DNA-binding protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA-binding protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3Q8IGW1_LEIDO

TriTrypDb:

LdBPK_366820.1 , LdCL_360080700 , LDHU3_36.9100

Length:

136

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A0A3Q8IGW1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3Q8IGW1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.336
CLV_PCSK_KEX2_1	11	13	PF00082	0.300
CLV_PCSK_KEX2_1	132	134	PF00082	0.336
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.300
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.309
DEG_Nend_UBRbox_3	1	3	PF02207	0.628
DOC_CDC14_PxL_1	41	49	PF14671	0.351
DOC_MAPK_FxFP_2	42	45	PF00069	0.351
DOC_MAPK_gen_1	11	17	PF00069	0.472
DOC_MAPK_gen_1	34	43	PF00069	0.272
DOC_PP4_FxxP_1	42	45	PF00568	0.351
DOC_USP7_MATH_1	3	7	PF00917	0.586
LIG_14-3-3_CanoR_1	102	111	PF00244	0.304
LIG_14-3-3_CterR_2	133	136	PF00244	0.523
LIG_eIF4E_1	44	50	PF01652	0.313
LIG_FHA_1	24	30	PF00498	0.339
LIG_FHA_1	36	42	PF00498	0.400
LIG_FHA_1	75	81	PF00498	0.504
LIG_LIR_Apic_2	60	66	PF02991	0.292
LIG_LIR_Gen_1	19	28	PF02991	0.347
LIG_LIR_Gen_1	4	15	PF02991	0.515
LIG_LIR_Gen_1	76	86	PF02991	0.500
LIG_LIR_Nem_3	19	23	PF02991	0.379
LIG_LIR_Nem_3	4	10	PF02991	0.601
LIG_LIR_Nem_3	76	81	PF02991	0.518
LIG_LIR_Nem_3	83	88	PF02991	0.360
LIG_LYPXL_S_1	43	47	PF13949	0.351
LIG_LYPXL_yS_3	44	47	PF13949	0.351
LIG_Pex14_2	14	18	PF04695	0.313
LIG_Pex14_2	53	57	PF04695	0.328
LIG_SH2_CRK	63	67	PF00017	0.519
LIG_SH2_CRK	7	11	PF00017	0.504
LIG_SH2_CRK	78	82	PF00017	0.297
LIG_SH2_STAP1	59	63	PF00017	0.401
LIG_SH2_STAT3	59	62	PF00017	0.302
LIG_SH2_STAT5	125	128	PF00017	0.454
LIG_SH2_STAT5	24	27	PF00017	0.455
LIG_SH2_STAT5	59	62	PF00017	0.459
LIG_SH3_1	63	69	PF00018	0.465
LIG_SH3_3	63	69	PF00018	0.457
LIG_SUMO_SIM_anti_2	46	51	PF11976	0.313
LIG_UBA3_1	126	134	PF00899	0.533
LIG_WRC_WIRS_1	17	22	PF05994	0.415
MOD_CK1_1	128	134	PF00069	0.578
MOD_GSK3_1	121	128	PF00069	0.313
MOD_NEK2_1	80	85	PF00069	0.296
MOD_Plk_1	3	9	PF00069	0.569
MOD_Plk_4	121	127	PF00069	0.351
MOD_Plk_4	43	49	PF00069	0.357
MOD_Plk_4	74	80	PF00069	0.548
TRG_DiLeu_BaEn_1	76	81	PF01217	0.500
TRG_ENDOCYTIC_2	44	47	PF00928	0.311
TRG_ENDOCYTIC_2	7	10	PF00928	0.559
TRG_ENDOCYTIC_2	78	81	PF00928	0.379
TRG_ER_diLys_1	132	136	PF00400	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1A5	Leptomonas seymouri	66%	95%
A0A3R7MNP5	Trypanosoma rangeli	22%	95%
A4HQH4	Leishmania braziliensis	79%	100%
A4ICB0	Leishmania infantum	98%	100%
E9AU87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q0A4	Leishmania major	94%	100%