Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IGY8_LEIDO

TriTrypDb:

LdBPK_340470.1 , LdCL_340009800 , LDHU3_34.0640

Length:

937

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.664
CLV_C14_Caspase3-7	154	158	PF00656	0.646
CLV_C14_Caspase3-7	51	55	PF00656	0.673
CLV_C14_Caspase3-7	687	691	PF00656	0.703
CLV_NRD_NRD_1	114	116	PF00675	0.732
CLV_NRD_NRD_1	413	415	PF00675	0.616
CLV_NRD_NRD_1	420	422	PF00675	0.662
CLV_NRD_NRD_1	457	459	PF00675	0.703
CLV_NRD_NRD_1	48	50	PF00675	0.557
CLV_NRD_NRD_1	701	703	PF00675	0.725
CLV_NRD_NRD_1	742	744	PF00675	0.699
CLV_NRD_NRD_1	929	931	PF00675	0.574
CLV_PCSK_KEX2_1	114	116	PF00082	0.732
CLV_PCSK_KEX2_1	190	192	PF00082	0.620
CLV_PCSK_KEX2_1	413	415	PF00082	0.616
CLV_PCSK_KEX2_1	420	422	PF00082	0.662
CLV_PCSK_KEX2_1	48	50	PF00082	0.559
CLV_PCSK_KEX2_1	513	515	PF00082	0.552
CLV_PCSK_KEX2_1	701	703	PF00082	0.722
CLV_PCSK_KEX2_1	741	743	PF00082	0.687
CLV_PCSK_KEX2_1	749	751	PF00082	0.617
CLV_PCSK_KEX2_1	855	857	PF00082	0.556
CLV_PCSK_KEX2_1	880	882	PF00082	0.639
CLV_PCSK_KEX2_1	929	931	PF00082	0.574
CLV_PCSK_PC1ET2_1	190	192	PF00082	0.663
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.631
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.555
CLV_PCSK_PC1ET2_1	855	857	PF00082	0.556
CLV_PCSK_PC1ET2_1	880	882	PF00082	0.639
CLV_PCSK_SKI1_1	42	46	PF00082	0.623
CLV_PCSK_SKI1_1	488	492	PF00082	0.529
CLV_PCSK_SKI1_1	513	517	PF00082	0.575
CLV_PCSK_SKI1_1	522	526	PF00082	0.494
CLV_PCSK_SKI1_1	858	862	PF00082	0.637
DEG_APCC_KENBOX_2	139	143	PF00400	0.718
DEG_SCF_FBW7_1	25	31	PF00400	0.632
DEG_SCF_FBW7_1	344	349	PF00400	0.680
DEG_SPOP_SBC_1	15	19	PF00917	0.644
DEG_SPOP_SBC_1	212	216	PF00917	0.550
DEG_SPOP_SBC_1	227	231	PF00917	0.550
DEG_SPOP_SBC_1	691	695	PF00917	0.659
DEG_SPOP_SBC_1	756	760	PF00917	0.611
DEG_SPOP_SBC_1	832	836	PF00917	0.635
DOC_CKS1_1	25	30	PF01111	0.633
DOC_CYCLIN_yCln2_LP_2	259	265	PF00134	0.598
DOC_CYCLIN_yCln2_LP_2	40	46	PF00134	0.547
DOC_MAPK_DCC_7	38	46	PF00069	0.617
DOC_MAPK_gen_1	525	536	PF00069	0.547
DOC_MAPK_gen_1	669	677	PF00069	0.557
DOC_MAPK_MEF2A_6	671	679	PF00069	0.556
DOC_PP2B_LxvP_1	210	213	PF13499	0.631
DOC_PP2B_LxvP_1	259	262	PF13499	0.620
DOC_PP2B_LxvP_1	323	326	PF13499	0.639
DOC_PP2B_LxvP_1	431	434	PF13499	0.688
DOC_PP2B_LxvP_1	491	494	PF13499	0.541
DOC_PP4_FxxP_1	22	25	PF00568	0.716
DOC_PP4_FxxP_1	358	361	PF00568	0.729
DOC_PP4_MxPP_1	359	362	PF00568	0.698
DOC_USP7_MATH_1	145	149	PF00917	0.679
DOC_USP7_MATH_1	194	198	PF00917	0.692
DOC_USP7_MATH_1	199	203	PF00917	0.633
DOC_USP7_MATH_1	2	6	PF00917	0.669
DOC_USP7_MATH_1	213	217	PF00917	0.570
DOC_USP7_MATH_1	227	231	PF00917	0.554
DOC_USP7_MATH_1	232	236	PF00917	0.579
DOC_USP7_MATH_1	244	248	PF00917	0.600
DOC_USP7_MATH_1	255	259	PF00917	0.648
DOC_USP7_MATH_1	34	38	PF00917	0.654
DOC_USP7_MATH_1	346	350	PF00917	0.669
DOC_USP7_MATH_1	434	438	PF00917	0.703
DOC_USP7_MATH_1	496	500	PF00917	0.554
DOC_USP7_MATH_1	515	519	PF00917	0.622
DOC_USP7_MATH_1	594	598	PF00917	0.671
DOC_USP7_MATH_1	627	631	PF00917	0.698
DOC_USP7_MATH_1	680	684	PF00917	0.613
DOC_USP7_MATH_1	7	11	PF00917	0.639
DOC_USP7_MATH_1	708	712	PF00917	0.625
DOC_USP7_MATH_1	745	749	PF00917	0.653
DOC_USP7_MATH_1	787	791	PF00917	0.596
DOC_USP7_MATH_1	801	805	PF00917	0.611
DOC_USP7_MATH_1	816	820	PF00917	0.566
DOC_USP7_MATH_1	832	836	PF00917	0.534
DOC_USP7_MATH_1	903	907	PF00917	0.634
DOC_USP7_MATH_1	98	102	PF00917	0.652
DOC_USP7_MATH_2	472	478	PF00917	0.533
DOC_USP7_UBL2_3	522	526	PF12436	0.580
DOC_USP7_UBL2_3	667	671	PF12436	0.613
DOC_WW_Pin1_4	21	26	PF00397	0.573
DOC_WW_Pin1_4	257	262	PF00397	0.609
DOC_WW_Pin1_4	28	33	PF00397	0.624
DOC_WW_Pin1_4	303	308	PF00397	0.809
DOC_WW_Pin1_4	342	347	PF00397	0.788
DOC_WW_Pin1_4	389	394	PF00397	0.725
DOC_WW_Pin1_4	405	410	PF00397	0.529
DOC_WW_Pin1_4	5	10	PF00397	0.718
DOC_WW_Pin1_4	590	595	PF00397	0.779
DOC_WW_Pin1_4	599	604	PF00397	0.665
DOC_WW_Pin1_4	618	623	PF00397	0.662
DOC_WW_Pin1_4	629	634	PF00397	0.755
DOC_WW_Pin1_4	785	790	PF00397	0.598
DOC_WW_Pin1_4	796	801	PF00397	0.612
DOC_WW_Pin1_4	899	904	PF00397	0.550
LIG_14-3-3_CanoR_1	26	32	PF00244	0.658
LIG_14-3-3_CanoR_1	277	287	PF00244	0.731
LIG_14-3-3_CanoR_1	292	300	PF00244	0.607
LIG_14-3-3_CanoR_1	351	356	PF00244	0.657
LIG_14-3-3_CanoR_1	420	425	PF00244	0.655
LIG_14-3-3_CanoR_1	426	434	PF00244	0.648
LIG_14-3-3_CanoR_1	577	583	PF00244	0.641
LIG_14-3-3_CanoR_1	584	594	PF00244	0.609
LIG_14-3-3_CanoR_1	660	666	PF00244	0.626
LIG_14-3-3_CanoR_1	734	739	PF00244	0.703
LIG_14-3-3_CanoR_1	782	787	PF00244	0.621
LIG_14-3-3_CanoR_1	809	817	PF00244	0.661
LIG_14-3-3_CanoR_1	865	874	PF00244	0.663
LIG_BIR_II_1	1	5	PF00653	0.625
LIG_BIR_III_4	120	124	PF00653	0.583
LIG_BRCT_BRCA1_1	215	219	PF00533	0.562
LIG_BRCT_BRCA1_1	232	236	PF00533	0.591
LIG_BRCT_BRCA1_1	505	509	PF00533	0.592
LIG_BRCT_BRCA1_1	642	646	PF00533	0.629
LIG_CaM_IQ_9	922	937	PF13499	0.580
LIG_deltaCOP1_diTrp_1	638	646	PF00928	0.628
LIG_FHA_1	392	398	PF00498	0.702
LIG_FHA_1	426	432	PF00498	0.623
LIG_FHA_1	594	600	PF00498	0.745
LIG_FHA_1	825	831	PF00498	0.594
LIG_FHA_2	122	128	PF00498	0.667
LIG_FHA_2	152	158	PF00498	0.572
LIG_FHA_2	297	303	PF00498	0.576
LIG_FHA_2	503	509	PF00498	0.641
LIG_Integrin_isoDGR_2	402	404	PF01839	0.699
LIG_LIR_Apic_2	19	25	PF02991	0.713
LIG_LIR_Apic_2	234	240	PF02991	0.640
LIG_LIR_Apic_2	357	361	PF02991	0.726
LIG_LIR_Gen_1	216	227	PF02991	0.536
LIG_LIR_Gen_1	506	515	PF02991	0.661
LIG_LIR_Nem_3	216	222	PF02991	0.544
LIG_LIR_Nem_3	481	486	PF02991	0.604
LIG_LIR_Nem_3	499	504	PF02991	0.630
LIG_LIR_Nem_3	506	512	PF02991	0.669
LIG_LYPXL_S_1	500	504	PF13949	0.520
LIG_LYPXL_yS_3	501	504	PF13949	0.519
LIG_MLH1_MIPbox_1	215	219	PF16413	0.535
LIG_NRP_CendR_1	935	937	PF00754	0.574
LIG_SH2_CRK	237	241	PF00017	0.640
LIG_SH2_CRK	483	487	PF00017	0.477
LIG_SH2_STAT5	218	221	PF00017	0.541
LIG_SH3_3	165	171	PF00018	0.744
LIG_SH3_3	22	28	PF00018	0.685
LIG_SH3_3	259	265	PF00018	0.660
LIG_SH3_3	315	321	PF00018	0.715
LIG_SH3_3	323	329	PF00018	0.593
LIG_SH3_3	702	708	PF00018	0.598
LIG_SH3_3	733	739	PF00018	0.750
LIG_SUMO_SIM_par_1	287	293	PF11976	0.618
LIG_SUMO_SIM_par_1	793	799	PF11976	0.532
LIG_TRAF2_1	530	533	PF00917	0.497
LIG_TRAF2_1	77	80	PF00917	0.543
LIG_TRAF2_1	887	890	PF00917	0.652
LIG_WRC_WIRS_1	475	480	PF05994	0.566
LIG_WRC_WIRS_1	925	930	PF05994	0.583
MOD_CDK_SPK_2	21	26	PF00069	0.712
MOD_CDK_SPxK_1	618	624	PF00069	0.634
MOD_CDK_SPxK_1	629	635	PF00069	0.655
MOD_CK1_1	148	154	PF00069	0.665
MOD_CK1_1	21	27	PF00069	0.565
MOD_CK1_1	214	220	PF00069	0.584
MOD_CK1_1	223	229	PF00069	0.580
MOD_CK1_1	230	236	PF00069	0.567
MOD_CK1_1	278	284	PF00069	0.759
MOD_CK1_1	296	302	PF00069	0.612
MOD_CK1_1	336	342	PF00069	0.727
MOD_CK1_1	349	355	PF00069	0.573
MOD_CK1_1	391	397	PF00069	0.662
MOD_CK1_1	419	425	PF00069	0.684
MOD_CK1_1	429	435	PF00069	0.645
MOD_CK1_1	5	11	PF00069	0.783
MOD_CK1_1	518	524	PF00069	0.534
MOD_CK1_1	560	566	PF00069	0.545
MOD_CK1_1	585	591	PF00069	0.644
MOD_CK1_1	593	599	PF00069	0.709
MOD_CK1_1	64	70	PF00069	0.606
MOD_CK1_1	692	698	PF00069	0.690
MOD_CK1_1	723	729	PF00069	0.627
MOD_CK1_1	758	764	PF00069	0.700
MOD_CK1_1	785	791	PF00069	0.584
MOD_CK1_1	808	814	PF00069	0.600
MOD_CK1_1	824	830	PF00069	0.616
MOD_CK1_1	835	841	PF00069	0.587
MOD_CK1_1	867	873	PF00069	0.658
MOD_CK1_1	899	905	PF00069	0.550
MOD_CK1_1	924	930	PF00069	0.582
MOD_CK2_1	277	283	PF00069	0.647
MOD_CK2_1	296	302	PF00069	0.622
MOD_CK2_1	364	370	PF00069	0.581
MOD_CK2_1	429	435	PF00069	0.614
MOD_CK2_1	599	605	PF00069	0.593
MOD_CK2_1	680	686	PF00069	0.675
MOD_CK2_1	692	698	PF00069	0.622
MOD_CK2_1	74	80	PF00069	0.679
MOD_CK2_1	763	769	PF00069	0.623
MOD_CK2_1	831	837	PF00069	0.640
MOD_GlcNHglycan	135	138	PF01048	0.646
MOD_GlcNHglycan	181	184	PF01048	0.704
MOD_GlcNHglycan	201	204	PF01048	0.621
MOD_GlcNHglycan	222	225	PF01048	0.603
MOD_GlcNHglycan	230	233	PF01048	0.584
MOD_GlcNHglycan	246	249	PF01048	0.524
MOD_GlcNHglycan	277	280	PF01048	0.650
MOD_GlcNHglycan	295	298	PF01048	0.673
MOD_GlcNHglycan	311	314	PF01048	0.601
MOD_GlcNHglycan	335	338	PF01048	0.650
MOD_GlcNHglycan	366	369	PF01048	0.709
MOD_GlcNHglycan	383	386	PF01048	0.723
MOD_GlcNHglycan	438	441	PF01048	0.790
MOD_GlcNHglycan	452	455	PF01048	0.641
MOD_GlcNHglycan	462	465	PF01048	0.591
MOD_GlcNHglycan	584	587	PF01048	0.692
MOD_GlcNHglycan	615	619	PF01048	0.731
MOD_GlcNHglycan	70	73	PF01048	0.561
MOD_GlcNHglycan	710	713	PF01048	0.716
MOD_GlcNHglycan	784	787	PF01048	0.733
MOD_GlcNHglycan	790	793	PF01048	0.659
MOD_GlcNHglycan	805	808	PF01048	0.622
MOD_GlcNHglycan	812	815	PF01048	0.758
MOD_GlcNHglycan	869	872	PF01048	0.610
MOD_GlcNHglycan	9	12	PF01048	0.540
MOD_GSK3_1	145	152	PF00069	0.651
MOD_GSK3_1	169	176	PF00069	0.646
MOD_GSK3_1	213	220	PF00069	0.585
MOD_GSK3_1	222	229	PF00069	0.685
MOD_GSK3_1	24	31	PF00069	0.551
MOD_GSK3_1	275	282	PF00069	0.771
MOD_GSK3_1	303	310	PF00069	0.711
MOD_GSK3_1	329	336	PF00069	0.708
MOD_GSK3_1	342	349	PF00069	0.581
MOD_GSK3_1	350	357	PF00069	0.678
MOD_GSK3_1	360	367	PF00069	0.534
MOD_GSK3_1	416	423	PF00069	0.651
MOD_GSK3_1	425	432	PF00069	0.684
MOD_GSK3_1	474	481	PF00069	0.513
MOD_GSK3_1	557	564	PF00069	0.562
MOD_GSK3_1	578	585	PF00069	0.735
MOD_GSK3_1	590	597	PF00069	0.514
MOD_GSK3_1	60	67	PF00069	0.628
MOD_GSK3_1	614	621	PF00069	0.629
MOD_GSK3_1	692	699	PF00069	0.660
MOD_GSK3_1	7	14	PF00069	0.686
MOD_GSK3_1	708	715	PF00069	0.664
MOD_GSK3_1	721	728	PF00069	0.691
MOD_GSK3_1	755	762	PF00069	0.640
MOD_GSK3_1	778	785	PF00069	0.626
MOD_GSK3_1	801	808	PF00069	0.663
MOD_GSK3_1	817	824	PF00069	0.681
MOD_GSK3_1	831	838	PF00069	0.544
MOD_GSK3_1	863	870	PF00069	0.603
MOD_GSK3_1	892	899	PF00069	0.709
MOD_LATS_1	511	517	PF00433	0.541
MOD_N-GLC_1	194	199	PF02516	0.581
MOD_N-GLC_1	220	225	PF02516	0.587
MOD_N-GLC_1	275	280	PF02516	0.598
MOD_N-GLC_1	349	354	PF02516	0.770
MOD_N-GLC_1	429	434	PF02516	0.717
MOD_N-GLC_1	824	829	PF02516	0.651
MOD_N-GLC_2	73	75	PF02516	0.622
MOD_NEK2_1	222	227	PF00069	0.707
MOD_NEK2_1	290	295	PF00069	0.570
MOD_NEK2_1	424	429	PF00069	0.626
MOD_NEK2_1	478	483	PF00069	0.521
MOD_NEK2_1	561	566	PF00069	0.531
MOD_NEK2_1	567	572	PF00069	0.507
MOD_NEK2_1	582	587	PF00069	0.675
MOD_NEK2_1	646	651	PF00069	0.651
MOD_NEK2_1	817	822	PF00069	0.642
MOD_NEK2_1	831	836	PF00069	0.549
MOD_NEK2_1	863	868	PF00069	0.602
MOD_NEK2_2	232	237	PF00069	0.644
MOD_NEK2_2	496	501	PF00069	0.529
MOD_PIKK_1	478	484	PF00454	0.496
MOD_PIKK_1	627	633	PF00454	0.647
MOD_PIKK_1	734	740	PF00454	0.619
MOD_PIKK_1	865	871	PF00454	0.658
MOD_PIKK_1	903	909	PF00454	0.640
MOD_PK_1	360	366	PF00069	0.647
MOD_PKA_1	420	426	PF00069	0.635
MOD_PKA_1	458	464	PF00069	0.640
MOD_PKA_1	48	54	PF00069	0.566
MOD_PKA_1	513	519	PF00069	0.533
MOD_PKA_2	244	250	PF00069	0.609
MOD_PKA_2	350	356	PF00069	0.658
MOD_PKA_2	419	425	PF00069	0.678
MOD_PKA_2	48	54	PF00069	0.566
MOD_PKA_2	513	519	PF00069	0.533
MOD_PKA_2	578	584	PF00069	0.596
MOD_PKA_2	659	665	PF00069	0.652
MOD_PKA_2	700	706	PF00069	0.802
MOD_PKA_2	778	784	PF00069	0.622
MOD_PKA_2	808	814	PF00069	0.569
MOD_PKA_2	864	870	PF00069	0.551
MOD_PKB_1	575	583	PF00069	0.585
MOD_Plk_1	194	200	PF00069	0.569
MOD_Plk_1	429	435	PF00069	0.676
MOD_Plk_1	502	508	PF00069	0.578
MOD_Plk_1	604	610	PF00069	0.660
MOD_Plk_1	903	909	PF00069	0.546
MOD_Plk_2-3	503	509	PF00069	0.539
MOD_Plk_4	214	220	PF00069	0.546
MOD_Plk_4	232	238	PF00069	0.584
MOD_Plk_4	354	360	PF00069	0.647
MOD_Plk_4	474	480	PF00069	0.613
MOD_Plk_4	496	502	PF00069	0.606
MOD_Plk_4	561	567	PF00069	0.612
MOD_Plk_4	594	600	PF00069	0.686
MOD_Plk_4	870	876	PF00069	0.597
MOD_ProDKin_1	21	27	PF00069	0.572
MOD_ProDKin_1	257	263	PF00069	0.611
MOD_ProDKin_1	28	34	PF00069	0.623
MOD_ProDKin_1	303	309	PF00069	0.811
MOD_ProDKin_1	342	348	PF00069	0.788
MOD_ProDKin_1	389	395	PF00069	0.725
MOD_ProDKin_1	405	411	PF00069	0.531
MOD_ProDKin_1	5	11	PF00069	0.720
MOD_ProDKin_1	590	596	PF00069	0.781
MOD_ProDKin_1	599	605	PF00069	0.666
MOD_ProDKin_1	618	624	PF00069	0.661
MOD_ProDKin_1	629	635	PF00069	0.755
MOD_ProDKin_1	785	791	PF00069	0.598
MOD_ProDKin_1	796	802	PF00069	0.614
MOD_ProDKin_1	899	905	PF00069	0.550
MOD_SUMO_for_1	670	673	PF00179	0.605
MOD_SUMO_rev_2	278	287	PF00179	0.639
TRG_DiLeu_BaEn_2	473	479	PF01217	0.500
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.588
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.614
TRG_ENDOCYTIC_2	483	486	PF00928	0.509
TRG_ENDOCYTIC_2	501	504	PF00928	0.557
TRG_ENDOCYTIC_2	93	96	PF00928	0.533
TRG_ER_diArg_1	114	117	PF00400	0.678
TRG_ER_diArg_1	413	415	PF00400	0.595
TRG_ER_diArg_1	534	537	PF00400	0.510
TRG_ER_diArg_1	574	577	PF00400	0.523
TRG_ER_diArg_1	700	702	PF00400	0.720
TRG_ER_diArg_1	741	743	PF00400	0.692
TRG_ER_diArg_1	928	930	PF00400	0.581
TRG_NLS_MonoCore_2	854	859	PF00514	0.555
TRG_NLS_MonoExtN_4	853	859	PF00514	0.555
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.587
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	537	541	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC30	Leptomonas seymouri	35%	94%
A4HAF9	Leishmania braziliensis	58%	98%
A4I9L5	Leishmania infantum	100%	100%
E9B4L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	94%
Q4Q3G3	Leishmania major	87%	100%