Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGY3_LEIDO

TriTrypDb:

LdBPK_322740.1 , LdCL_320033200 , LDHU3_32.3410

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	528	532	PF00656	0.641
CLV_NRD_NRD_1	217	219	PF00675	0.443
CLV_NRD_NRD_1	361	363	PF00675	0.426
CLV_NRD_NRD_1	436	438	PF00675	0.774
CLV_NRD_NRD_1	462	464	PF00675	0.487
CLV_NRD_NRD_1	609	611	PF00675	0.632
CLV_PCSK_KEX2_1	217	219	PF00082	0.387
CLV_PCSK_KEX2_1	361	363	PF00082	0.436
CLV_PCSK_KEX2_1	436	438	PF00082	0.615
CLV_PCSK_KEX2_1	462	464	PF00082	0.487
CLV_PCSK_SKI1_1	163	167	PF00082	0.433
CLV_PCSK_SKI1_1	217	221	PF00082	0.382
CLV_PCSK_SKI1_1	246	250	PF00082	0.625
CLV_PCSK_SKI1_1	361	365	PF00082	0.454
CLV_PCSK_SKI1_1	454	458	PF00082	0.518
DEG_APCC_DBOX_1	216	224	PF00400	0.394
DEG_SPOP_SBC_1	247	251	PF00917	0.517
DEG_SPOP_SBC_1	322	326	PF00917	0.657
DEG_SPOP_SBC_1	331	335	PF00917	0.558
DEG_SPOP_SBC_1	510	514	PF00917	0.690
DEG_SPOP_SBC_1	586	590	PF00917	0.682
DEG_SPOP_SBC_1	598	602	PF00917	0.579
DOC_CYCLIN_RxL_1	358	367	PF00134	0.454
DOC_CYCLIN_RxL_1	448	461	PF00134	0.568
DOC_CYCLIN_yCln2_LP_2	166	172	PF00134	0.444
DOC_MAPK_gen_1	217	225	PF00069	0.425
DOC_MAPK_MEF2A_6	23	32	PF00069	0.480
DOC_MAPK_MEF2A_6	393	400	PF00069	0.572
DOC_PP1_RVXF_1	53	60	PF00149	0.463
DOC_PP2B_LxvP_1	28	31	PF13499	0.419
DOC_PP2B_LxvP_1	344	347	PF13499	0.602
DOC_PP2B_LxvP_1	486	489	PF13499	0.577
DOC_PP4_FxxP_1	42	45	PF00568	0.447
DOC_USP7_MATH_1	247	251	PF00917	0.556
DOC_USP7_MATH_1	254	258	PF00917	0.560
DOC_USP7_MATH_1	287	291	PF00917	0.598
DOC_USP7_MATH_1	316	320	PF00917	0.634
DOC_USP7_MATH_1	322	326	PF00917	0.601
DOC_USP7_MATH_1	329	333	PF00917	0.559
DOC_USP7_MATH_1	417	421	PF00917	0.578
DOC_USP7_MATH_1	427	431	PF00917	0.545
DOC_USP7_MATH_1	490	494	PF00917	0.831
DOC_USP7_MATH_1	506	510	PF00917	0.632
DOC_USP7_MATH_1	558	562	PF00917	0.686
DOC_USP7_MATH_1	586	590	PF00917	0.637
DOC_USP7_MATH_1	62	66	PF00917	0.589
DOC_USP7_MATH_1	632	636	PF00917	0.574
DOC_USP7_MATH_1	71	75	PF00917	0.510
DOC_WW_Pin1_4	270	275	PF00397	0.590
DOC_WW_Pin1_4	345	350	PF00397	0.633
DOC_WW_Pin1_4	540	545	PF00397	0.634
DOC_WW_Pin1_4	553	558	PF00397	0.621
DOC_WW_Pin1_4	560	565	PF00397	0.536
DOC_WW_Pin1_4	604	609	PF00397	0.800
DOC_WW_Pin1_4	67	72	PF00397	0.606
LIG_14-3-3_CanoR_1	198	205	PF00244	0.424
LIG_14-3-3_CanoR_1	246	254	PF00244	0.688
LIG_14-3-3_CanoR_1	361	370	PF00244	0.437
LIG_14-3-3_CanoR_1	478	486	PF00244	0.673
LIG_14-3-3_CanoR_1	55	60	PF00244	0.586
LIG_14-3-3_CanoR_1	584	594	PF00244	0.643
LIG_Actin_WH2_2	100	115	PF00022	0.382
LIG_BRCT_BRCA1_1	289	293	PF00533	0.617
LIG_BRCT_BRCA1_1	38	42	PF00533	0.452
LIG_CaM_IQ_9	364	380	PF13499	0.464
LIG_deltaCOP1_diTrp_1	419	428	PF00928	0.560
LIG_DLG_GKlike_1	610	617	PF00625	0.615
LIG_EH1_1	138	146	PF00400	0.424
LIG_EH1_1	147	155	PF00400	0.337
LIG_FHA_1	101	107	PF00498	0.412
LIG_FHA_1	191	197	PF00498	0.416
LIG_FHA_1	227	233	PF00498	0.450
LIG_FHA_1	322	328	PF00498	0.618
LIG_FHA_1	336	342	PF00498	0.505
LIG_FHA_1	365	371	PF00498	0.493
LIG_FHA_1	481	487	PF00498	0.686
LIG_FHA_1	87	93	PF00498	0.386
LIG_FHA_2	287	293	PF00498	0.626
LIG_FHA_2	444	450	PF00498	0.587
LIG_FHA_2	528	534	PF00498	0.606
LIG_Integrin_RGD_1	350	352	PF01839	0.558
LIG_Integrin_RGD_1	79	81	PF01839	0.413
LIG_LIR_Apic_2	39	45	PF02991	0.450
LIG_LIR_Gen_1	20	29	PF02991	0.508
LIG_LIR_Gen_1	36	46	PF02991	0.335
LIG_LIR_LC3C_4	89	93	PF02991	0.434
LIG_LIR_Nem_3	167	173	PF02991	0.441
LIG_LIR_Nem_3	20	24	PF02991	0.353
LIG_LIR_Nem_3	36	41	PF02991	0.494
LIG_LIR_Nem_3	392	397	PF02991	0.611
LIG_LIR_Nem_3	563	569	PF02991	0.561
LIG_LYPXL_yS_3	170	173	PF13949	0.421
LIG_NRBOX	215	221	PF00104	0.420
LIG_Rb_pABgroove_1	379	387	PF01858	0.497
LIG_RPA_C_Fungi	74	86	PF08784	0.416
LIG_SH2_CRK	38	42	PF00017	0.452
LIG_SH2_STAP1	21	25	PF00017	0.531
LIG_SH2_STAP1	38	42	PF00017	0.381
LIG_SH2_STAP1	594	598	PF00017	0.578
LIG_SH2_STAT5	13	16	PF00017	0.389
LIG_SH2_STAT5	180	183	PF00017	0.350
LIG_SH2_STAT5	262	265	PF00017	0.552
LIG_SH3_3	493	499	PF00018	0.602
LIG_SH3_3	561	567	PF00018	0.614
LIG_SH3_CIN85_PxpxPR_1	345	350	PF14604	0.589
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.456
LIG_SUMO_SIM_par_1	152	158	PF11976	0.370
LIG_SUMO_SIM_par_1	396	401	PF11976	0.511
LIG_TRAF2_1	133	136	PF00917	0.368
LIG_TRAF2_1	447	450	PF00917	0.461
LIG_TRAF2_1	613	616	PF00917	0.600
LIG_TYR_ITIM	19	24	PF00017	0.320
LIG_UBA3_1	219	226	PF00899	0.468
LIG_WW_3	543	547	PF00397	0.631
MOD_CDC14_SPxK_1	543	546	PF00782	0.633
MOD_CDK_SPK_2	270	275	PF00069	0.556
MOD_CDK_SPK_2	345	350	PF00069	0.589
MOD_CDK_SPxK_1	540	546	PF00069	0.640
MOD_CDK_SPxK_1	604	610	PF00069	0.657
MOD_CDK_SPxxK_3	604	611	PF00069	0.698
MOD_CK1_1	115	121	PF00069	0.356
MOD_CK1_1	261	267	PF00069	0.682
MOD_CK1_1	269	275	PF00069	0.636
MOD_CK1_1	321	327	PF00069	0.619
MOD_CK1_1	332	338	PF00069	0.641
MOD_CK1_1	430	436	PF00069	0.644
MOD_CK1_1	442	448	PF00069	0.464
MOD_CK1_1	474	480	PF00069	0.612
MOD_CK1_1	509	515	PF00069	0.633
MOD_CK1_1	523	529	PF00069	0.580
MOD_CK1_1	551	557	PF00069	0.647
MOD_CK1_1	559	565	PF00069	0.608
MOD_CK1_1	587	593	PF00069	0.794
MOD_CK1_1	596	602	PF00069	0.614
MOD_CK1_1	604	610	PF00069	0.600
MOD_CK1_1	65	71	PF00069	0.588
MOD_CK2_1	130	136	PF00069	0.366
MOD_CK2_1	155	161	PF00069	0.392
MOD_CK2_1	443	449	PF00069	0.586
MOD_CK2_1	527	533	PF00069	0.605
MOD_CK2_1	610	616	PF00069	0.664
MOD_GlcNHglycan	233	236	PF01048	0.502
MOD_GlcNHglycan	256	259	PF01048	0.568
MOD_GlcNHglycan	263	266	PF01048	0.645
MOD_GlcNHglycan	318	321	PF01048	0.650
MOD_GlcNHglycan	334	337	PF01048	0.607
MOD_GlcNHglycan	569	572	PF01048	0.620
MOD_GlcNHglycan	628	631	PF01048	0.605
MOD_GlcNHglycan	64	67	PF01048	0.559
MOD_GlcNHglycan	73	76	PF01048	0.476
MOD_GSK3_1	248	255	PF00069	0.555
MOD_GSK3_1	266	273	PF00069	0.571
MOD_GSK3_1	316	323	PF00069	0.616
MOD_GSK3_1	331	338	PF00069	0.493
MOD_GSK3_1	439	446	PF00069	0.576
MOD_GSK3_1	470	477	PF00069	0.704
MOD_GSK3_1	478	485	PF00069	0.665
MOD_GSK3_1	506	513	PF00069	0.652
MOD_GSK3_1	520	527	PF00069	0.547
MOD_GSK3_1	547	554	PF00069	0.762
MOD_GSK3_1	556	563	PF00069	0.714
MOD_GSK3_1	574	581	PF00069	0.745
MOD_GSK3_1	584	591	PF00069	0.794
MOD_GSK3_1	592	599	PF00069	0.611
MOD_GSK3_1	600	607	PF00069	0.608
MOD_GSK3_1	626	633	PF00069	0.564
MOD_GSK3_1	67	74	PF00069	0.594
MOD_N-GLC_1	531	536	PF02516	0.576
MOD_N-GLC_1	71	76	PF02516	0.488
MOD_NEK2_1	112	117	PF00069	0.356
MOD_NEK2_1	191	196	PF00069	0.384
MOD_NEK2_1	231	236	PF00069	0.485
MOD_NEK2_1	364	369	PF00069	0.500
MOD_NEK2_1	398	403	PF00069	0.565
MOD_NEK2_1	464	469	PF00069	0.685
MOD_NEK2_1	471	476	PF00069	0.640
MOD_NEK2_1	511	516	PF00069	0.652
MOD_NEK2_1	593	598	PF00069	0.592
MOD_PIKK_1	280	286	PF00454	0.612
MOD_PIKK_1	364	370	PF00454	0.450
MOD_PIKK_1	578	584	PF00454	0.635
MOD_PIKK_1	602	608	PF00454	0.658
MOD_PK_1	372	378	PF00069	0.466
MOD_PKA_1	462	468	PF00069	0.624
MOD_PKA_1	610	616	PF00069	0.601
MOD_PKA_2	112	118	PF00069	0.361
MOD_PKA_2	439	445	PF00069	0.538
MOD_PKA_2	462	468	PF00069	0.614
MOD_PKA_2	477	483	PF00069	0.666
MOD_PKA_2	506	512	PF00069	0.649
MOD_PKA_2	515	521	PF00069	0.576
MOD_PKA_2	596	602	PF00069	0.620
MOD_Plk_1	295	301	PF00069	0.493
MOD_Plk_1	372	378	PF00069	0.466
MOD_Plk_1	531	537	PF00069	0.587
MOD_Plk_1	71	77	PF00069	0.494
MOD_Plk_4	100	106	PF00069	0.466
MOD_Plk_4	112	118	PF00069	0.301
MOD_Plk_4	137	143	PF00069	0.429
MOD_Plk_4	149	155	PF00069	0.312
MOD_Plk_4	258	264	PF00069	0.548
MOD_Plk_4	506	512	PF00069	0.649
MOD_Plk_4	589	595	PF00069	0.623
MOD_ProDKin_1	270	276	PF00069	0.591
MOD_ProDKin_1	345	351	PF00069	0.627
MOD_ProDKin_1	540	546	PF00069	0.634
MOD_ProDKin_1	553	559	PF00069	0.617
MOD_ProDKin_1	560	566	PF00069	0.537
MOD_ProDKin_1	604	610	PF00069	0.800
MOD_ProDKin_1	67	73	PF00069	0.603
TRG_DiLeu_BaEn_1	100	105	PF01217	0.459
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.474
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.496
TRG_DiLeu_BaLyEn_6	359	364	PF01217	0.448
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.547
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.310
TRG_ENDOCYTIC_2	170	173	PF00928	0.421
TRG_ENDOCYTIC_2	21	24	PF00928	0.525
TRG_ENDOCYTIC_2	38	41	PF00928	0.296
TRG_ER_diArg_1	216	218	PF00400	0.480
TRG_ER_diArg_1	228	231	PF00400	0.389
TRG_ER_diArg_1	361	363	PF00400	0.465
TRG_ER_diArg_1	436	438	PF00400	0.632
TRG_ER_diArg_1	462	464	PF00400	0.487
TRG_NES_CRM1_1	22	36	PF08389	0.437
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K7	Leptomonas seymouri	44%	93%
A4HKQ0	Leishmania braziliensis	64%	100%
A4I881	Leishmania infantum	100%	100%
E9B339	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q515	Leishmania major	90%	100%