ApaG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF525), putative

Species:

Leishmania donovani

UniProt:

A0A3Q8IGW6_LEIDO

TriTrypDb:

LdBPK_260550.1 , LdCL_260011200 , LDHU3_26.0720

Length:

578

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0009295	nucleoid	2	1
GO:0042645	mitochondrial nucleoid	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3Q8IGW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGW6

Function

Biological processes
Term	Name	Level	Count
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006301	postreplication repair	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0070987	error-free translesion synthesis	8	1
GO:0071704	organic substance metabolic process	2	1
GO:0071897	DNA biosynthetic process	5	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.580
CLV_NRD_NRD_1	182	184	PF00675	0.604
CLV_NRD_NRD_1	290	292	PF00675	0.772
CLV_NRD_NRD_1	321	323	PF00675	0.465
CLV_NRD_NRD_1	84	86	PF00675	0.459
CLV_PCSK_KEX2_1	102	104	PF00082	0.580
CLV_PCSK_KEX2_1	181	183	PF00082	0.657
CLV_PCSK_KEX2_1	321	323	PF00082	0.465
CLV_PCSK_KEX2_1	421	423	PF00082	0.501
CLV_PCSK_KEX2_1	84	86	PF00082	0.459
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.501
CLV_PCSK_PC7_1	178	184	PF00082	0.658
CLV_PCSK_SKI1_1	291	295	PF00082	0.738
CLV_PCSK_SKI1_1	519	523	PF00082	0.667
CLV_PCSK_SKI1_1	9	13	PF00082	0.467
CLV_Separin_Metazoa	318	322	PF03568	0.582
DEG_APCC_DBOX_1	312	320	PF00400	0.486
DEG_SCF_FBW7_1	128	133	PF00400	0.687
DEG_SPOP_SBC_1	369	373	PF00917	0.804
DOC_MAPK_gen_1	291	298	PF00069	0.685
DOC_MAPK_MEF2A_6	479	486	PF00069	0.430
DOC_PP4_FxxP_1	206	209	PF00568	0.590
DOC_PP4_FxxP_1	59	62	PF00568	0.523
DOC_SPAK_OSR1_1	205	209	PF12202	0.597
DOC_USP7_MATH_1	118	122	PF00917	0.722
DOC_USP7_MATH_1	130	134	PF00917	0.702
DOC_USP7_MATH_1	146	150	PF00917	0.664
DOC_USP7_MATH_1	210	214	PF00917	0.670
DOC_USP7_MATH_1	217	221	PF00917	0.512
DOC_USP7_MATH_1	246	250	PF00917	0.641
DOC_USP7_MATH_1	286	290	PF00917	0.744
DOC_USP7_MATH_1	353	357	PF00917	0.703
DOC_USP7_MATH_1	362	366	PF00917	0.809
DOC_USP7_MATH_1	369	373	PF00917	0.807
DOC_USP7_MATH_1	459	463	PF00917	0.376
DOC_USP7_MATH_1	561	565	PF00917	0.718
DOC_USP7_MATH_1	74	78	PF00917	0.585
DOC_WW_Pin1_4	124	129	PF00397	0.730
DOC_WW_Pin1_4	351	356	PF00397	0.796
DOC_WW_Pin1_4	371	376	PF00397	0.732
LIG_14-3-3_CanoR_1	13	19	PF00244	0.390
LIG_14-3-3_CanoR_1	268	275	PF00244	0.712
LIG_14-3-3_CanoR_1	504	508	PF00244	0.517
LIG_14-3-3_CanoR_1	75	83	PF00244	0.518
LIG_Actin_WH2_2	48	63	PF00022	0.505
LIG_Actin_WH2_2	76	92	PF00022	0.600
LIG_APCC_ABBA_1	484	489	PF00400	0.509
LIG_BIR_III_2	125	129	PF00653	0.674
LIG_BRCT_BRCA1_1	143	147	PF00533	0.754
LIG_BRCT_BRCA1_1	461	465	PF00533	0.430
LIG_BRCT_BRCA1_1	76	80	PF00533	0.526
LIG_Clathr_ClatBox_1	432	436	PF01394	0.430
LIG_CtBP_PxDLS_1	196	200	PF00389	0.638
LIG_EVH1_2	202	206	PF00568	0.631
LIG_FHA_1	153	159	PF00498	0.713
LIG_FHA_1	226	232	PF00498	0.459
LIG_FHA_1	298	304	PF00498	0.676
LIG_FHA_1	323	329	PF00498	0.480
LIG_FHA_1	338	344	PF00498	0.440
LIG_FHA_1	371	377	PF00498	0.734
LIG_FHA_1	504	510	PF00498	0.532
LIG_FHA_1	55	61	PF00498	0.502
LIG_FHA_2	15	21	PF00498	0.387
LIG_FHA_2	309	315	PF00498	0.501
LIG_LIR_Apic_2	19	25	PF02991	0.485
LIG_LIR_Apic_2	57	62	PF02991	0.511
LIG_LIR_Gen_1	27	37	PF02991	0.486
LIG_LIR_Gen_1	77	86	PF02991	0.516
LIG_LIR_LC3C_4	429	434	PF02991	0.430
LIG_LIR_Nem_3	220	225	PF02991	0.515
LIG_LIR_Nem_3	27	33	PF02991	0.431
LIG_LIR_Nem_3	49	54	PF02991	0.441
LIG_LIR_Nem_3	6	11	PF02991	0.458
LIG_LIR_Nem_3	77	83	PF02991	0.517
LIG_MYND_1	455	459	PF01753	0.376
LIG_PTB_Apo_2	41	48	PF02174	0.557
LIG_PTB_Phospho_1	41	47	PF10480	0.555
LIG_SH2_CRK	8	12	PF00017	0.458
LIG_SH2_NCK_1	22	26	PF00017	0.530
LIG_SH2_PTP2	408	411	PF00017	0.430
LIG_SH2_SRC	22	25	PF00017	0.532
LIG_SH2_SRC	408	411	PF00017	0.430
LIG_SH2_STAT5	214	217	PF00017	0.572
LIG_SH2_STAT5	342	345	PF00017	0.577
LIG_SH2_STAT5	408	411	PF00017	0.371
LIG_SH3_3	140	146	PF00018	0.639
LIG_SH3_3	155	161	PF00018	0.776
LIG_SH3_3	190	196	PF00018	0.601
LIG_SH3_3	206	212	PF00018	0.378
LIG_SUMO_SIM_par_1	213	221	PF11976	0.637
LIG_SUMO_SIM_par_1	228	235	PF11976	0.341
LIG_SUMO_SIM_par_1	331	337	PF11976	0.470
LIG_SUMO_SIM_par_1	431	436	PF11976	0.430
LIG_SUMO_SIM_par_1	505	511	PF11976	0.584
LIG_TRAF2_1	148	151	PF00917	0.614
LIG_TRAF2_1	281	284	PF00917	0.726
LIG_TRAF2_1	312	315	PF00917	0.565
LIG_TRAF2_1	521	524	PF00917	0.687
LIG_TYR_ITIM	406	411	PF00017	0.430
MOD_CDK_SPxK_1	371	377	PF00069	0.734
MOD_CK1_1	121	127	PF00069	0.734
MOD_CK1_1	149	155	PF00069	0.797
MOD_CK1_1	235	241	PF00069	0.447
MOD_CK1_1	345	351	PF00069	0.625
MOD_CK1_1	371	377	PF00069	0.717
MOD_CK1_1	390	396	PF00069	0.754
MOD_CK1_1	467	473	PF00069	0.376
MOD_CK1_1	73	79	PF00069	0.592
MOD_CK2_1	278	284	PF00069	0.717
MOD_CK2_1	308	314	PF00069	0.493
MOD_CK2_1	353	359	PF00069	0.779
MOD_CK2_1	469	475	PF00069	0.430
MOD_GlcNHglycan	112	115	PF01048	0.706
MOD_GlcNHglycan	120	123	PF01048	0.677
MOD_GlcNHglycan	133	136	PF01048	0.805
MOD_GlcNHglycan	234	237	PF01048	0.419
MOD_GlcNHglycan	254	257	PF01048	0.644
MOD_GlcNHglycan	264	267	PF01048	0.621
MOD_GlcNHglycan	269	272	PF01048	0.651
MOD_GlcNHglycan	347	350	PF01048	0.703
MOD_GlcNHglycan	355	358	PF01048	0.708
MOD_GlcNHglycan	387	390	PF01048	0.770
MOD_GlcNHglycan	466	469	PF01048	0.376
MOD_GlcNHglycan	471	474	PF01048	0.376
MOD_GlcNHglycan	5	8	PF01048	0.518
MOD_GlcNHglycan	510	513	PF01048	0.717
MOD_GlcNHglycan	531	535	PF01048	0.791
MOD_GlcNHglycan	537	540	PF01048	0.849
MOD_GlcNHglycan	555	558	PF01048	0.604
MOD_GlcNHglycan	72	75	PF01048	0.497
MOD_GlcNHglycan	76	79	PF01048	0.471
MOD_GSK3_1	126	133	PF00069	0.656
MOD_GSK3_1	149	156	PF00069	0.721
MOD_GSK3_1	258	265	PF00069	0.732
MOD_GSK3_1	324	331	PF00069	0.517
MOD_GSK3_1	503	510	PF00069	0.544
MOD_GSK3_1	70	77	PF00069	0.558
MOD_N-GLC_1	185	190	PF02516	0.681
MOD_N-GLC_1	287	292	PF02516	0.704
MOD_NEK2_1	232	237	PF00069	0.410
MOD_NEK2_1	262	267	PF00069	0.650
MOD_NEK2_1	297	302	PF00069	0.569
MOD_NEK2_1	370	375	PF00069	0.735
MOD_NEK2_1	478	483	PF00069	0.430
MOD_NEK2_1	515	520	PF00069	0.677
MOD_NEK2_1	89	94	PF00069	0.639
MOD_PIKK_1	146	152	PF00454	0.711
MOD_PKA_2	170	176	PF00069	0.626
MOD_PKA_2	177	183	PF00069	0.660
MOD_PKA_2	267	273	PF00069	0.767
MOD_PKA_2	478	484	PF00069	0.376
MOD_PKA_2	503	509	PF00069	0.531
MOD_PKA_2	529	535	PF00069	0.685
MOD_PKA_2	567	573	PF00069	0.760
MOD_PKA_2	60	66	PF00069	0.485
MOD_PKA_2	74	80	PF00069	0.472
MOD_PKB_1	528	536	PF00069	0.726
MOD_Plk_2-3	273	279	PF00069	0.780
MOD_Plk_4	170	176	PF00069	0.555
MOD_Plk_4	210	216	PF00069	0.680
MOD_Plk_4	235	241	PF00069	0.496
MOD_ProDKin_1	124	130	PF00069	0.730
MOD_ProDKin_1	351	357	PF00069	0.798
MOD_ProDKin_1	371	377	PF00069	0.734
MOD_SUMO_for_1	521	524	PF00179	0.668
MOD_SUMO_rev_2	398	402	PF00179	0.433
MOD_SUMO_rev_2	544	554	PF00179	0.717
TRG_DiLeu_BaEn_1	165	170	PF01217	0.627
TRG_DiLeu_BaEn_1	211	216	PF01217	0.608
TRG_DiLeu_BaEn_1	315	320	PF01217	0.615
TRG_DiLeu_BaLyEn_6	452	457	PF01217	0.376
TRG_ENDOCYTIC_2	408	411	PF00928	0.371
TRG_ENDOCYTIC_2	8	11	PF00928	0.458
TRG_ER_diArg_1	101	103	PF00400	0.577
TRG_ER_diArg_1	181	183	PF00400	0.657
TRG_ER_diArg_1	320	322	PF00400	0.478
TRG_ER_diArg_1	411	414	PF00400	0.430
TRG_ER_diArg_1	83	85	PF00400	0.465
TRG_ER_diArg_1	96	99	PF00400	0.560
TRG_ER_diLys_1	573	578	PF00400	0.833
TRG_NES_CRM1_1	27	41	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I464	Leptomonas seymouri	62%	97%
A0A1X0NSE4	Trypanosomatidae	32%	100%
A4HER3	Leishmania braziliensis	80%	100%
A4I1Z0	Leishmania infantum	100%	100%
E9AY37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9D6	Leishmania major	95%	100%