Tubulin-tyrosine_ligase-like_protein/GeneDB:LmjF. 32.2930

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tubulin-tyrosine ligase-like protein

Species:

Leishmania donovani

UniProt:

A0A3Q8IH06_LEIDO

TriTrypDb:

LdBPK_323080.1 , LdCL_320036800 , LDHU3_32.3860

Length:

638

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	1
GO:0005876	spindle microtubule	7	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IH06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH06

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004835	tubulin-tyrosine ligase activity	3	6
GO:0016874	ligase activity	2	9
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	6
GO:0016881	acid-amino acid ligase activity	4	6
GO:0140096	catalytic activity, acting on a protein	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	456	460	PF00656	0.499
CLV_NRD_NRD_1	209	211	PF00675	0.415
CLV_NRD_NRD_1	227	229	PF00675	0.591
CLV_NRD_NRD_1	382	384	PF00675	0.275
CLV_NRD_NRD_1	72	74	PF00675	0.676
CLV_NRD_NRD_1	8	10	PF00675	0.725
CLV_PCSK_KEX2_1	125	127	PF00082	0.720
CLV_PCSK_KEX2_1	135	137	PF00082	0.561
CLV_PCSK_KEX2_1	209	211	PF00082	0.415
CLV_PCSK_KEX2_1	214	216	PF00082	0.478
CLV_PCSK_KEX2_1	227	229	PF00082	0.591
CLV_PCSK_KEX2_1	382	384	PF00082	0.274
CLV_PCSK_KEX2_1	628	630	PF00082	0.479
CLV_PCSK_KEX2_1	72	74	PF00082	0.761
CLV_PCSK_KEX2_1	8	10	PF00082	0.725
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.701
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.550
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.570
CLV_PCSK_PC1ET2_1	382	384	PF00082	0.339
CLV_PCSK_PC1ET2_1	628	630	PF00082	0.507
CLV_PCSK_PC7_1	210	216	PF00082	0.539
CLV_PCSK_SKI1_1	118	122	PF00082	0.759
CLV_PCSK_SKI1_1	125	129	PF00082	0.586
CLV_PCSK_SKI1_1	156	160	PF00082	0.452
CLV_PCSK_SKI1_1	263	267	PF00082	0.380
CLV_PCSK_SKI1_1	350	354	PF00082	0.339
CLV_PCSK_SKI1_1	376	380	PF00082	0.302
CLV_PCSK_SKI1_1	469	473	PF00082	0.305
CLV_PCSK_SKI1_1	603	607	PF00082	0.498
DEG_APCC_DBOX_1	349	357	PF00400	0.564
DEG_APCC_DBOX_1	454	462	PF00400	0.499
DEG_APCC_DBOX_1	504	512	PF00400	0.493
DEG_SCF_FBW7_1	296	301	PF00400	0.517
DEG_SPOP_SBC_1	105	109	PF00917	0.720
DEG_SPOP_SBC_1	81	85	PF00917	0.804
DOC_CYCLIN_RxL_1	153	161	PF00134	0.486
DOC_CYCLIN_RxL_1	350	361	PF00134	0.542
DOC_CYCLIN_yClb5_NLxxxL_5	580	589	PF00134	0.413
DOC_MAPK_gen_1	626	636	PF00069	0.499
DOC_MAPK_MEF2A_6	234	243	PF00069	0.631
DOC_MAPK_MEF2A_6	608	615	PF00069	0.456
DOC_MAPK_NFAT4_5	608	616	PF00069	0.457
DOC_PP1_RVXF_1	252	259	PF00149	0.485
DOC_PP1_RVXF_1	352	359	PF00149	0.539
DOC_PP1_SILK_1	350	355	PF00149	0.564
DOC_PP2B_LxvP_1	241	244	PF13499	0.593
DOC_USP7_MATH_1	13	17	PF00917	0.652
DOC_USP7_MATH_1	230	234	PF00917	0.655
DOC_USP7_MATH_1	244	248	PF00917	0.392
DOC_USP7_MATH_1	298	302	PF00917	0.564
DOC_USP7_MATH_1	3	7	PF00917	0.755
DOC_USP7_MATH_1	331	335	PF00917	0.482
DOC_USP7_MATH_1	514	518	PF00917	0.441
DOC_USP7_MATH_1	555	559	PF00917	0.484
DOC_USP7_MATH_1	71	75	PF00917	0.779
DOC_USP7_MATH_1	81	85	PF00917	0.568
DOC_WW_Pin1_4	235	240	PF00397	0.688
DOC_WW_Pin1_4	294	299	PF00397	0.517
DOC_WW_Pin1_4	31	36	PF00397	0.674
DOC_WW_Pin1_4	421	426	PF00397	0.562
DOC_WW_Pin1_4	476	481	PF00397	0.549
DOC_WW_Pin1_4	49	54	PF00397	0.627
DOC_WW_Pin1_4	82	87	PF00397	0.640
LIG_14-3-3_CanoR_1	118	123	PF00244	0.681
LIG_14-3-3_CanoR_1	12	21	PF00244	0.697
LIG_14-3-3_CanoR_1	163	169	PF00244	0.414
LIG_14-3-3_CanoR_1	170	175	PF00244	0.471
LIG_14-3-3_CanoR_1	234	239	PF00244	0.659
LIG_14-3-3_CanoR_1	24	29	PF00244	0.703
LIG_14-3-3_CanoR_1	263	268	PF00244	0.381
LIG_14-3-3_CanoR_1	409	414	PF00244	0.474
LIG_14-3-3_CanoR_1	524	529	PF00244	0.531
LIG_14-3-3_CanoR_1	72	76	PF00244	0.626
LIG_14-3-3_CanoR_1	96	101	PF00244	0.678
LIG_Actin_WH2_2	252	270	PF00022	0.393
LIG_APCC_ABBA_1	400	405	PF00400	0.499
LIG_APCC_ABBA_1	526	531	PF00400	0.433
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_CaM_NSCaTE_8	588	595	PF13499	0.418
LIG_eIF4E_1	373	379	PF01652	0.474
LIG_eIF4E_1	401	407	PF01652	0.474
LIG_FHA_1	119	125	PF00498	0.707
LIG_FHA_1	173	179	PF00498	0.496
LIG_FHA_1	260	266	PF00498	0.437
LIG_FHA_1	271	277	PF00498	0.539
LIG_FHA_1	408	414	PF00498	0.523
LIG_FHA_1	424	430	PF00498	0.441
LIG_FHA_1	532	538	PF00498	0.517
LIG_FHA_1	569	575	PF00498	0.457
LIG_FHA_1	608	614	PF00498	0.377
LIG_FHA_1	620	626	PF00498	0.484
LIG_FHA_2	129	135	PF00498	0.633
LIG_FHA_2	181	187	PF00498	0.493
LIG_FHA_2	86	92	PF00498	0.620
LIG_Integrin_RGD_1	346	348	PF01839	0.317
LIG_Integrin_RGD_1	491	493	PF01839	0.317
LIG_LIR_Apic_2	233	239	PF02991	0.621
LIG_LIR_Gen_1	149	159	PF02991	0.405
LIG_LIR_Gen_1	161	169	PF02991	0.362
LIG_LIR_Gen_1	569	580	PF02991	0.353
LIG_LIR_LC3C_4	175	180	PF02991	0.488
LIG_LIR_Nem_3	161	167	PF02991	0.403
LIG_LIR_Nem_3	348	352	PF02991	0.577
LIG_LIR_Nem_3	396	401	PF02991	0.485
LIG_LIR_Nem_3	441	447	PF02991	0.484
LIG_LIR_Nem_3	476	481	PF02991	0.517
LIG_LIR_Nem_3	569	575	PF02991	0.365
LIG_Pex14_2	575	579	PF04695	0.374
LIG_SH2_CRK	236	240	PF00017	0.603
LIG_SH2_CRK	25	29	PF00017	0.652
LIG_SH2_CRK	349	353	PF00017	0.564
LIG_SH2_CRK	478	482	PF00017	0.517
LIG_SH2_CRK	577	581	PF00017	0.349
LIG_SH2_GRB2like	500	503	PF00017	0.517
LIG_SH2_NCK_1	236	240	PF00017	0.603
LIG_SH2_NCK_1	25	29	PF00017	0.622
LIG_SH2_PTP2	633	636	PF00017	0.418
LIG_SH2_SRC	447	450	PF00017	0.539
LIG_SH2_STAP1	151	155	PF00017	0.451
LIG_SH2_STAP1	398	402	PF00017	0.474
LIG_SH2_STAP1	577	581	PF00017	0.344
LIG_SH2_STAT5	139	142	PF00017	0.432
LIG_SH2_STAT5	236	239	PF00017	0.609
LIG_SH2_STAT5	289	292	PF00017	0.474
LIG_SH2_STAT5	373	376	PF00017	0.517
LIG_SH2_STAT5	401	404	PF00017	0.474
LIG_SH2_STAT5	478	481	PF00017	0.517
LIG_SH2_STAT5	618	621	PF00017	0.539
LIG_SH2_STAT5	633	636	PF00017	0.226
LIG_SH3_2	486	491	PF14604	0.517
LIG_SH3_2	596	601	PF14604	0.515
LIG_SH3_3	371	377	PF00018	0.564
LIG_SH3_3	483	489	PF00018	0.525
LIG_SH3_3	491	497	PF00018	0.525
LIG_SH3_3	558	564	PF00018	0.547
LIG_SH3_3	593	599	PF00018	0.491
LIG_SH3_3	614	620	PF00018	0.366
LIG_SUMO_SIM_par_1	524	531	PF11976	0.537
LIG_SUMO_SIM_par_1	533	538	PF11976	0.514
LIG_TRFH_1	294	298	PF08558	0.539
MOD_CDK_SPK_2	480	485	PF00069	0.525
MOD_CDK_SPxxK_3	235	242	PF00069	0.673
MOD_CDK_SPxxK_3	421	428	PF00069	0.564
MOD_CK1_1	165	171	PF00069	0.575
MOD_CK1_1	235	241	PF00069	0.718
MOD_CK1_1	270	276	PF00069	0.474
MOD_CK1_1	419	425	PF00069	0.541
MOD_CK1_1	501	507	PF00069	0.538
MOD_CK1_1	517	523	PF00069	0.436
MOD_CK1_1	52	58	PF00069	0.608
MOD_CK1_1	67	73	PF00069	0.525
MOD_CK1_1	82	88	PF00069	0.601
MOD_CK1_1	98	104	PF00069	0.645
MOD_CK2_1	1	7	PF00069	0.725
MOD_CK2_1	111	117	PF00069	0.773
MOD_CK2_1	128	134	PF00069	0.497
MOD_CK2_1	146	152	PF00069	0.354
MOD_CK2_1	299	305	PF00069	0.597
MOD_CK2_1	442	448	PF00069	0.477
MOD_CK2_1	85	91	PF00069	0.657
MOD_Cter_Amidation	38	41	PF01082	0.643
MOD_GlcNHglycan	1	4	PF01048	0.706
MOD_GlcNHglycan	113	116	PF01048	0.654
MOD_GlcNHglycan	128	131	PF01048	0.592
MOD_GlcNHglycan	246	249	PF01048	0.510
MOD_GlcNHglycan	29	32	PF01048	0.678
MOD_GlcNHglycan	333	336	PF01048	0.302
MOD_GlcNHglycan	418	421	PF01048	0.291
MOD_GlcNHglycan	54	57	PF01048	0.789
MOD_GlcNHglycan	69	72	PF01048	0.616
MOD_GSK3_1	106	113	PF00069	0.582
MOD_GSK3_1	126	133	PF00069	0.658
MOD_GSK3_1	158	165	PF00069	0.495
MOD_GSK3_1	226	233	PF00069	0.651
MOD_GSK3_1	23	30	PF00069	0.694
MOD_GSK3_1	259	266	PF00069	0.391
MOD_GSK3_1	290	297	PF00069	0.517
MOD_GSK3_1	358	365	PF00069	0.489
MOD_GSK3_1	419	426	PF00069	0.559
MOD_GSK3_1	438	445	PF00069	0.392
MOD_GSK3_1	476	483	PF00069	0.599
MOD_GSK3_1	48	55	PF00069	0.632
MOD_GSK3_1	514	521	PF00069	0.589
MOD_GSK3_1	60	67	PF00069	0.622
MOD_GSK3_1	77	84	PF00069	0.658
MOD_GSK3_1	85	92	PF00069	0.669
MOD_GSK3_1	94	101	PF00069	0.588
MOD_N-GLC_1	501	506	PF02516	0.328
MOD_N-GLC_1	514	519	PF02516	0.259
MOD_N-GLC_2	434	436	PF02516	0.274
MOD_NEK2_1	1	6	PF00069	0.692
MOD_NEK2_1	110	115	PF00069	0.657
MOD_NEK2_1	158	163	PF00069	0.446
MOD_NEK2_1	187	192	PF00069	0.590
MOD_NEK2_1	267	272	PF00069	0.474
MOD_NEK2_1	309	314	PF00069	0.474
MOD_NEK2_1	358	363	PF00069	0.539
MOD_NEK2_1	408	413	PF00069	0.477
MOD_NEK2_2	106	111	PF00069	0.622
MOD_NEK2_2	464	469	PF00069	0.564
MOD_PIKK_1	180	186	PF00454	0.524
MOD_PIKK_1	358	364	PF00454	0.499
MOD_PIKK_1	85	91	PF00454	0.622
MOD_PK_1	170	176	PF00069	0.599
MOD_PK_1	409	415	PF00069	0.474
MOD_PK_1	524	530	PF00069	0.493
MOD_PKA_1	8	14	PF00069	0.683
MOD_PKA_2	110	116	PF00069	0.552
MOD_PKA_2	162	168	PF00069	0.500
MOD_PKA_2	226	232	PF00069	0.629
MOD_PKA_2	23	29	PF00069	0.528
MOD_PKA_2	408	414	PF00069	0.474
MOD_PKA_2	416	422	PF00069	0.474
MOD_PKA_2	498	504	PF00069	0.555
MOD_PKA_2	549	555	PF00069	0.525
MOD_PKA_2	71	77	PF00069	0.656
MOD_PKA_2	8	14	PF00069	0.683
MOD_PKA_2	95	101	PF00069	0.714
MOD_PKB_1	116	124	PF00069	0.602
MOD_Plk_4	146	152	PF00069	0.396
MOD_Plk_4	267	273	PF00069	0.495
MOD_Plk_4	442	448	PF00069	0.504
MOD_Plk_4	504	510	PF00069	0.493
MOD_Plk_4	549	555	PF00069	0.506
MOD_ProDKin_1	235	241	PF00069	0.678
MOD_ProDKin_1	294	300	PF00069	0.517
MOD_ProDKin_1	31	37	PF00069	0.673
MOD_ProDKin_1	421	427	PF00069	0.562
MOD_ProDKin_1	476	482	PF00069	0.549
MOD_ProDKin_1	49	55	PF00069	0.626
MOD_ProDKin_1	82	88	PF00069	0.641
MOD_SUMO_for_1	473	476	PF00179	0.553
MOD_SUMO_rev_2	85	94	PF00179	0.640
TRG_DiLeu_BaEn_1	305	310	PF01217	0.499
TRG_DiLeu_BaEn_4	448	454	PF01217	0.474
TRG_DiLeu_BaLyEn_6	374	379	PF01217	0.474
TRG_ENDOCYTIC_2	151	154	PF00928	0.383
TRG_ENDOCYTIC_2	25	28	PF00928	0.683
TRG_ENDOCYTIC_2	289	292	PF00928	0.499
TRG_ENDOCYTIC_2	349	352	PF00928	0.585
TRG_ENDOCYTIC_2	478	481	PF00928	0.517
TRG_ENDOCYTIC_2	577	580	PF00928	0.334
TRG_ENDOCYTIC_2	633	636	PF00928	0.383
TRG_ER_diArg_1	209	211	PF00400	0.416
TRG_NES_CRM1_1	307	322	PF08389	0.457
TRG_NLS_MonoExtN_4	123	129	PF00514	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8M9	Leptomonas seymouri	63%	100%
A0A1X0NRN8	Trypanosomatidae	41%	100%
A0A422NZN7	Trypanosoma rangeli	39%	100%
A4HKT5	Leishmania braziliensis	86%	100%
A4I8B4	Leishmania infantum	100%	100%
E9B373	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q4Y1	Leishmania major	96%	100%