TauD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH01_LEIDO

TriTrypDb:

LdBPK_261010.1 , LdCL_260015700 , LDHU3_26.1290

Length:

768

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IH01

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH01

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.417
CLV_NRD_NRD_1	310	312	PF00675	0.372
CLV_NRD_NRD_1	48	50	PF00675	0.606
CLV_NRD_NRD_1	576	578	PF00675	0.368
CLV_NRD_NRD_1	73	75	PF00675	0.573
CLV_PCSK_FUR_1	574	578	PF00082	0.366
CLV_PCSK_KEX2_1	310	312	PF00082	0.372
CLV_PCSK_KEX2_1	48	50	PF00082	0.583
CLV_PCSK_KEX2_1	576	578	PF00082	0.385
CLV_PCSK_PC7_1	306	312	PF00082	0.402
CLV_PCSK_SKI1_1	104	108	PF00082	0.621
CLV_PCSK_SKI1_1	124	128	PF00082	0.370
CLV_PCSK_SKI1_1	374	378	PF00082	0.406
CLV_PCSK_SKI1_1	519	523	PF00082	0.401
CLV_PCSK_SKI1_1	555	559	PF00082	0.379
CLV_PCSK_SKI1_1	577	581	PF00082	0.375
DEG_APCC_DBOX_1	305	313	PF00400	0.405
DEG_APCC_DBOX_1	47	55	PF00400	0.580
DEG_APCC_DBOX_1	518	526	PF00400	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.652
DOC_CKS1_1	412	417	PF01111	0.518
DOC_CKS1_1	570	575	PF01111	0.405
DOC_CYCLIN_RxL_1	470	478	PF00134	0.365
DOC_MAPK_MEF2A_6	337	345	PF00069	0.315
DOC_PP1_RVXF_1	641	648	PF00149	0.312
DOC_PP2B_LxvP_1	391	394	PF13499	0.488
DOC_PP2B_LxvP_1	485	488	PF13499	0.386
DOC_PP2B_LxvP_1	679	682	PF13499	0.372
DOC_PP4_FxxP_1	167	170	PF00568	0.348
DOC_USP7_MATH_1	106	110	PF00917	0.403
DOC_USP7_MATH_1	135	139	PF00917	0.499
DOC_USP7_MATH_1	194	198	PF00917	0.330
DOC_USP7_MATH_1	286	290	PF00917	0.622
DOC_USP7_MATH_1	688	692	PF00917	0.463
DOC_USP7_MATH_1	89	93	PF00917	0.644
DOC_USP7_UBL2_3	591	595	PF12436	0.368
DOC_USP7_UBL2_3	719	723	PF12436	0.577
DOC_WW_Pin1_4	31	36	PF00397	0.689
DOC_WW_Pin1_4	318	323	PF00397	0.355
DOC_WW_Pin1_4	385	390	PF00397	0.316
DOC_WW_Pin1_4	411	416	PF00397	0.521
DOC_WW_Pin1_4	455	460	PF00397	0.421
DOC_WW_Pin1_4	480	485	PF00397	0.319
DOC_WW_Pin1_4	569	574	PF00397	0.445
DOC_WW_Pin1_4	628	633	PF00397	0.336
DOC_WW_Pin1_4	698	703	PF00397	0.468
LIG_14-3-3_CanoR_1	146	150	PF00244	0.375
LIG_14-3-3_CanoR_1	158	162	PF00244	0.336
LIG_14-3-3_CanoR_1	314	322	PF00244	0.374
LIG_14-3-3_CanoR_1	48	52	PF00244	0.587
LIG_14-3-3_CanoR_1	58	65	PF00244	0.656
LIG_Actin_RPEL_3	230	249	PF02755	0.254
LIG_APCC_ABBA_1	368	373	PF00400	0.320
LIG_BRCT_BRCA1_1	158	162	PF00533	0.356
LIG_BRCT_BRCA1_1	661	665	PF00533	0.340
LIG_Clathr_ClatBox_1	728	732	PF01394	0.655
LIG_deltaCOP1_diTrp_1	163	167	PF00928	0.434
LIG_deltaCOP1_diTrp_1	323	329	PF00928	0.348
LIG_eIF4E_1	650	656	PF01652	0.429
LIG_eIF4E_1	706	712	PF01652	0.618
LIG_FHA_1	264	270	PF00498	0.499
LIG_FHA_1	419	425	PF00498	0.512
LIG_FHA_1	67	73	PF00498	0.745
LIG_FHA_2	158	164	PF00498	0.368
LIG_FHA_2	257	263	PF00498	0.508
LIG_FHA_2	334	340	PF00498	0.329
LIG_FHA_2	349	355	PF00498	0.348
LIG_FHA_2	513	519	PF00498	0.356
LIG_GBD_Chelix_1	222	230	PF00786	0.401
LIG_LIR_Apic_2	410	415	PF02991	0.531
LIG_LIR_Apic_2	628	632	PF02991	0.414
LIG_LIR_Gen_1	238	248	PF02991	0.314
LIG_LIR_Gen_1	326	334	PF02991	0.338
LIG_LIR_Gen_1	495	504	PF02991	0.446
LIG_LIR_Gen_1	694	705	PF02991	0.540
LIG_LIR_Nem_3	238	243	PF02991	0.306
LIG_LIR_Nem_3	326	332	PF02991	0.338
LIG_LIR_Nem_3	438	444	PF02991	0.417
LIG_LIR_Nem_3	495	500	PF02991	0.468
LIG_LIR_Nem_3	564	569	PF02991	0.370
LIG_LIR_Nem_3	694	700	PF02991	0.513
LIG_LYPXL_yS_3	399	402	PF13949	0.465
LIG_MLH1_MIPbox_1	661	665	PF16413	0.340
LIG_MYND_1	389	393	PF01753	0.398
LIG_MYND_3	538	542	PF01753	0.417
LIG_Pex14_1	324	328	PF04695	0.340
LIG_Pex14_1	566	570	PF04695	0.362
LIG_Pex14_1	593	597	PF04695	0.329
LIG_Pex14_2	557	561	PF04695	0.335
LIG_Pex14_2	562	566	PF04695	0.338
LIG_PTB_Apo_2	328	335	PF02174	0.333
LIG_PTB_Apo_2	556	563	PF02174	0.341
LIG_PTB_Phospho_1	328	334	PF10480	0.333
LIG_Rb_pABgroove_1	347	355	PF01858	0.420
LIG_SH2_CRK	412	416	PF00017	0.561
LIG_SH2_CRK	570	574	PF00017	0.354
LIG_SH2_CRK	697	701	PF00017	0.511
LIG_SH2_GRB2like	497	500	PF00017	0.351
LIG_SH2_GRB2like	697	700	PF00017	0.505
LIG_SH2_NCK_1	697	701	PF00017	0.511
LIG_SH2_PTP2	629	632	PF00017	0.365
LIG_SH2_SRC	697	700	PF00017	0.558
LIG_SH2_STAP1	597	601	PF00017	0.361
LIG_SH2_STAT5	154	157	PF00017	0.347
LIG_SH2_STAT5	371	374	PF00017	0.325
LIG_SH2_STAT5	550	553	PF00017	0.346
LIG_SH2_STAT5	629	632	PF00017	0.365
LIG_SH2_STAT5	664	667	PF00017	0.333
LIG_SH2_STAT5	727	730	PF00017	0.595
LIG_SH3_1	397	403	PF00018	0.446
LIG_SH3_1	413	419	PF00018	0.518
LIG_SH3_1	730	736	PF00018	0.534
LIG_SH3_3	32	38	PF00018	0.666
LIG_SH3_3	383	389	PF00018	0.422
LIG_SH3_3	390	396	PF00018	0.403
LIG_SH3_3	397	403	PF00018	0.444
LIG_SH3_3	413	419	PF00018	0.484
LIG_SH3_3	441	447	PF00018	0.322
LIG_SH3_3	697	703	PF00018	0.449
LIG_SH3_3	730	736	PF00018	0.515
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.291
LIG_SUMO_SIM_par_1	342	347	PF11976	0.303
LIG_SUMO_SIM_par_1	683	691	PF11976	0.357
LIG_TRAF2_1	682	685	PF00917	0.447
LIG_TRAF2_1	76	79	PF00917	0.626
LIG_TRFH_1	706	710	PF08558	0.482
LIG_TYR_ITIM	381	386	PF00017	0.321
LIG_TYR_ITIM	480	485	PF00017	0.363
LIG_TYR_ITIM	695	700	PF00017	0.470
LIG_UBA3_1	273	281	PF00899	0.475
LIG_UBA3_1	368	377	PF00899	0.353
LIG_UBA3_1	707	716	PF00899	0.548
MOD_CDK_SPK_2	569	574	PF00069	0.414
MOD_CDK_SPxK_1	411	417	PF00069	0.522
MOD_CDK_SPxxK_3	569	576	PF00069	0.417
MOD_CK1_1	15	21	PF00069	0.531
MOD_CK1_1	284	290	PF00069	0.501
MOD_CK1_1	36	42	PF00069	0.600
MOD_CK1_1	56	62	PF00069	0.703
MOD_CK1_1	691	697	PF00069	0.474
MOD_CK1_1	73	79	PF00069	0.455
MOD_CK2_1	157	163	PF00069	0.362
MOD_CK2_1	256	262	PF00069	0.498
MOD_CK2_1	333	339	PF00069	0.336
MOD_CK2_1	480	486	PF00069	0.327
MOD_CK2_1	512	518	PF00069	0.337
MOD_CK2_1	73	79	PF00069	0.640
MOD_CK2_1	747	753	PF00069	0.610
MOD_GlcNHglycan	108	111	PF01048	0.414
MOD_GlcNHglycan	120	123	PF01048	0.434
MOD_GlcNHglycan	14	17	PF01048	0.612
MOD_GlcNHglycan	19	22	PF01048	0.578
MOD_GlcNHglycan	236	240	PF01048	0.416
MOD_GlcNHglycan	291	294	PF01048	0.520
MOD_GlcNHglycan	586	589	PF01048	0.445
MOD_GlcNHglycan	690	693	PF01048	0.510
MOD_GlcNHglycan	756	759	PF01048	0.708
MOD_GlcNHglycan	91	94	PF01048	0.677
MOD_GSK3_1	145	152	PF00069	0.354
MOD_GSK3_1	175	182	PF00069	0.363
MOD_GSK3_1	25	32	PF00069	0.579
MOD_GSK3_1	280	287	PF00069	0.488
MOD_GSK3_1	33	40	PF00069	0.680
MOD_GSK3_1	50	57	PF00069	0.531
MOD_GSK3_1	66	73	PF00069	0.615
MOD_GSK3_1	715	722	PF00069	0.576
MOD_GSK3_1	89	96	PF00069	0.685
MOD_N-GLC_1	448	453	PF02516	0.311
MOD_N-GLC_1	464	469	PF02516	0.342
MOD_N-GLC_1	698	703	PF02516	0.468
MOD_N-GLC_1	89	94	PF02516	0.683
MOD_NEK2_1	156	161	PF00069	0.434
MOD_NEK2_1	180	185	PF00069	0.481
MOD_NEK2_1	235	240	PF00069	0.418
MOD_NEK2_1	299	304	PF00069	0.500
MOD_NEK2_1	448	453	PF00069	0.330
MOD_NEK2_1	47	52	PF00069	0.502
MOD_NEK2_1	475	480	PF00069	0.318
MOD_NEK2_1	545	550	PF00069	0.322
MOD_NEK2_1	659	664	PF00069	0.344
MOD_NEK2_2	181	186	PF00069	0.350
MOD_NEK2_2	286	291	PF00069	0.626
MOD_NEK2_2	348	353	PF00069	0.343
MOD_PIKK_1	299	305	PF00454	0.454
MOD_PIKK_1	448	454	PF00454	0.337
MOD_PKA_2	12	18	PF00069	0.580
MOD_PKA_2	135	141	PF00069	0.458
MOD_PKA_2	145	151	PF00069	0.360
MOD_PKA_2	157	163	PF00069	0.342
MOD_PKA_2	294	300	PF00069	0.409
MOD_PKA_2	313	319	PF00069	0.376
MOD_PKA_2	47	53	PF00069	0.644
MOD_PKA_2	57	63	PF00069	0.605
MOD_PKA_2	73	79	PF00069	0.510
MOD_Plk_1	156	162	PF00069	0.401
MOD_Plk_1	256	262	PF00069	0.523
MOD_Plk_1	299	305	PF00069	0.454
MOD_Plk_1	464	470	PF00069	0.440
MOD_Plk_1	517	523	PF00069	0.390
MOD_Plk_2-3	157	163	PF00069	0.381
MOD_Plk_4	157	163	PF00069	0.381
MOD_Plk_4	20	26	PF00069	0.509
MOD_Plk_4	348	354	PF00069	0.353
MOD_Plk_4	545	551	PF00069	0.324
MOD_ProDKin_1	31	37	PF00069	0.690
MOD_ProDKin_1	318	324	PF00069	0.353
MOD_ProDKin_1	385	391	PF00069	0.315
MOD_ProDKin_1	411	417	PF00069	0.522
MOD_ProDKin_1	455	461	PF00069	0.429
MOD_ProDKin_1	480	486	PF00069	0.327
MOD_ProDKin_1	569	575	PF00069	0.441
MOD_ProDKin_1	628	634	PF00069	0.330
MOD_ProDKin_1	698	704	PF00069	0.472
MOD_SUMO_rev_2	503	509	PF00179	0.355
MOD_SUMO_rev_2	520	530	PF00179	0.372
MOD_SUMO_rev_2	709	718	PF00179	0.522
TRG_DiLeu_BaEn_1	486	491	PF01217	0.390
TRG_DiLeu_BaEn_4	684	690	PF01217	0.470
TRG_ENDOCYTIC_2	227	230	PF00928	0.346
TRG_ENDOCYTIC_2	383	386	PF00928	0.316
TRG_ENDOCYTIC_2	399	402	PF00928	0.403
TRG_ENDOCYTIC_2	425	428	PF00928	0.377
TRG_ENDOCYTIC_2	482	485	PF00928	0.364
TRG_ENDOCYTIC_2	497	500	PF00928	0.296
TRG_ENDOCYTIC_2	597	600	PF00928	0.324
TRG_ENDOCYTIC_2	697	700	PF00928	0.499
TRG_ER_diArg_1	269	272	PF00400	0.490
TRG_ER_diArg_1	309	311	PF00400	0.358
TRG_ER_diArg_1	47	49	PF00400	0.570
TRG_ER_diArg_1	575	577	PF00400	0.381
TRG_ER_diArg_1	605	608	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK7	Leptomonas seymouri	79%	100%
A0A0S4JUK7	Bodo saltans	62%	100%
A0A1X0NTZ9	Trypanosomatidae	75%	100%
A4HEV9	Leishmania braziliensis	90%	100%
C9ZRX3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AY82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q991	Leishmania major	97%	100%
V5BUF5	Trypanosoma cruzi	73%	100%