Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH40_LEIDO

TriTrypDb:

LdBPK_290470.1 , LdCL_290009500 , LDHU3_29.0670

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IH40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH40

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.645
CLV_C14_Caspase3-7	702	706	PF00656	0.748
CLV_NRD_NRD_1	128	130	PF00675	0.563
CLV_NRD_NRD_1	169	171	PF00675	0.453
CLV_NRD_NRD_1	250	252	PF00675	0.540
CLV_NRD_NRD_1	302	304	PF00675	0.724
CLV_NRD_NRD_1	350	352	PF00675	0.598
CLV_NRD_NRD_1	420	422	PF00675	0.566
CLV_NRD_NRD_1	461	463	PF00675	0.768
CLV_NRD_NRD_1	521	523	PF00675	0.680
CLV_NRD_NRD_1	569	571	PF00675	0.573
CLV_NRD_NRD_1	587	589	PF00675	0.616
CLV_NRD_NRD_1	605	607	PF00675	0.745
CLV_NRD_NRD_1	626	628	PF00675	0.823
CLV_NRD_NRD_1	644	646	PF00675	0.573
CLV_NRD_NRD_1	657	659	PF00675	0.619
CLV_NRD_NRD_1	669	671	PF00675	0.621
CLV_NRD_NRD_1	675	677	PF00675	0.453
CLV_NRD_NRD_1	685	687	PF00675	0.560
CLV_NRD_NRD_1	84	86	PF00675	0.725
CLV_PCSK_FUR_1	167	171	PF00082	0.458
CLV_PCSK_FUR_1	655	659	PF00082	0.705
CLV_PCSK_KEX2_1	128	130	PF00082	0.563
CLV_PCSK_KEX2_1	169	171	PF00082	0.486
CLV_PCSK_KEX2_1	302	304	PF00082	0.724
CLV_PCSK_KEX2_1	419	421	PF00082	0.540
CLV_PCSK_KEX2_1	461	463	PF00082	0.801
CLV_PCSK_KEX2_1	521	523	PF00082	0.680
CLV_PCSK_KEX2_1	569	571	PF00082	0.598
CLV_PCSK_KEX2_1	587	589	PF00082	0.616
CLV_PCSK_KEX2_1	605	607	PF00082	0.745
CLV_PCSK_KEX2_1	626	628	PF00082	0.822
CLV_PCSK_KEX2_1	657	659	PF00082	0.663
CLV_PCSK_KEX2_1	669	671	PF00082	0.617
CLV_PCSK_KEX2_1	675	677	PF00082	0.445
CLV_PCSK_KEX2_1	685	687	PF00082	0.574
CLV_PCSK_KEX2_1	84	86	PF00082	0.725
CLV_PCSK_PC7_1	416	422	PF00082	0.576
CLV_PCSK_SKI1_1	131	135	PF00082	0.485
CLV_PCSK_SKI1_1	188	192	PF00082	0.554
CLV_PCSK_SKI1_1	247	251	PF00082	0.546
CLV_PCSK_SKI1_1	266	270	PF00082	0.538
CLV_PCSK_SKI1_1	542	546	PF00082	0.518
CLV_PCSK_SKI1_1	558	562	PF00082	0.448
CLV_PCSK_SKI1_1	588	592	PF00082	0.735
CLV_Separin_Metazoa	164	168	PF03568	0.481
CLV_Separin_Metazoa	226	230	PF03568	0.442
DEG_APCC_DBOX_1	130	138	PF00400	0.550
DEG_APCC_DBOX_1	187	195	PF00400	0.634
DEG_SPOP_SBC_1	46	50	PF00917	0.647
DEG_SPOP_SBC_1	698	702	PF00917	0.771
DOC_CKS1_1	332	337	PF01111	0.715
DOC_CYCLIN_RxL_1	276	284	PF00134	0.578
DOC_CYCLIN_RxL_1	348	359	PF00134	0.555
DOC_CYCLIN_RxL_1	536	546	PF00134	0.675
DOC_MAPK_gen_1	277	285	PF00069	0.588
DOC_MAPK_MEF2A_6	277	285	PF00069	0.651
DOC_USP7_MATH_1	14	18	PF00917	0.699
DOC_USP7_MATH_1	205	209	PF00917	0.541
DOC_USP7_MATH_1	289	293	PF00917	0.607
DOC_USP7_MATH_1	390	394	PF00917	0.741
DOC_USP7_MATH_1	46	50	PF00917	0.684
DOC_USP7_MATH_1	475	479	PF00917	0.738
DOC_USP7_MATH_1	482	486	PF00917	0.804
DOC_USP7_MATH_1	501	505	PF00917	0.571
DOC_USP7_MATH_1	571	575	PF00917	0.589
DOC_USP7_MATH_1	699	703	PF00917	0.780
DOC_USP7_MATH_1	714	718	PF00917	0.525
DOC_WW_Pin1_4	10	15	PF00397	0.739
DOC_WW_Pin1_4	144	149	PF00397	0.653
DOC_WW_Pin1_4	293	298	PF00397	0.724
DOC_WW_Pin1_4	331	336	PF00397	0.799
DOC_WW_Pin1_4	485	490	PF00397	0.726
DOC_WW_Pin1_4	720	725	PF00397	0.755
DOC_WW_Pin1_4	88	93	PF00397	0.737
LIG_14-3-3_CanoR_1	173	177	PF00244	0.552
LIG_14-3-3_CanoR_1	24	29	PF00244	0.645
LIG_14-3-3_CanoR_1	251	260	PF00244	0.532
LIG_14-3-3_CanoR_1	266	271	PF00244	0.538
LIG_14-3-3_CanoR_1	536	544	PF00244	0.552
LIG_14-3-3_CanoR_1	587	591	PF00244	0.773
LIG_14-3-3_CanoR_1	605	615	PF00244	0.713
LIG_14-3-3_CanoR_1	685	694	PF00244	0.695
LIG_14-3-3_CanoR_1	7	14	PF00244	0.713
LIG_14-3-3_CanoR_1	720	724	PF00244	0.717
LIG_14-3-3_CanoR_1	85	91	PF00244	0.640
LIG_BIR_II_1	1	5	PF00653	0.742
LIG_BIR_III_1	1	5	PF00653	0.742
LIG_BIR_III_3	1	5	PF00653	0.742
LIG_BIR_III_4	155	159	PF00653	0.615
LIG_BIR_III_4	633	637	PF00653	0.725
LIG_BRCT_BRCA1_1	592	596	PF00533	0.557
LIG_FAT_LD_1	346	354	PF03623	0.548
LIG_FHA_1	222	228	PF00498	0.484
LIG_FHA_1	308	314	PF00498	0.713
LIG_FHA_1	361	367	PF00498	0.624
LIG_FHA_1	376	382	PF00498	0.459
LIG_FHA_1	427	433	PF00498	0.463
LIG_FHA_1	448	454	PF00498	0.645
LIG_FHA_1	550	556	PF00498	0.529
LIG_FHA_1	620	626	PF00498	0.688
LIG_FHA_1	721	727	PF00498	0.751
LIG_FHA_2	307	313	PF00498	0.681
LIG_FHA_2	409	415	PF00498	0.585
LIG_FHA_2	485	491	PF00498	0.739
LIG_FHA_2	574	580	PF00498	0.737
LIG_FHA_2	609	615	PF00498	0.591
LIG_GBD_Chelix_1	126	134	PF00786	0.645
LIG_LIR_Gen_1	659	668	PF02991	0.693
LIG_LIR_Gen_1	692	699	PF02991	0.648
LIG_LIR_Nem_3	659	665	PF02991	0.693
LIG_LIR_Nem_3	692	697	PF02991	0.753
LIG_LIR_Nem_3	77	81	PF02991	0.756
LIG_MYND_1	724	728	PF01753	0.708
LIG_PTB_Apo_2	544	551	PF02174	0.530
LIG_PTB_Phospho_1	544	550	PF10480	0.530
LIG_RPA_C_Fungi	517	529	PF08784	0.674
LIG_RPA_C_Fungi	653	665	PF08784	0.625
LIG_SH2_STAP1	592	596	PF00017	0.557
LIG_SH2_STAT3	550	553	PF00017	0.474
LIG_SH2_STAT5	112	115	PF00017	0.710
LIG_SH2_STAT5	550	553	PF00017	0.525
LIG_SH3_2	297	302	PF14604	0.647
LIG_SH3_3	294	300	PF00018	0.630
LIG_SH3_3	332	338	PF00018	0.710
LIG_SUMO_SIM_anti_2	222	229	PF11976	0.499
LIG_SUMO_SIM_anti_2	258	264	PF11976	0.509
LIG_SUMO_SIM_par_1	189	196	PF11976	0.530
LIG_SxIP_EBH_1	690	704	PF03271	0.649
MOD_CDK_SPxK_1	724	730	PF00069	0.712
MOD_CDK_SPxxK_3	12	19	PF00069	0.685
MOD_CK1_1	27	33	PF00069	0.511
MOD_CK1_1	331	337	PF00069	0.695
MOD_CK1_1	393	399	PF00069	0.755
MOD_CK1_1	485	491	PF00069	0.712
MOD_CK1_1	693	699	PF00069	0.717
MOD_CK1_1	9	15	PF00069	0.800
MOD_CK2_1	113	119	PF00069	0.485
MOD_CK2_1	133	139	PF00069	0.332
MOD_CK2_1	172	178	PF00069	0.552
MOD_CK2_1	306	312	PF00069	0.683
MOD_CK2_1	400	406	PF00069	0.632
MOD_CK2_1	408	414	PF00069	0.555
MOD_CK2_1	460	466	PF00069	0.777
MOD_CK2_1	47	53	PF00069	0.683
MOD_CK2_1	484	490	PF00069	0.744
MOD_CK2_1	535	541	PF00069	0.665
MOD_CK2_1	675	681	PF00069	0.677
MOD_CK2_1	74	80	PF00069	0.762
MOD_CK2_1	96	102	PF00069	0.792
MOD_Cter_Amidation	585	588	PF01082	0.741
MOD_Cter_Amidation	82	85	PF01082	0.740
MOD_DYRK1A_RPxSP_1	720	724	PF00069	0.717
MOD_GlcNHglycan	253	256	PF01048	0.432
MOD_GlcNHglycan	287	290	PF01048	0.612
MOD_GlcNHglycan	291	294	PF01048	0.631
MOD_GlcNHglycan	314	317	PF01048	0.724
MOD_GlcNHglycan	32	35	PF01048	0.677
MOD_GlcNHglycan	322	325	PF01048	0.644
MOD_GlcNHglycan	392	395	PF01048	0.664
MOD_GlcNHglycan	439	442	PF01048	0.450
MOD_GlcNHglycan	456	459	PF01048	0.549
MOD_GlcNHglycan	462	465	PF01048	0.591
MOD_GlcNHglycan	477	481	PF01048	0.726
MOD_GlcNHglycan	482	485	PF01048	0.742
MOD_GlcNHglycan	494	497	PF01048	0.713
MOD_GlcNHglycan	537	540	PF01048	0.604
MOD_GlcNHglycan	572	576	PF01048	0.675
MOD_GlcNHglycan	600	603	PF01048	0.769
MOD_GlcNHglycan	710	713	PF01048	0.752
MOD_GlcNHglycan	716	719	PF01048	0.682
MOD_GlcNHglycan	97	101	PF01048	0.725
MOD_GSK3_1	140	147	PF00069	0.615
MOD_GSK3_1	251	258	PF00069	0.531
MOD_GSK3_1	281	288	PF00069	0.516
MOD_GSK3_1	289	296	PF00069	0.566
MOD_GSK3_1	30	37	PF00069	0.730
MOD_GSK3_1	304	311	PF00069	0.682
MOD_GSK3_1	330	337	PF00069	0.763
MOD_GSK3_1	356	363	PF00069	0.507
MOD_GSK3_1	47	54	PF00069	0.511
MOD_GSK3_1	476	483	PF00069	0.828
MOD_GSK3_1	531	538	PF00069	0.692
MOD_GSK3_1	586	593	PF00069	0.637
MOD_GSK3_1	594	601	PF00069	0.661
MOD_GSK3_1	6	13	PF00069	0.738
MOD_GSK3_1	675	682	PF00069	0.667
MOD_GSK3_1	685	692	PF00069	0.665
MOD_GSK3_1	693	700	PF00069	0.557
MOD_GSK3_1	714	721	PF00069	0.743
MOD_GSK3_1	722	729	PF00069	0.662
MOD_GSK3_1	84	91	PF00069	0.748
MOD_N-GLC_1	266	271	PF02516	0.563
MOD_N-GLC_1	289	294	PF02516	0.551
MOD_N-GLC_1	328	333	PF02516	0.742
MOD_NEK2_1	133	138	PF00069	0.632
MOD_NEK2_1	230	235	PF00069	0.545
MOD_NEK2_1	281	286	PF00069	0.657
MOD_NEK2_1	32	37	PF00069	0.794
MOD_NEK2_1	360	365	PF00069	0.539
MOD_NEK2_1	590	595	PF00069	0.555
MOD_NEK2_1	708	713	PF00069	0.732
MOD_PIKK_1	261	267	PF00454	0.571
MOD_PIKK_1	336	342	PF00454	0.593
MOD_PIKK_1	398	404	PF00454	0.664
MOD_PIKK_1	531	537	PF00454	0.657
MOD_PIKK_1	549	555	PF00454	0.389
MOD_PIKK_1	594	600	PF00454	0.558
MOD_PIKK_1	648	654	PF00454	0.677
MOD_PK_1	657	663	PF00069	0.692
MOD_PKA_1	251	257	PF00069	0.531
MOD_PKA_1	657	663	PF00069	0.692
MOD_PKA_1	669	675	PF00069	0.514
MOD_PKA_1	685	691	PF00069	0.566
MOD_PKA_1	84	90	PF00069	0.827
MOD_PKA_2	172	178	PF00069	0.556
MOD_PKA_2	30	36	PF00069	0.766
MOD_PKA_2	460	466	PF00069	0.667
MOD_PKA_2	535	541	PF00069	0.686
MOD_PKA_2	562	568	PF00069	0.574
MOD_PKA_2	586	592	PF00069	0.773
MOD_PKA_2	6	12	PF00069	0.722
MOD_PKA_2	657	663	PF00069	0.567
MOD_PKA_2	669	675	PF00069	0.611
MOD_PKA_2	684	690	PF00069	0.551
MOD_PKA_2	719	725	PF00069	0.755
MOD_PKA_2	84	90	PF00069	0.773
MOD_PKB_1	22	30	PF00069	0.780
MOD_PKB_1	655	663	PF00069	0.643
MOD_Plk_1	221	227	PF00069	0.539
MOD_Plk_1	266	272	PF00069	0.566
MOD_Plk_2-3	150	156	PF00069	0.561
MOD_Plk_2-3	172	178	PF00069	0.606
MOD_Plk_2-3	196	202	PF00069	0.532
MOD_Plk_4	620	626	PF00069	0.630
MOD_Plk_4	657	663	PF00069	0.692
MOD_ProDKin_1	10	16	PF00069	0.738
MOD_ProDKin_1	144	150	PF00069	0.653
MOD_ProDKin_1	293	299	PF00069	0.726
MOD_ProDKin_1	331	337	PF00069	0.785
MOD_ProDKin_1	485	491	PF00069	0.724
MOD_ProDKin_1	720	726	PF00069	0.755
MOD_ProDKin_1	88	94	PF00069	0.739
MOD_SUMO_for_1	137	140	PF00179	0.613
MOD_SUMO_for_1	245	248	PF00179	0.552
MOD_SUMO_for_1	256	259	PF00179	0.530
MOD_SUMO_rev_2	538	545	PF00179	0.579
TRG_AP2beta_CARGO_1	659	669	PF09066	0.520
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.573
TRG_ENDOCYTIC_2	78	81	PF00928	0.764
TRG_ER_diArg_1	128	131	PF00400	0.557
TRG_ER_diArg_1	166	169	PF00400	0.464
TRG_ER_diArg_1	418	421	PF00400	0.652
TRG_ER_diArg_1	521	523	PF00400	0.680
TRG_ER_diArg_1	555	558	PF00400	0.518
TRG_ER_diArg_1	604	606	PF00400	0.730
TRG_ER_diArg_1	625	627	PF00400	0.830
TRG_ER_diArg_1	654	657	PF00400	0.669
TRG_ER_diArg_1	84	86	PF00400	0.699
TRG_NES_CRM1_1	345	358	PF08389	0.567
TRG_NES_CRM1_1	369	383	PF08389	0.508
TRG_Pf-PMV_PEXEL_1	272	276	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	521	526	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9M3	Leptomonas seymouri	35%	96%
A4HH47	Leishmania braziliensis	62%	100%
A4I491	Leishmania infantum	100%	100%
E9ADP7	Leishmania major	88%	100%
E9AM33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	94%