Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGW2_LEIDO

TriTrypDb:

LdBPK_322520.1 , LdCL_320030400 , LDHU3_32.3110

Length:

813

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3Q8IGW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGW2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.621
CLV_NRD_NRD_1	127	129	PF00675	0.444
CLV_NRD_NRD_1	255	257	PF00675	0.471
CLV_NRD_NRD_1	294	296	PF00675	0.388
CLV_NRD_NRD_1	409	411	PF00675	0.567
CLV_NRD_NRD_1	567	569	PF00675	0.629
CLV_NRD_NRD_1	660	662	PF00675	0.429
CLV_NRD_NRD_1	718	720	PF00675	0.512
CLV_PCSK_KEX2_1	127	129	PF00082	0.444
CLV_PCSK_KEX2_1	255	257	PF00082	0.471
CLV_PCSK_KEX2_1	294	296	PF00082	0.424
CLV_PCSK_KEX2_1	409	411	PF00082	0.602
CLV_PCSK_KEX2_1	560	562	PF00082	0.674
CLV_PCSK_KEX2_1	660	662	PF00082	0.429
CLV_PCSK_KEX2_1	718	720	PF00082	0.512
CLV_PCSK_KEX2_1	788	790	PF00082	0.432
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.674
CLV_PCSK_PC1ET2_1	788	790	PF00082	0.432
CLV_PCSK_SKI1_1	161	165	PF00082	0.436
CLV_PCSK_SKI1_1	202	206	PF00082	0.481
CLV_PCSK_SKI1_1	215	219	PF00082	0.460
CLV_PCSK_SKI1_1	311	315	PF00082	0.504
CLV_PCSK_SKI1_1	560	564	PF00082	0.620
CLV_PCSK_SKI1_1	604	608	PF00082	0.456
CLV_PCSK_SKI1_1	718	722	PF00082	0.402
DEG_SCF_FBW7_1	240	247	PF00400	0.442
DEG_SPOP_SBC_1	176	180	PF00917	0.572
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	450	453	PF00134	0.518
DOC_MAPK_gen_1	331	339	PF00069	0.453
DOC_MAPK_gen_1	481	491	PF00069	0.444
DOC_MAPK_gen_1	568	579	PF00069	0.527
DOC_MAPK_MEF2A_6	568	577	PF00069	0.531
DOC_PP2B_LxvP_1	450	453	PF13499	0.579
DOC_PP2B_LxvP_1	505	508	PF13499	0.404
DOC_USP7_MATH_1	176	180	PF00917	0.611
DOC_USP7_MATH_1	181	185	PF00917	0.633
DOC_USP7_MATH_1	191	195	PF00917	0.576
DOC_USP7_MATH_1	244	248	PF00917	0.459
DOC_USP7_MATH_1	388	392	PF00917	0.605
DOC_USP7_MATH_1	413	417	PF00917	0.576
DOC_USP7_MATH_1	482	486	PF00917	0.399
DOC_USP7_MATH_1	52	56	PF00917	0.656
DOC_USP7_MATH_1	588	592	PF00917	0.652
DOC_USP7_MATH_1	65	69	PF00917	0.518
DOC_USP7_MATH_1	70	74	PF00917	0.518
DOC_USP7_MATH_1	757	761	PF00917	0.416
DOC_WW_Pin1_4	110	115	PF00397	0.377
DOC_WW_Pin1_4	141	146	PF00397	0.479
DOC_WW_Pin1_4	177	182	PF00397	0.655
DOC_WW_Pin1_4	240	245	PF00397	0.403
DOC_WW_Pin1_4	452	457	PF00397	0.606
DOC_WW_Pin1_4	458	463	PF00397	0.509
DOC_WW_Pin1_4	560	565	PF00397	0.623
DOC_WW_Pin1_4	661	666	PF00397	0.592
DOC_WW_Pin1_4	753	758	PF00397	0.513
DOC_WW_Pin1_4	91	96	PF00397	0.789
LIG_14-3-3_CanoR_1	128	138	PF00244	0.387
LIG_14-3-3_CanoR_1	182	188	PF00244	0.636
LIG_14-3-3_CanoR_1	202	211	PF00244	0.458
LIG_14-3-3_CanoR_1	255	262	PF00244	0.501
LIG_14-3-3_CanoR_1	28	32	PF00244	0.444
LIG_14-3-3_CanoR_1	350	357	PF00244	0.396
LIG_14-3-3_CanoR_1	604	614	PF00244	0.502
LIG_14-3-3_CanoR_1	616	620	PF00244	0.515
LIG_14-3-3_CanoR_1	732	738	PF00244	0.493
LIG_14-3-3_CanoR_1	762	766	PF00244	0.341
LIG_14-3-3_CanoR_1	91	95	PF00244	0.588
LIG_Actin_WH2_2	336	352	PF00022	0.450
LIG_Actin_WH2_2	516	534	PF00022	0.320
LIG_Actin_WH2_2	68	83	PF00022	0.602
LIG_APCC_ABBA_1	765	770	PF00400	0.436
LIG_BIR_II_1	1	5	PF00653	0.483
LIG_BRCT_BRCA1_1	324	328	PF00533	0.454
LIG_BRCT_BRCA1_1	353	357	PF00533	0.427
LIG_BRCT_BRCA1_1	428	432	PF00533	0.574
LIG_Clathr_ClatBox_1	139	143	PF01394	0.478
LIG_Clathr_ClatBox_1	363	367	PF01394	0.366
LIG_CtBP_PxDLS_1	623	628	PF00389	0.528
LIG_deltaCOP1_diTrp_1	267	277	PF00928	0.306
LIG_FHA_1	158	164	PF00498	0.368
LIG_FHA_1	206	212	PF00498	0.371
LIG_FHA_1	244	250	PF00498	0.451
LIG_FHA_1	358	364	PF00498	0.325
LIG_FHA_1	502	508	PF00498	0.455
LIG_FHA_1	512	518	PF00498	0.331
LIG_FHA_1	551	557	PF00498	0.495
LIG_FHA_1	607	613	PF00498	0.654
LIG_FHA_1	630	636	PF00498	0.657
LIG_FHA_1	699	705	PF00498	0.418
LIG_FHA_1	738	744	PF00498	0.558
LIG_FHA_2	276	282	PF00498	0.360
LIG_FHA_2	354	360	PF00498	0.518
LIG_FHA_2	419	425	PF00498	0.616
LIG_FHA_2	434	440	PF00498	0.466
LIG_LIR_Gen_1	463	474	PF02991	0.478
LIG_LIR_Gen_1	574	583	PF02991	0.495
LIG_LIR_Gen_1	591	602	PF02991	0.507
LIG_LIR_Gen_1	636	646	PF02991	0.440
LIG_LIR_Nem_3	162	168	PF02991	0.496
LIG_LIR_Nem_3	30	35	PF02991	0.431
LIG_LIR_Nem_3	463	469	PF02991	0.438
LIG_LIR_Nem_3	49	53	PF02991	0.505
LIG_LIR_Nem_3	574	579	PF02991	0.497
LIG_LIR_Nem_3	591	597	PF02991	0.496
LIG_LIR_Nem_3	636	642	PF02991	0.448
LIG_NRBOX	377	383	PF00104	0.416
LIG_NRBOX	578	584	PF00104	0.443
LIG_PAM2_1	708	720	PF00658	0.440
LIG_PTB_Apo_2	163	170	PF02174	0.524
LIG_PTB_Phospho_1	163	169	PF10480	0.515
LIG_RPA_C_Fungi	326	338	PF08784	0.432
LIG_SH2_CRK	466	470	PF00017	0.476
LIG_SH2_CRK	594	598	PF00017	0.503
LIG_SH2_CRK	639	643	PF00017	0.448
LIG_SH2_PTP2	493	496	PF00017	0.399
LIG_SH2_STAP1	438	442	PF00017	0.576
LIG_SH2_STAT5	10	13	PF00017	0.527
LIG_SH2_STAT5	493	496	PF00017	0.373
LIG_SH2_STAT5	709	712	PF00017	0.374
LIG_SH3_2	116	121	PF14604	0.481
LIG_SH3_2	453	458	PF14604	0.584
LIG_SH3_3	108	114	PF00018	0.586
LIG_SH3_3	139	145	PF00018	0.497
LIG_SH3_3	45	51	PF00018	0.584
LIG_SH3_3	450	456	PF00018	0.712
LIG_SUMO_SIM_par_1	362	368	PF11976	0.377
LIG_SUMO_SIM_par_1	503	511	PF11976	0.396
LIG_TRAF2_1	673	676	PF00917	0.483
LIG_TYR_ITIM	491	496	PF00017	0.346
MOD_CDC14_SPxK_1	455	458	PF00782	0.663
MOD_CDK_SPK_2	177	182	PF00069	0.606
MOD_CDK_SPxK_1	452	458	PF00069	0.667
MOD_CK1_1	157	163	PF00069	0.391
MOD_CK1_1	321	327	PF00069	0.442
MOD_CK1_1	352	358	PF00069	0.416
MOD_CK1_1	383	389	PF00069	0.319
MOD_CK1_1	446	452	PF00069	0.611
MOD_CK1_1	645	651	PF00069	0.432
MOD_CK1_1	779	785	PF00069	0.444
MOD_CK2_1	143	149	PF00069	0.469
MOD_CK2_1	244	250	PF00069	0.453
MOD_CK2_1	302	308	PF00069	0.525
MOD_CK2_1	418	424	PF00069	0.676
MOD_CK2_1	433	439	PF00069	0.466
MOD_CK2_1	56	62	PF00069	0.642
MOD_Cter_Amidation	292	295	PF01082	0.410
MOD_DYRK1A_RPxSP_1	458	462	PF00069	0.607
MOD_DYRK1A_RPxSP_1	661	665	PF00069	0.452
MOD_DYRK1A_RPxSP_1	91	95	PF00069	0.533
MOD_GlcNHglycan	131	134	PF01048	0.462
MOD_GlcNHglycan	183	186	PF01048	0.573
MOD_GlcNHglycan	2	5	PF01048	0.523
MOD_GlcNHglycan	246	249	PF01048	0.462
MOD_GlcNHglycan	290	293	PF01048	0.500
MOD_GlcNHglycan	304	307	PF01048	0.438
MOD_GlcNHglycan	382	385	PF01048	0.449
MOD_GlcNHglycan	445	448	PF01048	0.585
MOD_GlcNHglycan	54	57	PF01048	0.635
MOD_GlcNHglycan	58	61	PF01048	0.599
MOD_GlcNHglycan	590	593	PF01048	0.637
MOD_GlcNHglycan	62	66	PF01048	0.565
MOD_GlcNHglycan	644	647	PF01048	0.441
MOD_GlcNHglycan	67	70	PF01048	0.510
MOD_GlcNHglycan	670	673	PF01048	0.515
MOD_GlcNHglycan	710	713	PF01048	0.429
MOD_GlcNHglycan	784	787	PF01048	0.421
MOD_GSK3_1	155	162	PF00069	0.421
MOD_GSK3_1	177	184	PF00069	0.605
MOD_GSK3_1	240	247	PF00069	0.466
MOD_GSK3_1	318	325	PF00069	0.471
MOD_GSK3_1	349	356	PF00069	0.552
MOD_GSK3_1	433	440	PF00069	0.620
MOD_GSK3_1	472	479	PF00069	0.524
MOD_GSK3_1	52	59	PF00069	0.654
MOD_GSK3_1	556	563	PF00069	0.553
MOD_GSK3_1	61	68	PF00069	0.734
MOD_GSK3_1	629	636	PF00069	0.599
MOD_GSK3_1	733	740	PF00069	0.470
MOD_GSK3_1	753	760	PF00069	0.299
MOD_GSK3_1	76	83	PF00069	0.510
MOD_GSK3_1	775	782	PF00069	0.559
MOD_GSK3_1	87	94	PF00069	0.599
MOD_N-GLC_1	357	362	PF02516	0.389
MOD_NEK2_1	154	159	PF00069	0.452
MOD_NEK2_1	205	210	PF00069	0.440
MOD_NEK2_1	27	32	PF00069	0.444
MOD_NEK2_1	349	354	PF00069	0.438
MOD_NEK2_1	357	362	PF00069	0.389
MOD_NEK2_1	432	437	PF00069	0.510
MOD_NEK2_1	582	587	PF00069	0.504
MOD_NEK2_1	624	629	PF00069	0.597
MOD_NEK2_1	659	664	PF00069	0.584
MOD_NEK2_1	80	85	PF00069	0.663
MOD_NEK2_2	192	197	PF00069	0.447
MOD_NEK2_2	733	738	PF00069	0.492
MOD_PKA_2	181	187	PF00069	0.643
MOD_PKA_2	254	260	PF00069	0.442
MOD_PKA_2	27	33	PF00069	0.406
MOD_PKA_2	349	355	PF00069	0.407
MOD_PKA_2	418	424	PF00069	0.657
MOD_PKA_2	615	621	PF00069	0.576
MOD_PKA_2	659	665	PF00069	0.628
MOD_PKA_2	733	739	PF00069	0.487
MOD_PKA_2	761	767	PF00069	0.332
MOD_PKA_2	90	96	PF00069	0.600
MOD_Plk_1	149	155	PF00069	0.387
MOD_Plk_1	357	363	PF00069	0.390
MOD_Plk_1	76	82	PF00069	0.528
MOD_Plk_1	779	785	PF00069	0.555
MOD_Plk_2-3	143	149	PF00069	0.485
MOD_Plk_4	27	33	PF00069	0.397
MOD_Plk_4	323	329	PF00069	0.557
MOD_Plk_4	433	439	PF00069	0.607
MOD_Plk_4	446	452	PF00069	0.645
MOD_Plk_4	733	739	PF00069	0.471
MOD_ProDKin_1	110	116	PF00069	0.374
MOD_ProDKin_1	141	147	PF00069	0.471
MOD_ProDKin_1	177	183	PF00069	0.655
MOD_ProDKin_1	240	246	PF00069	0.396
MOD_ProDKin_1	452	458	PF00069	0.606
MOD_ProDKin_1	560	566	PF00069	0.616
MOD_ProDKin_1	661	667	PF00069	0.600
MOD_ProDKin_1	753	759	PF00069	0.504
MOD_ProDKin_1	91	97	PF00069	0.786
MOD_SUMO_rev_2	671	679	PF00179	0.589
TRG_DiLeu_BaEn_1	19	24	PF01217	0.452
TRG_DiLeu_BaEn_4	149	155	PF01217	0.447
TRG_DiLeu_BaLyEn_6	578	583	PF01217	0.387
TRG_ENDOCYTIC_2	466	469	PF00928	0.470
TRG_ENDOCYTIC_2	493	496	PF00928	0.351
TRG_ENDOCYTIC_2	594	597	PF00928	0.495
TRG_ENDOCYTIC_2	639	642	PF00928	0.453
TRG_ER_diArg_1	254	256	PF00400	0.468
TRG_ER_diArg_1	408	410	PF00400	0.585
TRG_ER_diArg_1	483	486	PF00400	0.455
TRG_ER_diArg_1	659	661	PF00400	0.417
TRG_ER_diArg_1	717	719	PF00400	0.516
TRG_NES_CRM1_1	495	510	PF08389	0.455
TRG_Pf-PMV_PEXEL_1	687	691	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXT3	Leptomonas seymouri	47%	100%
A4HKM7	Leishmania braziliensis	72%	100%
A4I860	Leishmania infantum	99%	100%
D0AAC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B315	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q539	Leishmania major	90%	100%