Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IGY4_LEIDO

TriTrypDb:

LdBPK_090590.1 , LdCL_090011000 , LDHU3_09.0730

Length:

1108

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGY4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1042	1046	PF00656	0.593
CLV_NRD_NRD_1	113	115	PF00675	0.769
CLV_NRD_NRD_1	15	17	PF00675	0.729
CLV_NRD_NRD_1	31	33	PF00675	0.532
CLV_NRD_NRD_1	333	335	PF00675	0.690
CLV_NRD_NRD_1	401	403	PF00675	0.685
CLV_NRD_NRD_1	523	525	PF00675	0.721
CLV_NRD_NRD_1	614	616	PF00675	0.643
CLV_NRD_NRD_1	648	650	PF00675	0.665
CLV_NRD_NRD_1	667	669	PF00675	0.539
CLV_NRD_NRD_1	820	822	PF00675	0.622
CLV_NRD_NRD_1	926	928	PF00675	0.718
CLV_NRD_NRD_1	968	970	PF00675	0.648
CLV_PCSK_FUR_1	966	970	PF00082	0.616
CLV_PCSK_KEX2_1	113	115	PF00082	0.769
CLV_PCSK_KEX2_1	15	17	PF00082	0.729
CLV_PCSK_KEX2_1	257	259	PF00082	0.799
CLV_PCSK_KEX2_1	31	33	PF00082	0.532
CLV_PCSK_KEX2_1	333	335	PF00082	0.690
CLV_PCSK_KEX2_1	401	403	PF00082	0.701
CLV_PCSK_KEX2_1	523	525	PF00082	0.673
CLV_PCSK_KEX2_1	584	586	PF00082	0.705
CLV_PCSK_KEX2_1	614	616	PF00082	0.702
CLV_PCSK_KEX2_1	819	821	PF00082	0.645
CLV_PCSK_KEX2_1	926	928	PF00082	0.718
CLV_PCSK_KEX2_1	968	970	PF00082	0.666
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.736
CLV_PCSK_PC1ET2_1	584	586	PF00082	0.705
CLV_PCSK_PC1ET2_1	819	821	PF00082	0.629
CLV_PCSK_SKI1_1	287	291	PF00082	0.678
CLV_PCSK_SKI1_1	619	623	PF00082	0.661
CLV_PCSK_SKI1_1	73	77	PF00082	0.672
CLV_PCSK_SKI1_1	864	868	PF00082	0.692
DEG_SPOP_SBC_1	385	389	PF00917	0.633
DEG_SPOP_SBC_1	915	919	PF00917	0.625
DOC_CDC14_PxL_1	106	114	PF14671	0.638
DOC_CKS1_1	362	367	PF01111	0.664
DOC_CKS1_1	94	99	PF01111	0.638
DOC_CYCLIN_yCln2_LP_2	1065	1071	PF00134	0.664
DOC_CYCLIN_yCln2_LP_2	835	841	PF00134	0.524
DOC_MAPK_gen_1	31	38	PF00069	0.645
DOC_MAPK_gen_1	443	451	PF00069	0.596
DOC_MAPK_MEF2A_6	232	239	PF00069	0.672
DOC_MAPK_MEF2A_6	73	81	PF00069	0.672
DOC_PP1_RVXF_1	190	196	PF00149	0.576
DOC_PP1_RVXF_1	832	838	PF00149	0.529
DOC_USP7_MATH_1	1071	1075	PF00917	0.667
DOC_USP7_MATH_1	1076	1080	PF00917	0.638
DOC_USP7_MATH_1	1093	1097	PF00917	0.542
DOC_USP7_MATH_1	1099	1103	PF00917	0.608
DOC_USP7_MATH_1	218	222	PF00917	0.805
DOC_USP7_MATH_1	312	316	PF00917	0.699
DOC_USP7_MATH_1	335	339	PF00917	0.708
DOC_USP7_MATH_1	343	347	PF00917	0.630
DOC_USP7_MATH_1	377	381	PF00917	0.734
DOC_USP7_MATH_1	385	389	PF00917	0.614
DOC_USP7_MATH_1	4	8	PF00917	0.721
DOC_USP7_MATH_1	458	462	PF00917	0.759
DOC_USP7_MATH_1	484	488	PF00917	0.797
DOC_USP7_MATH_1	556	560	PF00917	0.722
DOC_USP7_MATH_1	621	625	PF00917	0.713
DOC_USP7_MATH_1	693	697	PF00917	0.681
DOC_USP7_MATH_1	727	731	PF00917	0.679
DOC_USP7_MATH_1	876	880	PF00917	0.657
DOC_USP7_MATH_1	88	92	PF00917	0.664
DOC_USP7_MATH_1	915	919	PF00917	0.625
DOC_USP7_MATH_1	975	979	PF00917	0.630
DOC_WW_Pin1_4	1083	1088	PF00397	0.639
DOC_WW_Pin1_4	114	119	PF00397	0.511
DOC_WW_Pin1_4	16	21	PF00397	0.714
DOC_WW_Pin1_4	214	219	PF00397	0.773
DOC_WW_Pin1_4	248	253	PF00397	0.733
DOC_WW_Pin1_4	280	285	PF00397	0.733
DOC_WW_Pin1_4	354	359	PF00397	0.712
DOC_WW_Pin1_4	361	366	PF00397	0.663
DOC_WW_Pin1_4	401	406	PF00397	0.645
DOC_WW_Pin1_4	48	53	PF00397	0.675
DOC_WW_Pin1_4	534	539	PF00397	0.702
DOC_WW_Pin1_4	548	553	PF00397	0.573
DOC_WW_Pin1_4	573	578	PF00397	0.604
DOC_WW_Pin1_4	928	933	PF00397	0.699
DOC_WW_Pin1_4	93	98	PF00397	0.672
DOC_WW_Pin1_4	99	104	PF00397	0.641
LIG_14-3-3_CanoR_1	192	196	PF00244	0.597
LIG_14-3-3_CanoR_1	209	218	PF00244	0.678
LIG_14-3-3_CanoR_1	25	30	PF00244	0.660
LIG_14-3-3_CanoR_1	287	292	PF00244	0.684
LIG_14-3-3_CanoR_1	333	342	PF00244	0.692
LIG_14-3-3_CanoR_1	369	373	PF00244	0.693
LIG_14-3-3_CanoR_1	401	405	PF00244	0.690
LIG_14-3-3_CanoR_1	596	606	PF00244	0.634
LIG_14-3-3_CanoR_1	823	832	PF00244	0.561
LIG_14-3-3_CanoR_1	842	846	PF00244	0.488
LIG_AP2alpha_2	489	491	PF02296	0.656
LIG_APCC_ABBA_1	740	745	PF00400	0.614
LIG_APCC_ABBAyCdc20_2	650	656	PF00400	0.609
LIG_BIR_II_1	1	5	PF00653	0.586
LIG_BIR_III_1	1	5	PF00653	0.586
LIG_BIR_III_2	271	275	PF00653	0.582
LIG_BIR_III_3	1	5	PF00653	0.586
LIG_BIR_III_4	162	166	PF00653	0.674
LIG_BRCT_BRCA1_1	825	829	PF00533	0.649
LIG_eIF4E_1	976	982	PF01652	0.666
LIG_FHA_1	17	23	PF00498	0.756
LIG_FHA_1	265	271	PF00498	0.710
LIG_FHA_1	409	415	PF00498	0.677
LIG_FHA_1	542	548	PF00498	0.690
LIG_FHA_1	597	603	PF00498	0.600
LIG_FHA_1	64	70	PF00498	0.697
LIG_FHA_1	748	754	PF00498	0.614
LIG_FHA_1	834	840	PF00498	0.633
LIG_FHA_1	975	981	PF00498	0.671
LIG_FHA_2	303	309	PF00498	0.594
LIG_FHA_2	491	497	PF00498	0.713
LIG_FHA_2	552	558	PF00498	0.599
LIG_FHA_2	981	987	PF00498	0.623
LIG_Integrin_isoDGR_2	222	224	PF01839	0.621
LIG_Integrin_isoDGR_2	666	668	PF01839	0.687
LIG_LIR_Apic_2	844	850	PF02991	0.679
LIG_LIR_Gen_1	1000	1011	PF02991	0.501
LIG_LIR_LC3C_4	410	414	PF02991	0.588
LIG_LIR_Nem_3	1000	1006	PF02991	0.493
LIG_LIR_Nem_3	631	637	PF02991	0.588
LIG_LIR_Nem_3	74	79	PF02991	0.670
LIG_LIR_Nem_3	826	832	PF02991	0.561
LIG_MYND_1	889	893	PF01753	0.635
LIG_PDZ_Class_2	1103	1108	PF00595	0.608
LIG_Pex14_2	943	947	PF04695	0.630
LIG_RPA_C_Fungi	204	216	PF08784	0.687
LIG_SH2_CRK	847	851	PF00017	0.715
LIG_SH2_CRK	976	980	PF00017	0.679
LIG_SH2_NCK_1	492	496	PF00017	0.709
LIG_SH2_NCK_1	847	851	PF00017	0.715
LIG_SH2_STAP1	976	980	PF00017	0.630
LIG_SH2_STAT3	173	176	PF00017	0.682
LIG_SH2_STAT3	317	320	PF00017	0.678
LIG_SH2_STAT3	706	709	PF00017	0.566
LIG_SH2_STAT5	1003	1006	PF00017	0.599
LIG_SH2_STAT5	492	495	PF00017	0.710
LIG_SH2_STAT5	752	755	PF00017	0.651
LIG_SH2_STAT5	800	803	PF00017	0.634
LIG_SH2_STAT5	941	944	PF00017	0.642
LIG_SH2_STAT5	976	979	PF00017	0.684
LIG_SH3_1	792	798	PF00018	0.609
LIG_SH3_1	886	892	PF00018	0.645
LIG_SH3_2	859	864	PF14604	0.661
LIG_SH3_3	112	118	PF00018	0.695
LIG_SH3_3	236	242	PF00018	0.667
LIG_SH3_3	353	359	PF00018	0.697
LIG_SH3_3	571	577	PF00018	0.617
LIG_SH3_3	74	80	PF00018	0.668
LIG_SH3_3	792	798	PF00018	0.609
LIG_SH3_3	835	841	PF00018	0.657
LIG_SH3_3	856	862	PF00018	0.634
LIG_SH3_3	886	892	PF00018	0.645
LIG_Sin3_3	1069	1076	PF02671	0.560
LIG_SUMO_SIM_anti_2	977	984	PF11976	0.650
LIG_SUMO_SIM_par_1	977	984	PF11976	0.650
LIG_TRAF2_1	1039	1042	PF00917	0.587
LIG_TRAF2_1	246	249	PF00917	0.583
LIG_TRAF2_1	306	309	PF00917	0.638
LIG_TRAF2_1	318	321	PF00917	0.579
LIG_TRAF2_1	52	55	PF00917	0.631
LIG_TRAF2_1	681	684	PF00917	0.684
LIG_TRFH_1	76	80	PF08558	0.668
LIG_WW_3	166	170	PF00397	0.732
LIG_WW_3	572	576	PF00397	0.714
LIG_WW_3	849	853	PF00397	0.674
MOD_CAAXbox	1105	1108	PF01239	0.604
MOD_CDK_SPK_2	1083	1088	PF00069	0.591
MOD_CDK_SPxxK_3	280	287	PF00069	0.685
MOD_CK1_1	102	108	PF00069	0.679
MOD_CK1_1	1060	1066	PF00069	0.580
MOD_CK1_1	1086	1092	PF00069	0.635
MOD_CK1_1	116	122	PF00069	0.644
MOD_CK1_1	210	216	PF00069	0.779
MOD_CK1_1	226	232	PF00069	0.611
MOD_CK1_1	251	257	PF00069	0.724
MOD_CK1_1	293	299	PF00069	0.606
MOD_CK1_1	371	377	PF00069	0.701
MOD_CK1_1	380	386	PF00069	0.622
MOD_CK1_1	432	438	PF00069	0.837
MOD_CK1_1	463	469	PF00069	0.710
MOD_CK1_1	548	554	PF00069	0.600
MOD_CK1_1	591	597	PF00069	0.715
MOD_CK1_1	7	13	PF00069	0.738
MOD_CK1_1	833	839	PF00069	0.649
MOD_CK1_1	879	885	PF00069	0.715
MOD_CK1_1	916	922	PF00069	0.715
MOD_CK2_1	214	220	PF00069	0.741
MOD_CK2_1	222	228	PF00069	0.667
MOD_CK2_1	243	249	PF00069	0.586
MOD_CK2_1	302	308	PF00069	0.660
MOD_CK2_1	470	476	PF00069	0.629
MOD_CK2_1	526	532	PF00069	0.732
MOD_CK2_1	551	557	PF00069	0.654
MOD_CK2_1	597	603	PF00069	0.684
MOD_CK2_1	693	699	PF00069	0.594
MOD_CK2_1	710	716	PF00069	0.589
MOD_CK2_1	727	733	PF00069	0.543
MOD_CK2_1	766	772	PF00069	0.641
MOD_Cter_Amidation	331	334	PF01082	0.694
MOD_Cter_Amidation	399	402	PF01082	0.655
MOD_Cter_Amidation	666	669	PF01082	0.682
MOD_DYRK1A_RPxSP_1	114	118	PF00069	0.674
MOD_GlcNHglycan	1073	1076	PF01048	0.624
MOD_GlcNHglycan	1095	1098	PF01048	0.689
MOD_GlcNHglycan	128	131	PF01048	0.710
MOD_GlcNHglycan	144	147	PF01048	0.593
MOD_GlcNHglycan	209	212	PF01048	0.822
MOD_GlcNHglycan	225	228	PF01048	0.643
MOD_GlcNHglycan	337	340	PF01048	0.606
MOD_GlcNHglycan	376	380	PF01048	0.646
MOD_GlcNHglycan	431	434	PF01048	0.778
MOD_GlcNHglycan	460	463	PF01048	0.718
MOD_GlcNHglycan	472	475	PF01048	0.629
MOD_GlcNHglycan	48	51	PF01048	0.656
MOD_GlcNHglycan	512	515	PF01048	0.695
MOD_GlcNHglycan	516	520	PF01048	0.655
MOD_GlcNHglycan	557	561	PF01048	0.679
MOD_GlcNHglycan	712	715	PF01048	0.652
MOD_GlcNHglycan	73	76	PF01048	0.674
MOD_GlcNHglycan	784	787	PF01048	0.635
MOD_GlcNHglycan	826	829	PF01048	0.668
MOD_GlcNHglycan	847	850	PF01048	0.713
MOD_GlcNHglycan	881	884	PF01048	0.692
MOD_GlcNHglycan	90	93	PF01048	0.513
MOD_GlcNHglycan	905	908	PF01048	0.705
MOD_GlcNHglycan	919	922	PF01048	0.551
MOD_GSK3_1	1023	1030	PF00069	0.564
MOD_GSK3_1	1071	1078	PF00069	0.663
MOD_GSK3_1	1095	1102	PF00069	0.571
MOD_GSK3_1	210	217	PF00069	0.821
MOD_GSK3_1	218	225	PF00069	0.716
MOD_GSK3_1	23	30	PF00069	0.544
MOD_GSK3_1	244	251	PF00069	0.644
MOD_GSK3_1	260	267	PF00069	0.576
MOD_GSK3_1	312	319	PF00069	0.731
MOD_GSK3_1	360	367	PF00069	0.792
MOD_GSK3_1	368	375	PF00069	0.703
MOD_GSK3_1	380	387	PF00069	0.580
MOD_GSK3_1	42	49	PF00069	0.622
MOD_GSK3_1	432	439	PF00069	0.777
MOD_GSK3_1	470	477	PF00069	0.637
MOD_GSK3_1	497	504	PF00069	0.704
MOD_GSK3_1	515	522	PF00069	0.613
MOD_GSK3_1	541	548	PF00069	0.638
MOD_GSK3_1	580	587	PF00069	0.680
MOD_GSK3_1	588	595	PF00069	0.681
MOD_GSK3_1	7	14	PF00069	0.726
MOD_GSK3_1	747	754	PF00069	0.592
MOD_GSK3_1	841	848	PF00069	0.674
MOD_GSK3_1	877	884	PF00069	0.716
MOD_GSK3_1	909	916	PF00069	0.672
MOD_GSK3_1	928	935	PF00069	0.619
MOD_GSK3_1	95	102	PF00069	0.691
MOD_N-GLC_1	1027	1032	PF02516	0.656
MOD_N-GLC_1	141	146	PF02516	0.651
MOD_N-GLC_1	324	329	PF02516	0.658
MOD_N-GLC_1	669	674	PF02516	0.671
MOD_NEK2_1	1012	1017	PF00069	0.577
MOD_NEK2_1	46	51	PF00069	0.596
MOD_NEK2_1	501	506	PF00069	0.715
MOD_NEK2_1	510	515	PF00069	0.629
MOD_NEK2_1	588	593	PF00069	0.687
MOD_NEK2_1	766	771	PF00069	0.663
MOD_NEK2_1	845	850	PF00069	0.705
MOD_NEK2_1	86	91	PF00069	0.639
MOD_NEK2_1	877	882	PF00069	0.722
MOD_NEK2_1	980	985	PF00069	0.634
MOD_NEK2_2	1027	1032	PF00069	0.656
MOD_NEK2_2	343	348	PF00069	0.620
MOD_NEK2_2	377	382	PF00069	0.572
MOD_NEK2_2	445	450	PF00069	0.680
MOD_NEK2_2	474	479	PF00069	0.576
MOD_PIKK_1	1005	1011	PF00454	0.621
MOD_PIKK_1	1060	1066	PF00454	0.532
MOD_PIKK_1	260	266	PF00454	0.770
MOD_PIKK_1	316	322	PF00454	0.684
MOD_PIKK_1	333	339	PF00454	0.555
MOD_PIKK_1	463	469	PF00454	0.671
MOD_PIKK_1	545	551	PF00454	0.625
MOD_PIKK_1	608	614	PF00454	0.687
MOD_PIKK_1	760	766	PF00454	0.647
MOD_PKA_1	113	119	PF00069	0.704
MOD_PKA_1	333	339	PF00069	0.689
MOD_PKA_1	584	590	PF00069	0.709
MOD_PKA_2	113	119	PF00069	0.704
MOD_PKA_2	191	197	PF00069	0.657
MOD_PKA_2	223	229	PF00069	0.686
MOD_PKA_2	312	318	PF00069	0.729
MOD_PKA_2	333	339	PF00069	0.689
MOD_PKA_2	368	374	PF00069	0.740
MOD_PKA_2	400	406	PF00069	0.619
MOD_PKA_2	478	484	PF00069	0.706
MOD_PKA_2	584	590	PF00069	0.725
MOD_PKA_2	591	597	PF00069	0.672
MOD_PKA_2	693	699	PF00069	0.642
MOD_PKA_2	720	726	PF00069	0.587
MOD_PKA_2	727	733	PF00069	0.567
MOD_PKA_2	822	828	PF00069	0.686
MOD_PKA_2	841	847	PF00069	0.492
MOD_PKB_1	821	829	PF00069	0.621
MOD_Plk_1	1027	1033	PF00069	0.662
MOD_Plk_1	1060	1066	PF00069	0.537
MOD_Plk_1	293	299	PF00069	0.616
MOD_Plk_1	542	548	PF00069	0.656
MOD_Plk_1	736	742	PF00069	0.601
MOD_Plk_2-3	1023	1029	PF00069	0.506
MOD_Plk_2-3	324	330	PF00069	0.707
MOD_Plk_4	119	125	PF00069	0.722
MOD_Plk_4	408	414	PF00069	0.672
MOD_Plk_4	497	503	PF00069	0.759
MOD_Plk_4	526	532	PF00069	0.696
MOD_Plk_4	584	590	PF00069	0.639
MOD_Plk_4	621	627	PF00069	0.592
MOD_Plk_4	63	69	PF00069	0.681
MOD_Plk_4	975	981	PF00069	0.623
MOD_ProDKin_1	1083	1089	PF00069	0.638
MOD_ProDKin_1	114	120	PF00069	0.643
MOD_ProDKin_1	16	22	PF00069	0.715
MOD_ProDKin_1	214	220	PF00069	0.774
MOD_ProDKin_1	248	254	PF00069	0.736
MOD_ProDKin_1	280	286	PF00069	0.733
MOD_ProDKin_1	354	360	PF00069	0.715
MOD_ProDKin_1	361	367	PF00069	0.664
MOD_ProDKin_1	401	407	PF00069	0.647
MOD_ProDKin_1	48	54	PF00069	0.674
MOD_ProDKin_1	534	540	PF00069	0.706
MOD_ProDKin_1	548	554	PF00069	0.575
MOD_ProDKin_1	573	579	PF00069	0.606
MOD_ProDKin_1	928	934	PF00069	0.695
MOD_ProDKin_1	93	99	PF00069	0.668
MOD_SUMO_for_1	396	399	PF00179	0.591
MOD_SUMO_rev_2	611	621	PF00179	0.666
TRG_DiLeu_BaLyEn_6	1032	1037	PF01217	0.698
TRG_DiLeu_BaLyEn_6	17	22	PF01217	0.724
TRG_DiLeu_BaLyEn_6	74	79	PF01217	0.670
TRG_ENDOCYTIC_2	1003	1006	PF00928	0.599
TRG_ENDOCYTIC_2	527	530	PF00928	0.627
TRG_ENDOCYTIC_2	976	979	PF00928	0.684
TRG_ER_diArg_1	112	114	PF00400	0.774
TRG_ER_diArg_1	153	156	PF00400	0.649
TRG_ER_diArg_1	168	171	PF00400	0.664
TRG_ER_diArg_1	310	313	PF00400	0.693
TRG_ER_diArg_1	820	823	PF00400	0.632
TRG_ER_diArg_1	925	927	PF00400	0.721
TRG_ER_diArg_1	966	969	PF00400	0.614
TRG_ER_diArg_1	987	990	PF00400	0.565
TRG_ER_FFAT_2	747	757	PF00635	0.651
TRG_NLS_MonoExtC_3	818	823	PF00514	0.606
TRG_NLS_MonoExtN_4	818	823	PF00514	0.606
TRG_Pf-PMV_PEXEL_1	959	964	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H5N1	Leishmania braziliensis	57%	98%
A4HTW8	Leishmania infantum	98%	100%
E9AMQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	99%
Q4QHX0	Leishmania major	87%	100%