Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IH37_LEIDO

TriTrypDb:

LdBPK_332980.1 , LdCL_330036900 , LDHU3_33.4130

Length:

469

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 1
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A0A3Q8IH37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	359	363	PF00656	0.746
CLV_NRD_NRD_1	319	321	PF00675	0.503
CLV_NRD_NRD_1	404	406	PF00675	0.618
CLV_NRD_NRD_1	8	10	PF00675	0.733
CLV_PCSK_KEX2_1	228	230	PF00082	0.748
CLV_PCSK_KEX2_1	319	321	PF00082	0.503
CLV_PCSK_KEX2_1	6	8	PF00082	0.752
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.748
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.700
CLV_PCSK_SKI1_1	188	192	PF00082	0.713
CLV_PCSK_SKI1_1	300	304	PF00082	0.483
DEG_SCF_FBW7_1	412	419	PF00400	0.752
DEG_SPOP_SBC_1	178	182	PF00917	0.603
DEG_SPOP_SBC_1	192	196	PF00917	0.510
DEG_SPOP_SBC_1	455	459	PF00917	0.763
DOC_PP4_FxxP_1	321	324	PF00568	0.731
DOC_USP7_MATH_1	101	105	PF00917	0.591
DOC_USP7_MATH_1	122	126	PF00917	0.578
DOC_USP7_MATH_1	130	134	PF00917	0.525
DOC_USP7_MATH_1	153	157	PF00917	0.484
DOC_USP7_MATH_1	161	165	PF00917	0.464
DOC_USP7_MATH_1	178	182	PF00917	0.579
DOC_USP7_MATH_1	184	188	PF00917	0.582
DOC_USP7_MATH_1	192	196	PF00917	0.499
DOC_USP7_MATH_1	328	332	PF00917	0.671
DOC_USP7_MATH_1	360	364	PF00917	0.770
DOC_USP7_MATH_1	397	401	PF00917	0.746
DOC_USP7_MATH_1	416	420	PF00917	0.682
DOC_USP7_MATH_1	456	460	PF00917	0.709
DOC_USP7_UBL2_3	398	402	PF12436	0.759
DOC_USP7_UBL2_3	69	73	PF12436	0.536
DOC_WW_Pin1_4	205	210	PF00397	0.599
DOC_WW_Pin1_4	221	226	PF00397	0.455
DOC_WW_Pin1_4	412	417	PF00397	0.793
DOC_WW_Pin1_4	425	430	PF00397	0.703
DOC_WW_Pin1_4	432	437	PF00397	0.637
LIG_14-3-3_CanoR_1	13	19	PF00244	0.648
LIG_14-3-3_CanoR_1	132	137	PF00244	0.503
LIG_14-3-3_CanoR_1	163	168	PF00244	0.480
LIG_14-3-3_CanoR_1	288	293	PF00244	0.756
LIG_BIR_II_1	1	5	PF00653	0.738
LIG_BIR_III_1	1	5	PF00653	0.706
LIG_BIR_III_3	1	5	PF00653	0.706
LIG_BRCT_BRCA1_1	132	136	PF00533	0.557
LIG_BRCT_BRCA1_1	163	167	PF00533	0.480
LIG_BRCT_BRCA1_1	362	366	PF00533	0.754
LIG_deltaCOP1_diTrp_1	464	469	PF00928	0.808
LIG_FHA_1	100	106	PF00498	0.496
LIG_FHA_1	236	242	PF00498	0.338
LIG_FHA_1	344	350	PF00498	0.743
LIG_FHA_1	388	394	PF00498	0.767
LIG_FHA_2	196	202	PF00498	0.516
LIG_FHA_2	82	88	PF00498	0.550
LIG_LIR_Gen_1	336	345	PF02991	0.786
LIG_LIR_Gen_1	361	372	PF02991	0.802
LIG_LIR_Nem_3	336	341	PF02991	0.733
LIG_Pex14_2	244	248	PF04695	0.394
LIG_SH2_CRK	289	293	PF00017	0.810
LIG_SH2_CRK	33	37	PF00017	0.512
LIG_SH2_CRK	68	72	PF00017	0.482
LIG_SH2_STAT3	322	325	PF00017	0.758
LIG_SH2_STAT5	289	292	PF00017	0.807
LIG_SH3_3	388	394	PF00018	0.809
LIG_TRAF2_1	86	89	PF00917	0.552
LIG_UBA3_1	337	344	PF00899	0.786
MOD_CDK_SPxxK_3	221	228	PF00069	0.564
MOD_CDK_SPxxK_3	432	439	PF00069	0.770
MOD_CK1_1	113	119	PF00069	0.518
MOD_CK1_1	135	141	PF00069	0.529
MOD_CK1_1	144	150	PF00069	0.501
MOD_CK1_1	166	172	PF00069	0.498
MOD_CK1_1	180	186	PF00069	0.587
MOD_CK1_1	193	199	PF00069	0.506
MOD_CK1_1	208	214	PF00069	0.511
MOD_CK1_1	382	388	PF00069	0.812
MOD_CK1_1	400	406	PF00069	0.814
MOD_CK1_1	419	425	PF00069	0.711
MOD_CK1_1	99	105	PF00069	0.544
MOD_CK2_1	191	197	PF00069	0.595
MOD_CK2_1	421	427	PF00069	0.783
MOD_CK2_1	83	89	PF00069	0.601
MOD_GlcNHglycan	115	118	PF01048	0.656
MOD_GlcNHglycan	120	123	PF01048	0.793
MOD_GlcNHglycan	151	154	PF01048	0.728
MOD_GlcNHglycan	182	185	PF01048	0.749
MOD_GlcNHglycan	261	264	PF01048	0.540
MOD_GlcNHglycan	270	273	PF01048	0.512
MOD_GlcNHglycan	275	278	PF01048	0.545
MOD_GlcNHglycan	350	353	PF01048	0.613
MOD_GlcNHglycan	356	359	PF01048	0.547
MOD_GlcNHglycan	381	384	PF01048	0.640
MOD_GlcNHglycan	421	424	PF01048	0.611
MOD_GlcNHglycan	445	448	PF01048	0.566
MOD_GlcNHglycan	50	53	PF01048	0.705
MOD_GlcNHglycan	98	101	PF01048	0.801
MOD_GSK3_1	113	120	PF00069	0.606
MOD_GSK3_1	122	129	PF00069	0.530
MOD_GSK3_1	131	138	PF00069	0.447
MOD_GSK3_1	144	151	PF00069	0.472
MOD_GSK3_1	153	160	PF00069	0.484
MOD_GSK3_1	162	169	PF00069	0.479
MOD_GSK3_1	179	186	PF00069	0.588
MOD_GSK3_1	188	195	PF00069	0.546
MOD_GSK3_1	205	212	PF00069	0.462
MOD_GSK3_1	214	221	PF00069	0.500
MOD_GSK3_1	268	275	PF00069	0.746
MOD_GSK3_1	354	361	PF00069	0.760
MOD_GSK3_1	378	385	PF00069	0.818
MOD_GSK3_1	396	403	PF00069	0.791
MOD_GSK3_1	412	419	PF00069	0.658
MOD_GSK3_1	421	428	PF00069	0.738
MOD_GSK3_1	437	444	PF00069	0.666
MOD_GSK3_1	92	99	PF00069	0.535
MOD_LATS_1	286	292	PF00433	0.752
MOD_N-GLC_1	214	219	PF02516	0.782
MOD_NEK2_1	190	195	PF00069	0.572
MOD_NEK2_1	213	218	PF00069	0.566
MOD_NEK2_1	236	241	PF00069	0.283
MOD_NEK2_1	302	307	PF00069	0.740
MOD_NEK2_1	378	383	PF00069	0.858
MOD_NEK2_1	437	442	PF00069	0.796
MOD_NEK2_2	345	350	PF00069	0.687
MOD_NEK2_2	397	402	PF00069	0.700
MOD_PIKK_1	141	147	PF00454	0.570
MOD_PIKK_1	172	178	PF00454	0.485
MOD_PIKK_1	456	462	PF00454	0.762
MOD_PKA_2	131	137	PF00069	0.502
MOD_PKA_2	14	20	PF00069	0.613
MOD_PKA_2	162	168	PF00069	0.480
MOD_PKA_2	184	190	PF00069	0.573
MOD_PKA_2	287	293	PF00069	0.707
MOD_PKA_2	438	444	PF00069	0.802
MOD_Plk_4	101	107	PF00069	0.511
MOD_Plk_4	14	20	PF00069	0.640
MOD_Plk_4	236	242	PF00069	0.335
MOD_ProDKin_1	205	211	PF00069	0.599
MOD_ProDKin_1	221	227	PF00069	0.455
MOD_ProDKin_1	412	418	PF00069	0.794
MOD_ProDKin_1	425	431	PF00069	0.702
MOD_ProDKin_1	432	438	PF00069	0.638
MOD_SUMO_rev_2	74	82	PF00179	0.490
TRG_ENDOCYTIC_2	289	292	PF00928	0.807
TRG_ENDOCYTIC_2	299	302	PF00928	0.690
TRG_ENDOCYTIC_2	68	71	PF00928	0.539
TRG_ER_diArg_1	318	320	PF00400	0.695
TRG_ER_diArg_1	7	9	PF00400	0.613
TRG_NLS_MonoCore_2	5	10	PF00514	0.607
TRG_NLS_MonoExtN_4	4	10	PF00514	0.607
TRG_NLS_MonoExtN_4	402	409	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.766

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HLZ5	Leishmania braziliensis	38%	82%
E9AEH4	Leishmania major	71%	93%
E9AHS1	Leishmania infantum	90%	93%