RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IH00_LEIDO

TriTrypDb:

LdBPK_332380.1 , LdCL_330030800 , LDHU3_33.3420

Length:

455

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IH00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IH00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.637
CLV_C14_Caspase3-7	428	432	PF00656	0.598
CLV_NRD_NRD_1	127	129	PF00675	0.522
CLV_NRD_NRD_1	307	309	PF00675	0.625
CLV_NRD_NRD_1	319	321	PF00675	0.621
CLV_PCSK_KEX2_1	118	120	PF00082	0.496
CLV_PCSK_KEX2_1	309	311	PF00082	0.673
CLV_PCSK_KEX2_1	319	321	PF00082	0.733
CLV_PCSK_KEX2_1	323	325	PF00082	0.707
CLV_PCSK_KEX2_1	443	445	PF00082	0.554
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.673
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.673
CLV_PCSK_PC1ET2_1	323	325	PF00082	0.716
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.563
CLV_PCSK_PC7_1	319	325	PF00082	0.689
CLV_PCSK_SKI1_1	138	142	PF00082	0.507
CLV_PCSK_SKI1_1	19	23	PF00082	0.532
CLV_PCSK_SKI1_1	232	236	PF00082	0.549
CLV_PCSK_SKI1_1	312	316	PF00082	0.641
CLV_PCSK_SKI1_1	355	359	PF00082	0.719
CLV_PCSK_SKI1_1	410	414	PF00082	0.577
DEG_APCC_DBOX_1	231	239	PF00400	0.400
DEG_Nend_UBRbox_2	1	3	PF02207	0.487
DEG_SPOP_SBC_1	371	375	PF00917	0.578
DOC_PP2B_LxvP_1	430	433	PF13499	0.627
DOC_PP2B_LxvP_1	72	75	PF13499	0.591
DOC_SPAK_OSR1_1	250	254	PF12202	0.493
DOC_USP7_MATH_1	14	18	PF00917	0.439
DOC_USP7_MATH_1	172	176	PF00917	0.741
DOC_USP7_MATH_1	184	188	PF00917	0.714
DOC_USP7_MATH_1	205	209	PF00917	0.620
DOC_USP7_MATH_1	259	263	PF00917	0.559
DOC_USP7_MATH_1	344	348	PF00917	0.754
DOC_USP7_MATH_1	367	371	PF00917	0.690
DOC_USP7_MATH_1	377	381	PF00917	0.725
DOC_USP7_MATH_1	75	79	PF00917	0.735
DOC_WW_Pin1_4	166	171	PF00397	0.693
DOC_WW_Pin1_4	186	191	PF00397	0.595
DOC_WW_Pin1_4	403	408	PF00397	0.641
LIG_14-3-3_CanoR_1	111	117	PF00244	0.451
LIG_14-3-3_CanoR_1	176	186	PF00244	0.715
LIG_14-3-3_CanoR_1	19	24	PF00244	0.467
LIG_14-3-3_CanoR_1	237	245	PF00244	0.615
LIG_14-3-3_CanoR_1	335	340	PF00244	0.717
LIG_14-3-3_CanoR_1	355	364	PF00244	0.613
LIG_14-3-3_CanoR_1	382	386	PF00244	0.598
LIG_14-3-3_CanoR_1	418	427	PF00244	0.569
LIG_14-3-3_CanoR_1	44	52	PF00244	0.537
LIG_BRCT_BRCA1_1	207	211	PF00533	0.596
LIG_FHA_1	111	117	PF00498	0.476
LIG_FHA_1	287	293	PF00498	0.755
LIG_FHA_1	30	36	PF00498	0.471
LIG_FHA_1	334	340	PF00498	0.598
LIG_FHA_1	356	362	PF00498	0.655
LIG_FHA_2	28	34	PF00498	0.483
LIG_FHA_2	382	388	PF00498	0.692
LIG_LIR_Gen_1	108	116	PF02991	0.414
LIG_LIR_Gen_1	17	26	PF02991	0.451
LIG_LIR_Nem_3	108	112	PF02991	0.443
LIG_LIR_Nem_3	151	157	PF02991	0.481
LIG_LIR_Nem_3	17	23	PF02991	0.445
LIG_MYND_1	70	74	PF01753	0.617
LIG_SH2_CRK	109	113	PF00017	0.420
LIG_SH2_CRK	7	11	PF00017	0.404
LIG_SH2_NCK_1	258	262	PF00017	0.545
LIG_SH2_STAT5	20	23	PF00017	0.534
LIG_SH3_2	171	176	PF14604	0.596
LIG_SH3_3	165	171	PF00018	0.776
LIG_SH3_3	187	193	PF00018	0.644
LIG_SH3_3	20	26	PF00018	0.520
LIG_SH3_3	67	73	PF00018	0.718
LIG_SUMO_SIM_par_1	112	117	PF11976	0.497
LIG_TRAF2_1	240	243	PF00917	0.574
LIG_TYR_ITIM	5	10	PF00017	0.396
LIG_UBA3_1	210	215	PF00899	0.624
LIG_WW_3	170	174	PF00397	0.590
MOD_CDK_SPxxK_3	166	173	PF00069	0.626
MOD_CDK_SPxxK_3	403	410	PF00069	0.572
MOD_CK1_1	149	155	PF00069	0.564
MOD_CK1_1	175	181	PF00069	0.671
MOD_CK1_1	218	224	PF00069	0.716
MOD_CK1_1	279	285	PF00069	0.609
MOD_CK1_1	370	376	PF00069	0.726
MOD_CK1_1	77	83	PF00069	0.735
MOD_CK2_1	124	130	PF00069	0.617
MOD_CK2_1	236	242	PF00069	0.555
MOD_CK2_1	257	263	PF00069	0.483
MOD_GlcNHglycan	148	151	PF01048	0.675
MOD_GlcNHglycan	16	19	PF01048	0.447
MOD_GlcNHglycan	179	182	PF01048	0.686
MOD_GlcNHglycan	218	221	PF01048	0.717
MOD_GlcNHglycan	238	241	PF01048	0.408
MOD_GlcNHglycan	259	262	PF01048	0.526
MOD_GlcNHglycan	279	282	PF01048	0.640
MOD_GlcNHglycan	346	349	PF01048	0.734
MOD_GlcNHglycan	369	372	PF01048	0.807
MOD_GlcNHglycan	377	380	PF01048	0.745
MOD_GlcNHglycan	394	397	PF01048	0.576
MOD_GlcNHglycan	436	439	PF01048	0.613
MOD_GlcNHglycan	65	68	PF01048	0.627
MOD_GlcNHglycan	76	80	PF01048	0.656
MOD_GlcNHglycan	84	87	PF01048	0.502
MOD_GSK3_1	110	117	PF00069	0.467
MOD_GSK3_1	253	260	PF00069	0.449
MOD_GSK3_1	279	286	PF00069	0.622
MOD_GSK3_1	367	374	PF00069	0.662
MOD_GSK3_1	377	384	PF00069	0.691
MOD_GSK3_1	388	395	PF00069	0.781
MOD_N-GLC_1	45	50	PF02516	0.436
MOD_NEK2_1	112	117	PF00069	0.443
MOD_NEK2_1	148	153	PF00069	0.570
MOD_NEK2_1	177	182	PF00069	0.556
MOD_NEK2_1	241	246	PF00069	0.608
MOD_NEK2_1	333	338	PF00069	0.621
MOD_NEK2_1	82	87	PF00069	0.673
MOD_OFUCOSY	252	257	PF10250	0.421
MOD_PIKK_1	205	211	PF00454	0.604
MOD_PK_1	335	341	PF00069	0.605
MOD_PKA_2	110	116	PF00069	0.445
MOD_PKA_2	172	178	PF00069	0.629
MOD_PKA_2	236	242	PF00069	0.459
MOD_PKA_2	334	340	PF00069	0.605
MOD_PKA_2	381	387	PF00069	0.750
MOD_Plk_1	241	247	PF00069	0.559
MOD_Plk_1	302	308	PF00069	0.768
MOD_Plk_1	45	51	PF00069	0.527
MOD_Plk_4	425	431	PF00069	0.554
MOD_ProDKin_1	166	172	PF00069	0.689
MOD_ProDKin_1	186	192	PF00069	0.592
MOD_ProDKin_1	403	409	PF00069	0.633
MOD_SUMO_for_1	314	317	PF00179	0.636
TRG_DiLeu_BaEn_1	328	333	PF01217	0.488
TRG_DiLeu_BaEn_1	53	58	PF01217	0.515
TRG_DiLeu_BaLyEn_6	5	10	PF01217	0.396
TRG_ENDOCYTIC_2	109	112	PF00928	0.412
TRG_ENDOCYTIC_2	20	23	PF00928	0.420
TRG_ENDOCYTIC_2	7	10	PF00928	0.370
TRG_ER_diArg_1	307	310	PF00400	0.624
TRG_ER_diArg_1	319	321	PF00400	0.621
TRG_NES_CRM1_1	417	431	PF08389	0.590
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.569
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE8	Leptomonas seymouri	48%	100%
A0A0S4J496	Bodo saltans	26%	100%
A0A1X0P415	Trypanosomatidae	29%	100%
A4HLT8	Leishmania braziliensis	74%	98%
D0A688	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AHP4	Leishmania infantum	99%	100%
E9B464	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q4Q3W2	Leishmania major	92%	99%