Ch34 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Ch34 protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IGZ7_LEIDO

TriTrypDb:

LdBPK_340550.1 , LdCL_340011100 , LDHU3_34.0920

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	200	204	PF00656	0.604
CLV_C14_Caspase3-7	234	238	PF00656	0.468
CLV_C14_Caspase3-7	470	474	PF00656	0.523
CLV_C14_Caspase3-7	81	85	PF00656	0.637
CLV_NRD_NRD_1	457	459	PF00675	0.566
CLV_NRD_NRD_1	59	61	PF00675	0.641
CLV_PCSK_KEX2_1	457	459	PF00082	0.566
DEG_APCC_DBOX_1	258	266	PF00400	0.471
DEG_SCF_FBW7_2	21	28	PF00400	0.590
DEG_SPOP_SBC_1	161	165	PF00917	0.641
DEG_SPOP_SBC_1	205	209	PF00917	0.525
DOC_CKS1_1	22	27	PF01111	0.592
DOC_CKS1_1	242	247	PF01111	0.454
DOC_CYCLIN_RxL_1	304	314	PF00134	0.435
DOC_MAPK_MEF2A_6	134	142	PF00069	0.543
DOC_PP1_RVXF_1	360	367	PF00149	0.576
DOC_PP2B_LxvP_1	486	489	PF13499	0.559
DOC_PP4_MxPP_1	459	462	PF00568	0.583
DOC_USP7_MATH_1	146	150	PF00917	0.587
DOC_USP7_MATH_1	161	165	PF00917	0.616
DOC_USP7_MATH_1	205	209	PF00917	0.603
DOC_USP7_MATH_1	379	383	PF00917	0.596
DOC_USP7_MATH_1	410	414	PF00917	0.634
DOC_USP7_MATH_1	51	55	PF00917	0.613
DOC_USP7_UBL2_3	158	162	PF12436	0.621
DOC_WW_Pin1_4	144	149	PF00397	0.669
DOC_WW_Pin1_4	162	167	PF00397	0.533
DOC_WW_Pin1_4	21	26	PF00397	0.584
DOC_WW_Pin1_4	216	221	PF00397	0.519
DOC_WW_Pin1_4	241	246	PF00397	0.545
DOC_WW_Pin1_4	260	265	PF00397	0.400
DOC_WW_Pin1_4	286	291	PF00397	0.477
DOC_WW_Pin1_4	299	304	PF00397	0.457
DOC_WW_Pin1_4	484	489	PF00397	0.561
LIG_14-3-3_CanoR_1	11	21	PF00244	0.566
LIG_14-3-3_CanoR_1	395	400	PF00244	0.604
LIG_BIR_III_2	145	149	PF00653	0.573
LIG_BIR_III_4	403	407	PF00653	0.581
LIG_FHA_1	13	19	PF00498	0.588
LIG_FHA_1	311	317	PF00498	0.476
LIG_FHA_1	367	373	PF00498	0.560
LIG_FHA_1	409	415	PF00498	0.601
LIG_FHA_1	53	59	PF00498	0.712
LIG_FHA_1	81	87	PF00498	0.633
LIG_FHA_2	22	28	PF00498	0.649
LIG_FHA_2	400	406	PF00498	0.622
LIG_FHA_2	449	455	PF00498	0.560
LIG_FHA_2	57	63	PF00498	0.682
LIG_LIR_Apic_2	208	214	PF02991	0.426
LIG_LIR_Gen_1	237	245	PF02991	0.434
LIG_LIR_Gen_1	439	448	PF02991	0.561
LIG_LIR_Nem_3	237	242	PF02991	0.437
LIG_LIR_Nem_3	304	309	PF02991	0.409
LIG_LIR_Nem_3	439	443	PF02991	0.565
LIG_MAD2	39	47	PF02301	0.586
LIG_PROFILIN_1	45	51	PF00235	0.592
LIG_SH2_CRK	211	215	PF00017	0.479
LIG_SH2_CRK	217	221	PF00017	0.532
LIG_SH2_CRK	306	310	PF00017	0.432
LIG_SH2_NCK_1	19	23	PF00017	0.544
LIG_SH2_NCK_1	217	221	PF00017	0.503
LIG_SH2_STAT5	397	400	PF00017	0.605
LIG_SH3_1	19	25	PF00018	0.547
LIG_SH3_1	43	49	PF00018	0.568
LIG_SH3_1	457	463	PF00018	0.562
LIG_SH3_3	163	169	PF00018	0.714
LIG_SH3_3	186	192	PF00018	0.577
LIG_SH3_3	19	25	PF00018	0.589
LIG_SH3_3	199	205	PF00018	0.647
LIG_SH3_3	41	47	PF00018	0.583
LIG_SH3_3	417	423	PF00018	0.592
LIG_SH3_3	457	463	PF00018	0.562
LIG_TRAF2_1	232	235	PF00917	0.512
LIG_TRAF2_1	268	271	PF00917	0.438
LIG_TRAF2_1	345	348	PF00917	0.569
LIG_TRAF2_1	383	386	PF00917	0.571
LIG_WW_1	462	465	PF00397	0.598
MOD_CDK_SPK_2	21	26	PF00069	0.639
MOD_CK1_1	149	155	PF00069	0.606
MOD_CK1_1	281	287	PF00069	0.594
MOD_CK1_1	29	35	PF00069	0.602
MOD_CK1_1	387	393	PF00069	0.580
MOD_CK1_1	408	414	PF00069	0.602
MOD_CK1_1	484	490	PF00069	0.616
MOD_CK1_1	54	60	PF00069	0.632
MOD_CK2_1	229	235	PF00069	0.648
MOD_CK2_1	270	276	PF00069	0.495
MOD_CK2_1	281	287	PF00069	0.496
MOD_CK2_1	367	373	PF00069	0.560
MOD_CK2_1	379	385	PF00069	0.589
MOD_CK2_1	399	405	PF00069	0.804
MOD_CK2_1	448	454	PF00069	0.561
MOD_CK2_1	56	62	PF00069	0.684
MOD_GlcNHglycan	148	151	PF01048	0.627
MOD_GlcNHglycan	186	189	PF01048	0.573
MOD_GlcNHglycan	27	31	PF01048	0.606
MOD_GlcNHglycan	479	482	PF01048	0.605
MOD_GSK3_1	301	308	PF00069	0.377
MOD_GSK3_1	335	342	PF00069	0.565
MOD_GSK3_1	380	387	PF00069	0.734
MOD_GSK3_1	395	402	PF00069	0.601
MOD_GSK3_1	410	417	PF00069	0.661
MOD_GSK3_1	477	484	PF00069	0.609
MOD_GSK3_1	52	59	PF00069	0.615
MOD_GSK3_1	7	14	PF00069	0.589
MOD_NEK2_1	193	198	PF00069	0.798
MOD_NEK2_1	206	211	PF00069	0.455
MOD_NEK2_1	305	310	PF00069	0.404
MOD_NEK2_1	448	453	PF00069	0.519
MOD_PIKK_1	270	276	PF00454	0.476
MOD_PIKK_1	405	411	PF00454	0.628
MOD_Plk_1	270	276	PF00069	0.494
MOD_Plk_1	384	390	PF00069	0.564
MOD_Plk_1	414	420	PF00069	0.586
MOD_Plk_2-3	339	345	PF00069	0.606
MOD_Plk_2-3	380	386	PF00069	0.571
MOD_Plk_4	105	111	PF00069	0.549
MOD_Plk_4	206	212	PF00069	0.446
MOD_Plk_4	281	287	PF00069	0.730
MOD_Plk_4	301	307	PF00069	0.453
MOD_Plk_4	481	487	PF00069	0.640
MOD_ProDKin_1	144	150	PF00069	0.670
MOD_ProDKin_1	162	168	PF00069	0.529
MOD_ProDKin_1	21	27	PF00069	0.588
MOD_ProDKin_1	216	222	PF00069	0.515
MOD_ProDKin_1	241	247	PF00069	0.549
MOD_ProDKin_1	260	266	PF00069	0.388
MOD_ProDKin_1	286	292	PF00069	0.472
MOD_ProDKin_1	299	305	PF00069	0.447
MOD_ProDKin_1	484	490	PF00069	0.562
MOD_SUMO_for_1	25	28	PF00179	0.658
MOD_SUMO_rev_2	81	91	PF00179	0.726
MOD_SUMO_rev_2	97	107	PF00179	0.520
TRG_DiLeu_BaEn_3	234	240	PF01217	0.479
TRG_ENDOCYTIC_2	306	309	PF00928	0.430
TRG_ER_diArg_1	259	262	PF00400	0.476
TRG_ER_diArg_1	456	458	PF00400	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P589	Leptomonas seymouri	31%	68%
A4H7D5	Leishmania braziliensis	51%	100%
A4I9M3	Leishmania infantum	99%	100%
E9B4M2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q3F4	Leishmania major	86%	100%