Sphingosine kinase A, B, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sphingosine kinase

Species:

Leishmania donovani

UniProt:

A0A3Q8IGX7_LEIDO

TriTrypDb:

LdBPK_260680.1 , LdCL_260012500 , LDHU3_26.0890

Length:

935

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3Q8IGX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGX7

Function

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Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0006665	sphingolipid metabolic process	4	1
GO:0006670	sphingosine metabolic process	6	1
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	4
GO:0008610	lipid biosynthetic process	4	1

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Molecular functions
Term	Name	Level	Count
GO:0001727	lipid kinase activity	5	5
GO:0003824	catalytic activity	1	10
GO:0003951	NAD+ kinase activity	5	1
GO:0008481	sphinganine kinase activity	5	5
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017050	D-erythro-sphingosine kinase activity	5	10

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	42	46	PF00656	0.636
CLV_C14_Caspase3-7	49	53	PF00656	0.606
CLV_C14_Caspase3-7	595	599	PF00656	0.383
CLV_C14_Caspase3-7	908	912	PF00656	0.447
CLV_NRD_NRD_1	384	386	PF00675	0.485
CLV_NRD_NRD_1	424	426	PF00675	0.404
CLV_NRD_NRD_1	590	592	PF00675	0.523
CLV_PCSK_KEX2_1	384	386	PF00082	0.485
CLV_PCSK_KEX2_1	424	426	PF00082	0.403
CLV_PCSK_KEX2_1	497	499	PF00082	0.720

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P530	Leptomonas seymouri	55%	96%
A0A1X0NSV1	Trypanosomatidae	31%	100%
A0A422NN92	Trypanosoma rangeli	33%	100%
A4HES6	Leishmania braziliensis	74%	100%
A4I203	Leishmania infantum	100%	100%
C9ZS12	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AY50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
Q4Q9C3	Leishmania major	88%	100%

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