Cytochrome_b5-like_Heme/Steroid_binding_domain_co ntaining_protein_putative/Pfam:PF00173

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGX1_LEIDO

TriTrypDb:

LdBPK_366980.1 , LdCL_360082400 , LDHU3_36.9320

Length:

146

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	1
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A0A3Q8IGX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	142	146	PF00082	0.627
CLV_PCSK_SKI1_1	24	28	PF00082	0.662
CLV_PCSK_SKI1_1	35	39	PF00082	0.376
DOC_MAPK_MEF2A_6	124	132	PF00069	0.571
DOC_PP2B_PxIxI_1	125	131	PF00149	0.344
DOC_PP4_FxxP_1	70	73	PF00568	0.454
DOC_USP7_MATH_1	73	77	PF00917	0.442
DOC_USP7_MATH_2	31	37	PF00917	0.528
DOC_USP7_UBL2_3	120	124	PF12436	0.469
DOC_WW_Pin1_4	104	109	PF00397	0.472
DOC_WW_Pin1_4	48	53	PF00397	0.346
LIG_14-3-3_CanoR_1	140	145	PF00244	0.584
LIG_14-3-3_CanoR_1	24	34	PF00244	0.703
LIG_14-3-3_CanoR_1	35	42	PF00244	0.347
LIG_BIR_II_1	1	5	PF00653	0.569
LIG_deltaCOP1_diTrp_1	115	121	PF00928	0.441
LIG_FHA_2	36	42	PF00498	0.404
LIG_LIR_Gen_1	51	62	PF02991	0.389
LIG_LIR_Gen_1	76	85	PF02991	0.481
LIG_LIR_Nem_3	122	128	PF02991	0.428
LIG_LIR_Nem_3	2	6	PF02991	0.662
LIG_LIR_Nem_3	51	57	PF02991	0.389
LIG_LIR_Nem_3	76	80	PF02991	0.452
LIG_LYPXL_yS_3	125	128	PF13949	0.409
LIG_Pex14_1	117	121	PF04695	0.432
LIG_SH2_CRK	54	58	PF00017	0.390
LIG_SH2_STAP1	77	81	PF00017	0.487
LIG_SH2_STAT3	138	141	PF00017	0.575
LIG_TRAF2_1	13	16	PF00917	0.577
LIG_TRAF2_1	133	136	PF00917	0.466
LIG_TRAF2_1	95	98	PF00917	0.435
LIG_WRC_WIRS_1	34	39	PF05994	0.610
MOD_CK1_1	8	14	PF00069	0.694
MOD_CK2_1	10	16	PF00069	0.661
MOD_CK2_1	110	116	PF00069	0.538
MOD_CK2_1	35	41	PF00069	0.374
MOD_CK2_1	92	98	PF00069	0.380
MOD_CMANNOS	4	7	PF00535	0.536
MOD_N-GLC_1	48	53	PF02516	0.346
MOD_PKA_2	8	14	PF00069	0.670
MOD_ProDKin_1	104	110	PF00069	0.472
MOD_ProDKin_1	48	54	PF00069	0.346
MOD_SUMO_rev_2	116	126	PF00179	0.559
TRG_ENDOCYTIC_2	125	128	PF00928	0.385
TRG_ENDOCYTIC_2	54	57	PF00928	0.385
TRG_ENDOCYTIC_2	77	80	PF00928	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8C7	Leptomonas seymouri	70%	99%
A0A0N1I2M9	Leptomonas seymouri	38%	90%
A0A0N1I427	Leptomonas seymouri	39%	78%
A0A0S4IM89	Bodo saltans	54%	100%
A0A0S4IWT4	Bodo saltans	42%	85%
A0A0S4KHZ8	Bodo saltans	45%	95%
A0A1X0NM31	Trypanosomatidae	54%	100%
A0A1X0NTL9	Trypanosomatidae	35%	92%
A0A1X0P9U9	Trypanosomatidae	36%	87%
A0A3R7L838	Trypanosoma rangeli	60%	100%
A0A3R7RC54	Trypanosoma rangeli	48%	81%
A0A3S7WTB2	Leishmania donovani	40%	90%
A0A3S7X865	Leishmania donovani	41%	82%
A0A422NSD0	Trypanosoma rangeli	33%	100%
A4H7Y9	Leishmania braziliensis	40%	100%
A4HB24	Leishmania braziliensis	41%	82%
A4HQJ0	Leishmania braziliensis	82%	100%
A4HWB7	Leishmania infantum	40%	100%
A4IA81	Leishmania infantum	41%	82%
C9ZM28	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	95%
C9ZNV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	92%
E9AHZ9	Leishmania infantum	100%	100%
E9AQ17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AUA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B594	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	82%
O00264	Homo sapiens	39%	75%
O13995	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	88%
O55022	Mus musculus	36%	75%
P70580	Rattus norvegicus	35%	75%
Q12091	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	96%
Q17QC0	Bos taurus	37%	75%
Q1JQA5	Bos taurus	39%	86%
Q4Q088	Leishmania major	92%	100%
Q4Q2N9	Leishmania major	41%	82%
Q4QFG4	Leishmania major	41%	100%
Q5RED0	Pongo abelii	39%	75%
Q5XIU9	Rattus norvegicus	36%	67%
Q5ZKN2	Gallus gallus	34%	76%
Q6IUR5	Rattus norvegicus	39%	85%
Q7YZW5	Caenorhabditis elegans	34%	80%
Q80UU9	Mus musculus	36%	67%
Q95250	Sus scrofa	36%	75%
Q9CQ45	Mus musculus	40%	85%
Q9UMX5	Homo sapiens	39%	85%
Q9XFM6	Arabidopsis thaliana	42%	66%
V5DM24	Trypanosoma cruzi	48%	82%