UBX domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UBX domain-containing protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IH33_LEIDO

TriTrypDb:

LdBPK_290350.1 , LdCL_290008300 , LDHU3_29.0480

Length:

428

Annotations

Annotations by Jardim et al.

Protein modification, UBX domain-containing Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0005783	endoplasmic reticulum	5	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Phosphorylation

Amastigote: 101
Promastigote: 285

Expansion

Sequence features

A0A3Q8IH33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH33

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.513
CLV_C14_Caspase3-7	281	285	PF00656	0.728
CLV_C14_Caspase3-7	335	339	PF00656	0.696
CLV_PCSK_SKI1_1	163	167	PF00082	0.525
CLV_PCSK_SKI1_1	398	402	PF00082	0.511
DEG_SPOP_SBC_1	303	307	PF00917	0.689
DEG_SPOP_SBC_1	350	354	PF00917	0.609
DOC_CKS1_1	360	365	PF01111	0.435
DOC_CKS1_1	89	94	PF01111	0.757
DOC_MAPK_DCC_7	382	391	PF00069	0.566

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T7	Leptomonas seymouri	58%	100%
A0A0S4JDU8	Bodo saltans	26%	83%
A0A1X0NZG7	Trypanosomatidae	27%	97%
A0A3R7M3Q4	Trypanosoma rangeli	29%	100%
A4HH35	Leishmania braziliensis	83%	100%
A4I486	Leishmania infantum	100%	100%
C9ZKP3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9ADN5	Leishmania major	95%	100%
E9AM45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B4U5	Trypanosoma cruzi	28%	100%

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