GRIP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH29_LEIDO

TriTrypDb:

LdBPK_091630.1 , LdCL_090022700 , LDHU3_09.1900

Length:

607

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IH29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.487
CLV_C14_Caspase3-7	39	43	PF00656	0.568
CLV_C14_Caspase3-7	525	529	PF00656	0.557
CLV_NRD_NRD_1	235	237	PF00675	0.501
CLV_NRD_NRD_1	532	534	PF00675	0.659
CLV_NRD_NRD_1	75	77	PF00675	0.427
CLV_NRD_NRD_1	84	86	PF00675	0.467
CLV_PCSK_KEX2_1	234	236	PF00082	0.538
CLV_PCSK_KEX2_1	45	47	PF00082	0.564
CLV_PCSK_KEX2_1	532	534	PF00082	0.622
CLV_PCSK_PC1ET2_1	45	47	PF00082	0.563
CLV_PCSK_SKI1_1	10	14	PF00082	0.516
CLV_PCSK_SKI1_1	204	208	PF00082	0.587
CLV_PCSK_SKI1_1	215	219	PF00082	0.485
CLV_PCSK_SKI1_1	521	525	PF00082	0.597
CLV_PCSK_SKI1_1	593	597	PF00082	0.549
DEG_APCC_DBOX_1	203	211	PF00400	0.528
DEG_APCC_DBOX_1	214	222	PF00400	0.471
DEG_APCC_DBOX_1	542	550	PF00400	0.486
DEG_Nend_UBRbox_1	1	4	PF02207	0.509
DOC_MAPK_gen_1	588	596	PF00069	0.478
DOC_MAPK_gen_1	83	92	PF00069	0.547
DOC_MAPK_MEF2A_6	409	417	PF00069	0.407
DOC_USP7_MATH_1	33	37	PF00917	0.538
DOC_USP7_MATH_1	365	369	PF00917	0.347
DOC_USP7_MATH_1	443	447	PF00917	0.543
DOC_USP7_MATH_1	56	60	PF00917	0.540
DOC_USP7_MATH_2	159	165	PF00917	0.554
DOC_USP7_UBL2_3	48	52	PF12436	0.571
DOC_WW_Pin1_4	155	160	PF00397	0.590
LIG_14-3-3_CanoR_1	103	110	PF00244	0.512
LIG_14-3-3_CanoR_1	139	145	PF00244	0.713
LIG_14-3-3_CanoR_1	162	172	PF00244	0.699
LIG_14-3-3_CanoR_1	2	7	PF00244	0.654
LIG_14-3-3_CanoR_1	317	323	PF00244	0.526
LIG_14-3-3_CanoR_1	543	547	PF00244	0.603
LIG_14-3-3_CanoR_1	555	564	PF00244	0.597
LIG_14-3-3_CterR_2	604	607	PF00244	0.589
LIG_BIR_III_2	174	178	PF00653	0.474
LIG_BRCT_BRCA1_1	373	377	PF00533	0.418
LIG_CaM_IQ_9	396	411	PF13499	0.465
LIG_deltaCOP1_diTrp_1	369	377	PF00928	0.282
LIG_FHA_1	140	146	PF00498	0.656
LIG_FHA_1	155	161	PF00498	0.566
LIG_FHA_1	412	418	PF00498	0.523
LIG_FHA_2	142	148	PF00498	0.574
LIG_FHA_2	169	175	PF00498	0.671
LIG_FHA_2	176	182	PF00498	0.502
LIG_FHA_2	228	234	PF00498	0.516
LIG_FHA_2	258	264	PF00498	0.555
LIG_Integrin_RGD_1	433	435	PF01839	0.437
LIG_LIR_Gen_1	5	12	PF02991	0.620
LIG_LIR_Nem_3	5	9	PF02991	0.627
LIG_NRBOX	447	453	PF00104	0.349
LIG_SH2_GRB2like	422	425	PF00017	0.432
LIG_SH2_SRC	6	9	PF00017	0.645
LIG_SH2_STAP1	16	20	PF00017	0.570
LIG_SH2_STAP1	301	305	PF00017	0.535
LIG_SH2_STAP1	345	349	PF00017	0.393
LIG_SH2_STAT5	398	401	PF00017	0.397
LIG_SUMO_SIM_anti_2	188	195	PF11976	0.432
LIG_SUMO_SIM_par_1	219	224	PF11976	0.599
LIG_SUMO_SIM_par_1	413	419	PF11976	0.525
LIG_SUMO_SIM_par_1	522	528	PF11976	0.660
LIG_TRAF2_1	364	367	PF00917	0.459
LIG_TRAF2_1	391	394	PF00917	0.532
LIG_TRAF2_1	580	583	PF00917	0.526
LIG_TRAF2_1	95	98	PF00917	0.501
MOD_CDK_SPxxK_3	155	162	PF00069	0.580
MOD_CK1_1	141	147	PF00069	0.716
MOD_CK1_1	155	161	PF00069	0.658
MOD_CK1_1	257	263	PF00069	0.543
MOD_CK1_1	467	473	PF00069	0.531
MOD_CK1_1	59	65	PF00069	0.502
MOD_CK2_1	11	17	PF00069	0.645
MOD_CK2_1	141	147	PF00069	0.599
MOD_CK2_1	148	154	PF00069	0.609
MOD_CK2_1	155	161	PF00069	0.608
MOD_CK2_1	175	181	PF00069	0.584
MOD_CK2_1	227	233	PF00069	0.477
MOD_CK2_1	257	263	PF00069	0.480
MOD_CK2_1	282	288	PF00069	0.438
MOD_CK2_1	33	39	PF00069	0.658
MOD_CK2_1	367	373	PF00069	0.512
MOD_CK2_1	388	394	PF00069	0.475
MOD_CK2_1	462	468	PF00069	0.410
MOD_CK2_1	577	583	PF00069	0.511
MOD_CK2_1	92	98	PF00069	0.527
MOD_GlcNHglycan	208	213	PF01048	0.511
MOD_GlcNHglycan	308	311	PF01048	0.484
MOD_GlcNHglycan	33	36	PF01048	0.636
MOD_GlcNHglycan	358	361	PF01048	0.433
MOD_GSK3_1	137	144	PF00069	0.635
MOD_GSK3_1	148	155	PF00069	0.612
MOD_GSK3_1	308	315	PF00069	0.422
MOD_GSK3_1	31	38	PF00069	0.754
MOD_GSK3_1	367	374	PF00069	0.571
MOD_GSK3_1	388	395	PF00069	0.472
MOD_GSK3_1	499	506	PF00069	0.453
MOD_GSK3_1	577	584	PF00069	0.628
MOD_GSK3_1	92	99	PF00069	0.523
MOD_N-GLC_1	243	248	PF02516	0.543
MOD_N-GLC_1	312	317	PF02516	0.523
MOD_N-GLC_1	477	482	PF02516	0.472
MOD_NEK2_1	163	168	PF00069	0.677
MOD_NEK2_1	221	226	PF00069	0.470
MOD_NEK2_1	308	313	PF00069	0.484
MOD_NEK2_1	371	376	PF00069	0.545
MOD_NEK2_1	462	467	PF00069	0.396
MOD_NEK2_1	497	502	PF00069	0.591
MOD_NEK2_1	511	516	PF00069	0.457
MOD_NEK2_1	563	568	PF00069	0.633
MOD_NEK2_1	577	582	PF00069	0.427
MOD_NEK2_1	96	101	PF00069	0.523
MOD_NEK2_2	16	21	PF00069	0.487
MOD_PIKK_1	11	17	PF00454	0.569
MOD_PIKK_1	115	121	PF00454	0.601
MOD_PIKK_1	152	158	PF00454	0.621
MOD_PIKK_1	161	167	PF00454	0.595
MOD_PIKK_1	282	288	PF00454	0.453
MOD_PIKK_1	371	377	PF00454	0.405
MOD_PKA_2	102	108	PF00069	0.572
MOD_PKA_2	122	128	PF00069	0.443
MOD_PKA_2	138	144	PF00069	0.700
MOD_PKA_2	161	167	PF00069	0.707
MOD_PKA_2	254	260	PF00069	0.577
MOD_PKA_2	542	548	PF00069	0.696
MOD_PKB_1	484	492	PF00069	0.425
MOD_Plk_1	16	22	PF00069	0.612
MOD_Plk_1	208	214	PF00069	0.505
MOD_Plk_1	243	249	PF00069	0.544
MOD_Plk_1	282	288	PF00069	0.442
MOD_Plk_1	392	398	PF00069	0.476
MOD_Plk_1	477	483	PF00069	0.572
MOD_Plk_1	503	509	PF00069	0.594
MOD_Plk_1	577	583	PF00069	0.555
MOD_Plk_1	59	65	PF00069	0.490
MOD_Plk_2-3	367	373	PF00069	0.529
MOD_Plk_2-3	416	422	PF00069	0.403
MOD_Plk_2-3	522	528	PF00069	0.660
MOD_Plk_4	367	373	PF00069	0.544
MOD_Plk_4	477	483	PF00069	0.474
MOD_Plk_4	486	492	PF00069	0.557
MOD_ProDKin_1	155	161	PF00069	0.591
MOD_SUMO_rev_2	188	197	PF00179	0.490
MOD_SUMO_rev_2	440	446	PF00179	0.447
TRG_DiLeu_BaEn_1	447	452	PF01217	0.462
TRG_DiLeu_BaEn_2	372	378	PF01217	0.527
TRG_DiLeu_BaEn_3	275	281	PF01217	0.452
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.482
TRG_ENDOCYTIC_2	6	9	PF00928	0.521
TRG_ER_diArg_1	234	236	PF00400	0.604
TRG_ER_diArg_1	483	486	PF00400	0.433
TRG_NES_CRM1_1	464	479	PF08389	0.479
TRG_Pf-PMV_PEXEL_1	10	15	PF00026	0.543
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	279	283	PF00026	0.586
TRG_Pf-PMV_PEXEL_1	376	381	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	457	461	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	579	583	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGV3	Leptomonas seymouri	54%	92%
A0A1X0NJR6	Trypanosomatidae	41%	81%
A0A422NZK3	Trypanosoma rangeli	40%	80%
A4H5Y1	Leishmania braziliensis	81%	100%
A4HU77	Leishmania infantum	99%	100%
D0A9Q9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	81%
E9AN07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QHM1	Leishmania major	91%	100%
V5BI13	Trypanosoma cruzi	38%	81%