TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH12_LEIDO

TriTrypDb:

LdBPK_091220.1 , LdCL_090018600 , LDHU3_09.1450

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3Q8IH12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH12

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.671
CLV_C14_Caspase3-7	265	269	PF00656	0.585
CLV_C14_Caspase3-7	452	456	PF00656	0.738
CLV_NRD_NRD_1	166	168	PF00675	0.477
CLV_NRD_NRD_1	21	23	PF00675	0.464
CLV_NRD_NRD_1	342	344	PF00675	0.577
CLV_NRD_NRD_1	479	481	PF00675	0.539
CLV_NRD_NRD_1	52	54	PF00675	0.600
CLV_NRD_NRD_1	678	680	PF00675	0.686
CLV_NRD_NRD_1	718	720	PF00675	0.700
CLV_NRD_NRD_1	73	75	PF00675	0.586
CLV_PCSK_FUR_1	676	680	PF00082	0.664
CLV_PCSK_KEX2_1	20	22	PF00082	0.564
CLV_PCSK_KEX2_1	290	292	PF00082	0.541
CLV_PCSK_KEX2_1	479	481	PF00082	0.535
CLV_PCSK_KEX2_1	678	680	PF00082	0.661
CLV_PCSK_KEX2_1	718	720	PF00082	0.728
CLV_PCSK_KEX2_1	73	75	PF00082	0.586
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.547
CLV_PCSK_SKI1_1	194	198	PF00082	0.517
CLV_PCSK_SKI1_1	21	25	PF00082	0.461
CLV_PCSK_SKI1_1	214	218	PF00082	0.468
CLV_PCSK_SKI1_1	287	291	PF00082	0.610
CLV_PCSK_SKI1_1	430	434	PF00082	0.459
CLV_PCSK_SKI1_1	462	466	PF00082	0.532
CLV_PCSK_SKI1_1	482	486	PF00082	0.559
CLV_PCSK_SKI1_1	59	63	PF00082	0.421
CLV_PCSK_SKI1_1	617	621	PF00082	0.523
CLV_PCSK_SKI1_1	98	102	PF00082	0.416
DEG_APCC_DBOX_1	549	557	PF00400	0.809
DEG_APCC_DBOX_1	635	643	PF00400	0.551
DEG_Nend_UBRbox_3	1	3	PF02207	0.766
DEG_SPOP_SBC_1	464	468	PF00917	0.775
DOC_ANK_TNKS_1	72	79	PF00023	0.718
DOC_CYCLIN_yCln2_LP_2	642	648	PF00134	0.429
DOC_MAPK_gen_1	167	176	PF00069	0.681
DOC_MAPK_gen_1	428	435	PF00069	0.672
DOC_MAPK_gen_1	726	735	PF00069	0.552
DOC_MAPK_HePTP_8	164	176	PF00069	0.714
DOC_MAPK_MEF2A_6	167	176	PF00069	0.657
DOC_MAPK_MEF2A_6	428	435	PF00069	0.683
DOC_PP1_RVXF_1	57	64	PF00149	0.630
DOC_PP2B_LxvP_1	642	645	PF13499	0.429
DOC_PP4_FxxP_1	186	189	PF00568	0.684
DOC_USP7_MATH_1	15	19	PF00917	0.777
DOC_USP7_MATH_1	361	365	PF00917	0.715
DOC_USP7_MATH_1	464	468	PF00917	0.786
DOC_USP7_UBL2_3	410	414	PF12436	0.719
DOC_USP7_UBL2_3	485	489	PF12436	0.716
DOC_USP7_UBL2_3	529	533	PF12436	0.649
DOC_WW_Pin1_4	274	279	PF00397	0.788
DOC_WW_Pin1_4	280	285	PF00397	0.781
DOC_WW_Pin1_4	554	559	PF00397	0.781
DOC_WW_Pin1_4	82	87	PF00397	0.748
LIG_14-3-3_CanoR_1	20	29	PF00244	0.782
LIG_14-3-3_CanoR_1	231	237	PF00244	0.805
LIG_14-3-3_CanoR_1	343	347	PF00244	0.750
LIG_BRCT_BRCA1_1	119	123	PF00533	0.605
LIG_BRCT_BRCA1_1	92	96	PF00533	0.668
LIG_Clathr_ClatBox_1	175	179	PF01394	0.645
LIG_CSL_BTD_1	642	645	PF09270	0.429
LIG_FHA_1	159	165	PF00498	0.773
LIG_FHA_1	471	477	PF00498	0.771
LIG_FHA_2	326	332	PF00498	0.635
LIG_FHA_2	495	501	PF00498	0.747
LIG_FHA_2	600	606	PF00498	0.673
LIG_LIR_Apic_2	202	208	PF02991	0.779
LIG_LIR_Gen_1	130	141	PF02991	0.731
LIG_LIR_Gen_1	308	319	PF02991	0.695
LIG_LIR_Gen_1	416	427	PF02991	0.661
LIG_LIR_Gen_1	584	594	PF02991	0.662
LIG_LIR_Nem_3	130	136	PF02991	0.728
LIG_LIR_Nem_3	308	314	PF02991	0.660
LIG_LIR_Nem_3	331	337	PF02991	0.635
LIG_LIR_Nem_3	416	422	PF02991	0.650
LIG_LIR_Nem_3	584	590	PF02991	0.664
LIG_LIR_Nem_3	60	66	PF02991	0.634
LIG_LIR_Nem_3	633	638	PF02991	0.686
LIG_LIR_Nem_3	656	660	PF02991	0.475
LIG_LIR_Nem_3	661	665	PF02991	0.381
LIG_LYPXL_yS_3	574	577	PF13949	0.737
LIG_MYND_1	554	558	PF01753	0.813
LIG_NRBOX	171	177	PF00104	0.665
LIG_NRBOX	684	690	PF00104	0.443
LIG_Pex14_1	333	337	PF04695	0.638
LIG_Pex14_2	186	190	PF04695	0.674
LIG_Pex14_2	62	66	PF04695	0.672
LIG_Pex14_2	96	100	PF04695	0.671
LIG_SH2_CRK	587	591	PF00017	0.593
LIG_SH2_GRB2like	336	339	PF00017	0.709
LIG_SH2_GRB2like	638	641	PF00017	0.444
LIG_SH2_SRC	379	382	PF00017	0.763
LIG_SH2_SRC	625	628	PF00017	0.661
LIG_SH2_SRC	638	641	PF00017	0.444
LIG_SH2_STAP1	587	591	PF00017	0.593
LIG_SH2_STAP1	92	96	PF00017	0.719
LIG_SH2_STAT3	359	362	PF00017	0.757
LIG_SH2_STAT3	492	495	PF00017	0.793
LIG_SH2_STAT3	72	75	PF00017	0.797
LIG_SH2_STAT3	92	95	PF00017	0.637
LIG_SH2_STAT5	133	136	PF00017	0.655
LIG_SH2_STAT5	406	409	PF00017	0.638
LIG_SH2_STAT5	597	600	PF00017	0.694
LIG_SH2_STAT5	618	621	PF00017	0.736
LIG_SH2_STAT5	638	641	PF00017	0.441
LIG_SH3_1	291	297	PF00018	0.726
LIG_SH3_2	294	299	PF14604	0.733
LIG_SH3_3	234	240	PF00018	0.748
LIG_SH3_3	278	284	PF00018	0.787
LIG_SH3_3	291	297	PF00018	0.635
LIG_SH3_3	548	554	PF00018	0.719
LIG_SUMO_SIM_par_1	221	230	PF11976	0.766
LIG_SUMO_SIM_par_1	325	331	PF11976	0.682
LIG_TRAF2_1	497	500	PF00917	0.777
LIG_TYR_ITIM	404	409	PF00017	0.729
LIG_UBA3_1	422	430	PF00899	0.705
LIG_UBA3_1	530	535	PF00899	0.699
LIG_WW_2	551	554	PF00397	0.769
MOD_CDK_SPxxK_3	280	287	PF00069	0.790
MOD_CK1_1	227	233	PF00069	0.759
MOD_CK1_1	277	283	PF00069	0.825
MOD_CK1_1	467	473	PF00069	0.811
MOD_CK1_1	566	572	PF00069	0.728
MOD_CK1_1	6	12	PF00069	0.781
MOD_CK2_1	230	236	PF00069	0.787
MOD_CK2_1	494	500	PF00069	0.779
MOD_CK2_1	599	605	PF00069	0.692
MOD_Cter_Amidation	51	54	PF01082	0.601
MOD_Cter_Amidation	727	730	PF01082	0.752
MOD_GlcNHglycan	232	235	PF01048	0.598
MOD_GlcNHglycan	268	271	PF01048	0.400
MOD_GlcNHglycan	30	33	PF01048	0.592
MOD_GlcNHglycan	347	350	PF01048	0.565
MOD_GlcNHglycan	401	404	PF01048	0.542
MOD_GlcNHglycan	451	454	PF01048	0.542
MOD_GlcNHglycan	50	53	PF01048	0.574
MOD_GlcNHglycan	587	590	PF01048	0.431
MOD_GlcNHglycan	87	90	PF01048	0.490
MOD_GlcNHglycan	9	12	PF01048	0.606
MOD_GSK3_1	2	9	PF00069	0.749
MOD_GSK3_1	462	469	PF00069	0.808
MOD_GSK3_1	511	518	PF00069	0.703
MOD_GSK3_1	713	720	PF00069	0.522
MOD_GSK3_1	77	84	PF00069	0.754
MOD_LATS_1	544	550	PF00433	0.769
MOD_N-GLC_1	698	703	PF02516	0.699
MOD_N-GLC_1	706	711	PF02516	0.704
MOD_N-GLC_1	713	718	PF02516	0.728
MOD_NEK2_1	1	6	PF00069	0.808
MOD_NEK2_1	342	347	PF00069	0.742
MOD_NEK2_1	399	404	PF00069	0.704
MOD_NEK2_1	418	423	PF00069	0.743
MOD_NEK2_1	463	468	PF00069	0.732
MOD_NEK2_1	511	516	PF00069	0.692
MOD_NEK2_1	706	711	PF00069	0.518
MOD_NEK2_1	713	718	PF00069	0.456
MOD_NEK2_2	15	20	PF00069	0.804
MOD_PIKK_1	21	27	PF00454	0.815
MOD_PIKK_1	342	348	PF00454	0.704
MOD_PKA_1	21	27	PF00069	0.662
MOD_PKA_1	718	724	PF00069	0.494
MOD_PKA_2	158	164	PF00069	0.749
MOD_PKA_2	21	27	PF00069	0.759
MOD_PKA_2	230	236	PF00069	0.803
MOD_PKA_2	342	348	PF00069	0.740
MOD_PKA_2	373	379	PF00069	0.772
MOD_PKA_2	717	723	PF00069	0.525
MOD_Plk_1	566	572	PF00069	0.737
MOD_Plk_1	706	712	PF00069	0.512
MOD_Plk_1	713	719	PF00069	0.532
MOD_Plk_4	117	123	PF00069	0.670
MOD_Plk_4	136	142	PF00069	0.494
MOD_Plk_4	325	331	PF00069	0.647
MOD_Plk_4	418	424	PF00069	0.683
MOD_Plk_4	630	636	PF00069	0.650
MOD_Plk_4	653	659	PF00069	0.362
MOD_ProDKin_1	274	280	PF00069	0.788
MOD_ProDKin_1	554	560	PF00069	0.782
MOD_ProDKin_1	82	88	PF00069	0.743
MOD_SUMO_rev_2	162	169	PF00179	0.668
TRG_DiLeu_BaEn_1	526	531	PF01217	0.684
TRG_DiLeu_BaEn_4	626	632	PF01217	0.682
TRG_DiLeu_BaLyEn_6	642	647	PF01217	0.444
TRG_ENDOCYTIC_2	104	107	PF00928	0.612
TRG_ENDOCYTIC_2	133	136	PF00928	0.655
TRG_ENDOCYTIC_2	336	339	PF00928	0.680
TRG_ENDOCYTIC_2	406	409	PF00928	0.654
TRG_ENDOCYTIC_2	415	418	PF00928	0.693
TRG_ENDOCYTIC_2	574	577	PF00928	0.725
TRG_ENDOCYTIC_2	587	590	PF00928	0.617
TRG_ENDOCYTIC_2	657	660	PF00928	0.549
TRG_ER_diArg_1	19	22	PF00400	0.777
TRG_ER_diArg_1	43	46	PF00400	0.751
TRG_ER_diArg_1	479	482	PF00400	0.737
TRG_ER_diArg_1	676	679	PF00400	0.453
TRG_ER_diArg_1	717	719	PF00400	0.527
TRG_ER_diArg_1	72	74	PF00400	0.779
TRG_NLS_Bipartite_1	718	733	PF00514	0.414
TRG_NLS_MonoExtC_3	728	734	PF00514	0.430
TRG_NLS_MonoExtN_4	726	733	PF00514	0.427
TRG_Pf-PMV_PEXEL_1	424	429	PF00026	0.532
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTV6	Leptomonas seymouri	54%	100%
A0A0S4JUS6	Bodo saltans	24%	100%
A0A422NZM2	Trypanosoma rangeli	30%	100%
A4H5U4	Leishmania braziliensis	77%	100%
A4HU38	Leishmania infantum	100%	100%
E9AMW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4QHQ9	Leishmania major	94%	100%
V5DEB6	Trypanosoma cruzi	33%	100%