Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH23_LEIDO

TriTrypDb:

LdBPK_290170.1 , LdCL_290006500 , LDHU3_29.0220

Length:

569

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3Q8IH23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.680
CLV_NRD_NRD_1	273	275	PF00675	0.363
CLV_NRD_NRD_1	438	440	PF00675	0.356
CLV_NRD_NRD_1	44	46	PF00675	0.612
CLV_NRD_NRD_1	557	559	PF00675	0.345
CLV_NRD_NRD_1	6	8	PF00675	0.448
CLV_PCSK_KEX2_1	200	202	PF00082	0.687
CLV_PCSK_KEX2_1	273	275	PF00082	0.363
CLV_PCSK_KEX2_1	342	344	PF00082	0.289
CLV_PCSK_KEX2_1	438	440	PF00082	0.356
CLV_PCSK_KEX2_1	559	561	PF00082	0.345
CLV_PCSK_KEX2_1	6	8	PF00082	0.414
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.657
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.289
CLV_PCSK_PC1ET2_1	559	561	PF00082	0.325
CLV_PCSK_SKI1_1	113	117	PF00082	0.355
CLV_PCSK_SKI1_1	201	205	PF00082	0.581
CLV_PCSK_SKI1_1	274	278	PF00082	0.339
CLV_PCSK_SKI1_1	343	347	PF00082	0.280
CLV_PCSK_SKI1_1	402	406	PF00082	0.300
CLV_PCSK_SKI1_1	409	413	PF00082	0.313
CLV_PCSK_SKI1_1	453	457	PF00082	0.330
CLV_PCSK_SKI1_1	548	552	PF00082	0.407
DEG_APCC_DBOX_1	342	350	PF00400	0.480
DEG_APCC_DBOX_1	401	409	PF00400	0.447
DEG_APCC_DBOX_1	5	13	PF00400	0.551
DEG_MDM2_SWIB_1	118	125	PF02201	0.420
DEG_SPOP_SBC_1	384	388	PF00917	0.210
DOC_CDC14_PxL_1	303	311	PF14671	0.387
DOC_CYCLIN_RxL_1	399	407	PF00134	0.466
DOC_CYCLIN_RxL_1	4	14	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	125	131	PF00134	0.324
DOC_CYCLIN_yCln2_LP_2	471	477	PF00134	0.409
DOC_MAPK_gen_1	273	282	PF00069	0.548
DOC_MAPK_gen_1	341	350	PF00069	0.482
DOC_MAPK_gen_1	558	568	PF00069	0.611
DOC_MAPK_gen_1	59	67	PF00069	0.388
DOC_MAPK_gen_1	6	12	PF00069	0.543
DOC_MAPK_MEF2A_6	341	349	PF00069	0.507
DOC_MAPK_MEF2A_6	367	374	PF00069	0.477
DOC_MAPK_MEF2A_6	453	462	PF00069	0.524
DOC_MAPK_MEF2A_6	548	555	PF00069	0.554
DOC_MAPK_MEF2A_6	61	69	PF00069	0.338
DOC_MAPK_NFAT4_5	341	349	PF00069	0.520
DOC_PP1_RVXF_1	546	553	PF00149	0.611
DOC_PP2B_LxvP_1	125	128	PF13499	0.348
DOC_PP2B_LxvP_1	471	474	PF13499	0.496
DOC_PP4_FxxP_1	327	330	PF00568	0.392
DOC_USP7_MATH_1	323	327	PF00917	0.415
DOC_USP7_MATH_1	384	388	PF00917	0.292
DOC_USP7_MATH_1	432	436	PF00917	0.603
DOC_USP7_MATH_1	447	451	PF00917	0.449
DOC_USP7_MATH_1	90	94	PF00917	0.412
DOC_USP7_MATH_2	447	453	PF00917	0.516
DOC_WW_Pin1_4	195	200	PF00397	0.376
DOC_WW_Pin1_4	428	433	PF00397	0.617
DOC_WW_Pin1_4	99	104	PF00397	0.664
LIG_14-3-3_CanoR_1	229	238	PF00244	0.639
LIG_14-3-3_CanoR_1	268	272	PF00244	0.559
LIG_14-3-3_CanoR_1	273	277	PF00244	0.494
LIG_14-3-3_CanoR_1	438	444	PF00244	0.601
LIG_14-3-3_CanoR_1	453	458	PF00244	0.553
LIG_14-3-3_CanoR_1	500	508	PF00244	0.394
LIG_Actin_WH2_2	48	63	PF00022	0.412
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BRCT_BRCA1_1	26	30	PF00533	0.233
LIG_BRCT_BRCA1_1	503	507	PF00533	0.441
LIG_CaM_IQ_9	260	276	PF13499	0.537
LIG_CaM_IQ_9	550	566	PF13499	0.622
LIG_Clathr_ClatBox_1	39	43	PF01394	0.392
LIG_eIF4E_1	34	40	PF01652	0.372
LIG_FHA_1	138	144	PF00498	0.429
LIG_FHA_1	435	441	PF00498	0.483
LIG_FHA_1	454	460	PF00498	0.399
LIG_FHA_1	511	517	PF00498	0.424
LIG_FHA_1	526	532	PF00498	0.293
LIG_FHA_2	239	245	PF00498	0.694
LIG_FHA_2	257	263	PF00498	0.605
LIG_LIR_Apic_2	326	330	PF02991	0.388
LIG_LIR_Nem_3	121	125	PF02991	0.323
LIG_LIR_Nem_3	262	266	PF02991	0.586
LIG_LIR_Nem_3	27	33	PF02991	0.304
LIG_LIR_Nem_3	463	469	PF02991	0.390
LIG_NRBOX	345	351	PF00104	0.423
LIG_NRBOX	396	402	PF00104	0.406
LIG_Pex14_1	539	543	PF04695	0.493
LIG_Pex14_2	114	118	PF04695	0.306
LIG_Pex14_2	203	207	PF04695	0.340
LIG_Pex14_2	26	30	PF04695	0.420
LIG_Pex14_2	462	466	PF04695	0.454
LIG_Pex14_2	503	507	PF04695	0.371
LIG_REV1ctd_RIR_1	362	371	PF16727	0.450
LIG_SH2_GRB2like	542	545	PF00017	0.586
LIG_SH2_SRC	288	291	PF00017	0.388
LIG_SH2_SRC	34	37	PF00017	0.372
LIG_SH2_STAP1	288	292	PF00017	0.340
LIG_SH2_STAT5	34	37	PF00017	0.328
LIG_SH3_3	125	131	PF00018	0.433
LIG_SH3_3	319	325	PF00018	0.472
LIG_SH3_3	441	447	PF00018	0.580
LIG_SH3_3	467	473	PF00018	0.626
LIG_SUMO_SIM_anti_2	456	461	PF11976	0.356
LIG_SUMO_SIM_anti_2	517	525	PF11976	0.331
LIG_SUMO_SIM_par_1	38	44	PF11976	0.414
LIG_SUMO_SIM_par_1	517	525	PF11976	0.364
LIG_SUMO_SIM_par_1	8	14	PF11976	0.576
LIG_TRAF2_1	166	169	PF00917	0.691
LIG_TRAF2_1	241	244	PF00917	0.658
LIG_UBA3_1	551	559	PF00899	0.435
MOD_CDC14_SPxK_1	198	201	PF00782	0.497
MOD_CDK_SPK_2	195	200	PF00069	0.467
MOD_CDK_SPK_2	99	104	PF00069	0.521
MOD_CDK_SPxK_1	195	201	PF00069	0.474
MOD_CDK_SPxxK_3	195	202	PF00069	0.423
MOD_CDK_SPxxK_3	99	106	PF00069	0.518
MOD_CK1_1	132	138	PF00069	0.396
MOD_CK1_1	246	252	PF00069	0.687
MOD_CK1_1	480	486	PF00069	0.645
MOD_CK1_1	502	508	PF00069	0.650
MOD_CK1_1	525	531	PF00069	0.443
MOD_CK2_1	229	235	PF00069	0.596
MOD_CK2_1	238	244	PF00069	0.666
MOD_CK2_1	256	262	PF00069	0.388
MOD_Cter_Amidation	339	342	PF01082	0.353
MOD_GlcNHglycan	106	109	PF01048	0.596
MOD_GlcNHglycan	131	134	PF01048	0.370
MOD_GlcNHglycan	179	182	PF01048	0.391
MOD_GlcNHglycan	214	217	PF01048	0.399
MOD_GlcNHglycan	222	225	PF01048	0.386
MOD_GlcNHglycan	252	255	PF01048	0.603
MOD_GlcNHglycan	26	29	PF01048	0.434
MOD_GlcNHglycan	309	312	PF01048	0.471
MOD_GlcNHglycan	334	337	PF01048	0.571
MOD_GlcNHglycan	387	390	PF01048	0.416
MOD_GlcNHglycan	486	489	PF01048	0.670
MOD_GlcNHglycan	504	507	PF01048	0.593
MOD_GSK3_1	144	151	PF00069	0.476
MOD_GSK3_1	173	180	PF00069	0.545
MOD_GSK3_1	246	253	PF00069	0.609
MOD_GSK3_1	379	386	PF00069	0.669
MOD_GSK3_1	428	435	PF00069	0.430
MOD_GSK3_1	449	456	PF00069	0.397
MOD_GSK3_1	480	487	PF00069	0.635
MOD_GSK3_1	510	517	PF00069	0.515
MOD_N-GLC_1	238	243	PF02516	0.505
MOD_N-GLC_1	478	483	PF02516	0.659
MOD_N-GLC_1	514	519	PF02516	0.403
MOD_NEK2_1	11	16	PF00069	0.476
MOD_NEK2_1	118	123	PF00069	0.358
MOD_NEK2_1	299	304	PF00069	0.428
MOD_NEK2_1	404	409	PF00069	0.396
MOD_NEK2_1	460	465	PF00069	0.330
MOD_NEK2_1	60	65	PF00069	0.545
MOD_NEK2_1	78	83	PF00069	0.222
MOD_NEK2_2	522	527	PF00069	0.388
MOD_PIKK_1	160	166	PF00454	0.589
MOD_PIKK_1	480	486	PF00454	0.539
MOD_PKA_2	173	179	PF00069	0.358
MOD_PKA_2	267	273	PF00069	0.410
MOD_PKA_2	307	313	PF00069	0.502
MOD_PKA_2	499	505	PF00069	0.482
MOD_PKA_2	60	66	PF00069	0.519
MOD_PKB_1	104	112	PF00069	0.470
MOD_PKB_1	227	235	PF00069	0.514
MOD_Plk_1	243	249	PF00069	0.702
MOD_Plk_1	256	262	PF00069	0.373
MOD_Plk_1	478	484	PF00069	0.665
MOD_Plk_4	118	124	PF00069	0.317
MOD_Plk_4	13	19	PF00069	0.306
MOD_Plk_4	256	262	PF00069	0.610
MOD_Plk_4	313	319	PF00069	0.443
MOD_Plk_4	323	329	PF00069	0.300
MOD_Plk_4	356	362	PF00069	0.433
MOD_Plk_4	396	402	PF00069	0.340
MOD_Plk_4	439	445	PF00069	0.522
MOD_Plk_4	453	459	PF00069	0.321
MOD_Plk_4	516	522	PF00069	0.334
MOD_Plk_4	78	84	PF00069	0.392
MOD_Plk_4	90	96	PF00069	0.470
MOD_ProDKin_1	195	201	PF00069	0.474
MOD_ProDKin_1	428	434	PF00069	0.519
MOD_ProDKin_1	99	105	PF00069	0.583
MOD_SUMO_for_1	166	169	PF00179	0.567
TRG_DiLeu_BaEn_1	546	551	PF01217	0.433
TRG_DiLeu_BaEn_2	261	267	PF01217	0.507
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.457
TRG_ENDOCYTIC_2	542	545	PF00928	0.414
TRG_ER_diArg_1	103	106	PF00400	0.551
TRG_ER_diArg_1	438	440	PF00400	0.438
TRG_ER_diArg_1	58	61	PF00400	0.517
TRG_NES_CRM1_1	20	32	PF08389	0.402
TRG_NLS_MonoExtN_4	199	204	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	402	406	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVM9	Leptomonas seymouri	44%	100%
A0A1X0NZT8	Trypanosomatidae	24%	100%
A0A3R7KT94	Trypanosoma rangeli	26%	100%
A4HH24	Leishmania braziliensis	73%	100%
A4I453	Leishmania infantum	100%	100%
C9ZKQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9ADL8	Leishmania major	90%	100%
E9AM63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B4T3	Trypanosoma cruzi	25%	100%