 0.516
MOD_GlcNHglycan 216 219 PF01048 0.240
MOD_GlcNHglycan 220 223 PF01048 0.241
MOD_GlcNHglycan 255 258 PF01048 0.238
MOD_GlcNHglycan 288 291 PF01048 0.439
MOD_GlcNHglycan 307 310 PF01048 0.141
MOD_GlcNHglycan 316 319 PF01048 0.217
MOD_GlcNHglycan 363 366 PF01048 0.451
MOD_GlcNHglycan 370 374 PF01048 0.451
MOD_GlcNHglycan 413 416 PF01048 0.398
MOD_GlcNHglycan 519 522 PF01048 0.549
MOD_GlcNHglycan 756 759 PF01048 0.723
MOD_GlcNHglycan 802 805 PF01048 0.474
MOD_GlcNHglycan 816 820 PF01048 0.512
MOD_GSK3_1 13 20 PF00069 0.673
MOD_GSK3_1 143 150 PF00069 0.372
MOD_GSK3_1 181 188 PF00069 0.367
MOD_GSK3_1 214 221 PF00069 0.252
MOD_GSK3_1 282 289 PF00069 0.226
MOD_GSK3_1 313 320 PF00069 0.243
MOD_GSK3_1 400 407 PF00069 0.232
MOD_GSK3_1 422 429 PF00069 0.442
MOD_GSK3_1 449 456 PF00069 0.342
MOD_GSK3_1 499 506 PF00069 0.269
MOD_GSK3_1 549 556 PF00069 0.359
MOD_GSK3_1 606 613 PF00069 0.418
MOD_GSK3_1 665 672 PF00069 0.259
MOD_GSK3_1 754 761 PF00069 0.509
MOD_GSK3_1 800 807 PF00069 0.388
MOD_GSK3_1 91 98 PF00069 0.703
MOD_N-GLC_1 147 152 PF02516 0.588
MOD_N-GLC_1 154 159 PF02516 0.581
MOD_NEK2_1 154 159 PF00069 0.479
MOD_NEK2_1 164 169 PF00069 0.513
MOD_NEK2_1 185 190 PF00069 0.352
MOD_NEK2_1 206 211 PF00069 0.238
MOD_NEK2_1 253 258 PF00069 0.258
MOD_NEK2_1 286 291 PF00069 0.254
MOD_NEK2_1 453 458 PF00069 0.267
MOD_NEK2_1 503 508 PF00069 0.255
MOD_NEK2_1 514 519 PF00069 0.255
MOD_NEK2_1 546 551 PF00069 0.425
MOD_NEK2_1 657 662 PF00069 0.396
MOD_NEK2_1 687 692 PF00069 0.230
MOD_NEK2_1 769 774 PF00069 0.341
MOD_NEK2_1 846 851 PF00069 0.386
MOD_NEK2_2 17 22 PF00069 0.630
MOD_NEK2_2 632 637 PF00069 0.312
MOD_NEK2_2 651 656 PF00069 0.376
MOD_NEK2_2 831 836 PF00069 0.286
MOD_OFUCOSY 352 359 PF10250 0.298
MOD_PIKK_1 846 852 PF00454 0.256
MOD_PIKK_1 869 875 PF00454 0.463
MOD_PK_1 380 386 PF00069 0.220
MOD_PK_1 790 796 PF00069 0.285
MOD_PKA_2 146 152 PF00069 0.469
MOD_PKA_2 426 432 PF00069 0.500
MOD_PKA_2 517 523 PF00069 0.232
MOD_PKA_2 595 601 PF00069 0.263
MOD_PKA_2 857 863 PF00069 0.240
MOD_PKA_2 90 96 PF00069 0.684
MOD_PKB_1 145 153 PF00069 0.443
MOD_Plk_1 147 153 PF00069 0.392
MOD_Plk_1 154 160 PF00069 0.411
MOD_Plk_1 369 375 PF00069 0.314
MOD_Plk_1 380 386 PF00069 0.278
MOD_Plk_1 393 399 PF00069 0.282
MOD_Plk_1 610 616 PF00069 0.444
MOD_Plk_4 195 201 PF00069 0.385
MOD_Plk_4 269 275 PF00069 0.238
MOD_Plk_4 289 295 PF00069 0.326
MOD_Plk_4 358 364 PF00069 0.245
MOD_Plk_4 395 401 PF00069 0.246
MOD_Plk_4 404 410 PF00069 0.248
MOD_Plk_4 437 443 PF00069 0.462
MOD_Plk_4 449 455 PF00069 0.327
MOD_Plk_4 549 555 PF00069 0.289
MOD_Plk_4 632 638 PF00069 0.245
MOD_Plk_4 669 675 PF00069 0.303
MOD_Plk_4 676 682 PF00069 0.266
MOD_Plk_4 84 90 PF00069 0.539
MOD_Plk_4 857 863 PF00069 0.359
MOD_ProDKin_1 13 19 PF00069 0.634
MOD_ProDKin_1 318 324 PF00069 0.277
MOD_ProDKin_1 462 468 PF00069 0.419
MOD_ProDKin_1 504 510 PF00069 0.268
MOD_ProDKin_1 666 672 PF00069 0.243
MOD_SUMO_rev_2 130 137 PF00179 0.364
MOD_SUMO_rev_2 170 179 PF00179 0.360
MOD_SUMO_rev_2 640 646 PF00179 0.246
MOD_SUMO_rev_2 772 782 PF00179 0.350
TRG_DiLeu_BaEn_1 84 89 PF01217 0.574
TRG_DiLeu_BaLyEn_6 104 109 PF01217 0.227
TRG_DiLeu_BaLyEn_6 510 515 PF01217 0.251
TRG_DiLeu_BaLyEn_6 562 567 PF01217 0.277
TRG_ENDOCYTIC_2 151 154 PF00928 0.472
TRG_ENDOCYTIC_2 402 405 PF00928 0.398
TRG_ENDOCYTIC_2 442 445 PF00928 0.489
TRG_ENDOCYTIC_2 509 512 PF00928 0.217
TRG_ENDOCYTIC_2 707 710 PF00928 0.210
TRG_ENDOCYTIC_2 77 80 PF00928 0.485
TRG_ENDOCYTIC_2 808 811 PF00928 0.278
TRG_ENDOCYTIC_2 832 835 PF00928 0.304
TRG_ER_diArg_1 144 147 PF00400 0.404
TRG_ER_diArg_1 21 24 PF00400 0.714
TRG_ER_diArg_1 431 434 PF00400 0.453
TRG_ER_diArg_1 71 73 PF00400 0.545
TRG_NES_CRM1_1 127 138 PF08389 0.348
TRG_NES_CRM1_1 715 727 PF08389 0.355

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IHR6 Leptomonas seymouri 35% 76%
A0A0N1IJL2 Leptomonas seymouri 75% 100%
A0A0S4IKD3 Bodo saltans 24% 100%
A0A0S4JG93 Bodo saltans 47% 100%
A0A0S4JSW7 Bodo saltans 26% 100%
A0A1X0NSH7 Trypanosomatidae 55% 96%
A0A3R7KRB4 Trypanosoma rangeli 52% 97%
A0A3S7WNV9 Leishmania donovani 36% 75%
A0A422NY59 Trypanosoma rangeli 24% 100%
A0A451EJ75 Leishmania donovani 24% 100%
A4H342 Leishmania braziliensis 24% 100%
A4HKY2 Leishmania braziliensis 87% 100%
A4HRD9 Leishmania infantum 24% 100%
A4HS98 Leishmania infantum 36% 75%
D0A4W6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 90%
D0AAR0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 96%
E9AC07 Leishmania major 24% 100%
E9AHM3 Leishmania infantum 100% 100%
E9AJA4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9AK82 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 78%
E9B3C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
O18894 Oryctolagus cuniculus 25% 100%
O70496 Mus musculus 30% 100%
P21564 Torpedo marmorata 26% 100%
P35522 Tetronarce californica 26% 100%
P51788 Homo sapiens 23% 99%
P51790 Homo sapiens 25% 100%
P51791 Mus musculus 26% 100%
P51792 Rattus norvegicus 25% 100%
P51793 Homo sapiens 25% 100%
P51794 Rattus norvegicus 25% 100%
P51798 Homo sapiens 29% 100%
P51799 Rattus norvegicus 30% 100%
P60300 Arabidopsis thaliana 28% 100%
P92941 Arabidopsis thaliana 29% 100%
P92942 Arabidopsis thaliana 31% 100%
P92943 Arabidopsis thaliana 27% 100%
Q4PKH3 Bos taurus 32% 100%
Q4Q4T5 Leishmania major 95% 99%
Q54AX6 Dictyostelium discoideum 28% 100%
Q5RDJ7 Pongo abelii 24% 100%
Q61418 Mus musculus 25% 100%
Q75JF3 Dictyostelium discoideum 31% 100%
Q86AZ6 Dictyostelium discoideum 28% 100%
Q96282 Arabidopsis thaliana 29% 100%
Q9R279 Cavia porcellus 25% 100%
Q9TTU3 Oryctolagus cuniculus 27% 100%
V5AY77 Trypanosoma cruzi 33% 91%
V5BEI7 Trypanosoma cruzi 25% 100%
V5BPC2 Trypanosoma cruzi 28% 100%
V5BVK3 Trypanosoma cruzi 53% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS