LeishMANIAdb
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Sphingosine kinase A, B, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Sphingosine kinase A, B, putative
Gene product:
Sphingosine kinase
Species:
Leishmania donovani
UniProt:
A0A3Q8IGX7_LEIDO
TriTrypDb:
LdBPK_260680.1 * , LdCL_260012500 , LDHU3_26.0890
Length:
935

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0016020 membrane 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A0A3Q8IGX7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGX7

Function

Biological processes
Term Name Level Count
GO:0006066 alcohol metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0006665 sphingolipid metabolic process 4 1
GO:0006670 sphingosine metabolic process 6 1
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 4
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009987 cellular process 1 4
GO:0016310 phosphorylation 5 4
GO:0019751 polyol metabolic process 4 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0034311 diol metabolic process 5 1
GO:0034312 diol biosynthetic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0046173 polyol biosynthetic process 5 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0046512 sphingosine biosynthetic process 5 1
GO:0046519 sphingoid metabolic process 5 1
GO:0046520 sphingoid biosynthetic process 6 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901617 organic hydroxy compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0001727 lipid kinase activity 5 5
GO:0003824 catalytic activity 1 10
GO:0008481 sphinganine kinase activity 5 5
GO:0016301 kinase activity 4 10
GO:0016740 transferase activity 2 10
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 10
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 6
GO:0017050 D-erythro-sphingosine kinase activity 5 10
GO:0003951 NAD+ kinase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 42 46 PF00656 0.636
CLV_C14_Caspase3-7 49 53 PF00656 0.606
CLV_C14_Caspase3-7 595 599 PF00656 0.383
CLV_C14_Caspase3-7 908 912 PF00656 0.447
CLV_NRD_NRD_1 384 386 PF00675 0.485
CLV_NRD_NRD_1 424 426 PF00675 0.404
CLV_NRD_NRD_1 590 592 PF00675 0.523
CLV_PCSK_KEX2_1 384 386 PF00082 0.485
CLV_PCSK_KEX2_1 424 426 PF00082 0.403
CLV_PCSK_KEX2_1 497 499 PF00082 0.720
CLV_PCSK_KEX2_1 589 591 PF00082 0.616
CLV_PCSK_KEX2_1 707 709 PF00082 0.552
CLV_PCSK_PC1ET2_1 497 499 PF00082 0.720
CLV_PCSK_PC1ET2_1 707 709 PF00082 0.552
CLV_PCSK_SKI1_1 189 193 PF00082 0.531
CLV_PCSK_SKI1_1 223 227 PF00082 0.593
CLV_PCSK_SKI1_1 368 372 PF00082 0.406
CLV_PCSK_SKI1_1 426 430 PF00082 0.480
CLV_PCSK_SKI1_1 434 438 PF00082 0.513
CLV_PCSK_SKI1_1 622 626 PF00082 0.451
CLV_PCSK_SKI1_1 630 634 PF00082 0.550
CLV_PCSK_SKI1_1 665 669 PF00082 0.404
CLV_PCSK_SKI1_1 704 708 PF00082 0.548
CLV_PCSK_SKI1_1 710 714 PF00082 0.485
DEG_APCC_DBOX_1 423 431 PF00400 0.513
DEG_APCC_KENBOX_2 307 311 PF00400 0.583
DEG_SCF_FBW7_1 271 278 PF00400 0.701
DEG_SCF_FBW7_1 776 783 PF00400 0.726
DEG_SCF_TRCP1_1 110 115 PF00400 0.691
DEG_SPOP_SBC_1 120 124 PF00917 0.720
DEG_SPOP_SBC_1 62 66 PF00917 0.713
DEG_SPOP_SBC_1 73 77 PF00917 0.650
DOC_CYCLIN_yCln2_LP_2 30 33 PF00134 0.674
DOC_CYCLIN_yCln2_LP_2 842 848 PF00134 0.444
DOC_MAPK_DCC_7 813 822 PF00069 0.456
DOC_MAPK_gen_1 187 196 PF00069 0.533
DOC_MAPK_gen_1 341 349 PF00069 0.430
DOC_MAPK_gen_1 365 373 PF00069 0.401
DOC_MAPK_gen_1 618 627 PF00069 0.627
DOC_MAPK_gen_1 813 822 PF00069 0.456
DOC_MAPK_gen_1 867 876 PF00069 0.351
DOC_MAPK_gen_1 895 903 PF00069 0.434
DOC_MAPK_gen_1 921 931 PF00069 0.444
DOC_MAPK_HePTP_8 810 822 PF00069 0.455
DOC_MAPK_MEF2A_6 187 196 PF00069 0.558
DOC_MAPK_MEF2A_6 365 373 PF00069 0.420
DOC_MAPK_MEF2A_6 665 673 PF00069 0.483
DOC_MAPK_MEF2A_6 813 822 PF00069 0.456
DOC_MAPK_MEF2A_6 895 903 PF00069 0.481
DOC_PP1_RVXF_1 221 227 PF00149 0.621
DOC_PP1_RVXF_1 312 319 PF00149 0.535
DOC_PP1_RVXF_1 663 669 PF00149 0.424
DOC_PP2B_LxvP_1 192 195 PF13499 0.512
DOC_PP2B_LxvP_1 30 33 PF13499 0.674
DOC_PP2B_LxvP_1 625 628 PF13499 0.502
DOC_PP2B_LxvP_1 842 845 PF13499 0.444
DOC_SPAK_OSR1_1 693 697 PF12202 0.471
DOC_USP7_MATH_1 118 122 PF00917 0.724
DOC_USP7_MATH_1 275 279 PF00917 0.710
DOC_USP7_MATH_1 292 296 PF00917 0.635
DOC_USP7_MATH_1 399 403 PF00917 0.408
DOC_USP7_MATH_1 438 442 PF00917 0.648
DOC_USP7_MATH_1 450 454 PF00917 0.741
DOC_USP7_MATH_1 506 510 PF00917 0.625
DOC_USP7_MATH_1 540 544 PF00917 0.452
DOC_USP7_MATH_1 667 671 PF00917 0.363
DOC_USP7_MATH_1 717 721 PF00917 0.537
DOC_USP7_MATH_1 780 784 PF00917 0.785
DOC_USP7_MATH_1 847 851 PF00917 0.387
DOC_USP7_MATH_1 91 95 PF00917 0.650
DOC_USP7_MATH_1 916 920 PF00917 0.427
DOC_USP7_UBL2_3 724 728 PF12436 0.541
DOC_WW_Pin1_4 121 126 PF00397 0.749
DOC_WW_Pin1_4 269 274 PF00397 0.691
DOC_WW_Pin1_4 33 38 PF00397 0.711
DOC_WW_Pin1_4 446 451 PF00397 0.782
DOC_WW_Pin1_4 481 486 PF00397 0.670
DOC_WW_Pin1_4 504 509 PF00397 0.701
DOC_WW_Pin1_4 576 581 PF00397 0.520
DOC_WW_Pin1_4 6 11 PF00397 0.694
DOC_WW_Pin1_4 636 641 PF00397 0.592
DOC_WW_Pin1_4 76 81 PF00397 0.675
DOC_WW_Pin1_4 776 781 PF00397 0.754
LIG_14-3-3_CanoR_1 164 169 PF00244 0.560
LIG_14-3-3_CanoR_1 257 265 PF00244 0.631
LIG_14-3-3_CanoR_1 375 379 PF00244 0.401
LIG_14-3-3_CanoR_1 431 437 PF00244 0.560
LIG_14-3-3_CanoR_1 589 597 PF00244 0.559
LIG_14-3-3_CanoR_1 630 638 PF00244 0.613
LIG_APCC_ABBA_1 474 479 PF00400 0.587
LIG_APCC_ABBA_1 796 801 PF00400 0.550
LIG_BIR_III_4 54 58 PF00653 0.732
LIG_BRCT_BRCA1_1 173 177 PF00533 0.510
LIG_BRCT_BRCA1_1 669 673 PF00533 0.389
LIG_eIF4E_1 799 805 PF01652 0.538
LIG_FHA_1 186 192 PF00498 0.583
LIG_FHA_1 219 225 PF00498 0.662
LIG_FHA_1 231 237 PF00498 0.733
LIG_FHA_1 25 31 PF00498 0.742
LIG_FHA_1 262 268 PF00498 0.760
LIG_FHA_1 288 294 PF00498 0.522
LIG_FHA_1 443 449 PF00498 0.760
LIG_FHA_1 637 643 PF00498 0.595
LIG_FHA_2 202 208 PF00498 0.456
LIG_FHA_2 511 517 PF00498 0.593
LIG_FHA_2 577 583 PF00498 0.558
LIG_FHA_2 631 637 PF00498 0.655
LIG_FHA_2 73 79 PF00498 0.760
LIG_FHA_2 743 749 PF00498 0.488
LIG_Integrin_isoDGR_2 229 231 PF01839 0.695
LIG_Integrin_RGD_1 823 825 PF01839 0.525
LIG_LIR_Gen_1 486 495 PF02991 0.747
LIG_LIR_Gen_1 527 537 PF02991 0.397
LIG_LIR_Gen_1 855 863 PF02991 0.423
LIG_LIR_Nem_3 486 491 PF02991 0.727
LIG_LIR_Nem_3 527 532 PF02991 0.408
LIG_LIR_Nem_3 603 607 PF02991 0.525
LIG_LIR_Nem_3 855 861 PF02991 0.423
LIG_LIR_Nem_3 889 893 PF02991 0.444
LIG_PCNA_yPIPBox_3 152 164 PF02747 0.401
LIG_PCNA_yPIPBox_3 328 341 PF02747 0.438
LIG_PTB_Apo_2 688 695 PF02174 0.419
LIG_SH2_CRK 700 704 PF00017 0.520
LIG_SH2_SRC 87 90 PF00017 0.599
LIG_SH2_STAP1 299 303 PF00017 0.340
LIG_SH2_STAT3 302 305 PF00017 0.517
LIG_SH2_STAT3 799 802 PF00017 0.515
LIG_SH2_STAT5 170 173 PF00017 0.549
LIG_SH2_STAT5 302 305 PF00017 0.468
LIG_SH2_STAT5 392 395 PF00017 0.414
LIG_SH2_STAT5 715 718 PF00017 0.386
LIG_SH2_STAT5 756 759 PF00017 0.522
LIG_SH2_STAT5 799 802 PF00017 0.551
LIG_SH2_STAT5 858 861 PF00017 0.439
LIG_SH2_STAT5 893 896 PF00017 0.348
LIG_SH3_3 479 485 PF00018 0.708
LIG_SUMO_SIM_anti_2 550 555 PF11976 0.448
LIG_SUMO_SIM_anti_2 572 577 PF11976 0.482
LIG_SUMO_SIM_par_1 552 558 PF11976 0.516
LIG_TYR_ITIM 856 861 PF00017 0.429
LIG_UBA3_1 346 353 PF00899 0.401
LIG_UBA3_1 702 710 PF00899 0.569
LIG_UBA3_1 712 721 PF00899 0.552
LIG_WRC_WIRS_1 1 6 PF05994 0.595
LIG_WW_3 627 631 PF00397 0.571
MOD_CDK_SPxxK_3 636 643 PF00069 0.563
MOD_CDK_SPxxK_3 76 83 PF00069 0.628
MOD_CK1_1 11 17 PF00069 0.602
MOD_CK1_1 111 117 PF00069 0.658
MOD_CK1_1 121 127 PF00069 0.731
MOD_CK1_1 3 9 PF00069 0.730
MOD_CK1_1 312 318 PF00069 0.512
MOD_CK1_1 351 357 PF00069 0.326
MOD_CK1_1 374 380 PF00069 0.416
MOD_CK1_1 446 452 PF00069 0.705
MOD_CK1_1 481 487 PF00069 0.758
MOD_CK1_1 61 67 PF00069 0.799
MOD_CK1_1 654 660 PF00069 0.558
MOD_CK1_1 76 82 PF00069 0.724
MOD_CK1_1 765 771 PF00069 0.679
MOD_CK1_1 98 104 PF00069 0.698
MOD_CK2_1 201 207 PF00069 0.470
MOD_CK2_1 510 516 PF00069 0.566
MOD_CK2_1 552 558 PF00069 0.473
MOD_CK2_1 576 582 PF00069 0.527
MOD_CK2_1 72 78 PF00069 0.761
MOD_CK2_1 742 748 PF00069 0.588
MOD_CK2_1 788 794 PF00069 0.580
MOD_CK2_1 907 913 PF00069 0.369
MOD_GlcNHglycan 110 113 PF01048 0.678
MOD_GlcNHglycan 13 16 PF01048 0.788
MOD_GlcNHglycan 173 176 PF01048 0.517
MOD_GlcNHglycan 22 25 PF01048 0.592
MOD_GlcNHglycan 241 244 PF01048 0.737
MOD_GlcNHglycan 320 323 PF01048 0.621
MOD_GlcNHglycan 350 353 PF01048 0.372
MOD_GlcNHglycan 445 448 PF01048 0.798
MOD_GlcNHglycan 452 455 PF01048 0.705
MOD_GlcNHglycan 467 470 PF01048 0.749
MOD_GlcNHglycan 508 511 PF01048 0.668
MOD_GlcNHglycan 542 545 PF01048 0.464
MOD_GlcNHglycan 592 595 PF01048 0.614
MOD_GlcNHglycan 70 73 PF01048 0.679
MOD_GlcNHglycan 790 793 PF01048 0.583
MOD_GlcNHglycan 881 884 PF01048 0.369
MOD_GlcNHglycan 97 100 PF01048 0.721
MOD_GSK3_1 106 113 PF00069 0.701
MOD_GSK3_1 116 123 PF00069 0.614
MOD_GSK3_1 13 20 PF00069 0.771
MOD_GSK3_1 177 184 PF00069 0.509
MOD_GSK3_1 2 9 PF00069 0.753
MOD_GSK3_1 22 29 PF00069 0.628
MOD_GSK3_1 253 260 PF00069 0.617
MOD_GSK3_1 269 276 PF00069 0.571
MOD_GSK3_1 288 295 PF00069 0.666
MOD_GSK3_1 434 441 PF00069 0.599
MOD_GSK3_1 442 449 PF00069 0.638
MOD_GSK3_1 506 513 PF00069 0.650
MOD_GSK3_1 57 64 PF00069 0.722
MOD_GSK3_1 68 75 PF00069 0.811
MOD_GSK3_1 742 749 PF00069 0.498
MOD_GSK3_1 776 783 PF00069 0.768
MOD_GSK3_1 91 98 PF00069 0.745
MOD_GSK3_1 916 923 PF00069 0.412
MOD_LATS_1 255 261 PF00433 0.592
MOD_LATS_1 588 594 PF00433 0.372
MOD_N-GLC_1 20 25 PF02516 0.562
MOD_N-GLC_1 247 252 PF02516 0.578
MOD_N-GLC_1 450 455 PF02516 0.666
MOD_N-GLC_1 576 581 PF02516 0.511
MOD_N-GLC_1 6 11 PF02516 0.700
MOD_N-GLC_1 771 776 PF02516 0.763
MOD_N-GLC_1 780 785 PF02516 0.768
MOD_N-GLC_1 95 100 PF02516 0.792
MOD_NEK2_1 177 182 PF00069 0.559
MOD_NEK2_1 236 241 PF00069 0.736
MOD_NEK2_1 253 258 PF00069 0.688
MOD_NEK2_1 318 323 PF00069 0.565
MOD_NEK2_1 371 376 PF00069 0.355
MOD_NEK2_1 39 44 PF00069 0.732
MOD_NEK2_1 535 540 PF00069 0.389
MOD_NEK2_1 592 597 PF00069 0.597
MOD_NEK2_1 63 68 PF00069 0.607
MOD_NEK2_1 669 674 PF00069 0.389
MOD_NEK2_1 746 751 PF00069 0.518
MOD_NEK2_1 925 930 PF00069 0.444
MOD_NEK2_2 261 266 PF00069 0.554
MOD_NEK2_2 462 467 PF00069 0.621
MOD_NEK2_2 682 687 PF00069 0.590
MOD_NEK2_2 742 747 PF00069 0.560
MOD_NEK2_2 818 823 PF00069 0.515
MOD_NEK2_2 916 921 PF00069 0.444
MOD_OFUCOSY 744 750 PF10250 0.537
MOD_PIKK_1 129 135 PF00454 0.600
MOD_PIKK_1 602 608 PF00454 0.501
MOD_PKA_1 590 596 PF00069 0.513
MOD_PKA_2 17 23 PF00069 0.746
MOD_PKA_2 177 183 PF00069 0.472
MOD_PKA_2 230 236 PF00069 0.708
MOD_PKA_2 374 380 PF00069 0.406
MOD_PKA_2 590 596 PF00069 0.573
MOD_PKA_2 68 74 PF00069 0.631
MOD_PKA_2 746 752 PF00069 0.512
MOD_PKA_2 920 926 PF00069 0.444
MOD_Plk_1 218 224 PF00069 0.657
MOD_Plk_1 247 253 PF00069 0.607
MOD_Plk_1 25 31 PF00069 0.606
MOD_Plk_1 478 484 PF00069 0.793
MOD_Plk_1 602 608 PF00069 0.516
MOD_Plk_2-3 552 558 PF00069 0.558
MOD_Plk_4 247 253 PF00069 0.620
MOD_Plk_4 26 32 PF00069 0.730
MOD_Plk_4 330 336 PF00069 0.470
MOD_Plk_4 401 407 PF00069 0.444
MOD_Plk_4 559 565 PF00069 0.415
MOD_Plk_4 58 64 PF00069 0.578
MOD_ProDKin_1 121 127 PF00069 0.746
MOD_ProDKin_1 269 275 PF00069 0.690
MOD_ProDKin_1 33 39 PF00069 0.715
MOD_ProDKin_1 446 452 PF00069 0.782
MOD_ProDKin_1 481 487 PF00069 0.665
MOD_ProDKin_1 504 510 PF00069 0.692
MOD_ProDKin_1 576 582 PF00069 0.527
MOD_ProDKin_1 6 12 PF00069 0.689
MOD_ProDKin_1 636 642 PF00069 0.580
MOD_ProDKin_1 76 82 PF00069 0.677
MOD_ProDKin_1 776 782 PF00069 0.753
MOD_SUMO_for_1 812 815 PF00179 0.470
MOD_SUMO_rev_2 603 613 PF00179 0.579
TRG_DiLeu_BaLyEn_6 263 268 PF01217 0.566
TRG_ENDOCYTIC_2 700 703 PF00928 0.421
TRG_ENDOCYTIC_2 709 712 PF00928 0.499
TRG_ENDOCYTIC_2 858 861 PF00928 0.425
TRG_ER_diArg_1 589 591 PF00400 0.636
TRG_ER_diArg_1 618 621 PF00400 0.627
TRG_NLS_MonoExtN_4 704 711 PF00514 0.448
TRG_Pf-PMV_PEXEL_1 314 319 PF00026 0.532
TRG_Pf-PMV_PEXEL_1 522 526 PF00026 0.475
TRG_Pf-PMV_PEXEL_1 714 719 PF00026 0.451

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P530 Leptomonas seymouri 55% 96%
A0A1X0NSV1 Trypanosomatidae 31% 100%
A0A422NN92 Trypanosoma rangeli 33% 100%
A4HES6 Leishmania braziliensis 74% 100%
A4I203 Leishmania infantum 100% 100%
C9ZS12 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AY50 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 98%
Q4Q9C3 Leishmania major 88% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS