DnaJ domain family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ family-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IH27_LEIDO

TriTrypDb:

LdBPK_332830.1 , LdCL_330035400 , LDHU3_33.3970

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IH27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH27

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.621
CLV_C14_Caspase3-7	240	244	PF00656	0.557
CLV_C14_Caspase3-7	39	43	PF00656	0.412
CLV_NRD_NRD_1	256	258	PF00675	0.629
CLV_NRD_NRD_1	84	86	PF00675	0.358
CLV_NRD_NRD_1	88	90	PF00675	0.329
CLV_PCSK_KEX2_1	258	260	PF00082	0.619
CLV_PCSK_KEX2_1	84	86	PF00082	0.351
CLV_PCSK_KEX2_1	88	90	PF00082	0.319
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.619
CLV_PCSK_PC7_1	84	90	PF00082	0.444
CLV_PCSK_SKI1_1	105	109	PF00082	0.406
CLV_PCSK_SKI1_1	174	178	PF00082	0.637
CLV_PCSK_SKI1_1	230	234	PF00082	0.518
CLV_Separin_Metazoa	213	217	PF03568	0.600
DEG_APCC_KENBOX_2	37	41	PF00400	0.546
DEG_SCF_FBW7_1	52	58	PF00400	0.677
DEG_SPOP_SBC_1	6	10	PF00917	0.706
DOC_CKS1_1	203	208	PF01111	0.475
DOC_CKS1_1	52	57	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	203	209	PF00134	0.628
DOC_MAPK_gen_1	84	94	PF00069	0.348
DOC_MAPK_MEF2A_6	85	94	PF00069	0.444
DOC_PP2B_PxIxI_1	75	81	PF00149	0.572
DOC_USP7_MATH_1	137	141	PF00917	0.668
DOC_USP7_MATH_1	245	249	PF00917	0.606
DOC_USP7_MATH_1	6	10	PF00917	0.760
DOC_USP7_MATH_1	60	64	PF00917	0.723
DOC_USP7_UBL2_3	230	234	PF12436	0.575
DOC_WW_Pin1_4	202	207	PF00397	0.472
DOC_WW_Pin1_4	30	35	PF00397	0.754
DOC_WW_Pin1_4	51	56	PF00397	0.645
LIG_14-3-3_CanoR_1	194	203	PF00244	0.549
LIG_14-3-3_CanoR_1	88	93	PF00244	0.441
LIG_BIR_II_1	1	5	PF00653	0.727
LIG_BRCT_BRCA1_1	90	94	PF00533	0.444
LIG_FHA_1	163	169	PF00498	0.501
LIG_FHA_1	190	196	PF00498	0.506
LIG_FHA_1	198	204	PF00498	0.469
LIG_FHA_1	227	233	PF00498	0.624
LIG_FHA_2	111	117	PF00498	0.358
LIG_FHA_2	128	134	PF00498	0.312
LIG_LIR_Gen_1	205	215	PF02991	0.546
LIG_LIR_Gen_1	42	52	PF02991	0.494
LIG_LIR_Nem_3	243	249	PF02991	0.590
LIG_LIR_Nem_3	42	47	PF02991	0.463
LIG_SH2_CRK	87	91	PF00017	0.444
LIG_SH2_STAT5	127	130	PF00017	0.525
LIG_SH2_STAT5	249	252	PF00017	0.503
LIG_SH2_STAT5	46	49	PF00017	0.538
LIG_SUMO_SIM_par_1	221	229	PF11976	0.512
LIG_TRAF2_1	143	146	PF00917	0.681
LIG_TRAF2_1	184	187	PF00917	0.548
LIG_WRC_WIRS_1	41	46	PF05994	0.595
MOD_CK1_1	197	203	PF00069	0.624
MOD_CK1_1	9	15	PF00069	0.737
MOD_CK2_1	110	116	PF00069	0.494
MOD_CK2_1	127	133	PF00069	0.298
MOD_CK2_1	5	11	PF00069	0.750
MOD_GlcNHglycan	11	14	PF01048	0.681
MOD_GlcNHglycan	133	137	PF01048	0.672
MOD_GlcNHglycan	2	5	PF01048	0.694
MOD_GlcNHglycan	240	243	PF01048	0.647
MOD_GlcNHglycan	26	29	PF01048	0.574
MOD_GlcNHglycan	58	61	PF01048	0.664
MOD_GlcNHglycan	66	69	PF01048	0.693
MOD_GSK3_1	110	117	PF00069	0.444
MOD_GSK3_1	194	201	PF00069	0.501
MOD_GSK3_1	226	233	PF00069	0.604
MOD_GSK3_1	30	37	PF00069	0.650
MOD_GSK3_1	5	12	PF00069	0.792
MOD_GSK3_1	51	58	PF00069	0.602
MOD_GSK3_1	60	67	PF00069	0.719
MOD_N-GLC_1	4	9	PF02516	0.749
MOD_NEK2_1	199	204	PF00069	0.623
MOD_PIKK_1	189	195	PF00454	0.415
MOD_PKA_1	88	94	PF00069	0.444
MOD_PKA_2	88	94	PF00069	0.438
MOD_Plk_4	114	120	PF00069	0.444
MOD_Plk_4	127	133	PF00069	0.472
MOD_Plk_4	162	168	PF00069	0.518
MOD_Plk_4	245	251	PF00069	0.658
MOD_ProDKin_1	202	208	PF00069	0.473
MOD_ProDKin_1	30	36	PF00069	0.733
MOD_ProDKin_1	51	57	PF00069	0.656
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.574
TRG_ENDOCYTIC_2	46	49	PF00928	0.439
TRG_ENDOCYTIC_2	87	90	PF00928	0.344
TRG_ER_diArg_1	83	85	PF00400	0.358
TRG_ER_diArg_1	87	89	PF00400	0.329
TRG_NLS_MonoExtC_3	256	261	PF00514	0.706
TRG_Pf-PMV_PEXEL_1	129	133	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.574

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5Q0	Leptomonas seymouri	61%	100%
A0A1X0NSQ5	Trypanosomatidae	37%	100%
A4HLY0	Leishmania braziliensis	73%	99%
A4I9A9	Leishmania infantum	100%	100%
C9ZJB7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9B4A9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q3R7	Leishmania major	89%	100%
V5BF66	Trypanosoma cruzi	38%	100%