Prolyl endopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligopeptidase b

Species:

Leishmania donovani

UniProt:

A0A3Q8IGZ3_LEIDO

TriTrypDb:

LdBPK_090820.1 , LdCL_090013600 , LDHU3_09.0970

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

A0A3Q8IGZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGZ3

PDB structure(s): 2xe4_A

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004175	endopeptidase activity	4	12
GO:0004252	serine-type endopeptidase activity	5	12
GO:0008233	peptidase activity	3	12
GO:0008236	serine-type peptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0017171	serine hydrolase activity	3	12
GO:0070012	oligopeptidase activity	5	1
GO:0140096	catalytic activity, acting on a protein	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.541
CLV_MEL_PAP_1	122	128	PF00089	0.305
CLV_NRD_NRD_1	283	285	PF00675	0.368
CLV_NRD_NRD_1	366	368	PF00675	0.364
CLV_NRD_NRD_1	462	464	PF00675	0.537
CLV_NRD_NRD_1	55	57	PF00675	0.410
CLV_PCSK_KEX2_1	186	188	PF00082	0.375
CLV_PCSK_KEX2_1	283	285	PF00082	0.462
CLV_PCSK_KEX2_1	366	368	PF00082	0.364
CLV_PCSK_KEX2_1	462	464	PF00082	0.507

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7J4	Leptomonas seymouri	82%	100%
A0A0N1PDP3	Leptomonas seymouri	23%	84%
A0A0S4IIS9	Bodo saltans	25%	100%
A0A0S4JND1	Bodo saltans	57%	98%
A0A1X0NKN5	Trypanosomatidae	25%	80%
A0A1X0NMH6	Trypanosomatidae	66%	100%
A0A3S5H5P5	Leishmania donovani	24%	81%
A0A422N761	Trypanosoma rangeli	66%	100%
A4H4J9	Leishmania braziliensis	24%	100%
A4H5Q8	Leishmania braziliensis	87%	100%

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