Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH17_LEIDO

TriTrypDb:

LdBPK_322170.1 , LdCL_320027100 , LDHU3_32.2690

Length:

877

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IH17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	710	714	PF00656	0.747
CLV_C14_Caspase3-7	751	755	PF00656	0.529
CLV_NRD_NRD_1	192	194	PF00675	0.542
CLV_NRD_NRD_1	238	240	PF00675	0.572
CLV_NRD_NRD_1	26	28	PF00675	0.512
CLV_NRD_NRD_1	274	276	PF00675	0.606
CLV_NRD_NRD_1	41	43	PF00675	0.400
CLV_NRD_NRD_1	427	429	PF00675	0.510
CLV_NRD_NRD_1	439	441	PF00675	0.481
CLV_NRD_NRD_1	607	609	PF00675	0.533
CLV_NRD_NRD_1	638	640	PF00675	0.557
CLV_PCSK_FUR_1	39	43	PF00082	0.543
CLV_PCSK_KEX2_1	192	194	PF00082	0.542
CLV_PCSK_KEX2_1	238	240	PF00082	0.572
CLV_PCSK_KEX2_1	26	28	PF00082	0.511
CLV_PCSK_KEX2_1	274	276	PF00082	0.606
CLV_PCSK_KEX2_1	41	43	PF00082	0.436
CLV_PCSK_KEX2_1	427	429	PF00082	0.510
CLV_PCSK_KEX2_1	439	441	PF00082	0.476
CLV_PCSK_KEX2_1	638	640	PF00082	0.557
CLV_PCSK_KEX2_1	724	726	PF00082	0.581
CLV_PCSK_KEX2_1	786	788	PF00082	0.664
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.506
CLV_PCSK_PC1ET2_1	724	726	PF00082	0.548
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.640
CLV_PCSK_PC7_1	423	429	PF00082	0.454
CLV_PCSK_SKI1_1	192	196	PF00082	0.490
CLV_PCSK_SKI1_1	211	215	PF00082	0.592
CLV_PCSK_SKI1_1	252	256	PF00082	0.532
CLV_PCSK_SKI1_1	531	535	PF00082	0.647
CLV_PCSK_SKI1_1	561	565	PF00082	0.723
CLV_PCSK_SKI1_1	702	706	PF00082	0.654
DEG_APCC_DBOX_1	247	255	PF00400	0.457
DEG_APCC_DBOX_1	701	709	PF00400	0.679
DEG_SCF_FBW7_1	111	117	PF00400	0.579
DEG_SCF_FBW7_1	568	574	PF00400	0.643
DEG_SPOP_SBC_1	562	566	PF00917	0.651
DOC_CKS1_1	111	116	PF01111	0.760
DOC_CKS1_1	568	573	PF01111	0.722
DOC_MAPK_gen_1	336	345	PF00069	0.478
DOC_MAPK_MEF2A_6	336	345	PF00069	0.481
DOC_PP2B_PxIxI_1	805	811	PF00149	0.497
DOC_PP4_FxxP_1	467	470	PF00568	0.574
DOC_USP7_MATH_1	414	418	PF00917	0.615
DOC_USP7_MATH_1	494	498	PF00917	0.739
DOC_USP7_MATH_1	524	528	PF00917	0.568
DOC_USP7_MATH_1	535	539	PF00917	0.665
DOC_USP7_MATH_1	585	589	PF00917	0.714
DOC_USP7_MATH_1	714	718	PF00917	0.665
DOC_USP7_MATH_1	798	802	PF00917	0.685
DOC_USP7_MATH_1	838	842	PF00917	0.645
DOC_USP7_UBL2_3	155	159	PF12436	0.529
DOC_USP7_UBL2_3	28	32	PF12436	0.589
DOC_USP7_UBL2_3	97	101	PF12436	0.676
DOC_WW_Pin1_4	107	112	PF00397	0.750
DOC_WW_Pin1_4	119	124	PF00397	0.646
DOC_WW_Pin1_4	127	132	PF00397	0.630
DOC_WW_Pin1_4	134	139	PF00397	0.570
DOC_WW_Pin1_4	5	10	PF00397	0.655
DOC_WW_Pin1_4	564	569	PF00397	0.706
LIG_14-3-3_CanoR_1	192	199	PF00244	0.492
LIG_14-3-3_CanoR_1	229	235	PF00244	0.729
LIG_14-3-3_CanoR_1	248	252	PF00244	0.443
LIG_14-3-3_CanoR_1	274	283	PF00244	0.656
LIG_14-3-3_CanoR_1	450	456	PF00244	0.622
LIG_14-3-3_CanoR_1	536	542	PF00244	0.682
LIG_14-3-3_CanoR_1	553	562	PF00244	0.660
LIG_14-3-3_CanoR_1	597	603	PF00244	0.625
LIG_14-3-3_CanoR_1	638	642	PF00244	0.575
LIG_14-3-3_CanoR_1	665	671	PF00244	0.672
LIG_14-3-3_CanoR_1	682	688	PF00244	0.769
LIG_14-3-3_CanoR_1	829	838	PF00244	0.569
LIG_Actin_WH2_2	383	400	PF00022	0.497
LIG_Actin_WH2_2	526	544	PF00022	0.558
LIG_APCC_ABBA_1	344	349	PF00400	0.500
LIG_APCC_ABBAyCdc20_2	440	446	PF00400	0.605
LIG_BH_BH3_1	304	320	PF00452	0.362
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_4	487	491	PF00653	0.640
LIG_BIR_III_4	698	702	PF00653	0.585
LIG_BRCT_BRCA1_1	498	502	PF00533	0.542
LIG_CaM_IQ_9	808	823	PF13499	0.530
LIG_eIF4E_1	14	20	PF01652	0.573
LIG_FHA_1	111	117	PF00498	0.615
LIG_FHA_1	185	191	PF00498	0.590
LIG_FHA_1	528	534	PF00498	0.662
LIG_FHA_1	568	574	PF00498	0.685
LIG_FHA_1	740	746	PF00498	0.622
LIG_FHA_1	755	761	PF00498	0.615
LIG_FHA_2	104	110	PF00498	0.695
LIG_FHA_2	199	205	PF00498	0.679
LIG_FHA_2	212	218	PF00498	0.556
LIG_FHA_2	248	254	PF00498	0.459
LIG_FHA_2	276	282	PF00498	0.562
LIG_FHA_2	284	290	PF00498	0.491
LIG_FHA_2	400	406	PF00498	0.467
LIG_FHA_2	518	524	PF00498	0.707
LIG_FHA_2	717	723	PF00498	0.648
LIG_FHA_2	809	815	PF00498	0.511
LIG_HP1_1	341	345	PF01393	0.466
LIG_IBAR_NPY_1	604	606	PF08397	0.521
LIG_IRF3_LxIS_1	494	501	PF10401	0.619
LIG_LIR_Apic_2	291	297	PF02991	0.553
LIG_LIR_Apic_2	601	605	PF02991	0.513
LIG_LIR_Gen_1	640	648	PF02991	0.587
LIG_LIR_Gen_1	673	680	PF02991	0.677
LIG_LIR_Gen_1	685	695	PF02991	0.532
LIG_LIR_Nem_3	137	142	PF02991	0.632
LIG_LIR_Nem_3	217	221	PF02991	0.648
LIG_LIR_Nem_3	640	644	PF02991	0.585
LIG_LIR_Nem_3	673	677	PF02991	0.684
LIG_LIR_Nem_3	844	849	PF02991	0.546
LIG_MYND_3	345	349	PF01753	0.427
LIG_NRBOX	760	766	PF00104	0.482
LIG_Pex14_1	602	606	PF04695	0.520
LIG_SH2_CRK	266	270	PF00017	0.584
LIG_SH2_CRK	294	298	PF00017	0.524
LIG_SH2_NCK_1	266	270	PF00017	0.584
LIG_SH2_NCK_1	504	508	PF00017	0.650
LIG_SH2_STAP1	199	203	PF00017	0.601
LIG_SH2_STAT3	157	160	PF00017	0.542
LIG_SH2_STAT3	611	614	PF00017	0.599
LIG_SH2_STAT5	14	17	PF00017	0.590
LIG_SH2_STAT5	157	160	PF00017	0.457
LIG_SH2_STAT5	23	26	PF00017	0.474
LIG_SH2_STAT5	314	317	PF00017	0.464
LIG_SH2_STAT5	430	433	PF00017	0.473
LIG_SH2_STAT5	466	469	PF00017	0.538
LIG_SH2_STAT5	504	507	PF00017	0.607
LIG_SH2_STAT5	606	609	PF00017	0.543
LIG_SH2_STAT5	611	614	PF00017	0.513
LIG_SH2_STAT5	830	833	PF00017	0.619
LIG_SH3_3	108	114	PF00018	0.802
LIG_SH3_3	117	123	PF00018	0.681
LIG_SH3_3	293	299	PF00018	0.469
LIG_SH3_3	340	346	PF00018	0.487
LIG_SH3_3	471	477	PF00018	0.615
LIG_SH3_3	565	571	PF00018	0.716
LIG_SH3_3	6	12	PF00018	0.667
LIG_SH3_3	700	706	PF00018	0.679
LIG_SH3_3	800	806	PF00018	0.556
LIG_SUMO_SIM_anti_2	340	346	PF11976	0.463
LIG_SUMO_SIM_par_1	178	185	PF11976	0.546
LIG_TRAF2_1	202	205	PF00917	0.639
LIG_TRAF2_1	410	413	PF00917	0.496
LIG_TRAF2_1	520	523	PF00917	0.651
LIG_UBA3_1	243	252	PF00899	0.484
LIG_UBA3_1	344	353	PF00899	0.394
LIG_UBA3_1	764	771	PF00899	0.491
LIG_WRC_WIRS_1	674	679	PF05994	0.694
LIG_WW_1	11	14	PF00397	0.611
MOD_CDC14_SPxK_1	130	133	PF00782	0.718
MOD_CDK_SPxK_1	127	133	PF00069	0.723
MOD_CK1_1	198	204	PF00069	0.615
MOD_CK1_1	2	8	PF00069	0.824
MOD_CK1_1	449	455	PF00069	0.557
MOD_CK1_1	496	502	PF00069	0.586
MOD_CK1_1	527	533	PF00069	0.582
MOD_CK1_1	566	572	PF00069	0.703
MOD_CK1_1	574	580	PF00069	0.594
MOD_CK1_1	673	679	PF00069	0.693
MOD_CK1_1	715	721	PF00069	0.788
MOD_CK1_1	723	729	PF00069	0.622
MOD_CK1_1	767	773	PF00069	0.612
MOD_CK1_1	841	847	PF00069	0.602
MOD_CK2_1	198	204	PF00069	0.727
MOD_CK2_1	230	236	PF00069	0.555
MOD_CK2_1	247	253	PF00069	0.380
MOD_CK2_1	275	281	PF00069	0.597
MOD_CK2_1	283	289	PF00069	0.504
MOD_CK2_1	386	392	PF00069	0.437
MOD_CK2_1	450	456	PF00069	0.536
MOD_CK2_1	517	523	PF00069	0.712
MOD_CK2_1	644	650	PF00069	0.548
MOD_CK2_1	716	722	PF00069	0.651
MOD_CK2_1	808	814	PF00069	0.538
MOD_Cter_Amidation	784	787	PF01082	0.665
MOD_GlcNHglycan	36	39	PF01048	0.666
MOD_GlcNHglycan	459	462	PF01048	0.623
MOD_GlcNHglycan	467	470	PF01048	0.564
MOD_GlcNHglycan	633	636	PF01048	0.724
MOD_GlcNHglycan	653	656	PF01048	0.511
MOD_GlcNHglycan	678	681	PF01048	0.556
MOD_GlcNHglycan	725	728	PF01048	0.672
MOD_GlcNHglycan	792	795	PF01048	0.692
MOD_GlcNHglycan	862	868	PF01048	0.543
MOD_GSK3_1	103	110	PF00069	0.646
MOD_GSK3_1	180	187	PF00069	0.542
MOD_GSK3_1	195	202	PF00069	0.599
MOD_GSK3_1	207	214	PF00069	0.637
MOD_GSK3_1	265	272	PF00069	0.694
MOD_GSK3_1	330	337	PF00069	0.508
MOD_GSK3_1	446	453	PF00069	0.556
MOD_GSK3_1	494	501	PF00069	0.596
MOD_GSK3_1	518	525	PF00069	0.597
MOD_GSK3_1	527	534	PF00069	0.618
MOD_GSK3_1	537	544	PF00069	0.633
MOD_GSK3_1	553	560	PF00069	0.645
MOD_GSK3_1	562	569	PF00069	0.666
MOD_GSK3_1	666	673	PF00069	0.647
MOD_GSK3_1	712	719	PF00069	0.652
MOD_GSK3_1	730	737	PF00069	0.562
MOD_GSK3_1	760	767	PF00069	0.495
MOD_GSK3_1	77	84	PF00069	0.612
MOD_GSK3_1	786	793	PF00069	0.627
MOD_GSK3_1	794	801	PF00069	0.588
MOD_GSK3_1	833	840	PF00069	0.572
MOD_N-GLC_1	798	803	PF02516	0.582
MOD_NEK2_1	247	252	PF00069	0.437
MOD_NEK2_1	254	259	PF00069	0.492
MOD_NEK2_1	302	307	PF00069	0.529
MOD_NEK2_1	315	320	PF00069	0.369
MOD_NEK2_1	397	402	PF00069	0.507
MOD_NEK2_1	498	503	PF00069	0.662
MOD_NEK2_1	541	546	PF00069	0.728
MOD_NEK2_1	563	568	PF00069	0.680
MOD_NEK2_1	690	695	PF00069	0.741
MOD_NEK2_1	734	739	PF00069	0.582
MOD_NEK2_1	760	765	PF00069	0.531
MOD_NEK2_1	820	825	PF00069	0.537
MOD_NEK2_2	537	542	PF00069	0.616
MOD_NEK2_2	548	553	PF00069	0.635
MOD_PIKK_1	192	198	PF00454	0.500
MOD_PIKK_1	55	61	PF00454	0.502
MOD_PIKK_1	808	814	PF00454	0.648
MOD_PK_1	439	445	PF00069	0.545
MOD_PKA_1	192	198	PF00069	0.500
MOD_PKA_1	274	280	PF00069	0.543
MOD_PKA_1	439	445	PF00069	0.570
MOD_PKA_1	786	792	PF00069	0.667
MOD_PKA_2	192	198	PF00069	0.490
MOD_PKA_2	247	253	PF00069	0.424
MOD_PKA_2	274	280	PF00069	0.610
MOD_PKA_2	397	403	PF00069	0.504
MOD_PKA_2	439	445	PF00069	0.570
MOD_PKA_2	449	455	PF00069	0.519
MOD_PKA_2	535	541	PF00069	0.696
MOD_PKA_2	637	643	PF00069	0.560
MOD_PKA_2	786	792	PF00069	0.667
MOD_PKA_2	820	826	PF00069	0.522
MOD_PKA_2	841	847	PF00069	0.675
MOD_Plk_1	494	500	PF00069	0.558
MOD_Plk_1	798	804	PF00069	0.611
MOD_Plk_2-3	386	392	PF00069	0.416
MOD_Plk_4	165	171	PF00069	0.474
MOD_Plk_4	283	289	PF00069	0.504
MOD_Plk_4	414	420	PF00069	0.450
MOD_Plk_4	439	445	PF00069	0.562
MOD_Plk_4	475	481	PF00069	0.590
MOD_Plk_4	488	494	PF00069	0.566
MOD_Plk_4	670	676	PF00069	0.644
MOD_Plk_4	760	766	PF00069	0.492
MOD_Plk_4	798	804	PF00069	0.619
MOD_Plk_4	841	847	PF00069	0.602
MOD_ProDKin_1	107	113	PF00069	0.748
MOD_ProDKin_1	119	125	PF00069	0.648
MOD_ProDKin_1	127	133	PF00069	0.652
MOD_ProDKin_1	134	140	PF00069	0.567
MOD_ProDKin_1	5	11	PF00069	0.651
MOD_ProDKin_1	564	570	PF00069	0.705
MOD_SUMO_rev_2	399	408	PF00179	0.433
MOD_SUMO_rev_2	412	417	PF00179	0.429
MOD_SUMO_rev_2	717	726	PF00179	0.569
MOD_SUMO_rev_2	809	818	PF00179	0.574
MOD_SUMO_rev_2	84	94	PF00179	0.585
TRG_DiLeu_BaEn_1	392	397	PF01217	0.422
TRG_DiLeu_BaEn_1	52	57	PF01217	0.495
TRG_DiLeu_BaEn_4	52	58	PF01217	0.499
TRG_DiLeu_BaLyEn_6	512	517	PF01217	0.618
TRG_DiLeu_BaLyEn_6	589	594	PF01217	0.557
TRG_DiLeu_LyEn_5	52	57	PF01217	0.553
TRG_ENDOCYTIC_2	266	269	PF00928	0.586
TRG_ENDOCYTIC_2	687	690	PF00928	0.623
TRG_ER_diArg_1	192	194	PF00400	0.522
TRG_ER_diArg_1	273	275	PF00400	0.608
TRG_ER_diArg_1	335	338	PF00400	0.493
TRG_ER_diArg_1	39	42	PF00400	0.589
TRG_ER_diArg_1	552	555	PF00400	0.634
TRG_ER_diArg_1	61	64	PF00400	0.519
TRG_NES_CRM1_1	143	156	PF08389	0.587
TRG_NLS_MonoExtN_4	605	612	PF00514	0.542
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.577
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	592	596	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	657	662	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6A7	Leptomonas seymouri	40%	100%
A4HKJ4	Leishmania braziliensis	60%	100%
A4I826	Leishmania infantum	100%	100%
E9B2Y4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q572	Leishmania major	89%	100%