Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania donovani

UniProt:

A0A3Q8IGX5_LEIDO

TriTrypDb:

LdBPK_360630.1 , LdCL_360011200 , LDHU3_36.0790

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15

Expansion

Sequence features

A0A3Q8IGX5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGX5

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	3
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	467	471	PF00656	0.508
CLV_NRD_NRD_1	137	139	PF00675	0.588
CLV_NRD_NRD_1	2	4	PF00675	0.629
CLV_NRD_NRD_1	230	232	PF00675	0.230
CLV_NRD_NRD_1	375	377	PF00675	0.527
CLV_NRD_NRD_1	432	434	PF00675	0.448
CLV_PCSK_KEX2_1	137	139	PF00082	0.484
CLV_PCSK_KEX2_1	2	4	PF00082	0.618
CLV_PCSK_KEX2_1	230	232	PF00082	0.497
CLV_PCSK_KEX2_1	375	377	PF00082	0.582
CLV_PCSK_KEX2_1	388	390	PF00082	0.504
CLV_PCSK_KEX2_1	419	421	PF00082	0.315
CLV_PCSK_KEX2_1	431	433	PF00082	0.416
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.496
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.308
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.398
CLV_PCSK_SKI1_1	156	160	PF00082	0.375
CLV_PCSK_SKI1_1	175	179	PF00082	0.248
CLV_PCSK_SKI1_1	231	235	PF00082	0.338
CLV_PCSK_SKI1_1	295	299	PF00082	0.400
CLV_PCSK_SKI1_1	476	480	PF00082	0.598
CLV_PCSK_SKI1_1	486	490	PF00082	0.530
DEG_APCC_DBOX_1	406	414	PF00400	0.327
DEG_Nend_UBRbox_1	1	4	PF02207	0.521
DEG_SCF_FBW7_1	67	74	PF00400	0.477
DEG_SPOP_SBC_1	210	214	PF00917	0.496
DOC_CYCLIN_yCln2_LP_2	93	99	PF00134	0.417
DOC_MAPK_gen_1	322	331	PF00069	0.329
DOC_PP1_RVXF_1	154	161	PF00149	0.300
DOC_PP1_RVXF_1	474	480	PF00149	0.594
DOC_PP2B_LxvP_1	93	96	PF13499	0.417
DOC_PP4_FxxP_1	314	317	PF00568	0.325
DOC_USP7_MATH_1	105	109	PF00917	0.484
DOC_USP7_MATH_1	129	133	PF00917	0.676
DOC_USP7_MATH_1	211	215	PF00917	0.456
DOC_USP7_MATH_1	284	288	PF00917	0.381
DOC_USP7_MATH_1	299	303	PF00917	0.413
DOC_USP7_MATH_1	414	418	PF00917	0.439
DOC_USP7_MATH_1	465	469	PF00917	0.521
DOC_USP7_MATH_1	71	75	PF00917	0.615
DOC_USP7_MATH_1	81	85	PF00917	0.629
DOC_WW_Pin1_4	201	206	PF00397	0.475
DOC_WW_Pin1_4	369	374	PF00397	0.625
DOC_WW_Pin1_4	461	466	PF00397	0.494
DOC_WW_Pin1_4	67	72	PF00397	0.667
LIG_14-3-3_CanoR_1	106	110	PF00244	0.521
LIG_14-3-3_CanoR_1	115	121	PF00244	0.585
LIG_14-3-3_CanoR_1	137	143	PF00244	0.571
LIG_14-3-3_CanoR_1	175	184	PF00244	0.582
LIG_14-3-3_CanoR_1	230	236	PF00244	0.384
LIG_14-3-3_CanoR_1	243	251	PF00244	0.517
LIG_14-3-3_CanoR_1	261	266	PF00244	0.442
LIG_14-3-3_CanoR_1	322	331	PF00244	0.357
LIG_14-3-3_CanoR_1	389	393	PF00244	0.602
LIG_14-3-3_CanoR_1	432	438	PF00244	0.454
LIG_14-3-3_CanoR_1	463	473	PF00244	0.669
LIG_14-3-3_CanoR_1	49	59	PF00244	0.591
LIG_BRCT_BRCA1_1	116	120	PF00533	0.655
LIG_BRCT_BRCA1_1	87	91	PF00533	0.558
LIG_FHA_1	216	222	PF00498	0.446
LIG_FHA_1	346	352	PF00498	0.370
LIG_FHA_1	36	42	PF00498	0.410
LIG_FHA_2	211	217	PF00498	0.448
LIG_FHA_2	341	347	PF00498	0.452
LIG_FHA_2	379	385	PF00498	0.507
LIG_FHA_2	87	93	PF00498	0.439
LIG_LIR_Apic_2	312	317	PF02991	0.334
LIG_LIR_Nem_3	405	411	PF02991	0.477
LIG_SH2_STAT5	307	310	PF00017	0.415
LIG_SH2_STAT5	32	35	PF00017	0.489
LIG_SH2_STAT5	422	425	PF00017	0.423
LIG_SH2_STAT5	487	490	PF00017	0.468
LIG_SH3_5	28	32	PF00018	0.509
LIG_Sin3_3	155	162	PF02671	0.278
LIG_Sin3_3	408	415	PF02671	0.312
LIG_SUMO_SIM_par_1	326	332	PF11976	0.361
LIG_SUMO_SIM_par_1	455	461	PF11976	0.491
LIG_TRAF2_1	343	346	PF00917	0.297
LIG_TRFH_1	142	146	PF08558	0.388
LIG_UBA3_1	220	228	PF00899	0.487
MOD_CDC14_SPxK_1	372	375	PF00782	0.416
MOD_CDK_SPxK_1	369	375	PF00069	0.397
MOD_CDK_SPxxK_3	369	376	PF00069	0.423
MOD_CK1_1	100	106	PF00069	0.637
MOD_CK1_1	116	122	PF00069	0.739
MOD_CK1_1	125	131	PF00069	0.635
MOD_CK1_1	169	175	PF00069	0.344
MOD_CK1_1	246	252	PF00069	0.427
MOD_CK1_1	383	389	PF00069	0.499
MOD_CK1_1	452	458	PF00069	0.667
MOD_CK1_1	461	467	PF00069	0.563
MOD_CK1_1	468	474	PF00069	0.495
MOD_CK1_1	55	61	PF00069	0.556
MOD_CK1_1	73	79	PF00069	0.582
MOD_CK2_1	244	250	PF00069	0.496
MOD_CK2_1	340	346	PF00069	0.360
MOD_CK2_1	378	384	PF00069	0.757
MOD_CK2_1	55	61	PF00069	0.563
MOD_CK2_1	63	69	PF00069	0.564
MOD_GlcNHglycan	127	130	PF01048	0.678
MOD_GlcNHglycan	246	249	PF01048	0.278
MOD_GlcNHglycan	265	268	PF01048	0.452
MOD_GlcNHglycan	301	304	PF01048	0.383
MOD_GlcNHglycan	314	317	PF01048	0.416
MOD_GlcNHglycan	325	328	PF01048	0.416
MOD_GlcNHglycan	433	436	PF01048	0.600
MOD_GlcNHglycan	451	454	PF01048	0.664
MOD_GlcNHglycan	470	473	PF01048	0.526
MOD_GlcNHglycan	52	55	PF01048	0.508
MOD_GlcNHglycan	79	82	PF01048	0.634
MOD_GSK3_1	123	130	PF00069	0.704
MOD_GSK3_1	201	208	PF00069	0.469
MOD_GSK3_1	211	218	PF00069	0.413
MOD_GSK3_1	242	249	PF00069	0.587
MOD_GSK3_1	261	268	PF00069	0.429
MOD_GSK3_1	284	291	PF00069	0.301
MOD_GSK3_1	31	38	PF00069	0.511
MOD_GSK3_1	323	330	PF00069	0.381
MOD_GSK3_1	378	385	PF00069	0.754
MOD_GSK3_1	452	459	PF00069	0.577
MOD_GSK3_1	461	468	PF00069	0.523
MOD_GSK3_1	63	70	PF00069	0.566
MOD_GSK3_1	71	78	PF00069	0.567
MOD_GSK3_1	81	88	PF00069	0.619
MOD_NEK2_1	168	173	PF00069	0.430
MOD_NEK2_1	209	214	PF00069	0.406
MOD_NEK2_1	244	249	PF00069	0.464
MOD_NEK2_1	288	293	PF00069	0.343
MOD_NEK2_1	396	401	PF00069	0.403
MOD_NEK2_1	403	408	PF00069	0.401
MOD_NEK2_1	426	431	PF00069	0.395
MOD_NEK2_1	442	447	PF00069	0.438
MOD_NEK2_1	458	463	PF00069	0.561
MOD_NEK2_1	479	484	PF00069	0.572
MOD_NEK2_1	63	68	PF00069	0.554
MOD_NEK2_1	75	80	PF00069	0.492
MOD_OFUCOSY	127	133	PF10250	0.470
MOD_PIKK_1	437	443	PF00454	0.481
MOD_PKA_1	388	394	PF00069	0.481
MOD_PKA_1	431	437	PF00069	0.432
MOD_PKA_2	105	111	PF00069	0.532
MOD_PKA_2	114	120	PF00069	0.576
MOD_PKA_2	229	235	PF00069	0.352
MOD_PKA_2	242	248	PF00069	0.496
MOD_PKA_2	388	394	PF00069	0.481
MOD_PKA_2	431	437	PF00069	0.451
MOD_Plk_1	205	211	PF00069	0.462
MOD_Plk_1	215	221	PF00069	0.426
MOD_Plk_1	345	351	PF00069	0.406
MOD_Plk_1	363	369	PF00069	0.498
MOD_Plk_1	383	389	PF00069	0.499
MOD_Plk_1	55	61	PF00069	0.554
MOD_Plk_4	105	111	PF00069	0.368
MOD_Plk_4	205	211	PF00069	0.501
MOD_Plk_4	345	351	PF00069	0.415
MOD_Plk_4	55	61	PF00069	0.578
MOD_ProDKin_1	201	207	PF00069	0.475
MOD_ProDKin_1	369	375	PF00069	0.633
MOD_ProDKin_1	461	467	PF00069	0.495
MOD_ProDKin_1	67	73	PF00069	0.671
MOD_SUMO_for_1	355	358	PF00179	0.256
TRG_DiLeu_BaEn_1	187	192	PF01217	0.352
TRG_DiLeu_BaEn_1	345	350	PF01217	0.293
TRG_ER_diArg_1	1	3	PF00400	0.628
TRG_ER_diArg_1	137	139	PF00400	0.578
TRG_ER_diArg_1	374	376	PF00400	0.572
TRG_NLS_Bipartite_1	419	435	PF00514	0.356
TRG_NLS_MonoExtC_3	430	436	PF00514	0.424
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I384	Leptomonas seymouri	26%	69%
A0A0N1ILR3	Leptomonas seymouri	50%	88%
A0A0S4J2H1	Bodo saltans	29%	100%
A0A1X0NT03	Trypanosomatidae	26%	88%
A0A3Q8IDW5	Leishmania donovani	28%	70%
A0A3R7NBP1	Trypanosoma rangeli	26%	91%
A4H8W6	Leishmania braziliensis	25%	70%
A4HX90	Leishmania infantum	28%	80%
A4ICS7	Leishmania infantum	99%	100%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	90%
E9AQZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	70%
E9ASH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QEH1	Leishmania major	27%	74%