Charged multivesicular body protein 1a

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicular protein trafficking mediator, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGX6_LEIDO

TriTrypDb:

LdBPK_332010.1 , LdCL_330026900 , LDHU3_33.2920

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000815	ESCRT III complex	3	8
GO:0016363	nuclear matrix	2	8
GO:0032991	protein-containing complex	1	8
GO:0036452	ESCRT complex	2	8
GO:0098796	membrane protein complex	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005768	endosome	7	1
GO:0005770	late endosome	8	1
GO:0005771	multivesicular body	9	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3Q8IGX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGX6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006996	organelle organization	4	8
GO:0007034	vacuolar transport	4	11
GO:0007076	mitotic chromosome condensation	4	8
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	8
GO:0016192	vesicle-mediated transport	4	8
GO:0022402	cell cycle process	2	8
GO:0030261	chromosome condensation	6	8
GO:0046907	intracellular transport	3	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051276	chromosome organization	5	8
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0071840	cellular component organization or biogenesis	2	8
GO:1903047	mitotic cell cycle process	3	8
GO:0008104	protein localization	4	1
GO:0015031	protein transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	73	77	PF00656	0.300
CLV_NRD_NRD_1	184	186	PF00675	0.735
CLV_NRD_NRD_1	59	61	PF00675	0.311
CLV_PCSK_KEX2_1	61	63	PF00082	0.354
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.354
CLV_PCSK_SKI1_1	104	108	PF00082	0.375
CLV_PCSK_SKI1_1	113	117	PF00082	0.397
CLV_PCSK_SKI1_1	40	44	PF00082	0.334
CLV_PCSK_SKI1_1	89	93	PF00082	0.391
DOC_MAPK_gen_1	3	12	PF00069	0.496
DOC_USP7_MATH_1	138	142	PF00917	0.372
DOC_USP7_MATH_1	175	179	PF00917	0.670
DOC_USP7_MATH_1	25	29	PF00917	0.384
DOC_USP7_MATH_1	77	81	PF00917	0.325
DOC_USP7_UBL2_3	100	104	PF12436	0.359
DOC_USP7_UBL2_3	15	19	PF12436	0.330
DOC_USP7_UBL2_3	36	40	PF12436	0.355
DOC_USP7_UBL2_3	41	45	PF12436	0.366
DOC_USP7_UBL2_3	89	93	PF12436	0.469
LIG_14-3-3_CanoR_1	81	90	PF00244	0.354
LIG_FAT_LD_1	152	160	PF03623	0.378
LIG_FHA_1	144	150	PF00498	0.362
LIG_FHA_2	105	111	PF00498	0.365
LIG_LIR_Gen_1	5	16	PF02991	0.441
LIG_LIR_Nem_3	5	11	PF02991	0.457
LIG_Pex14_2	12	16	PF04695	0.316
LIG_PTB_Apo_2	10	17	PF02174	0.462
LIG_SH2_CRK	8	12	PF00017	0.549
LIG_SH2_STAP1	54	58	PF00017	0.354
LIG_SH2_STAP1	8	12	PF00017	0.442
LIG_SH2_STAT5	68	71	PF00017	0.354
LIG_TYR_ITIM	66	71	PF00017	0.384
LIG_UBA3_1	10	19	PF00899	0.337
LIG_UBA3_1	105	113	PF00899	0.380
MOD_CK1_1	143	149	PF00069	0.356
MOD_CK2_1	151	157	PF00069	0.315
MOD_GlcNHglycan	142	145	PF01048	0.329
MOD_GlcNHglycan	166	170	PF01048	0.429
MOD_GlcNHglycan	23	26	PF01048	0.354
MOD_GSK3_1	139	146	PF00069	0.346
MOD_GSK3_1	15	22	PF00069	0.334
MOD_GSK3_1	77	84	PF00069	0.377
MOD_GSK3_1	89	96	PF00069	0.288
MOD_NEK2_1	139	144	PF00069	0.336
MOD_NEK2_1	176	181	PF00069	0.726
MOD_NEK2_1	21	26	PF00069	0.354
MOD_NEK2_1	95	100	PF00069	0.320
MOD_Plk_4	151	157	PF00069	0.354
TRG_ENDOCYTIC_2	68	71	PF00928	0.354
TRG_ENDOCYTIC_2	8	11	PF00928	0.488
TRG_ER_diArg_1	59	62	PF00400	0.354

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2G2	Leptomonas seymouri	50%	100%
A0A0N1IMC7	Leptomonas seymouri	81%	100%
A0A0S4IQI9	Bodo saltans	58%	96%
A0A0S4JPB9	Bodo saltans	45%	100%
A0A1X0P5A2	Trypanosomatidae	45%	99%
A0A3R7NNK8	Trypanosoma rangeli	39%	99%
A0A3S7X9V9	Leishmania donovani	45%	99%
A0A422N603	Trypanosoma rangeli	63%	97%
A4HLQ2	Leishmania braziliensis	86%	100%
A4HNA9	Leishmania braziliensis	46%	100%
A4I952	Leishmania infantum	100%	100%
A4IBY0	Leishmania infantum	45%	100%
C9ZYM6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	99%
D0A6C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	82%
E9AFR7	Leishmania major	45%	100%
E9B427	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B6X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
O60074	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
O96552	Dictyostelium discoideum	42%	100%
P69771	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
Q3SX42	Bos taurus	26%	96%
Q4Q3Z7	Leishmania major	96%	100%
Q54DB1	Dictyostelium discoideum	28%	100%
Q5E994	Bos taurus	41%	100%
Q5F3A2	Gallus gallus	24%	95%
Q5R605	Pongo abelii	47%	100%
Q5RAV2	Pongo abelii	25%	96%
Q5ZKX1	Gallus gallus	40%	100%
Q66IV6	Xenopus laevis	25%	95%
Q6DF27	Xenopus tropicalis	42%	100%
Q6NUD8	Xenopus laevis	46%	100%
Q6NVL7	Xenopus tropicalis	24%	95%
Q6NXD2	Danio rerio	26%	95%
Q6PHF0	Danio rerio	46%	100%
Q7LBR1	Homo sapiens	42%	100%
Q7SYR0	Xenopus laevis	25%	95%
Q7SZB5	Xenopus laevis	42%	100%
Q7ZVB1	Danio rerio	41%	100%
Q84VG1	Oryza sativa subsp. japonica	41%	100%
Q8BJF9	Mus musculus	26%	96%
Q8LE58	Arabidopsis thaliana	43%	100%
Q921W0	Mus musculus	47%	100%
Q941D5	Arabidopsis thaliana	27%	97%
Q99LU0	Mus musculus	42%	100%
Q9CQD4	Mus musculus	42%	100%
Q9HD42	Homo sapiens	47%	100%
Q9SKI2	Arabidopsis thaliana	28%	91%
Q9SSM4	Arabidopsis thaliana	42%	100%
Q9UQN3	Homo sapiens	25%	96%